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All Journal Indonesia Berdaya Jurnal EduHealth Jurnal Ilmiah Kesehatan Masyarakat Indonesian Health Journal Bosowa Medical Journal
Saleh, Adriandy
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Deteksi Mutasi A3243G MTDNA pada Penderita Diabetes Melitus Tipe 2 Menggunakan PCR Alelle’s Specific Amplification (PASA) Lestari, Windi; Kasmuddin, Kasmuddin; Rantisari T, A. Meinar Dwi; Saleh, Adriandy
SEHATMAS: Jurnal Ilmiah Kesehatan Masyarakat Vol. 2 No. 3 (2023): Juli 2023
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/sehatmas.v2i3.2588

Abstract

Type 2 diabetes mellitus is one of the most common metabolic disorders caused by a combination of two men factors: impaired insulin secretion by pancreatic β cells and the inability of insulin-sensitive tissues to respond properly to insulin. The genetically predisposed from of diabetes known as type 2 diabetes mellitus produce the ATP required for the secretory process. An A to G mutation at the 3243-nucleotide position of mitochondrial DNA tRNALeu gene is associated with damage. Maternally Inherited Diabetes and Deafness (MIDD), which was identified as the cause of the mutation, the Allele’s Specific Amplification (PASA) PCR method was chosen because it had not been widely used by other researchers and to increase detection accuracy because the A3243G mtDNA mutation is a heteropblastic mutation. The aim of th research was to detect the A3243G mtDNA mutation in type II diabetes mellitus patiens by using Allele’s Specific Amplification (PASA) PCR. This type of qualitative descriptive research. The result showed the appearance of a 200 bp band in 10 out of 15 samples amplified with D1/DN primer pairs for normal mtDNA and D1/DMt prime pairs.
Evaluation Of Side Effects Of First-Line Antiretroviral (ARV) Therapy In HIV Patients At Kassi-Kassi Public Health Center Of Makassar Dwi Rantisari Thayeb, Andi Meinar; Kesrianti, A. Maya; Saputri, Rizky; Saleh, Adriandy
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

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Abstract

The treatment for HIV/AIDS therapy is by administering antiretrovirals (ARVs) for life, therefore it is necessary to monitor patients for side effects or symptoms of ARV toxicity. The aim of this study is to evaluate the side effects of drugs in HIV sufferers who were taking first-line antiretroviral (ARV) drugs at the Kassi-Kassi Public Health Centre of Makassar. This research was quantitative research with descriptive research type. The results showed that of the 36 patients who met the inclusion and exclusion criteria based on their characteristics, the majority of respondents were male (91.67%), in the 25-54 year age group (72.22%), and had a tertiary level education ( 58.33%). Based on the length of time they received antiretroviral drug therapy (ARV), the majority of patients were in the 6 months-5 years category (80.56%), with the most widely used ARV combination being tenofovir + lamivudine + efavirenz (47.22%). The number of patients who did not experience ARV side effects was greater (50.7%) than those who experienced side effects. The most common side effects include:dizziness, nausea, rash, fatigue and sleep disturbances. Even though several patients experienced ARV side effects, judging from the medical records, after treatment of ARV side effects, the patients continued therapy well.
Analisis Sedimen Urine Pada Penduduk Tempat Pembuangan Akhir (TPA) Antang Rantisari Thayeb, Andi Meinar Dwi; Kesrianti, Andi Maya; Saleh, Adriandy
INHEALTH : INDONESIAN HEALTH JOURNAL Vol. 4 No. 1 (2025): INHEALTH JOURNAL
Publisher : CV. Eureka Murakabi Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56314/inhealth.v4i1.291

Abstract

Penelitian ini bertujuan untuk mengetahui indikasi kontaminasi lingkungan yang dapat memengaruhi kesehatan penduduk di sekitar Tempat Pembuangan Akhir (TPA) berdasarkan hasil analisa pemeriksaan sedimen urine. Jenis penelitian yang digunakan adalah Deskripstif observasional untuk mendeteksi sampel urine penduduk Tempat Pembuangan Akhir (TPA) Antang menggunakan metode mikroskopik. Hasil penelitian ini menunjukkan bahwa dari 50 sampel urine yang diperiksa, ditemukan beberapa responden mengalami kelainan pada parameter sedimen urine, dengan persentase abnormalitas tertinggi pada kristal oksalat (20%), eritrosit (16%), dan leukosit (10%). Hal ini dapat mengindikasikan adanya gangguan kesehatan, seperti infeksi saluran kemih atau gangguan fungsi ginjal, yang mungkin dipengaruhi oleh faktor lingkungan di sekitar TPA. Keberadaan bakteri dalam urine (2%) juga mengisyaratkan potensi infeksi yang dapat berhubungan dengan sanitasi yang kurang baik. Oleh karena itu, diperlukan upaya lebih lanjut dalam pemantauan kualitas lingkungan serta peningkatan kesadaran masyarakat terhadap pentingnya menjaga kebersihan dan kesehatan guna mengurangi risiko penyakit akibat paparan limbah.
Hal-Hal Yang Ada Hubungan Dengan Kanker Payudara Pada Penderita Di Beberapa Lokasi Di Wilayah Asia, Eropa Periode Tahun 2010 Sampai Dengan Tahun 2021 Nur, Ajeng Maulidya; Murnita, Ika Azdah; Saleh, Adriandy
Bosowa Medical Journal Vol. 2 No. 1 (2024): Bosowa Medical Journal Januari 2024
Publisher : Fakultas Kedokteran Universitas Bosowa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56326/bmj.v2i1.5376

Abstract

Breast cancer is a disease in which cells in the breast tissue change and divide uncontrollably and form lumps or masses, generally affecting women and mostly starting in the lobules (mammary glands) or in the ducts that connect the lobules to the nipple. The purpose of this study was to find out things that related with breast cancer there were family history of breast cancer, age at first menstruation, menopausal status, age at first childbearing, hormonal contraception, obesity, alcohol. The reasearch method was descriptive using literature objective approach on matters related to breast cancer in the journal of medical research in the literature. The results of the twenty studies analyzed showed that things that were related to breast cancer in several locations in Asia, Europe for the period 2010 to 2021, there were family history of breast cancer (p-value = <0.001), age at first menstruation (p-value = <0.001), menopausal status (p-value = <0.001), age at first childbearing (p-value = 0.002),  hormonal contraception (p-value = <0.001), obesity (p-value = <0.001),  alcohol (p-value = 0.006), had a significant relationship to breast cancer in several locations in Asia, Europe for the period 2010 to 2021. This research hoped to be used as an additional information for improving the role of health workers for prevent and handle the breast cancer.
Formulation and Test of Antibacterial Activity Gel Mask Peel Off Stem and Suruhan Leaves (Peperomia Pellucida L.) Extract Against Propionibacterium Acne Farid, Nurfiddin; Dwi Rantisari Thayeb, Andi Meinar; Sulfiani, Sulfiani; Saleh, Adriandy
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.849 KB)

Abstract

Stems and leaves of suruhan (Peperomia Pellucida L.) contain compounds belonging to the class of flavonoids, alkaloids, tannins, phenols, terpenes and essential oils which have potential as antibacterials. This study aimed to find out whether the stem and leaf extracts of suruhan (Peperomia pellucida L.) can be formulated into a gel peel-off mask preparation that is physically and chemically stable, and can inhibit the acne-causing bacteria Propionibacterium acne. This study used a laboratory experimental method, namely the formulation of Peel off gel mask preparations of stem and leaf extracts with different base concentration variations. Testing the characteristics of the preparation which includes organoleptic test, homogeneity, spreadability test, pH test, drying time test, viscosity test using the cycling test method and for antibacterial activity test using the well diffusion method. The results showed that the gel peel-off mask preparation of suruhan stem and leaf extract (Peperomia pellucida L.) fulfilled the requirements for the characteristics of the preparation both physically and chemically, and could inhibit the growth of acne-causing bacteria (Propionibacterium acne) at a concentration of 2% (15.1 mm), 3%, (17.8 mm) and 4% (19.4 mm) in the zone of strong inhibition. It can be concluded that formulation gel mask preparations Peel off stems and leaves of suruhan (Peperomia pellucida L.) can provide antibacterial activity against Propionibacterium acne with respective inhibition zones of 15.1 mm, 17.8 mm and 19.4 mm which are equally strong in inhibiting Propionibacterium acne bacteria
Pemanfaatan teh kombucha untuk kesehatan dan kecantikan kulit pada masyarakat di Kabupaten Maros Dwi Rantisari, Andi Meinar; Sulfiani, Sulfiani; Rosmayanti, Vivit; Saleh, Adriandy
Indonesia Berdaya Vol 4, No 4 (2023)
Publisher : UKInstitute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/ib.2023553

Abstract

Pemanfaatan Kombucha bukan hanya sebagai minuman probiotik untuk mengatasi permasalahan metabolisme tubuh tapi juga memiliki banyak manfaat untuk memelihara kesehatan kulit dan mengatasi permasalahan kesehatan yang bermanifestasi pada kulit. Kombucha kaya akan antioksidan yang mampu melawan radikal bebas untuk mencegah penuaan dini, dan juga mengandung berbagai macam nutrisi yang bermanfaat untuk kulit seperti vitamin B2, B6 dan B12. Kegiatan Pengabdian Kepada Masyarakat ini dilaksanakan pada hari Rabu, 07 Desember 2022 dan disajikan dalam bentuk edukasi tentang manfaat teh kombucha bagi kesehatan kulit dan praktik pembuatan minuman fermentasi probiotik teh kombucha. Kegiatan ini dilaksanakan di Kantor Desa Moncongloe Bulu, Kecamatan Moncongloe Kabupaten Maros yang dihadiri oleh 33 perserta terdiri dari aparat desa dan ibu-ibu PKK setempat. Tujuan dari kegiatan ini adalah untuk meningkatkan keterampilan masyarakat tentang pembuatan minuman fermentasi probiotik dari teh kombucha sebagai minuman untuk membantu menjaga kesehatan kondisi kulit dari dalam dan juga dapat dimanfaatkan sebagai toner untuk menghidrasi kulit wajah. Metode yang digunakan meliputi persiapan tempat pelatihan, pengisian absensi peserta dan kuisioner, pembukaan acara pelatihan, pelaksanaan dan pelatihan pembuatan minuman kombucha serta dosis dan cara konsumsi kombucha. Berdasarkan hasil kegiatan menunjukkan bahwa informasi tentang pemanfaatan kombucha sebagai minuman fungsional bagi kesehatan kulit sebagian besar belum diketahui oleh masyarakat Desa Moncongloe. Kesimpulan dari kegiatan ini adalah masyarakat mampu memahami materi edukasi tentang pentingnya menjaga kesehatan kulit dan mampu membuat minuman fungsional berbahan dasar fermentasi probiotik kombucha.
Co-Authors Dwi Rantisari Thayeb, Andi Meinar Dwi Rantisari, Andi Meinar Farid, Nurfiddin Kasmuddin, Kasmuddin Kesrianti, A. Maya Kesrianti, Andi Maya Lestari, Windi Murnita, Ika Azdah Nur, Ajeng Maulidya Rantisari T, A. Meinar Dwi Rantisari Thayeb, Andi Meinar Dwi Rizky Saputri, Rizky Sulfiani, Sulfiani Vivit Rosmayanti