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All Journal Paediatrica Indonesiana Majalah Kedokteran Nusantara The Journal Of Medical School SCRIPTA SCORE Scientific Medical Journal Cermin Dunia Kedokteran Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Journal of Society Medicine (JSOCMED) Cermin Dunia Kedokteran

Arto, Karina Sugih

Department Of Child Health University Of Sumatera Utara Medical School/H. Adam Malik Hospital, Medan, North Sumatera

Author-ID : 782804

Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 14 Documents Claim Missing Document

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Pengaruh Stres Psikologis terhadap Kadar Testosteron Saliva Anak Masa Pubertas Bagus Prastyo, Dimas; Deliana, Melda; Mayasari Lubis, Siska; Sugih Arto, Karina
Cermin Dunia Kedokteran Vol 45, No 4 (2018): Cidera Kepala
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i4.665

Pubertas merupakan tahap penting proses tumbuh kembang anak yang merupakan sebuah proses biologis kompleks perkembangan maturasi seksual. Proses tersebut dipengaruhi oleh faktor genetik dan lingkungan, salah satunya stres. Kondisi stres akan mengganggu sistem reproduksi. Penelitian menemukan bahwa kadar testosteron dipengaruhi oleh stres. Pengukuran kadar testosteron melalui saliva tidak invasif dan hasilnya serupa dengan kadar testosteron bebas dalam serum. Pengukuran kadar testosteron saliva dapat menggambarkan pengaruh stres terhadap aksis HPG pada anak masa pubertas.Puberty is an important stage in the child's development; it is a complex biological process of sexual maturation. The process is influenced by genetic and environmental factors, like stress. Stress conditions can disrupt the reproductive system. Studies found that testosterone levels are affected by stress. Measurement of testosterone levels through saliva is not invasive and correlate with serum free testosterone levels. Salivary testosterone levels can potrays the effect of stress on the HPG axis during puberty.

Kontrol Metabolik pada Diabetes Melitus Tipe-1 Adelita, Miranda; Arto, Karina Sugih; Deliana, Melda
Cermin Dunia Kedokteran Vol 47, No 3 (2020): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Diabetes Mellitus (DM) tipe-1 adalah kondisi yang disebabkan kerusakan sel-Î² pankreas baik oleh proses autoimun ataupun idiopatik sehingga produksi insulin berkurang atau berhenti. DM tipe-1 sampai saat ini belum dapat disembuhkan tetapi kualitas pertumbuhan dan perkembangan anak dan remaja dapat dipertahankan seoptimal mungkin dengan upaya kontrol metabolik dengan baik. Untuk tujuan tersebut, diperlukan komponen pengelolaan DM tipe-1 yang terdiri dari lima pilar terintegrasi meliputi pemberian insulin, nutrisi, olahraga, dan edukasi didukung oleh pemantauan mandiri. Kontrol metabolik yang baik adalah mengusahakan kadar glukosa darah berada dalam batas normal atau mendekati nilai normal, tanpa menyebabkan hipoglikemia dengantarget kontrol HbA1c <7%.Type-1 Diabetes Mellitus (DM) is a condition caused by pancreatic Î²-cell damage either by an autoimmune or idiopathic process resulting reduced or stopped insulin production. Type-1 DM can not be cured yet but the quality of growth and development of children and adolescents can be maintained optimally by metabolic control. These goals and objectives can be achieved through type-1 DM management that consists of integrated five pillars including insulin, nutrition, exercise, education and supported by independent monitoring. Good metabolic control is to keep blood glucose levels within normal limits or close to normal values, without causing hypoglycemia. HbA1c <7% is a target of good metabolic control.

Puberty onset in rural and urban children Hariadi Edi Saputra; Hakimi Hakimi; Melda Deliana; Siska Mayasari Lubis; Karina Sugih Arto
Paediatrica Indonesiana Vol 57 No 1 (2017): January 2017
Publisher : Indonesian Pediatric Society

Background Accelerated pubertal onset has been reported in recent years. Environmental factors are assumed to influence this condition.Objective To assess differences in pubertal onset between children in rural and urban areas, as well as to evaluate body mass index (BMI) and socioeconomic status that affect pubertal onset.Methods This cross-sectional study was conducted in July 2010 at junior high schools in Mandailing Natal and Medan, North Sumatera. Data were collected with purposive sampling of children aged 8 to 13 years. Sexual maturity was assessed by Tanner stage and risk factors was determined by questionnaires. The comparison between pubertal onset in rural and urban areas was assessed by Mann-Whitney U test. The relationships between nutritional status, socioeconomic status, sexual maturity, and pubertal onset were assessed by Spearmanâ€™s correlation.Results Eighty-four subjects (38 boys and 46 girls) from a rural area and 87 subjects (40 boys and 47 girls) from an urban area participated in this study. There were significant differences in mean pubertal age of onset between subjects living in rural vs. urban areas, for both girls and boys [girls: 10.2 vs. 9.5 years, respectively (P=0.008); boys: 11.7 vs. 10.1 years, respectively, (P=0.001)]. We found weak negative correlations between BMI and pubertal onset in boys (r=-0.246; P=0.03) and in girls (r=-0.548; P=0.001). We also found weak negative correlations between socioeconomic status and Â pubertal onset in boys (r=-0.406; P=0.0001) and in girls (r=-0.575; P=0.001).Conclusion Pubertal onset is faster in girls and boys who lived in an urban area. Â There are negative correlations between BMI and socioeconomic status with pubertal onset.

Comparison of Growth Diagrams Of Indonesian Children to 2006 World Health Organization Growth Standards in diagnosing stunting Rizki Aryo Wicaksono; Karina Sugih Arto; Rina Amalia Karomina Saragih; Melda Deliana; Munar Lubis; Jose Rizal Latief Batubara
Paediatrica Indonesiana Vol 60 No 2 (2020): March 2020
Publisher : Indonesian Pediatric Society

Background Stunting represents a linear growth disturbance due to chronic malnutrition, recurrent infection, and inadequate psychosocial stimulation. The 2006 World Health Organization (WHO) Growth Standards are utilized as a modality in monitoring children's growth, but to date, there has been no recommendation on use of the Growth Diagrams of Indonesian Children to monitor the growth of Indonesian children. Objective To determine the proportion of stunting, the sensitivity and specificity of Growth Diagrams of Indonesian Children for diagnosing stunting. In addition, we aimed to compare proportions of stunting using the 2006 WHO Growth Standards and Growth Diagrams of Indonesian Children. Method A cross-sectional study was conducted in Lawe Alas District, Southeast Aceh, Indonesia, from December 2017 to May 2018. Subjects were children aged 1-59 months who fulfilled the inclusion criteria. Subjects were obtained using a consecutive sampling method. Weight and height measurements were plotted on the Growth Diagrams of Indonesian Children and on the 2006 WHO Growth Standards to determine the stature o subjects. Stunting was defined as the index Z-score for HAZ of less than -2 SD for the 2006 WHO Growth Standards, and an HAZ index of below the 10th percentile (p10th) for the Growth Diagrams of Indonesian Children. Results Of 141 subjects, 66 (46.8%) had stunting based on the 2006 WHO Growth Standards and 51 (34.8%) had stunting based on Growth Diagrams of Indonesian Children. The sensitivity and specificity of the Growth Diagrams of Indonesian Children were 75.5% and 98.66%, respectively. Significantly more children were considered to be stunted using the 2006 WHO Growth Standards than using the Growth Diagrams of Indonesian Children. Conclusion Stunting prevalence is high in Southeast Aceh. The Growth Diagrams of Indonesian Children is a spesific and sensitive tool to diagnosed stunting in accordance with Indonesian children's growth patterns.

Risk factors of stunting in Indonesian children aged 1 to 60 months Rizki Aryo Wicaksono; Karina Sugih Arto; Erna Mutiara; Melda Deliana; Munar Lubis; Jose Rizal Latief Batubara
Paediatrica Indonesiana Vol 61 No 1 (2021): January 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.1.2021.12-9

Background The Indonesian province of Aceh has a high prevalence of stunting. Identifying risk factors for stunting may help prevention efforts. The Growth Diagrams of Indonesian Children are a specific tool to diagnose stunting in Indonesian pediatric populations. Objective To determine the risk factors of stunting in children aged 1-60 months using the Growth Diagrams of Indonesian Children. Methods This observational, analytic study with case-control design was conducted in the Lawe Alas District, Southeast Aceh, Indonesia to compare prior risk factors exposure between stunted children (cases) and non-stunted children (controls) from January-April 2018. Subjects were children aged 1-60 months and recruited by consecutive sampling. Results The subjects comprised 97 cases and 97 controls, totaling 194 subjects, internal risk factors of stunting were short birth length (OR 2.87; 95%CI 1.24 to 6.61; P=0.011), inadequate calorie intake (OR 2.37; 95%CI 1.32 to 4.27; P=0.004), non-exclusive breastfeeding (OR 3.64; 95%CI 2.01 to 6.61; P<0.001), chronic diarrhea (OR 6.56; 95%CI 3.33 to 13.01; P<0.001) and upper respiratory tract infections (OR 3.47; 95%CI 1.89 to 6.35; P<0.001). External risk factors of stunting were unimproved sanitation (OR 2.98; 95%CI 1.62 to 5.48; P<0.001), unimproved water sources (OR 2.71; 95%CI 1.50 to 4.88; P=0.001), low family income (OR 2.49; 95%CI 1.38 to 4.49; P=0.002), low paternal educational level (OR 2.98; 95%CI 1.62 to 5.48; P<0.001), low maternal educational level (OR 2.64; 95%CI 1.38 to 5.04; P=0.003), and living in households with >4 family members (OR 1.23; 95%CI 0.69 to 2.17; P=0.469). Regression analysis showed that the dominant risk factor of stunting was chronic diarrhea (OR 5.41; 95%CI 2.20 to 13.29; P<0.001). Conclusion The history of chronic diarrhea and non-exclusive breastfeeding are the main risk factors of childhood stunting.

Hubungan Pengetahuan Anak tentang Cuci Tangan dengan Kejadian Diare di Desa Panobasan Nurul Wahida Harahap; Karina Sugih Arto; Supriatmo; Dina Arwina Dalimunthe
SCRIPTA SCORE Scientific Medical Journal Vol. 2 No. 1 (2020): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v2i1.3392

Background: Diarrhea is a condition in which feces are discharged from the bowel in loose consistency or even liquid form, and the frequency is usually more often ( usually three times or more) in one day. Non-hygienic lifestyles, such as not washing hands before consuming food and after doing activities can cause negative impact to health, particularly the occurrence of diseases that related to poor sanitation, such as diarrhea. The prevalence are more common by 10 % in rural areas compared to 7.4% in urban areas. Incidence rate in diarrhea tends to be higher in group with lower education whom work as farmer, fisherman, or labor. Objectives: This study aims to analyze the relationship of childrend`s knowledge about hand washing and diarrhea occurence. Methods: This study is an analytic study with a cross sectional design. The data is primary data that were collected directly from respondents through questionnaire. The respondents were chosen by stratified random sampling method. Results: From data of 35 respondents, the p-value 0.005 ( p <0.05), PR value 0.364 ( 0.177 – 0.749). Conclusion: There is a significant relationship between childrend`s knowledge about hand washing with diarrhea in Panobasan village. Keywords: children's knowledge, diarrhea, hand washing Latar Belakang: Diare adalah suatu kondisi dimana seseorang buang air besar dengan konsistensi lembek atau cair, bahkan dapat berupa air saja dan frekuensinya lebih sering (biasanya tiga kali atau lebih) dalam satu hari. Kebiasaan kurang higienis berupa tidak mencuci tangan sebelum makan atau tidak mencuci tangan setelah melakukan aktivitas yang berhubungan dengan lingkungan dapat menimbulkan dampak negatif bagi kesehatan masyarakat, terutama munculnya penyakit yang berkaitan dengan perilaku hidup bersih dan sehat yang rendah salah satunya yaitu diare. Prevalensi diare lebih banyak di pedesaan dibandingkan perkotaan, yaitu sebesar 10% di pedesaan dan 7,4 % di perkotaan. Diare cenderung lebih tinggi pada kelompok pendidikan rendah dan bekerja sebagai petani, nelayan dan buruh. Tujuan: Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan anak tentang cuci tangan dengan kejadian diare. Metode: Penelitian ini merupakan studi penelitian analitik dengan desain penelitian cross sectional, metode pengumpulan data penelitian ini adalah data primer, yaitu data yang diperoleh langsung dari sampel menggunakan kuesioner. Sampel dalam penelitian ini diperoleh dengan menggunakan cara stratified random sampling. Hasil: Dari 135 responden, hubungan pengetahuan anak tentang cuci tangan dengan kejadian diare didapatkan hasil dengan nilai p = 0,005 (p < 0,05), dan nilai PR = 0,364 (0,177 – 0,749). Kesimpulan: Terdapat hubungan yang signifikan antara pengetahauan anak tentang cuci tangan dengan kejadian diare di desa Panobasan. Kata kunci: cuci tangan, diare, pengetahuan anak

Gangguan fungsi hormon tiroid pada anak penderita infeksi susunan saraf pusat Rahmad Sumiko; Melda Deliana; Hakimi dr; Siska Mayasari Lubis; Karina Sugih Arto
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 47, No 3 (2014): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

Show Abstract | Download Original | Original Source | Check in Google Scholar

Dysfunction of thyroid hormone can occur in children with central nervous system (CNS) infections characterized by decreasing levels of triiodothyronine (T3). Severe CNS infections have symptoms such as seizures, respiratory failure, impaired consciousness, fever, and typical abnormalities on Elektroencephalografi (EEG). Central nervous system infected children with low T3 have tendency of lower survival rate compare to CNS infected children with low thyroxine (T4). Examination of thyroid hormone performed by using vena puncture and lumbar puncture. It was performed before treatment is given. Until now, there are onlyfew case reports of thyroid hormone dysfunction in children with central nervous system infections.Keywords : CNS infection, children, thyroid dysfunction

Kontrol Metabolik pada Diabetes Melitus Tipe-1 Miranda Adelita; Karina Sugih Arto; Melda Deliana
Cermin Dunia Kedokteran Vol 47, No 3 (2020): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i3.377

Diabetes Mellitus (DM) tipe-1 adalah kondisi yang disebabkan kerusakan sel-β pankreas baik oleh proses autoimun ataupun idiopatik sehingga produksi insulin berkurang atau berhenti. DM tipe-1 sampai saat ini belum dapat disembuhkan tetapi kualitas pertumbuhan dan perkembangan anak dan remaja dapat dipertahankan seoptimal mungkin dengan upaya kontrol metabolik dengan baik. Untuk tujuan tersebut, diperlukan komponen pengelolaan DM tipe-1 yang terdiri dari lima pilar terintegrasi meliputi pemberian insulin, nutrisi, olahraga, dan edukasi didukung oleh pemantauan mandiri. Kontrol metabolik yang baik adalah mengusahakan kadar glukosa darah berada dalam batas normal atau mendekati nilai normal, tanpa menyebabkan hipoglikemia dengantarget kontrol HbA1c <7%.Type-1 Diabetes Mellitus (DM) is a condition caused by pancreatic β-cell damage either by an autoimmune or idiopathic process resulting reduced or stopped insulin production. Type-1 DM can not be cured yet but the quality of growth and development of children and adolescents can be maintained optimally by metabolic control. These goals and objectives can be achieved through type-1 DM management that consists of integrated five pillars including insulin, nutrition, exercise, education and supported by independent monitoring. Good metabolic control is to keep blood glucose levels within normal limits or close to normal values, without causing hypoglycemia. HbA1c <7% is a target of good metabolic control.

Kontrol Metabolik pada Diabetes Melitus Tipe-1 Miranda Adelita; Karina Sugih Arto; Melda Deliana
Cermin Dunia Kedokteran Vol. 47 No. 3 (2020): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i3.360

Diabetes melitus (DM) tipe-1 adalah kondisi yang disebabkan oleh kerusakan sel-β pankreas baik oleh proses autoimun maupun idiopatik, sehingga produksi insulin berkurang atau berhenti. DM tipe-1 sampai saat ini belum dapat disembuhkan, tetapi kualitas pertumbuhan dan perkembangan anak dan remaja dapat dipertahankan seoptimal mungkin dengan upaya kontrol metabolik dengan baik. Untuk tujuan tersebut, diperlukan komponen pengelolaan DM tipe-1 yang terdiri dari lima pilar terintegrasi meliputi pemberian insulin, nutrisi, olahraga, dan edukasi didukung oleh pemantauan secara mandiri. Kontrol metabolik yang baik adalah mengusahakan kadar glukosa darah berada dalam batas normal atau mendekati nilai normal, tanpa menyebabkan hipoglikemia dengan target kontrol HbA1c <7%. Type-1 diabetes mellitus (DM) is a condition caused by pancreatic β-cell damage either by an autoimmune or idiopathic process resulting reduced or stopped insulin production. Type-1 DM can not be cured yet but the quality of growth and development of children and adolescents can be maintained optimally by metabolic control. These goals and objectives can be achieved through type-1 DM management that consists of integrated five pillars including insulin, nutrition, exercise, education, and supported by independent monitoring. Good metabolic control is to keep blood glucose levels within normal limits or close to normal values, without causing hypoglycemia. HbA1c <7% is a target of good metabolic control.

Intelligence quotient (IQ) outcome in children with early-treated congenital hypothyroidism: a systematic review and meta-analysis Whyra Pratama Said; Karina Sugih Arto; Winra Pratita; Sufitni Sufitni
Paediatrica Indonesiana Vol 63 No 4 (2023): July 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.4.2023.290-7

Background Congenital hypothyroidism (CH) is the most common congenital endocrine disorder in childhood and is one of the most preventable causes of intellectual disability (ID). Late initiation of thyroid hormone substitution therapy has a negative impact on intellectual abilities in CH patients. Objective To compare Intelligence Quotient (IQ) between children with CH who underwent early treatment among the children without CH. Methods We performed online literature searches of ScienceDirect, Pubmed, Cochrane Library, and Google Scholar. We included clinical studies that examined IQ scores in patients with early-treated CH and without CH. Review Manager 5.4 was used to perform the meta-analysis. Results Twelve studies comparing pediatric patients with and without CH were included in this meta-analysis, for a total of 808 patients. Based on data analysis, IQ levels of verbal IQ [mean difference (MD) -9.05; (95%CI -14.51 to -3.59); (P<0.00001)], performance IQ [MD -11.70; (95%CI -17.41 to -5.99); (P<0.00001)], and total IQ [MD -10.78; (95%CI -14.03 to -7.54); (P<0.00001)]. While verbal, performance, total, of the early-treated CH group were within the normal range, they were each significantly lower than those in the non-CH group. Conclusion This meta-analysis reveals that IQ scores in early-treated CH subjects were within normal limits, but significantly lower than that of normal controls.

Co-Authors Adelita, Miranda Bagus Prastyo, Dimas Bugis Mardina Lubis, Bugis Mardina Dina Arwina Dalimunthe Erna Mutiara Hakimi dr Hakimi Hakimi Hariadi Edi Saputra Heny Syahrini Jose Rizal Latief Batubara Jose RL Batubara Lubis, Dian Anindita Mayasari Lubis, Siska Melda Deliana Melda Deliana Melda Deliana Melda Deliana Melda Deliana Melda Deliana, Melda Miranda Adelita Munar Lubis Nasution, Indah Nurul Wahida Harahap Purba, Siska Octaviani Rahmad Sumiko Rina Amalia C. Saragih, Rina Amalia C. Rina Amalia Karomina Saragih Rizki Aryo Wicaksono Rizki Aryo Wicaksono Siska Mayasari Lubis Siska Mayasari Lubis Sufitni Supriatmo Whyra Pratama Said Winra Pratita

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