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Ariesti, Wiwin
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology Medicine & Pharmacology

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Effectiveness of Calina Papaya Leaf Ethanol Extract on The Red Blood Profile of Wistar Rats Exposed to Cigarette Smoke setiawan, haris; Ariesti, Wiwin
Journal of Biotechnology and Natural Science Vol. 4 No. 1 (2024): June
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jbns.v4i1.10062

Abstract

Cigarette smoke is a source of exogenous free radicals that can affect the blood. Calina Papaya leaves contain secondary metabolites that act as antioxidants. The purpose of the study was to analyze the antioxidant activity of ethanol extract of Calina Papaya leaves using DPPH method and to analyze the difference in red blood profile of wistar rats exposed to cigarette smoke after administration of Calina Papaya Leaves Ethanol Extract (CPLEE). The research method used 24 wistar rats with oral administration of CPLEE for 23 days and exposure to cigarette smoke for 15 days. There are 4 treatments, namely rats not exposed to cigarette smoke and given distilled water (K), rats exposed to cigarette smoke (KN), rats given CPLEE 100 mg/Kg BW then exposed to cigarette smoke (P1) and rats given CPLEE 200 mg/Kg BW then exposed to cigarette smoke (P2). Parameters observed were red blood profile (erythrocyte number, hemoglobin, hematocrit, MCV, MCH, MCHC, RDW). Blood was collected through the orbital sinus and analyzed using a hematology analyzer. Data were analyzed using one way ANOVA and Duncan Multiple Range Test (P<0.05). The results showed the IC50 value of the extract was 1,194.1 ppm while ascorbic acid was 22.92 ppm. The number of erythrocytes, MCV, MCH and RDW showed significant differences between groups with the highest treatment in P1. The conclusion shows that the antioxidant activity of CPLEE is very weak compared to ascorbic acid but the red blood profile (erythrocytes, MCV, MCH, MCHC, RDW) in treatment P1 is higher than other treatments.
Histopathological Effects of Mangosteen (Garcinia mangostana L.) Peel Decoction on Betta Fish (Betta sp.) Liver Ariesti, Wiwin; Aeniah, Siti; Halim, Shuha Ma’muriyah; Sofyantoro, Fajar; Wijayanti, Nastiti; Retnoaji, Bambang; Nuriliani, Ardaning; Saragih, Hendry T.S.S.G.; Rohmah, Zuliyati; Widiyanto, Slamet; Pusparini, Nur Ainun Oktavia; Empra, Desi Eka Putri; Septriani, Nur Indah
Biota Vol 17 No 2 (2024)
Publisher : Universitas Islam Negeri Mataram

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Abstract

Mangosteen (Garcinia mangostana L.) peel contains bioactive compounds known for their health benefits, yet potential toxicity at certain doses remains a concern. This study evaluates the histopathological effects of mangosteen peel decoction on the liver of Betta fish (Betta sp.), a sensitive model organism. Mangosteen peel decoction was prepared and administered to Betta fish at concentrations of 5, 25, and 50 ppm, with a control group receiving no treatment. Fish were observed for changes in swimming activity and appetite over five days. Liver tissues were collected, processed, and analyzed histologically to assess tissue damage including vacuolization, pyknosis, hemorrhage, and necrosis. Data were analyzed using the Kruskal-Wallis and Mann-Whitney tests. Behavioral analysis indicated a dose-dependent reduction in swimming activity and appetite in treated groups. Histopathological examination revealed significant liver damage across all treatment groups, with higher concentrations of decoction correlating with increased hemorrhage, pyknosis, and necrosis. Vacuolization was highest in the control group and lowest in the 50-ppm group. The overall hepatic damage was categorized as moderate, with the control group showing the least damage. Mangosteen peel decoction induced significant hepatic damage in Betta fish, highlighting the cytotoxic effects at higher doses. The observed behavioral and histopathological changes underscore the need for careful consideration of decoction concentrations to avoid adverse effects in aquatic organisms. This study provides crucial insights into the toxicological impacts of mangosteen peel decoction on fish liver health, emphasizing the importance of dose regulation in practical applications. Further research is recommended to explore protective measures and alternative treatments to mitigate liver damage.
Co-Authors Aeniah, Siti Ardaning Nuriliani Bambang Retnoaji Elfrida Ratnawati Empra, Desi Eka Putri Fajar Sofyantoro Halim, Shuha Ma’muriyah Hendry Tri Sakti Saragih Nastiti Wijayanti Pusparini, Nur Ainun Oktavia Rohmah, Zuliyati Septriani, Nur Indah Slamet Widiyanto