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All Journal Journal of Tropical Biodiversity and Biotechnology BIOEDUSCIENCE
Prastita, Nenes
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology

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Profiling of Single Garlic Extract Microencapsulation: Characterization, Antioxidant Activity, and Release Kinetic Lestari, Sri Rahayu; Ghofur, Abdul; Maslikah, Siti Imroatul; Sunaryono, Sunaryono; Rahma, Amalia Nur; Aisyah, Dahniar Nur; Mufidah, Ikfi Nihayatul; Rifqi, Nadiya Dini; Prastita, Nenes; Miasih, Dewi Sekar; Baroroh, Alif Rosyidah El
Journal of Tropical Biodiversity and Biotechnology Vol 8, No 3 (2023): December
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jtbb.79072

Abstract

Single garlic is known to have many benefits as an alternative therapy for various types of metabolic syndrome. The bioactive compounds, allicin and alliin, in garlic are unstable and easily degraded in digestion. Chitosan-alginate microencapsulation is thought to increase stability and protect active compound so its therapeutic effect is more optimal. This study aimed to characterize the microencapsulation chitosan-alginate of single garlic extract (MCA- SGE), as well as to examine the antioxidant activity and kinetic release of MCA-SGE in vitro. The research procedure includes the steps of single garlic extraction, preparation of MCA-SGE, characterization of MCA-SGE (PSA, SEM, and FTIR) as well as biological testing of MCA-SGE through antioxidant activity and kinetic release tests. PSA results showed the mean particle size of MCA-SGE was 439.0 ± 1.9 nm or 0.4 m with a polydispersity index (PDI) value of 0.579 ± 0.046 and a zeta potential value of 15.4 ± 0.3 mV. The SEM results showed that the morphology of MCA-SGE was spherical with a smooth surface and a micrometre size of 0.4 - 0.7 µm. The FTIR results describe a shift in absorption and addition of SGE functional groups after encapsulation. The results of the antioxidant activity test showed the antioxidant activity of MCA-SGE was 65%, while SGE was 55%. The results of the kinetic release showed that more allicin and alliin were released by SGE than MCA-SGE during the 4-hour kinetic release simulation. MCA-SGE has the potential to be used as a drug delivery system with controlled release.
Formulation and Physicochemical Characterization of a Macroemulsion Containing Ethanolic Extract of Kemuning Leaves (Murraya paniculata (L.) Jack) Weningtyas, Anditri; Wiratama, Arif Ladika; Wibisono, Taurisma Aulia Nanda; Septiananda, Farsya Hidayah; Prastita, Nenes
BIOEDUSCIENCE Vol 10 No 1 (2026): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/20395

Abstract

Background: Ethanolic extract of Murraya paniculata leaves contains several bioactive constituents, but its direct application is limited by physicochemical instability and solubility issues. Objective: This study aimed to formulate and characterize macroemulsions containing ethanolic extract of Murraya paniculata leaves and to identify the most promising formulation based on physicochemical evaluation.   Methods: The extract was prepared by maceration using 96% ethanol. Four macroemulsion formulations were developed using different ratios of virgin coconut oil, Tween 80, PEG 400, and water. The formulations were evaluated through phytochemical screening, organoleptic properties, emulsion type, transmittance, particle size distribution, pH, zeta potential, centrifugation, and cycling test.   Results: The extract contained flavonoids, alkaloids, tannins/phenolics, and triterpenoids. All formulations were identified as oil-in-water emulsions. Based on the reported data, F2 showed high transmittance and a low polydispersity index, while F1 and F2 demonstrated better physical stability than F3 and F4.   Conclusions: The study indicates that F1 and F2 were the most promising formulations; however, the claim of a single best formulation should be supported by complete, consistently presented particle-size, zeta-potential, and stability data.
Co-Authors Abdul Ghofur Aisyah, Dahniar Nur Anditri Weningtyas Baroroh, Alif Rosyidah El Miasih, Dewi Sekar Mufidah, Ikfi Nihayatul Rahma, Amalia Nur Rifqi, Nadiya Dini Septiananda, Farsya Hidayah Siti Imroatul Maslikah Sri Rahayu Lestari Sunaryono Sunaryono, Sunaryono Wibisono, Taurisma Aulia Nanda Wiratama, Arif Ladika