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All Journal Jurnal Ilmiah Farmasi Indonesian Journal of Pharmaceutical Science and Technology MPI (Media Pharmaceutica Indonesiana) Jurnal Ilmiah Farmasi Farmasyifa Borneo Journal Of Pharmascientech SPIN: Jurnal Kimia & Pendidikan Kimia Lombok Journal of Science Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal Borneo Literasi: Jurnal Pengabdian Masyarakat dan Inovasi Jurnal Penelitian dan Kajian Ilmiah Kesehatan Politeknik Medica Farma Husada Mataram Jurnal Farmasi SYIFA Jurnal Farmasi dan Farmakoinformatika Borneo Journal of Pharmacy Jurnal Abdimas Multidisiplin Jurnal Pharma Bhakta Jurnal Sains dan Kesehatan Journal of Pharmascience

Astuti, Karunita Ika

Fakultas Farmasi, Universitas Borneo Lestari, Banjarbaru, Kalimantan Selatan, Indonesia

Author-ID : 1699739

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Perbandingan tingkat kepatuhan pasien hipertensi yang diberikan konseling dengan alat bantu pesan pengingat dan brosur Akhmad Junaidi; Herliana Dewi; Hendrya Legenda; Dita Ayulia Dwi Sandi; Satrio Wibowo Rahmatullah; Karunita Ika Astuti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 5 No 1 (2021): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v5i1.374

Hypertension is a condition with blood pressure in 140/90 > mmHg. Medication compliance in hypertension patient can control blood pressure. Complience can improve with counseling and use tools of counselling. The aim of this study was to know the effect of counselling with the tools i.e an SMS reminder and brochure for compliance of hypertension patient. The study was observational analytical study by using the instrument of Adherence Morisky questionnaire Modified Scale (MMAS-8) to measure the level of compliance of the patient. Patients (n=61) were divided into 3 groups i.e the patients were only given counselling, given counselling and sms reminder (2 weeks), given counseling and brochures. Results of this study was compliance levels respectively high, medium and low were 21.74%; 43.48% and 34.78% (group counselling), 46.67%; 13.33% and 40% (group counseling and sms reminder) and 39.13%; 34.78% and 26.09% (group counseling and brochures). There was effect of counselling with an SMS reminder and brochure for compliance of hypertension patient (sig. 0,000) and there was no difference for compliance of hypertension patients in patients who given counseling with an SMS reminder or brochure (sig 0,497)

Uji Toksisitas Infusa Daun Sukun (Artocarpus communis Fost.) terhadap Mencit (Mus musculus) dengan Metode OECD425 Karunita Ika Astuti; Muhammad Nazhir; Revita Saputri
LOMBOK JOURNAL OF SCIENCE Vol 3 No 1 (2021): Lombok Journal of Science
Publisher : LOMBOK JOURNAL OF SCIENCE

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Tanaman Sukun dapat digunakan sebagai beberapa kondisi penyakit seperti diabetes, hepatitis, gatal-gatal, dan beberapa pernyakit lainnya. Penelitian yang dilakukan untuk mengetahui kandungan senyawa kimia dan LD50 dari infusa daun sukun (A.communis). Penelitian ini merupakan penelitian eksperimental secara in vivo pada 5 ekor mencit betina galur DDY dengan menggunakan metode OECD (The Organisation for Economic Co-operation and Development) 425. Hasil pada skrinning fitokimia bahwa infusa daun sukun (A.communis) mengandung senyawa flavonoid, tannin dan saponin. Uji toksisitas menggunakan dosis 2000 mg/ kgBB selama 14 p.o menunjukkan seluruh hewan tidak ada yang mati maupun mengalami tanda-tanda toksisitas, dan tidak terjadi perubahan yang bermakna pada bobot mencit pada dosis 2000 mg/ kgBB pada hasil uji statistik (p≥0,05). Berdasarkan software AOT 425StatPgm menunjukan LD50 sebesar 2000 mg/ KgBB.

KARAKTERISTIK PROTEIN IKAN SEPAT RAWA (Trichopodus thricopterus) ASAL KALIMANTAN SELATAN YANG BERPOTENSI SEBAGAI ANTIDIABETES Karunita Ika Astuti; Fitriyanti Fitriyanti
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 5 No 1 (2020): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

/KgBB berbeda signifikan dengan kontrol negatif dan tidak berbeda signifikan dengan kelompok glibenklamid yang memiliki persentase penurunan kadar gula sebesar 37,91%. Kata kunci: Antidiabetes, Tepung ikan Sepat Rawa, Kalimantan. ABSTRACT Diabetes treatment using fish is still not much developed. High protein potential in fish as antidiabetic where amino acids such as lysine arginine, leucine, isoleucine and several other amino acids can increase insulin action by increasing energy in the cell metabolism cycle. The purpose of this study is to develop the Kalimantan Sepat Swamp fish as an alternative therapy in patients with diabetes mellitus. Testing the characteristics of protein samples is carried out qualitatively in the form of biuret, ninhydrin, milon, fohl, xantoprotein, and sakhaguchi and testing the antidiabetic potential using test animals in the form of mice and measured levels of mice blood sugar using a glucometer. The treatment group was divided into 5 groups: positive control using Glibenclamide at a dose of 0.5 mg / kgBB, negative control NaCMC, fish meal 100 mg / KgBB; 200 mg / kg, and 300 mg / kg. The results of protein characteristics test showed positive swamp fish meal contained alpha amino acids, tyrosine, amino acids containing sulfur, cyclic, and arginine. In testing the antidiabetic potential of swamp fish meal the results showed that a dose of 300 mg / KgBB was the dose that had the best antidiabetic activity with a percentage decrease of 21.84%, followed by a dose of 200 mg / KgBB of 21.11% and a dose of 100mg / KgBB 6.33%. Antidiabetic activity of swampy fish meal 300 mg / KgBB differ significant with negative control and did not differ significantly from the glibenclamide group which had a decreased percentage of sugar by 37.91%.

UJI POTENSIASI EFEK SEDATIF-HIPNOTIK EKSTRAK ETANOL KANGKUNG AIR (Ipomoea aquatic) ASAL GAMBUT KALIMANTAN SELATAN Potential Test Of Sedative-Hypnotic Effect Extract Ethanol Ipomoea Aquatica Form Gambut, South Kalimantan. Karunita Ika Astuti; Fitriyanti Fitriyanti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 2 No 2 (2018): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

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UJI POTENSIASI EFEK SEDATIF-HIPNOTIK EKSTRAK ETANOL KANGKUNG AIR (Ipomoea aquatic) ASAL GAMBUT KALIMANTAN SELATAN Potential Test Of Sedative-Hypnotic Effect Extract Ethanol Ipomoea Aquatica Form Gambut, South Kalimantan. Karunita Ika Astuti* dan Fitriyanti STIKES Borneo Lestari, Kelapa Sawit 8 Bumi Berkat, Banjarbaru, Indonesia *karunitaika@gmail.com ABSTRAK Pengobatan Sedatif-hipnotik menggunakan golongan obat depresan Susunan Saraf Pusat (SSP) yang relatif tidak selektif namun obat dari golongan ini jika digunakan berkepanjangan dapat bersifat toksik dan menyebabkan kematian. Kangkung air (Ipomoea aquatic) memiliki efek antioksidan yang baik. Tujuan dari penelitian ini adalah untuk mengetahui kandungan senyawa kimia dan efek tanaman Kangkung air terhadap Uji sedative-Hipnotik. Sebanyak 30 mencit dalam 5 kelompok uji yaitu Kelompok control negatif, control positif dengan pemberian diazepam 10 mg/KgBB secara oral, Kelompok perlakuan dengan ekstrak Kangkung Air dosis 1 mg/KgBB, 2 mg/KgBB, dan $ mg/KgBB dengan metode rotaryroad dan Fireplace Test. Data yang didapat dianalisis dengan Shapiro-Wilk, kemudian dilanjutkan uji one way ANOVA dan Post Hoc Tests. Hasil menunjukkan adanaya efek sedasi ekstrak etanol kangkung air pada dosis 4 mg/20 BB. Kata kunci: SedatiF-Hipnotik, kangkung air, rotarod. ABSTRACT Treatment Sedatives-hypnotics using the class of depressants of Central Nervous System (CNS) are relatively not selective. However, drugs of this class if used prolonged can be toxic and cause death. Ipomoea aquatica has a good antioxidant effect. The aim of the test are to the show contains chemical coumpound and the effect of sedative-hypnotic test. Twenty five male mice divided into 5 group (N=5) which is called as negative control group, positive control group will be given Diazepam at dose 10mg/KgBW p.o and 3 treatment groups will be given Ipomea Aquatica Ectract (EKA) ad dose 1 mg/KgBW(I); 2 mg/kgBW(II); and 4mg/KgBW(III) p.o, In this study used rotarod and Fireplace method. Data were analyzed using Saphiro Wilk Test then One ways ANOVA and post hoc test. There is a sedation effect of Ipomea aquatica Extract at 4 mg/20 BB dose. Keywords: Sedative-Hypnotive Test, Ipomoea Aquatica, rotarod

AKTIVITAS KEMAMPUAN MEMORI SPASIAL FRAKSI ETIL ASETAT HERBA MENIRAN MERAH (PHYLLANTHUS URINARIA L.) DENGAN METODE RADIAL ARM MAZE Karunita Ika Astuti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 3 No 2 (2019): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

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ABSTRACTIntelligence is an ability to adjust with the environment by blends of attention, concentrationand short term memory. Phyllanthus urinary L. is a plant that have active content offlavonoid compound especially quersetin which efficacious in spatial memory activity. Thepurpose of this study was to determine, effective dose and histopathology of gyrus dentatus inanimal test after given ethyl acetate fraction of meniran herb. The research was conducted by administration of ethyl acetate fraction with doses 50 mg/kgBW, 100 mg/kgBW and 150mg/kgBW for 10 days to white male mice. The research to view error in memory by radialarm maze (RAM). Positive control using quercetin 42 mg/kg BW and negative control usingNa-CMC 0.5%. The most effective result at dose 100 mg/kgBW with shows value of 38.619%± 2.56, the best and smaller value if compared with 50 mg/kgBW and 100 mg/KgBW andnegative control, 49.195%±4.27; 53.130%±1.70; and 63.419%±4.55, respectively withpositive control value of 32.424%±9.13.Keywords: Radial arm maze, ethyl acetate fraction, red meniran (Phyllanthus urinary L.)

UJI AKTIVITAS ANTIDIARE EKSTRAK ETANOL 96% HERBA PUTRI MALU (Mimosa pudica L.) TERHADAP MENCIT JANTAN YANG DIINDUKSI Oleum ricini Karunita Ika Astuti; Fitriyanti; Nur Huda
BORNEO JOURNAL OF PHARMASCIENTECH Vol 4 No 1 (2020): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v4i1.276

Mimosa pudica L. is one of plants which is used as antidiarrhea by the common people in the society. The objectives of this research is to determine the compounds and antidiarrhea activity of ethanolic 96% Mimosa pudica L extract by using masers method. The method is divided 5 groups and its has 5 mices, which negatif group is given by NaCMC 0,5%, positive group given by Loperamide HCL with doses 0,0052 mg/20g, and the ethanol extract with doses (100, 200, dan 400 mg/kgBB). After 30 minutes treatment to animal study, it is continued by Oleum ricini p.o. Observation is done during 4 hours by observed some parameter such as frequency of diarrhea and weight of feses. The result of compound Mimosa pudica L. extract such as alkaloid, flavonoid, tanin, saponin, and steroid. The data is analyzed by using Man Whitney showed Mimosa pudica L extract doses 400 mg/kgBB is efectives doses such as antidiarrhea which is able to decrease the frequency of diarrhea (P>0,585) and weight of feses (P>0,754).

Analısıs karakterıstık organoleptıs dan kimia tepung ıkan sepat rawa (Trıchopodus trıchopterus) Bella Rosalina Endah; Fitri Yanti; Karunita Ika Astuti; Vebruati Vebruati
Journal Borneo Vol. 2 No. 2 (2022): Volume 2 Issue 2 tahun 2022
Publisher : Politeknik Kaltara

Ikan sepat rawa (Trıchopodus trıchopterus) merupakan hewan yang banyak ditemukan di Kalimantan Selatan. Ikan sepat rawa muncul musiman namun belum dimanfaatkan secara maksimal. Penelitian ini bertujuan untuk mengatahui karakteristik oraganoleptis dan kimia berupa kadar air, kadar abu, kadar serat, kadar lemak dan kadar protein tepung ikan sepat rawa. Pembuatan tepung ikan sepat rawa dengan menggunakan metode pengukusan pada suhu 90˚C selama 20 menit dan pemanasan oven dengan suhu 70˚C selama 80 menit. Hasil penelitian ikan sepat rawa menunjukkan karakteristik organoleptis berupa warna cokelat muda, aroma harum/khas, rasa hambar kemanisan, dan tekstur kering sedangkan hasil analisis kimia didapatkan kadar protein sebesar 44,84%, kadar serat 1,88%, kadar lemak 4,12%, kadar abu 14,63%, dan kadar air 5,98%. Berdasarkan Standar Nasional Indonesi (SNI), dari kelima pengujian karakteristik kimia didapatkan hasil uji kadar protein termasuk dalam standar mutu III, serat termasuk dalam standar mutu II, kadar lemak termasuk dalam standar mutu I, kadar abu termasuk standar mutu I, kadar air temasuk standar mutu I.

Pendampingan Pengolahan Sediaan Wedang Telang (Clitoria ternatea L.) pada Masyarakat Landasan Ulin Utara, Banjarbaru Fitriyanti Fitriyanti; , Karunita Ika Astuti
Literasi: Jurnal Pengabdian Masyarakat dan Inovasi Vol 3 No 1 (2023)
Publisher : Pengelola Jurnal Politeknik Negeri Ketapang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58466/literasi.v3i1.940

Clitoria ternatae has many health benefits, one of which is to increase body immunity. As a flower that is easy to find and grows in various regions, this is one of the plants that can be used as a health drink in the form of wedang. This community service aims to provide knowledge and skills in making wedang with the main ingredients from nature. The training materials (theory and practice) were place at the houses of RT.07, RW.01 in the Landasan Ulin Village, Liang Anggang District, Banjarbaru. Apart from being aimed at providing education to local residents regarding the benefits of the butterfly pea flower, they are also educated on how to cultivate it, how to use it and how to pack it. So that later the local residents/communities can carry out the processing in an independent manner independently both for personal consumption and used as business.

UJI TOKSISITAS AKUT EKSTRAK ETANOL 70% BUNGA TELANG (Clitoria ternatea L.) TERHADAP TIKUS BETINA GALUR WISTAR DENGAN METODE OECD 425 Sartika Dewi; Karunita Ika Astuti; Esty Restiana Rusida
Jurnal Ilmiah Farmasi Farmasyifa Vol 6, No 1 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v6i1.10420

Bunga telang (Clitoria ternatea L.) sebagai alternatif pengobatan penyakit degeneratif salah satunya untuk penurunan kadar glukosa dalam darah dan dalam pengembangannya sebagai obat, perlu dilakukan uji keamanan bahan alam dengan menguji toksisitas dari bunga telang. Penelitian ini untuk mengetahui gejala toksisitas dan nilai LD50 dengan metode OECD 425. Hewan uji tikus betina galur wistar dibagi menjadi kontrol negatif (Na-CMC) dan kelompok perlakuan (ekstrak etanol 70% bunga telang (Clitoria ternatea L.)) dengan dosis 2000 mg/kgBB. Hewan uji diamati gejala-gejala toksisitas meliputi berat badannya dan tanda toksisitas lainnya selama 14 hari. Pengamatan yang dilakukan meliputi tremor (gemetar), konvulsi (kejang), latergi (lesu), diare, koma dan mati. Hasil menunjukkan nilai LD50 ekstrak etanol 70% bunga telang (Clitoria ternatea L.) adalah >2000 mg/kgBB, berdasarkan klasifikasi BPOM termasuk dalam kategori 4 yaitu toksik ringan. Hasil pengamatan hewan uji tidak mengalami gejala-gejala toksisitas, dan tidak mengalami perubahan bermakna pada berat badan hewan uji pada kontrol negatif dan kontrol perlakuan (p>0,05)

UJI EFEKTIVITAS ANTIBAKTERI INFUSA DAUN SIRSAK TUA (Annona muricata L.) TERHADAP Propionibacterium acnes Fitriyanti; Ari Surya Pratama; Karunita Ika Astuti
Jurnal Penelitian dan Kajian Ilmiah Kesehatan Politeknik Medica Farma Husada Mataram Vol. 5 No. 2 (2019): JURNAL PENELITIAN DAN KAJIAN ILMIAH KESEHATAN POLITEKNIK MEDICA FARMA HUSADA MA
Publisher : Politeknik Medica Farma Husada Mataram

Acne is a skin disease. One of the common bacteria that infects acne is Propionibacterium acnes. Natural ingredient that can be used to treat acne is Annona muricata L. leaves. This study aims to determine the compound content and effective concentration of antibacterial infusion of old Annona muricata L leaves against p.acnes bacteria. This research is experimental by using the liquid dilution method, solid dilution method, and the diffusion well method. The extraction method used in this study is an infusion. Infusion test solution using concentrations of 1.56%; 3.12%; 6.25%; 12.5%; 25%; 50%; 100%; and 200%. The results of this study are old Annona muricata L leaves infusion containing flavonoid compounds, saponins, and tannins. The results of the dilution test obtained the MIC value at a concentration of 25% and the MBC value was found at a concentration of 100%. In the dilution test the infusion of old Annona muricata L leaves infusion with concentrations of 100% and 200% has strong antibacterial activity and effective concentrations or MEC infusion and old Annona muricata L are found at concentrations of 100% with an average inhibition zone diameter of 11 mm (strong category).

Co-Authors Agung Biworo Akbar, Depy Oktapian Akhmad Junaidi Alista, Siti Aprilia Rahmadina Ari Surya Pratama Aristha N. Putri Baiq Nurdiana Ulfa Bella Rosalina Endah Dharmayati, Evy Eka Fitri Susiani fitriyanti fitriyanti Fitriyanti, Fitriyanti Guntur Kurniawan Hadirvika Tjuthiyanda Helmina Wati Hendrya Legenda Herliana Dewi Hidayati, Listya Nor Hidayatullah, Muhammad Ika P. Sari Khoerul Anwar Lusiana Dwi Wulandari Mariani Monalissa Indriani Muhammad Nazhir Muhammad Nur Rahman Hendrawan Norhasanah Norhasanah Noviadi, Aditya Nur Huda Nurul Hikmah Pangestika, Indira Adi Rahmatullah, Satrio Wibowo Rahmi Muthia Rizaldi, Gusti Rusida, Esty Restiana Sandi, Dita Ayulia Dwi Saputri, Revita Sari Wahyunita Sartika Dewi Sunarti, Lisa Syahrizal Ramadhani Syaid Nofal Assegaf Teuku N.S. Sulaiman Uswatun Rahimah Vebruati Vebruati Wahyudin Wahyudin

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