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All Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Mustikarani, Dewi
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Medicine & Pharmacology

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Prevalence and Association of Helicobacter Pylori Infection in Bowel Disease at Dr. Cipto Mangunkusumo General National Hospital 2010–2021 Simadibrata, Marcellus; Mustikarani, Dewi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 3 (2023): VOLUME 24, NUMBER 3, December, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2432023222

Abstract

BSTRACT[WU1] [DM2] Background: Recent studies showed contrasting associations between Helicobacter pylori infection and organic bowel disorders, where positive associations were reported in colorectal carcinoma (CRC) and colorectal polyp, while a protective association was observed in patients with inflammatory bowel diseases (IBD). We aim to determine the association between H. pylori infection and CRC, colorectal polyps, and IBD in Indonesian tertiary Hospital.Method: We retrospectively collected data from patients referred to Dr. Cipto Mangunkusumo General National Hospital from 2010 to 2021 with a complete H. pylori test from electronic medical records. We performed a chi-square analysis and logistic regression with a significant p-value of 0.05.Results: Three hundred and fourteen patients were enrolled. Overall, the prevalence of H. pylori infection in organic bowel disease was 61.7% (n = 194), with 9.9% (n = 31) of them having CRC, 20.3% having colorectal polyps (n = 64), and 31.5% (n = 99) having IBD. A proven association between H. pylori infection and IBD was observed (RR = 0.36; 95% CI: 0.18‒0.70; p = 0.000). However, no significant association was found between H. pylori infection and CRC (RR = 0.60; 95% CI: 0.22–1.66; p = 0.31) and colon polyps (RR = 0.59; 95% CI: 0.30–1.15; p = 0.10).Conclusion: Our study suggested an association between H. pylori infection and IBD patients. However, an insignificant association was observed between H. pylori infection, CRC, and colorectal polyps. Keywords: Helicobacter pylori, inflammatory bowel disease, colorectal cancer, colorectal polyps 
Evidence-Based Case Report: Comparison of Potassium Competitive Acid Blocker and Proton Pump Inhibitor as First Line Therapy in Adult Patients with H. pylori Infection Mustikarani, Dewi; Citrawijaya, Henrico; Nursyirwan, Saskia Aziza
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 2 (2024): VOLUME 25, NUMBER 2, August, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2522024%p

Abstract

ABSTRACTBackground: Increased eradication of Helicobacter pylori decreases the incidence of gastric cancer. Vonoprazan is a potassium-competitive acid blocker (PCAB) with a stronger acid production suppression effect than proton pump inhibitors (PPI). Vonoprazan has been recognized as a therapy for gastric acid reflux disease since 2015 in Japan, but the comparison of the effectiveness of PCAB first-line therapy with PPI for adult patients with H. pylori infection is still controversial.Method: A literature search was carried out on three databases: Pubmed, Cochrane, and Scopus on March 30th 2023, using keywords vonoprazan, potassium competitive acid blocker (PCAB), proton pump inhibitor, and H. pylori. There were 7 studies on Pubmed, 26 studies on Cochrane, and 144 studies on Scopus. Critical screening was conducted using the Oxford Centre for Evidence-Based Medicine for systematic reviews and randomized controlled trials. Results: Based on screening of inclusion and exclusion criteria, one study met the criteria. The intention to treat analysis (ITT) showed eradication of H. pylori in the combination of three therapies with PCAB vs PPI of 91.81% vs 75.5% (1,18 [1.08−1.28], p0,0001), no heterogeneity found (I2 = 43%). Analysis per protocol showed PCAB versus PPI eradications of 92.99% vs 78.57% (1,13 [1,02−1,26], p = 0.02), heterogeneity obtained (I 2 = 75%). Conclusion: Generally, PCAB has better eradication than PPI as first-line therapy for adult patients with H. pylori infection Keywords: potassium competitive acid blocker, proton pump inhibitors, helicobacter pylori
Prevalence and Association of Helicobacter pylori Infection in Gastric Disease at Dr. Cipto Mangunkusumo General National Hospital 2010–2021 Simadibrata, Marcellus; Mustikarani, Dewi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 3 (2023): VOLUME 24, NUMBER 3, December, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2432023216

Abstract

Background: Several studies showed contrasting associations between Helicobacter pylori infection and organic gastric disorders. We aim to determine the association between H. pylori infection and gastroesophageal reflux disease (GERD), gastric polyp, and gastric cancer in an Indonesian national referral hospital.Method: Data collected from patients referred to Cipto Mangunkusumo General National Hospital, Jakarta, Indonesia, from 2010 to 2021, with complete H. pylori test and endoscopy from electronic medical record. Chi-square analysis and logistic regression were performed to determine the association with a significant p-value of 0.05.Results: Three hundred and fourteen consecutive patients were enrolled, with a median age of 51.0 (16‒85), and 131 (41.7%) of them were males. The prevalence of H. pylori infection in organic gastric disease was 7.6% (n = 24) with 0.3% (n = 1) of them has gastric cancer, 3.2% gastric polyp (n = 10), and 4.1% (n = 13) GERD. A proven association between H. pylori infection and GERD was observed (RR = 26.42; 95% CI: 76.12‒114.05; p = 0.000) and esophagitis (RR = 2.44; 95% CI: 1.71‒3.49; p = 0.000). However, no significant association was found between H. pylori infection and gastric cancer (RR = 4.07; 95% CI: 0.26‒64.09; p = 0.28), and gastric polyp (RR = 1.16; 95% CI: 0.61‒2.22; p = 0.65).Conclusion: Our study suggested association of H. pylori infection in GERD and oesophagitis patients. Insignificant association was observed between H. pylori infection and gastric cancer, and gastric polyp.Keywords: Helicobacter pylori, esophagitis, GERD, gastric polyps, gastric cancer
The Effectiveness of a High-Protein Liquid Dietary Supplementation in Improving Nutritional Status of Malnourished Patients in Hospital Care: a Preliminary Study Simadibrata, Marcellus; Abdullah, Murdani; Witjaksono, Fiastuti; Muzellina, Virly Nanda; Utari, Amanda Pitarini; Wulandari, Yohannessa; Wijayanti, Ari; Mustikarani, Dewi; Haloho, Raja Mangatur; Rachman, Aditya; Simadibrata, Daniel Martin; Mutiara, Rizka; Renaldi, Kaka
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 1 (2022): VOLUME 23, NUMBER 1, April 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (671.108 KB) | DOI: 10.24871/231202243-51

Abstract

Background: Malnutrition is a very common problem in hospitalized patients. Based on studies conducted in various countries, the prevalence of hospital malnutrition ranges from 20-45%. Hospital malnutrition can occur as a result of insufficient nutrient intake, impaired absorption of nutrients in the gastrointestinal (GI) tract, loss of nutrients due to disease, or increased metabolic requirement during illness. Nutrition is the basis for the healing process as it requires good nutrients through various enzymatic reactions. Some studies have shown that hospital malnutrition increases morbidity, mortality, prolongs the duration of hospitalization, and delays recovery. To improve nutritional status, a high-protein diet can be given. Liquid diet is one of the alternative forms of nutrition because it is easier to swallow.Method: This study was a double-blind randomized controlled trial conducted to assess the effectiveness of high protein liquid dietary supplementation in malnourished hospitalized patients. The patients were assessed for their nutritional status based on ESPEN 2015 criteria. Patients who experienced malnutrition will be divided into 2 groups, namely the control group which was given normal protein liquid diet, while the intervention group was given high protein liquid diet supplementation as much as 2 bottles (200 mL) per day for 7-10 days. Furthermore, the nutritional status of the patient was assessed.Results: By administering high-protein liquid diet supplementation, there was a tendency to increase the strength of the right handgrip in 3 subjects (50%), the tendency to increase body mass index (BMI) in 3 subjects (50%), Subjective Global Assessment (SGA) score improved in 2 subjects with mild/moderate malnutrition (33.3%) and 1 subject with normal nutrition (16.7%), and the tendency to increase the fat-free mass in 3 subjects (50%).Conclusion: The administration of high protein liquid dietary supplementation tended to increase the strength of the right handgrip, BMI, SGA score, and body fat-free mass index.
Combination Treatment in Ulcerative Colitis using 5-Aminosalysilic Acid (5-ASA) and Polysaccharide Peptide of Indonesian Ganoderma lucidum Mycelium Extract Simadibrata, Marcellus; Rachman, Aditya; Budimutiar, Felix; Simadibrata, Paulus; Abdullah, Murdani; Haloho, Raja Mangatur; Wijaya, Anthony Eka; Bisuk, Batara; Maharani, Shabrina; Mustikarani, Dewi; Simadibrata, Daniel Martin; Sugita, Peter
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/24120232-11

Abstract

Background:  Inflammatory bowel disease (IBD) is idiopathic disease characterized by chronic inflammation of the gastrointestinal tract. Polysaccharide peptide of Ganoderma lucidum mycelium extract (PPGL) is considerably a good option for adjunctive therapy of IBD. This study aims to evaluate the benefit of PPGL in patients treated with 5-ASA.Method: A retrospective observational cohort study was conducted to examine the medical records of 124 ulcerative colitis patients. There were 80 patients in intervention group who were treated with a combination of 5-ASA and PPGL, and there were 44 patients in the control group who were treated with 5-ASA only. Clinical and laboratory endpoints were observed at the baseline and after 30, 60, and 90 days. Clinical endpoints included abdominal pain, bloody diarrhea, aphthous stomatitis, and polyarthritis; meanwhile, laboratory endpoints included hemoglobin level, ESR, CRP, fecal calprotectin, M2-pyruvate kinase (MP2K), fecal culture, C. difficile culture, and colonoscopy results. Clinical trials conducted after patient enrollment with registry number ClinicalTrials.gov NCT04029649.Results: On day-30 there was a significant difference between intervention group 45.6%  and control group 2.3% in abdominal pain complaints (p 0.001). Moreover, laboratory parameters of fecal calprotectin (p 0.001), fecal MP2K (p = 0.015), and hemoglobin (p 0.001) were considerably better in intervention group on day-30. These differences were consistently found on day 60 and 90.Conclusion: The study implies potential correlation between PPGL administration and improvement of clinical and laboratory endpoints up to 90 days. A larger randomized, blinded, prospective study is required to confirm these effects in ulcerative colitis.
Co-Authors Aditya Rachman, Aditya Amanda Pitarini Utari Ari Wijayanti Bisuk, Batara Budimutiar, Felix Citrawijaya, Henrico Fiastuti Witjaksono Haloho, Raja Mangatur Kaka Renaldi Maharani, Shabrina Marcellus Simadibrata Murdani Abdullah Mutiara, Rizka Muzellina, Virly Nanda Paulus Simadibrata Saskia Aziza Nursyirwan, Saskia Aziza Simadibrata, Daniel Martin Sugita, Peter Wijaya, Anthony Eka Wulandari, Yohannessa