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All Journal Bioma : Berkala Ilmiah Biologi Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Biota Biological Environment and Pollution
Pusparini, Nur Ainun Oktavia
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Energy Environmental Science Medicine & Pharmacology

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Histopathological evaluation of hepatic tissue of yellow Rasbora (Rasbora lateristriata) exposed to paracetamol Septriani, Nur Indah; Saribu, Ruth Liananda Citra Dolok; Apriliyani, Tia; Karlina, Ina; Pusparini, Nur Ainun Oktavia; Zusrina, Laili Mufli; Sari, Ria Vinola Septhya; Allimi, Hayu Swari; Supraitno, Murtiadi Erlan; Saeed, Faisal; Simanungkalit, Eben Ezer; Paramita, Pradnya; Retnoaji, Bambang; Sofyantoro, Fajar; Wijayanti, Nastiti
Biological Environment and Pollution Vol. 3 No. 1 (2023)
Publisher : Association for Scientific Computing, Electronics, and Engineering (ASCEE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31763/bioenvipo.v3i1.595

Abstract

Excessive consumption of paracetamol may lead to hepatic necrosis, nephrotoxicity, extra-hepatic lesions, and even fatality in both humans and animals. The objective of this study was to examine the histological changes in the hepatocytes of yellow rasbora (Rasbora lateristriata) exposed to paracetamol. The fish were subjected to varying concentrations of paracetamol over a period of four days. Group I served as the control group without any paracetamol exposure. Groups II, III, and IV were exposed to 2, 3, and 4 mg/L of paracetamol, respectively. A total of six individuals were allocated to each of the four experimental groups. The histological analysis of the hepatic tissue following paracetamol exposure at concentrations of 2, 3, and 4 mg/L revealed hepatic damage characterized by picnosis, necrosis, and vacuolization. In summary, higher concentrations of paracetamol were associated with an increase in the severity of histopathological changes in the hepatic tissues of yellow rasbora.
Mekanisme Penyakit Kardiovaskular terkait Penuaan Nuriliani, Ardaning; Apriliyani, Tia; Pusparini, Nur Ainun Oktavia; Karmilah, Karmilah; Rohmah, Zuliyati; Tunjung, Woro Anindito Sri
Bioma : Berkala Ilmiah Biologi Vol. 26 No 2, Tahun 2024
Publisher : Departemen Biologi, Fakultas Sains dan Matematika, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/bioma.2024.59115

Abstract

Penuaan merupakan proses patofisiologis ditandai dengan penurunan fungsi sel dan jaringan yang menyebabkan peningkatan risiko penyakit terkait penuaan, salah satunya penyakit kardiovaskular. Kajian pustaka ini bertujuan untuk mempelajari mekanisme beberapa penyakit kardiovaskular seperti hipertensi, aritmia, dan stroke. Data kajian berupa data sekunder yang berasal dari jurnal dan artikel tanpa batasan tahun terbit. Basis data yang digunakan yaitu Science direct, google scholar, NCBI, scopus, dan web. Kata kunci yang digunakan untuk pencarian buku, jurnal, dan artikel adalah hipertensi, hypertension mechanism, hypertension factor, stroke diseases, stroke mechanisms, risk factor causes stroke, stroke molecular mechanisms, arrhythmia, arrhythmia disease, arrhythmia mechanism, risk factor of arrhythmia, risk factor of arrhythmia. Hipertensi disebabkan oleh ROS  yang mengikat nitrat oksida (NO) menghasilkan peroksinitrit (ONOO2) sehingga terjadi disfungsi endotel. Aritmia terjadi akibat kondisi inflamasi yang mengaktivasi oksidase NADPH menyebabkan perkembangan fibrilasi atrium kronis. Stroke terjadi akibat penyempitan pembuluh darah yang menyebabkan akumulasi sel senesen dan menginduksi peradangan serta penuaan endotel. Penyakit kardiovaskular seperti hipertensi, aritmia, dan stroke dapat disebabkan oleh mekanisme yang berkaitan dengan penuaan.
Histopathological Effects of Mangosteen (Garcinia mangostana L.) Peel Decoction on Betta Fish (Betta sp.) Liver Ariesti, Wiwin; Aeniah, Siti; Halim, Shuha Ma’muriyah; Sofyantoro, Fajar; Wijayanti, Nastiti; Retnoaji, Bambang; Nuriliani, Ardaning; Saragih, Hendry T.S.S.G.; Rohmah, Zuliyati; Widiyanto, Slamet; Pusparini, Nur Ainun Oktavia; Empra, Desi Eka Putri; Septriani, Nur Indah
Biota Vol 17 No 2 (2024)
Publisher : Universitas Islam Negeri Mataram

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Abstract

Mangosteen (Garcinia mangostana L.) peel contains bioactive compounds known for their health benefits, yet potential toxicity at certain doses remains a concern. This study evaluates the histopathological effects of mangosteen peel decoction on the liver of Betta fish (Betta sp.), a sensitive model organism. Mangosteen peel decoction was prepared and administered to Betta fish at concentrations of 5, 25, and 50 ppm, with a control group receiving no treatment. Fish were observed for changes in swimming activity and appetite over five days. Liver tissues were collected, processed, and analyzed histologically to assess tissue damage including vacuolization, pyknosis, hemorrhage, and necrosis. Data were analyzed using the Kruskal-Wallis and Mann-Whitney tests. Behavioral analysis indicated a dose-dependent reduction in swimming activity and appetite in treated groups. Histopathological examination revealed significant liver damage across all treatment groups, with higher concentrations of decoction correlating with increased hemorrhage, pyknosis, and necrosis. Vacuolization was highest in the control group and lowest in the 50-ppm group. The overall hepatic damage was categorized as moderate, with the control group showing the least damage. Mangosteen peel decoction induced significant hepatic damage in Betta fish, highlighting the cytotoxic effects at higher doses. The observed behavioral and histopathological changes underscore the need for careful consideration of decoction concentrations to avoid adverse effects in aquatic organisms. This study provides crucial insights into the toxicological impacts of mangosteen peel decoction on fish liver health, emphasizing the importance of dose regulation in practical applications. Further research is recommended to explore protective measures and alternative treatments to mitigate liver damage.
Natural Dye as an Alternative to Hematoxylin-Eosin Staining on Histological Preparations Karlina, Ina; Pusparini, Nur Ainun Oktavia; Maharesi, Chesa Ekani; Saeed, Faisal; Retnoaji, Bambang; Saragih, Hendry; Septriani, Nur Indah; Rohmah, Zuliyati; Hadi, Susilo; Nuriliani, Ardaning
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 10, No 2 (2025): June 2025
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v10i2.7909

Abstract

Hematoxylin-eosin is widely utilized in the field of animal microtechniques. However, the need to develop alternative dyes from natural sources such as plants has gained attention. Several studies have shown that many plants contain secondary metabolites with the potential to be developed as natural dyes. Lonchocarpus cyanescens and Syzygium cumini are promising candidates as alternative dyes for hematoxylin, while Lawsonia inermis and Hibiscus sabdariffa have shown potential as substitute dyes for eosin. These plants contain various secondary metabolites, including anthocyanins, flavonoids, chlorophyll, betalains, alkaloids, saponins, tannins, carbohydrates, proteins, phenolics, terpenoids, quinones, coumarins, xanthones, and resins. L. cyanescens exhibits a strong binding affinity to cells and tissues, particularly testicular tissue. Dyes derived from Syzygium cumini have been shown to provide a good staining result for rat liver cells. In contrast, dyes from Lawsonia inermis can stain cytoplasmic components and muscle fibers. Additionally, the dye from Hibiscus sabdariffa is capable of staining various biological components, including sperm, nerve cells, and blood cells. The dye preparation process involved extraction from different plant organs, such as leaves, flowers, and fruit. These findings suggest that secondary metabolites from these four plants hold significant potential for development as natural dyes to replace hematoxylin-eosin in histological applications.
Natural Dye as an Alternative to Hematoxylin-Eosin Staining on Histological Preparations Karlina, Ina; Pusparini, Nur Ainun Oktavia; Maharesi, Chesa Ekani; Saeed, Faisal; Retnoaji, Bambang; Saragih, Hendry; Septriani, Nur Indah; Rohmah, Zuliyati; Hadi, Susilo; Nuriliani, Ardaning
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 10, No 2 (2025): June 2025
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v10i2.7909

Abstract

Hematoxylin-eosin is widely utilized in the field of animal microtechniques. However, the need to develop alternative dyes from natural sources such as plants has gained attention. Several studies have shown that many plants contain secondary metabolites with the potential to be developed as natural dyes. Lonchocarpus cyanescens and Syzygium cumini are promising candidates as alternative dyes for hematoxylin, while Lawsonia inermis and Hibiscus sabdariffa have shown potential as substitute dyes for eosin. These plants contain various secondary metabolites, including anthocyanins, flavonoids, chlorophyll, betalains, alkaloids, saponins, tannins, carbohydrates, proteins, phenolics, terpenoids, quinones, coumarins, xanthones, and resins. L. cyanescens exhibits a strong binding affinity to cells and tissues, particularly testicular tissue. Dyes derived from Syzygium cumini have been shown to provide a good staining result for rat liver cells. In contrast, dyes from Lawsonia inermis can stain cytoplasmic components and muscle fibers. Additionally, the dye from Hibiscus sabdariffa is capable of staining various biological components, including sperm, nerve cells, and blood cells. The dye preparation process involved extraction from different plant organs, such as leaves, flowers, and fruit. These findings suggest that secondary metabolites from these four plants hold significant potential for development as natural dyes to replace hematoxylin-eosin in histological applications.
Co-Authors Aeniah, Siti Allimi, Hayu Swari Apriliyani, Tia Ardaning Nuriliani Ariesti, Wiwin Bambang Retnoaji Empra, Desi Eka Putri Fajar Sofyantoro Halim, Shuha Ma’muriyah Hendry Tri Sakti Saragih Karlina, Ina Karmilah, Karmilah Maharesi, Chesa Ekani Nastiti Wijayanti Pradnya Paramita Rohmah, Zuliyati Saeed, Faisal Saragih, Hendry Sari, Ria Vinola Septhya Saribu, Ruth Liananda Citra Dolok Septriani, Nur Indah Septriani, Nur Indah Simanungkalit, Eben Ezer Slamet Widiyanto Supraitno, Murtiadi Erlan Susilo Hadi, Susilo Woro Anindito Sri Tunjung Zusrina, Laili Mufli