Garuda - Garba Rujukan Digital

REVIEW ARTIKEL PENGARUH VARIASI KOSOLVEN TERHADAP STABILITAS SIRUP PARACETAMOL Fatimi, Hana Anisa; Manurung, Devi Yanthre Sari; Larasati, Rizky Dwi; Ramadhana, Irma Hazira Awalinda; Putranti, Inneke Nurul Dwi; Kholifatuzzahroh; Shafwa, Mayra
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 8 No. 1 (2024): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v8i1.1767

The syrup is made with the aim of increasing patient acceptance in taking medicine because it is convenient and practical when consumed. Paracetamol is classified as a drug that is rather difficult to dissolve in water with a water solubility of 1: 70 so that in the formulation of syrups it is necessary to assist the dissolution process with several methods such as cosolvention and the addition of surfactants. This review article aims to analyze the studies that have been conducted related to the effect of cosolvent variations on the stability of paracetamol syrup preparation formulations. Several tests were conducted to evaluate the preparation of paracetamol syrup, namely organoleptic test, content determination test, pH test, viscosity test, and specific gravity test. Data was obtained from relevant literature sources such as Google Scholar, ResearchgateNet and Science direct and obtained 10 journals that met the criteria. The use of different cosolvents in syrup will produce different physical values. Paracetamol syrup with PEG 400 and glycerin cosolvents had greater viscosity than paracetamol syrup with propylene glycol and Ryoto sugar ester cosolvents. Paracetamol syrup with PEG 400 and glycerin cosolvents had a greater specific gravity than paracetamol syrup with propylene glycol cosolvents and Ryoto sugar ester surfactant. Based on the results of a review of 10 journal articles, it appears that the use of different cosolvents in paracetamol syrup preparations can modify the preparation and affect the level of stability of the resulting syrup preparation.

Characterization of Banana Peel Pectin (Musa acuminata Colla) as a Potential Halal Pharmaceutical Excipient Tugon, Titian Daru Asmara; Larasati, Rizky Dwi; Adnan, Saepul; Sucimilawati, Eris; Agustiani, Fuji Sintya; Jaswir, Irwandi
Indonesian Journal of Halal Research Vol 5, No 1 (2023): February
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ijhar.v5i1.21285

Indonesian Halal Product Assurance Law No. 33 of 2014 states all products circulating in Indonesia must be halal-certified, including pharmaceuticals. Banana peel waste has the potential to produce pectin compounds as pharmaceutical excipients. This study is aimed at determining the characteristics of banana peel pectin as a potential halal pharmaceutical excipient. It has involved qualitative tests and established characteristics of extract pectin by organoleptic test, acidity (pH) test, solubility, equivalent weight, methoxyl concentration, galacturonic acid concentration, esterification degree, moisture content, and ash content. The yield of pectin produced was 17.19%. The qualitative test showed positive pectin, the characteristics of a white powder that is slightly ash, odorless, has a pH of 6.02, is soluble in water, insoluble in ethanol 96%, has an equivalent weight of 5,000 mg, methoxyl concentration of 2.6%, galacturonic acid concentration of 73.92%, esterification degree of 20.19%, moisture content of 7.139% and ash content of 1.6%. Based on the characterization results, banana peel pectin is, by pectin quality standards, a pharmaceutical excipient, especially as a raw material for manufacturing capsule shells, thickeners, and coating and gelling agents.

FORMULATION AND IN VITRO PENETRATION TESTING OF NUTMEG SEED OIL (Myristica fragrans Houtt.) NANOEMULGEL Lailah, Nashfiatun Nur; Syaputri, Fauziah Ningrum; Larasati, Rizky Dwi; Fatimi, Hana Anisa; Manurung, Devi Yanthre Sari
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1635

Nutmeg seed oil has a low absorption time and is unstable during storage; therefore, so to facilitate this it is made in a nanoemulgel form because it can increase contact time and increase drug penetration into the skin. This study aimed to determine the effect of variations in nutmeg seed oil concentration on the physical characteristics and penetration rate of nanoemulgel preparations. Nanoemulgel was made by mixing the nanoemulsion phase into a gel base with oil concentrations of 4.5%, 5%, and 5.5%. The nanoemulsion physical characteristics results are 90.7–91.1% for the turbidimetry test, 453–516 nm for particle size, 42.4–48.6 mV for the zeta potential test, 6.46–6.66 for the pH test, and O/W for nanoemulsion type. Physical characteristics included organoleptic tests, homogeneity, pH, adhesive power, spreadability, viscosity, and rheology. The penetration rate was determined using the Franz diffusion-cell method. The results showed that the nanoemulgel preparation was white in color and had a characteristic smell of nutmeg oil, a semisolid, homogeneous texture, skin pH of 4.5–6.5, spreadability met the range of 5–7 cm, adhesion of >4 seconds, viscosity of 4000–50000 cPs, and pseudoplastic flow properties. The best formulas are found in Formulas 1 and 2 because the stability test meets the requirements for good physical characteristics. Variations in the concentration of nutmeg oil did not show any influence on the penetration rate, with the flux values ??obtained for each formula being F1 0.0117 mg/cm2hour-1, F2 0.0126 mg/cm2hour-11, and F3 0.0246 mg/cm2hour-1.

Characterization of Banana Peel Pectin (Musa acuminata Colla) as a Potential Halal Pharmaceutical Excipient Tugon, Titian Daru Asmara; Larasati, Rizky Dwi; Adnan, Saepul; Sucimilawati, Eris; Agustiani, Fuji Sintya; Jaswir, Irwandi
Indonesian Journal of Halal Research Vol. 5 No. 1 (2023): February
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ijhar.v5i1.21285

Indonesian Halal Product Assurance Law No. 33 of 2014 states all products circulating in Indonesia must be halal-certified, including pharmaceuticals. Banana peel waste has the potential to produce pectin compounds as pharmaceutical excipients. This study is aimed at determining the characteristics of banana peel pectin as a potential halal pharmaceutical excipient. It has involved qualitative tests and established characteristics of extract pectin by organoleptic test, acidity (pH) test, solubility, equivalent weight, methoxyl concentration, galacturonic acid concentration, esterification degree, moisture content, and ash content. The yield of pectin produced was 17.19%. The qualitative test showed positive pectin, the characteristics of a white powder that is slightly ash, odorless, has a pH of 6.02, is soluble in water, insoluble in ethanol 96%, has an equivalent weight of 5,000 mg, methoxyl concentration of 2.6%, galacturonic acid concentration of 73.92%, esterification degree of 20.19%, moisture content of 7.139% and ash content of 1.6%. Based on the characterization results, banana peel pectin is, by pectin quality standards, a pharmaceutical excipient, especially as a raw material for manufacturing capsule shells, thickeners, and coating and gelling agents.

Edukasi Bahaya Kosmetik Ilegal di Desa Plesungan Kecamatan Gondangrejo Kabupaten Karanganyar Jawa Tengah: Education on the Danger of Illegal Cosmetics in Plesungan Village, Gondangrejo District, Karanganyar District, Central Java Puspitasari, Lia; Larasati, Rizky Dwi; Astuti, Rini Budi; Prabowo, Imam; Sari, Putri Kharisma Novita; Fatimi, Hana Anisa; Nugraha, Akbar Eka; Pribadi, Fitrawan Hernuza
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 10 No. 3 (2025): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v10i3.8449

Cosmetics are one of the products to improve appearance which are increasingly widely used in Indonesia. However, the large number of cosmetic uses is not in line with the quality. In recent years, Badan Pengawas Obat dan Makanan (BPOM) has noticed an increase in the spread of illegal cosmetics in Indonesia. Educational videos are one practical medium that can be used to promote the dangers of illicit cosmetics. This community service program aims to increase public understanding of the dangers of illegal cosmetics circulating on the market. Community service activities are created by creating educational materials and videos that are disseminated to the public directly or via social media. So that through this educational video, the public can understand it well. The activities then looked at the public's initial level of understanding of the dangers of cosmetics by conducting a pre-test. After that, the videos and materials that had been prepared were shown, and then the public's knowledge increased through the post-test. From the results of the pre-test and post-test, it was found that public understanding of the dangers of cosmetics increased by 17.1%. So it can be concluded that this service activity successfully educated the community.

Title

Found 5 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 5 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 5 Documents
Search