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Uji Toksisitas Akut Limit Test Ekstrak Etanol 70% Bunga Telang (Clitoria ternatea L.) Hidayati, Listya Nor; Astuti, Karunita Ika; Rizaldi, Gusti
MPI (Media Pharmaceutica Indonesiana) Vol. 6 No. 1 (2024): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v6i1.6364

Bunga Telang (Clitoria ternatea L.) dapat digunakan untuk berbagai pengobatan penyakit, salah satunya sebagai antidiabetes. Pengujian keamanan dari bunga telang masih terbatas untuk pengembangan obat baru. Tujuan penelitian ini untuk mengetahui gejala toksisitas serta nilai LD50 dari uji toksisitas akut. Metode OECD menggunakan hewan uji tikus betina galur wistar, yang dibagi menjadi kelompok kontrol negatif (Na-CMC) dan kelompok perlakuan (ekstrak etanol 70% bunga telang dengan dosis 5000 mg/kgBB). Hewan uji diamati gejala-gejala toksisitas dan berat badannya selama 14 hari. Pengamatan yang dilakukan meliputi kulit dan bulu, mata, tremor (gemetar), konvulsi (kejang), letargi (lesu), diare, dan mati. Hasil menunjukkan ekstrak mengandung alkaloid, fenol, flavonoid, saponin, tanin dan triterpernoid. Positif flavonoid dipertegas dengan identifikasi menggunakan kromatografi lapis tipis. Eluen yang digunakan n-heksan:etil asetat (4:2) dengan penampak bercak AlCl3 5%, nilai Rf yang didapat yaitu 0,77 dan 0,92. Berdasarkan hasil pengamatan, hewan uji tidak mengalami gejala-gejala toksisitas dan tidak mengalami perubahan bermakna pada berat badan hewan uji kontrol negatif dan perlakuan dengan nilai sig (2- tailed) pada Independent T-Test lebih dari 0,05. Hasil uji toksisitas akut menunjukkan nilai LD50 ekstrak etanol 70% bunga telang adalah >5000 mg/kgBB. Berdasarkan klasifikasi BPOM, nilai tersebut termasuk dalam kategori 5 yaitu praktis tidak toksik. Telang Flower (Clitoria ternatea L.) can be used for various treatments of diseases, like antidiabetic. Telang flower needs to be carried about the level of safety samplefor the development of new drugs. This study aimed to determine the symptoms and LD50 value of the acute toxicity with OECD 425 method. The test animals were female Wistar rats divided into controls (Na-CMC) and group with 70% ethanolic extract of telang flower at a doses of 5000 mg/kgBW. The test animals were observed for the symptoms of toxicity and body weight for 14 days. Observations were included skin, eyes, tremors, convulsions, lethargy, diarrhea, and death. The result obtained on alkaloids, phenols, flavonoids, saponins, tannins and triterpenoids. The flavonoids was confirmed by identification using thin layer chromatography with n-hexane: ethyl acetate (4:2) on AlCl3 5% spots, and the RF values obtained were 0.77 and 0.92. The result showed not experience significant changes in the body weight of controls (Na-CMC) and group at a doses of 5000 mg/kgBW with a sig (2-tailed) value on the Independent T-Test of more than 0.05. LD50 value showed of the 70% ethanolic extract of telang flower was > 5000 mg/kgBW. Based in category BPOM classification, it is include in category 5, practically non toxic.

Pharmacokinetics and Toxicity Prediction of Lansium domesticum Corr. Rizaldi, Gusti; Norhayati
MPI (Media Pharmaceutica Indonesiana) Vol. 6 No. 1 (2024): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v6i1.6416

A wide range of compounds has been isolated from Lansium domesticum Corr. Secondary metabolites are commonly utilised as valuable resources for potential drug for research and development. An exemplary drug candidate must possess efficacy against the therapeutic target, safety, and favourable pharmacokinetic characteristics. The objective of this study was to determine the pharmacokinetic characteristics and toxicity potentials of 23 compounds derived from Lansium domesticum Corr. utilising the pKCSM online tool and the drug-likeness using swissADME online tool. Based on pKCSM prediction, compounds 14 (methyl angolensate) and 22 (7,14(27)-Onoceradiene-3,21-dione) from Lansium domesticum Corr. are identified as having favourable pharmacokinetic properties and are not expected to exhibit mutagenic or hepatotoxic effects. The LD50 values for compounds 14 and 22 were 2.983 and 1.813 (mol/kg), respectively, indicating their lethal dosages. In conclusion, only compound 14 that also met all the Lipinski’s Rule of Five.

Rendemen dan Skrining Fitokimia Simplisia Daun Bayam (Amaranthus viridis) Norhayati; Rizaldi, Gusti; Noorwina, Syifa; Anida
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 1 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i1.522

Indonesia is rich in biodiversity. One of the plants that grows widely in Indonesia is spinach (Amaranthus viridis). The aim of this research was to determine the secondary metabolite content of the ethanol extract of spinach leaves (A. viridis) qualitatively. This research consisted of 2 stages. The first stage is making simplicia and the second stage is screening phytochemical simplicia. The yield obtained from making simplicia was 20.83%. Based on the results, it can be concluded that spinach leaves (A. viridis) contain secondary metabolites of alkaloids, tannins, phenols, and saponins. The suggestion for this research is that the secondary metabolites can be isolated and then continued with activity tests.

Studi in silico tentang naringin sebagai reseptor anti-HER-2 dalam pengobatan kanker payudara Abdurrahman, Abdurrahman; Rijal, Muh. Agus Syamsur; Yusuf, Helmy; Norhayati; Rizaldi, Gusti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.535

Overexpression of Human Epidermal Receptor-2 (HER-2) is the cause of the development of breast cancer, so HER-2 can be a target for anticancer therapy. Trastuzumab is the drug of choice in inhibiting the HER-2 receptor and tyrosine kinase, but the weakness of this drug is that drug resistance can occur. Naringin has potential as a breast cancer therapy. The research aims to determine the inhibiting overexpression of the HER-2 receptor by naringin using in silico method. Molecular docking has been carried out by optimizing naringin and trastuzumab, preparing the HER-2 protein target (PDB ID 3PP0), validating the molecular docking protocol, and docking naringin and trastuzumab on HER-2. The research produced a binding energy of -8,66 kcal/mol, while the binding energies of the original ligand and trastuzumab to HER-2 were -9,94 kcal/mol and -5,87 kcal/mol, respectively. The binding energy shows that naringin has potential as an anti-breast cancer agent as indicated by its stronger affinity for HER2.

Uji Efektivitas Sediaan Emulgel Ekstrak Etanol 70% Daun Murbei (Morus alba L.) Sebagai Antiinflamasi Rizaldi, Gusti; Wahyunita, Sari Wahyunita; Rahmiati, Nur
Bioscientist : Jurnal Ilmiah Biologi Vol 12, No 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.13744

Non-steroidal anti-inflammatory drugs (NSAIDs) commonly used have associated side effects, necessitating the search for safer alternatives based on natural ingredients. This study aims to evaluate the effectiveness of a 70% ethanol extract emulgel of mulberry leaves (Morus alba L.) as an anti-inflammatory agent. The methodology employed is an experimental study involving the formulation of emulgel, which was tested on Wistar rats. The extraction process utilized maceration of mulberry leaves with 70% ethanol, yielding a concentrated extract that was then formulated into an emulgel. Anti-inflammatory activity was assessed using carrageenan induction and measuring edema volume in the test animals. The results indicated that the mulberry leaf extract emulgel exhibited significant anti-inflammatory activity, with a p-value of <0.023, demonstrating a meaningful difference compared to the positive control. The formula with a concentration of 0.32% showed the best efficacy at 180 minutes. The conclusion of this study highlights the potential of the 70% ethanol extract emulgel of mulberry leaves as a safe and effective alternative for anti-inflammatory therapy, recommending further safety testing to ensure its safe use in the community.

In Vitro Cholesterol Reduction Activity Test Of 70% Ethanol Extract of Hiyung Cayenne Pepper Fruit (Capsicum frutescens L. var hiyung) Originating from Tapin South Kalimantan Mu'mina Hayati; Rizaldi, Gusti; Saputri, Revita
Pharmacon: Jurnal Farmasi Indonesia Volume 22, No 1 (2025)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v22i1.7025

Kalimantan Island has an endemic plants that holds potential as a medical one of them namely hiyung cayenne pepper fruit (Capsicum frutescens L. var hiyung) the local commodity of Tapin, South Kalimantan and known as the hottest pepper in Indonesia. It containts secondary metabolites and capsaicin that has potential to lower cholesterol. This study aims to identify secondary metabolite compounds and cholesterol-lowering activity of 70% ethanol extract of hiyung cayenne pepper fruit. Cholesterol lowering test was conducted in vitro by cholesterol complex formation method with FeCl3 using UV-Vis Spectrophotometer at maximum wavelength of 525 nm. The results of the phytochemical screening test showed positively contained alkaloids, triterpenoids, phenols, saponins, tannins and flavonoids. The result of cholesterol reduction test from concentrations of 20, 40, 60, 80, and 100 µg/mL were 53.62%, 58.30%; 64.19%; 70.02%; and 74.91%, respectively. So, the 70% ethanol extract of hiyung cayenne pepper fruit has the potential to reduce cholesterol with the lowest concentration being able to reduce cholesterol by more than 50%.

Uji Efektivitas Sediaan Emulgel Ekstrak Etanol 70% Daun Murbei (Morus alba L.) Sebagai Antiinflamasi Rizaldi, Gusti; Wahyunita, Sari Wahyunita; Rahmiati, Nur
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.13744

Non-steroidal anti-inflammatory drugs (NSAIDs) commonly used have associated side effects, necessitating the search for safer alternatives based on natural ingredients. This study aims to evaluate the effectiveness of a 70% ethanol extract emulgel of mulberry leaves (Morus alba L.) as an anti-inflammatory agent. The methodology employed is an experimental study involving the formulation of emulgel, which was tested on Wistar rats. The extraction process utilized maceration of mulberry leaves with 70% ethanol, yielding a concentrated extract that was then formulated into an emulgel. Anti-inflammatory activity was assessed using carrageenan induction and measuring edema volume in the test animals. The results indicated that the mulberry leaf extract emulgel exhibited significant anti-inflammatory activity, with a p-value of <0.023, demonstrating a meaningful difference compared to the positive control. The formula with a concentration of 0.32% showed the best efficacy at 180 minutes. The conclusion of this study highlights the potential of the 70% ethanol extract emulgel of mulberry leaves as a safe and effective alternative for anti-inflammatory therapy, recommending further safety testing to ensure its safe use in the community.

Pemberdayaan Masyarakat Desa Sungai Batang Kecamatan Martapura Barat melalui Pelatihan Diversifikasi Produk Olahan Berbasis Ikan Sepat Rawa Fitriyanti, Fitriyanti; Rizaldi, Gusti; Rahmadina, Aprillia; Pasaribu, Cindy; Sauqi, Muhammad; Azzahra, Tania Nasyawa; Khairunnisa, Gustii
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 7, No 3 (2024): Volume 7 No 3 2024
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v7i3.13359

ABSTRAK Ikan merupakan sumber daya yang bernilai ekonomis, selain itu juga memiliki nutrisi yang dibutuhkan dalam kesehatan. Di Provinsi Kalimantan terdapat komoditi ikan, salah satunya ikan sepat rawa (Trichopodus trichopterus) yang merupakan ikan lokal potensial dan digemari Masyarakat yang memiliki manfaat mencegah penyakit Diabetes Mellitus. Pengolahan diversifikasi produk olahan berbasis ikan sepat rawa. Meliputi proses permohonan izin pelaksanaan, persiapan bahan-alat, sosialisasi dan penjelasan terkait diversifikasi produk olahan berbasis ikan sepat rawa, pengolahan produk, dan evaluasi kegiatan. Pelaku usaha dan tim kader sangat setuju produk-produk yang telah didemokan untuk diolah mandiri (95), alat yang digunakan mudah (85%), kemasan yang didiskusikan dianggap menarik (85%) dan pemanfaatan sosial media dalam pemasaran dapat dilakukan mandiri (95%). Dari hasil evaluasi kegiatan pengabdian masyarakat ini menghasilkan data peserta sangat setuju dengan materi kegiatan yang sesuai dengan kebutuhan (85%), pengabdian ini dilaksanakan sesuai harapan (95%), dan tim pelaksana telah memberikan pelayanan dan kesempatan yang baik (100%), kepuasaan mitra memiliki persentase 95%, serta harapan kegiatan kedepannya dapat dilaksanakan terus menerus (100%). Produk yang dihasilkan pelaku usaha Desa Sungai Batang berupa serbuk ikan sepat dan stik ikan sepat dapat digunakan sebagai alternatif makanan yang tidak hanya praktis , namun juga sehat dan cocok untuk makanan pendamping pasien diabetes mellitus. Diharapkan dari pengabdian masyarakat ini adanya peningkatan pengetahuan, ekonomi, dan kesehatan masyarakat. Kata Kunci: Desa Sungai Batang, Diversifikasi Produk Olahan, Ikan Sepat Rawa ABSTRACT Fish is a resource that has economic value, besides that it also has the nutrients needed for health. In Kalimantan Province there are fish commodities, one of which is the swamp sepat fish (Trichopodus trichopterus) which is a potential local fish and is popular with the community and has the benefit of preventing diabetes mellitus. Diversified processing of processed products based on swamp sepat fish. Includes the process of applying for an implementation permit, preparing materials and equipment, socializing and explaining the diversification of processed products based on swamp sepat fish, product processing, packaging planning and activity evaluation. Results: Business actors and the cadre team strongly agree that the products demonstrated can be processed independently (95), the tools used are easy (85%), the packaging discussed is considered attractive (85%) and the use of social media in marketing can be done independently ( 95%). The results of the activity evaluation showed that the majority of participants strongly agreed that the activity material met their needs (85%), the activities carried out met expectations (95%), the lecturer team provided good service (100%), partners were satisfied with the activities (95%) and Activities are expected to be carried out sustainably (100%). The products produced by Sungai Batang Village business in the form of sepat fish powder and sepat fish sticks can be used as alternative food which is not only practical, but also healthy and suitable as a complementary food for diabetes mellitus patients. Keywords: Sungai Batang Village, Diversification of Processed Products, Swamp Sepat Fish

EDUKASI PEMANFAATAN PANGAN LOKAL DALAM RANGKA MENDORONG PENURUNAN ANGKA STUNTING DI KELURAHAN SUNGAI BESAR, KOTA BANJARBARU Hastuti, Eny; Ismail, Hasan; Rizaldi, Gusti; Norhayati, Norhayati
Jurnal Abdi Insani Vol 11 No 2 (2024): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v11i2.1627

Indonesia is one of the countries that has experienced a reduction in the incidence of stunting, from 30.8% in 2018 to 21% in 2022 and is targeted at 14% in 2024. Stunting is caused by a lack of nutritional intake in the first 1000 days of life. Based on a preliminary study in Sungai Besar Subdistrict, there is still a fairly high prevalence of babies below the red line which leads to stunting, which occurs at the age of 0 months to 4 years, as many as 17 toddlers. This community service aims to provide information and education regarding stunting and local food that can be used to prevent stunting with the hope of reducing stunting rates in the Sungai Besar subdistrict. Community service activities were carried out on April 30 2024 in the Sungai Besar Village Hall and via Zoom Meeting. Partners in this activity are PKK Sungai Besar cadres, Banjarbaru City. Information and education is provided using powerpoint and leaflet. The average pretest score of the participants was 6.375 while the posttest was 8. Based on the paired t-test, the significance value was 0.002 (<0.05), which shows that there is a significant difference between the pretest and posttest scores regarding understanding stunting and local food that can be used as prevention of stunting. Based on the average pretest and posttest scores, the percentage increase in understanding was 20%. Through this community service, it is hoped that participants can make efforts to prevent and utilize local food so that the reduction in stunting rates can be increased. Based on the results of the service activities carried out, it was concluded that the information and education carried out were able to increase participants' knowledge and understanding regarding stunting and its prevention using local food.

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