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Journal : Edumatsains

Gambaran Persepsi Peserta Didik tentang Kebermanfaatan Buku Pengayaan Ujian Nasional Biologi Fajar Adinugraha
EduMatSains : Jurnal Pendidikan, Matematika dan Sains Vol 2 No 2 (2018): Januari
Publisher : Fakultas Keguruan dan Ilmu Pendidikan, Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/edumatsains.v2i2.600

Abstract

The objective of research is to describe the form and content of the book of enrichment for biology national exam. The title of this book is PREDIKSI. This research also describes the perceptions of students on the advantage of the book PREDIKSI. This research is a descriptive research. The methods applied for the research were study literature and survey. There were 21 samples taken from students who were using the book PREDIKSI with the number of respondents 21 students. The enrichment book entitled PREDIKSI is a book consisting of material summaries used for the enrichment sessions of the biology national exam. This book are contains of a summary of the biology materials, practical memorizing tips, short answeres, essay exercises, and a discussion of questions. The students' perceptions about this book are very positive. It is shown from the average score of students' perceptions of the usefulness of the book is 4.19. This book is expected to be the solution for the students in overcoming anxiety toward Biology National Exam. Keywords: content of PREDIKSI book, students’ perception, advantage
Penentuan Suhu Kalsinasi Optimum CaO dari Cangkang Telur Bebek dan Cangkang Telur Burung Puyuh Nya Daniaty Malau; Fajar Adinugraha
EduMatSains : Jurnal Pendidikan, Matematika dan Sains Vol 4 No 2 (2020): Januari
Publisher : Fakultas Keguruan dan Ilmu Pendidikan, Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/edumatsains.v4i2.1388

Abstract

The need for implants increases with the high number of fracture sufferers resulting from accidents both on the road and workplace accidents. Bioceramics is a ceramic product or component used in the medical and dental industry, especially as an implant or organ replacement. Hydroxyapatite is one type of bioceramics that is widely used because it has osteoconductive properties (can stimulate bone growth), bioactive and biocompatible. This study aims to find the optimal temperature of the calcination process of duck egg shells and quails as the basic ingredients of HAp. The research method is calcination of duck eggshells then the optimum temperature produces the best CaO. The calcination results obtained that the optimum temperature of calcination of duck eggshells and quail eggs was 1000oC for 6 hours. The results obtained are CaO with clean white color powder and fine grain size. Keywords : Quail eggshell, calcination, dugg egg shell
Systematic Review: Anticancer Activity of Chromolaena odorata L. Rivaldi Sitinjak; Marina Silalahi; Fajar Adinugraha
EduMatSains : Jurnal Pendidikan, Matematika dan Sains Vol 10 No 2 (2025): October
Publisher : Fakultas Keguruan dan Ilmu Pendidikan, Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/edumatsains.v10i2.7416

Abstract

Cancer is one of the leading causes of death in the world, and conventional therapies such as chemotherapy and radiotherapy often cause significant side effects. Therefore, natural ingredients are a promising alternative, one of which is Chromolaena odorata, which is known to be rich in flavonoids, alkaloids, and terpenoids. This study aims to systematically review the evidence of anticancer activity of C. odorata based on in vitro and in vivo studies. The literature review was conducted through PubMed, ScienceDirect, Google Scholar, and Web of Science databases using the PRISMA 2020 method, and ten articles were obtained that met the inclusion criteria. The analysis showed that C. odorata extracts and fractions have cytotoxic activity against various cancer cell lines, including breast (MCF-7, T47D, MDA-MB-231, 4T1), cervical (HeLa), liver (HepG2), colon (HT-29, WiDr, HTB), and skin keratinocyte models (HaCaT). The identified mechanisms include induction of apoptosis, arrest of the G₀-G₁ phase of the cell cycle, suppression of proliferation, and modulation of apoptosis-regulating protein expression. Kaempferide compounds emerged as the most potent candidates with low toxicity to normal cells. However, differences in the extraction method, dose, and cell type led to variations in effectiveness, and the combination with cisplatin on MDA-MB-231 cells showed antagonistic effects. Thus, C. odorata has great potential to be developed as a complementary therapy as well as a source of new lead compounds, although further research is needed to evaluate bioavailability, pharmacokinetics, and safety through preclinical and clinical trials.