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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Science and Technology Indonesia PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline Jurnal Layanan Masyarakat (Journal of Public Service) Borneo Journal Of Pharmascientech JAMAS: Jurnal Abdi Masyarakat
Muhammad Agus Syamsur Rijal
Faculty Of Pharmacy, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Other

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Efek Imunomodulator Kombinasi Susu Probiotik dan Ekstrak Daun Jambu Biji Isnaeni, .; Sugiyartono, .; Kusumawati, Idha; Rijal, Muh. Agus Syamsur
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 8, No 1 (2016)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACT : This research studied the potential and action mechanism of probiotic milk-guava leaf extract combination as an immunomodulator using mice as an experimental animal. The mouse were given the combination of probiotic milk-guava leaf extract for 7 days, then the levels of TNF-α in serum and lymphocites proliferation were measured. The results showed that the extract of guava leaf can increase levels of TNF-α in serum and the number of lymphoblast, either in single preparation or in combination with probiotic milk. However, administration of probiotic milk cannot improve the TNF-α in serum or increase the number of lymphoblast. It can be concluded that the immunomodulatory effects of the probiotics- milk-guava leaf extract combination was caused by the substances in the extract of guava leaf rather than by the probiotic milk. Keywords: probiotic milk, guava leaf extract, immunomodulator ABSTRAK: Konsorsium mikroba probiotik yang dikembangkan dalam bentuk sediaan susu probiotik telah dilaporkan memiliki berbagai aktivitas, antara lain sebagai imunomodulator dan antimikroba. Jus buah jambu biji telah digunakan secara tradisional oleh masyarakat untuk membantu meningkatkan jumlah trombosit penderita demam berdarah dengue. Kombinasi susu probiotik-ekstrak daun jambu biji telah terbukti mempunyai efek anti bakteri penyebab diare, namun mekanisme kerjanya belum diketahui. Dalam penelitian ini dilakukan kajian potensi dan mekanisme kerja kombinasi susu probiotik-ekstrak daun jambu biji sebagai imunomodulator. Sejumlah mencit diberi perlakuan kombinasi susu probiotik-ekstrak daun jambu biji selama 7 hari, kemudian diukur kadar TNF-α dalam serum dan kecepatan proliferasi limfositnya. Hasil penelitian menunjukkan bahwa ekstrak daun jambu biji dapat meningkatkan kadar TNF-α dalam serum dan dapat meningkatkan jumlah limfoblast, baik dalam bentuk tunggal maupun kombinasinya dengan susu probiotik. Pemberian susu probiotik saja tidak dapat meningkatkan TNF-α dalam serum ataupun meningkatkan jumlah limfoblast. Dari hasil penelitian ini dapat disimpulkan bahwa efek imunomodulator kombinasi susu probiotik-ekstrak daun jambu biji lebih disebabkan oleh kandungan zat zat berkhasiat dalam ekstrak daun jambu biji dari pada oleh susu probiotik. Kata kunci: probiotik, Lactobacillus acidophilus, jambu biji, Psidium guajava, imunomodulator.  
Efek Imunomodulator Kombinasi Susu Probiotik dan Ekstrak Daun Jambu Biji Isnaeni, .; Sugiyartono, .; Kusumawati, Idha; Rijal, Muh. Agus Syamsur
Jurnal Farmasi Indonesia Vol 8, No 1 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.889 KB) | DOI: 10.35617/jfi.v8i1.197

Abstract

ABSTRACT : This research studied the potential and action mechanism of probiotic milk-guava leaf extract combination as an immunomodulator using mice as an experimental animal. The mouse were given the combination of probiotic milk-guava leaf extract for 7 days, then the levels of TNF-α in serum and lymphocites proliferation were measured. The results showed that the extract of guava leaf can increase levels of TNF-α in serum and the number of lymphoblast, either in single preparation or in combination with probiotic milk. However, administration of probiotic milk cannot improve the TNF-α in serum or increase the number of lymphoblast. It can be concluded that the immunomodulatory effects of the probiotics- milk-guava leaf extract combination was caused by the substances in the extract of guava leaf rather than by the probiotic milk. Keywords: probiotic milk, guava leaf extract, immunomodulator ABSTRAK: Konsorsium mikroba probiotik yang dikembangkan dalam bentuk sediaan susu probiotik telah dilaporkan memiliki berbagai aktivitas, antara lain sebagai imunomodulator dan antimikroba. Jus buah jambu biji telah digunakan secara tradisional oleh masyarakat untuk membantu meningkatkan jumlah trombosit penderita demam berdarah dengue. Kombinasi susu probiotik-ekstrak daun jambu biji telah terbukti mempunyai efek anti bakteri penyebab diare, namun mekanisme kerjanya belum diketahui. Dalam penelitian ini dilakukan kajian potensi dan mekanisme kerja kombinasi susu probiotik-ekstrak daun jambu biji sebagai imunomodulator. Sejumlah mencit diberi perlakuan kombinasi susu probiotik-ekstrak daun jambu biji selama 7 hari, kemudian diukur kadar TNF-α dalam serum dan kecepatan proliferasi limfositnya. Hasil penelitian menunjukkan bahwa ekstrak daun jambu biji dapat meningkatkan kadar TNF-α dalam serum dan dapat meningkatkan jumlah limfoblast, baik dalam bentuk tunggal maupun kombinasinya dengan susu probiotik. Pemberian susu probiotik saja tidak dapat meningkatkan TNF-α dalam serum ataupun meningkatkan jumlah limfoblast. Dari hasil penelitian ini dapat disimpulkan bahwa efek imunomodulator kombinasi susu probiotik-ekstrak daun jambu biji lebih disebabkan oleh kandungan zat zat berkhasiat dalam ekstrak daun jambu biji dari pada oleh susu probiotik. Kata kunci: probiotik, Lactobacillus acidophilus, jambu biji, Psidium guajava, imunomodulator.  
PELATIHAN PEMBUATAN ES KRIM SAYURAN (MELORIN) KAYA KAROTEN SEBAGAI PROGRAM PEMBERDAYAAN IBU-IBU RUMAH TANGGA DI KECAMATAN GUBENG, SURABAYA Andang Miatmoko; Tutiek Purwati; Noorma Rosita; Muhammad Agus Syamsur Rijal; Dini Retnowati
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 1 No. 2 (2017): Jurnal Layanan Masyarakat
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (930.774 KB) | DOI: 10.20473/jlm.v1i2.2017.64-68

Abstract

The low consumption rate of vegetables and fruits in Indonesian population becomes major concerns for health improvement. Ice cream is a type of food that is favored by all people in various ages, even for adults. Training on making vegetable-based ice cream or melorin was held as an effort to provide alternative intake form of vegetables and fruits. The training program was implemented with the partner are housewives community in Gubeng district, Surabaya, especially for those of residents of Gubeng and Mojo sub-districts areas, which have relatively big number of members. The training on making vegetable-based ice cream can be an alternative way to improve people’s nutrition and provide skills to empower local communities.AbstrakRendahnya angka kecukupan konsumsi sayur dan buah dibandingkan angka gizi seimbang pada penduduk Indonesia menjadi perhatian utama bagi upaya peningkatan kesehatan keluarga. Pelatihan pembuatan es krim berbasis sayuran atau melorin diadakan sebagai salah satu wadah untuk memberikan bentuk asupan sayur alternatif dikarenakan produk ini gemar dikonsumsi oleh berbagai kalangan, baik anak-anak, remaja, maupun dewasa. Program ini dilaksanakan dengan mitra sasaran adalah ibu-ibu rumah tangga anggota PKK di wilayah Kecamatan Gubeng Kotamadya Surabaya khususnya warga Kelurahan Gubeng dan Kelurahan Mojo, yang mana memiliki jumlah anggota yang berprofesi sebagai ibu rumah tangga relatif besar. Dengan demikian, pelatihan ini dapat menjadi salah satu upaya untuk memperbaiki gizi masyarakat sekaligus memberikan bekal keterampilan untuk pemberdayaan masyarakat setempat. 
Quercetin Solid Lipid Microparticle Stability and Deposition in Rat Lungs: A Study of Surfactant Effect Hariyadi, Dewi Melani; Sairiyah, Siti Nasikatus; Rahman, Fakhrinnisa Wildani; Rijal, Muhammad Agus Syamsur; Rosita, Noorma; Rahmadi, Mahardian
Science and Technology Indonesia Vol. 9 No. 3 (2024): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.3.682-696

Abstract

This study aims to determine the effect of surfactant concentration on Quercetin SLM as a potential carrier of respiratory diseases, especially ones resulting from oxidative stress injury. Quercetin is a natural antioxidant with high activity. SLM was formed with 5% compritol 888 ATO as a lipid and different concentrations of poloxamer 188 as a surfactant. SLM was produced by a combination of emulsification and sonication involving freeze drying. SLM is characterized by organolepsis, morphology, yield, particle size, drug loading, and entrapment efficiency. The antioxidant activity of quercetin SLMs was tested using the ABTS method. SLMs are characterized as having round and smooth morphology, high yield (F1 88.53%; F2 91.44%; F3 92.87%); particle size (F1 1.81 um; F2 1.90 um; F3 1.94 um); high drug loading (F1 15.96%; F2 13.74%; F3 13.19%); and high entrapment efficiency (F1 96.53%; F2 87.94%; F3 87.48%). Increasing surfactant concentration did not produce a significant difference between formulas. Quercetin SLM showed high antioxidant activity (Quercetin 94.43%; F1 94.35%; F2 94.36%; F3 94.37%). SLM was stable at storage temperatures between 25°C and 40°C. The effect of surfactant can be seen on particle size, drug loading, and entrapment efficiency at 40°C. Results of in vivo deposition study indicated that all SLM formulas were able to deliver quercetin to the lungs. Increasing the concentration of surfactant in Quercetin SLMs made no difference to the lung deposition as confirmed by observations conducted at 1 hour and 4 hours. Quercetin SLM has the potential for lung delivery by inhalation.
Studi in silico tentang naringin sebagai reseptor anti-HER-2 dalam pengobatan kanker payudara Abdurrahman, Abdurrahman; Rijal, Muh. Agus Syamsur; Yusuf, Helmy; Norhayati; Rizaldi, Gusti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.535

Abstract

Overexpression of Human Epidermal Receptor-2 (HER-2) is the cause of the development of breast cancer, so HER-2 can be a target for anticancer therapy. Trastuzumab is the drug of choice in inhibiting the HER-2 receptor and tyrosine kinase, but the weakness of this drug is that drug resistance can occur. Naringin has potential as a breast cancer therapy. The research aims to determine the inhibiting overexpression of the HER-2 receptor by naringin using in silico method. Molecular docking has been carried out by optimizing naringin and trastuzumab, preparing the HER-2 protein target (PDB ID 3PP0), validating the molecular docking protocol, and docking naringin and trastuzumab on HER-2. The research produced a binding energy of -8,66 kcal/mol, while the binding energies of the original ligand and trastuzumab to HER-2 were -9,94 kcal/mol and -5,87 kcal/mol, respectively. The binding energy shows that naringin has potential as an anti-breast cancer agent as indicated by its stronger affinity for HER2.
PELATIHAN DISPENSING ASEPTIK SEDIAAN STERIL DI LAYANAN KESEHATAN KOTA MAKASSAR CITY DAN SEKITARNYA: Training on Aseptic Dispensing of Sterile Preparations in The Health Services of Makassar and Surroundings Isadiartuti, Dewi; Sari, Retno; Rijal, Muh. Agus Syamsur; Ratri, Dinda Monika Nusantara; Retnowati, Dini; Rudyanto, Marcellino; Miatmoko, Andang
JAMAS : Jurnal Abdi Masyarakat Vol. 3 No. 1 (2025)
Publisher : Forind Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62085/jms.v3i1.172

Abstract

Sediaan steril adalah sediaan yang tidak boleh mengandung mikroorganisme, partikel, serta sedapat mungkin dibuat isotonis. Kondisi steril tersebut harus dapat dijamin oleh apoteker sampai sediaan digunakan oleh pasien. Salah satu jenis pelayanan kefarmasian yang dilakukan oleh apoteker di fasilitas kesehatan adalah disepensing sediaan steril. Proses dispensing sediaan steril memerlukan teknik aseptis. Teknik aseptis merupakan salah satu aspek penting yang perlu diperhatikan oleh apoteker dalam menjalankan praktik kefarmasian khususnya di rumah sakit. Makassar yang merupakan ibukota Provinsi Sulawesi Selatan merupakan kota keempat terbesar di Indonesia. Kota Makassar merupakan tempat tinggal bagi lebih dari 15% penduduk Provinsi Sulawesi Selatan. Jumlah penduduk yang terus meningkat dan kualitas sumber daya yang baik sangat berguna untuk mendorong pertumbuhan ekonomi. Namun, jika tidak didukung dengan sumber daya manusia yang berkualitas, masalah sosial di Kota Makassar akan semakin meningkat. Salah satu cara dalam meningkatkan sumber daya manusia dapat melalui pengabdian masyarakat. Tujuan dari pengabdian masyarakat adalah untuk meningkatkan pengetahuan serta ketrampilan apoteker dalam hal dispensing aseptik sediaan steril di layanan kesehatan Kota Makassar dan sekitarnya. Kegiatan dilaksanakan di Auditorium Universitas Islam Makassar pada hari Sabtu 19 Oktober 2024 diikuti 34 peserta apoteker dari Rumah Sakit dan Puskesmas yang melakukan layanan pengelolaan sediaan steril. Dari hasil pre/post test tentang materi yang diberikan dan evaluasi kegiatan menunjukkan peningkatan pemahaman peserta dan respon positif terhadap pelatihan yang diselenggarakan oleh tim pengabdian masyarakat Fakultas Farmasi Universitas Airlangga. Harapan peserta pelatihan di masa mendatang kegiatan diperbanyak dan alokasi waktu pelaksanaan dapat lebih diperpanjang.
Influence of Hesperetin Concentration in Poloxamer P84 and TPGS Mixed Micelles on Physical Characteristics and Cytotoxicity in T47D Cell Line Aulia, Nanda Intan; Rijal, Muh. Agus Syamsur; Yusuf, Helmy
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.104-113

Abstract

Background: Hesperetin is a natural compound that has several properties including anticancer, but has limitation on low solubility in water. In this case, the development of a hesperetin delivery system using the micellar system is carried out. Objective: The current study aims to determine the effect of drug concentration on the physical characteristics and cytotoxicity of the mixed micelle. Methods: In this study, mixed micelles were formulated with D-a-tocopheryl polyethylene glycol 1000 succinate (TPGS) and poloxamer P84 as polymers through the thin film method, with hesperetin loaded at four different concentrations, i.e., 5 mg (F1), 10 mg (F2), 20 mg (F3), and 40 mg (F4). The mixed micelles were formulated using thin film hydration method. The evaluation of micelle’s physical characteristics was the measurement of particle size, Critical Micelle Concentration (CMC) value, drug loading, and drug entrapment efficiency. The evaluation of cytotoxicity used the T47D cell line and Micro Tetrazolium (MTT) method. Results: The CMC value of the mixed micelle was 0.0029% w/v, which was lower than the CMC of TPGS and poloxamer P84 only. The particle size of the micelles produced was between 17.07–20.37 nm. Among the various formulations, F3 showed relatively small particle size and has homogeneous particle size, high drug loading and encapsulation efficiency, and low IC50. Based on the study, particle size of F3 was 17.93  0.32 nm with polydispersity index (PDI) of 0.256 0.034. The drug loading percentage of F3 was 4.0092  0.0048% with an encapsulation efficiency of 94.5492 0.0013%. Based on cytotoxicity test using MTT method, F3 has low IC50, there was 4.036 ppm. Conclusion: Hesperetin-loaded mixed micelles offer potential as anticancer drugs that improve hesperetin efficacy. The results showed that F3 was the most potent anticancer formulation based on the physical characteristics and cytotoxicity tests.
Upaya Peningkatan Kualitas Produk UMKM Makanan Minuman di Surabaya Melalui Pelatihan Keamanan Aditif dan Kemasan Pangan serta Program Self Declare Halal Menggunakan Aplikasi SEHATI: Efforts to Improve the Quality of Food and Beverage MSME Products in Surabaya Through Additive and Food Packaging Safety Training as well as a Self-declare Halal Program Using the SEHATI Application Nofianti, Kholis Amalia; Ekowati, Juni; Purwanto, Bambang Tri; Prayoga , Adistiar; Yuwono, Mochammad; Prayoga, Adistiar; Rijal, Muhammad Agus Syamsur; Suciati, Suciati; Paramita, Diajeng Putri; Sulistyowaty, Melanny Ika; Hakim, Luqmanul
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 8 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i8.7044

Abstract

MSMEs in the food sector are the dominant economic support in Indonesia. Surabaya has more than 60 thousand MSMEs. In food production at the MSME level, food additives and packaging is inevitable. Despite the current regulations, people still encounter dangerous food additives or packaging. This is caused by a lack of knowledge and awareness of food producers and consumers. On the other hand, since the implementation of the halal guarantee system, the use of halal labels on food and beverage products has become very important. For MSMEs, the government makes it easy to get a halal label through the self-declare halal program using the SEHATI. This activity aims to provide training on safe food additives and packaging, halal food, and the self-declare halal program using the SEHATI application in Surabaya. Carrying out activities using presentation and two-way interaction. Evaluate activities through pretest and posttest for each topic. The lowest values for food packaging, it is 52.92 and 79.58. The highest value was shown by the halal topic with an average of 69.58 and 97.92. The significance of the increase in value was demonstrated by the Wilcoxon test using SPSS 22 which showed the Asymp. Sig (2-tailed) value for the three topics less than 0.05. Thus, it can be concluded that this activity has proven to be able to improve participants' abilities regarding safe food additives and packaging, as well as halal food and the introduction of the self-declare halal program.
Co-Authors Abdurahman Abdurrahman Andang Miatmoko Aulia, Nanda Intan Bambang Tri Purwanto Dewi Isadiartuti Dewi Melani Hariyadi Dinda Monika Nusantara Ratri Dini Retnowati Dini Retnowati Idha Kusumawati Isnaeni Juni Ekowati Kholis Amalia Nofianti Luqmanul Hakim Mahardian Rahmadi Marcellino Rudyanto Melanny Ika Sulistyowaty Miatmoko, Andang Mochammad Yuwono Noorma Rosita Norhayati Paramita, Diajeng Putri Prayoga, Adistiar Rahman, Fakhrinnisa Wildani Retno Sari Rizaldi, Gusti Sairiyah, Siti Nasikatus Suciati Suciati Sugiyartono, . Sugiyartono, . Tutiek Purwati Yusuf, Helmy