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All Journal Dental Journal (Majalah Kedokteran Gigi) Jurnal Pengabdian Masyarakat Dentmas
Mayangsari, Regilia Shinta
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Dentistry

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Amelogenin and alkaline phosphatase expression in ameloblast after saltwater fish consumption in pregnant mice (Mus musculus) Christiono, Sandy; Pradopo, Seno; Sudiana, I Ketut; Hutami, Islamy Rahma; Mayangsari, Regilia Shinta; Rochmah, Yayun Siti; Ibrahim, Zurairah
Dental Journal (Majalah Kedokteran Gigi) Vol. 56 No. 3 (2023): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i3.p166-171

Abstract

Background: The intricate process of tooth formation during embryonic development ensures sufficient nutrition for the growth of healthy dental tissues. Amelogenin and alkaline phosphatase (ALP) are serine proteinases secreted by the ameloblast during the transition and maturation phases of the amelogenesis process. Consumption of saltwater fish is predicted to increase the expression of amelogenin and ALP in ameloblast cells during tooth formation. Only now have the function of each gene, tooth-forming cells, and the proteins they produce in the biomolecular amelogenesis of tooth enamel, which began during prenatal development, been clarified. Purpose: This study aims to determine how saltwater fish powder affects the ability of mother mice to increase the expression of amelogenin and ALP in cell ameloblast. Methods: Using a completely randomized design, this study was experimental and aimed to examine the effects of sardine (Sardinella fimbriata), splendid ponyfish (Leiognathus splendens), and tuna (Euthynnus affinis) powder. As samples, twenty-four female mice (Mus musculus) were used. Two groups of mice were created: group 1 (2.14 mg/0.5 ml) and the control group. The expression of amelogenin and ALP was determined using immunohistochemistry (IHC) and t-test (p0.05). Results: Expression of ameloblast was significantly different between the treatment and control groups (p0.05). Conclusion: The consumption of saltwater fish reduces the amelogenin and ALP expressions of mouse fetal ameloblast cells during tooth development in vivo.
Co-Authors Arlina Nurhapsari Dimas P. P., Muhammad Eko Hadianto, Eko Helmi Fathurrahman, Helmi Ibrahim, Zurairah Indrawati, Silvia Vera Islamy Rahma Hutami, Islamy Rahma Muhammad Dian Firdausy, Muhammad Novianti, Shella Indri Nurazky, Savira Poetri, Adisty Restu Pratama, Muhammad Dimas Putra Putra Pratama, Muhammad Dimas Putri, Adisty Restu Rahadian, Arief Ratnawati, Irma Dewi Rosa Pratiwi, Rosa S.Pd. M Kes I Ketut Sudiana . Sandy Christiono Seno Pradopo Setyaningrum, Yunita Shella Indri Novianty, Shella Indri Suhartono, Budi Yayun Siti Rochmah Yuniar, Savira Nurazky