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All Journal Paediatrica Indonesiana Majalah Kedokteran Nusantara The Journal Of Medical School Majalah Patologi Indonesia Sumatera Medical Journal Health Care : Jurnal Kesehatan International Journal Of Science, Technology & Management (IJSTM) Indonesian Journal of Cancer Molekul: Jurnal Ilmiah Kimia

Sufitni

Department Of Anatomical Pathology, Universitas Sumatera Utara, Medan, North Sumatera

Author-ID : 1054892

Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Transportation

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Articles

The Effect of Torbangun Leaves Tea on Msg-induced Fetal Develop-ment Disorder in Mice M.Kes, Sufitni; Feriyawati, Lita; Pane, Yunita Sari; Lelo, Aznan
Sumatera Medical Journal Vol. 2 No. 1 (2019): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

The safety of MSG on the fetus has not been confirmed yet. The objective of this research is to determine the effect of tea of torbangun leaves on fetal development disorder of mice. The present study is experimental with a Completely Randomized Design (CRD). Data obtained were then analyzed by ANOVA, with p<0,05 as the level of significant. The comparison of mean values ± SEM increase number of live fetuses group C1-T1 (4,60 ± 0,93; 11,40 ± 0,87), p=0,018. The comparison of mean values ± SEM decrease number of embryo re-sorption percentage group C0-C1 (00,00 ± 00,00; 36,74 ± 15,13), group C1-C2 (36,74 ± 15,13; 00,00 ± 0,00), group C1-T1 (36,74 ± 15,13; 00,00 ± 0,00), and group C1-T2 (36,74 ± 15,13; 15,00 ± 22,36), p=0,020. This study concluded that T1 group is giving the best effect on increasing life fetuses and decreasing embryo re-sorption percentage.

Efek Jus Semangka Terhadap Jumlah Dan Motilitas Spermatozoa Tikus Wistar Yang Dipapari MSG Tengku Muhammad Reza Syahputra; Muhammad Ichwan; Sufitni
HEALTH CARE : JURNAL KESEHATAN Vol 8 No 2 (2019): Health Care : Jurnal Kesehatan
Publisher : STIKes Payung Negeri Pekanbaru

Background: MSG is a glutamic acid uses as a food flavoring especially processed food products. MSG in processed foods can exceed the estimated levels because some processed foods do not put on the packaging label. Some studies report the effects of MSG on various organs, especially the testes. Long-term and excessive consumption of MSG causes testicular damage due to oxidative stress resulting in lipid peroxidation. Antioxidants in watermelons play a role in preventing oxidative damage. Aim: to find out the effect of watermelon juice on the number and motility of sperm exposed to MSG. Method: Experimental research design of post test only control group, 35 male Wistar rats were randomly divided into five groups: KN(pellet), KP(MSG 10mg/grBB), P1(MSG 10mg/grBB + watermelon juice 25%), P2(MSG 10mg/grBB + watermelon juice 50%), P3(MSG 10mg/grBB + watermelon juice 100%). Rats were treated for 30 days, then killed and taken vas deferens used to check sperm count and motility. Result: The KP group experienced a decrease in the number and motility of spermatozoa. There was a significant difference in the number(p=0,009) and motility(p=0,003) spermatozoa of the KP group compared to KN. There was a significant difference in the motility of the P3 group(p=0,040) compared to the KP. There was an improvement in motility in groups P1, P2, and P3 which approached KN. Conclusion: The administration of MSG showed significant results on the number and motility of spermatozoa. Giving watermelon juice can improve the number and motility of spermatozoa exposed to MSG.

Efek Pemberian Madu terhadap Lesi Hepar Maternal Mencit Terpapar Monosodium Glutamate (MSG) selama Masa Kehamilan Sufitni -; Delyuzar -; Emita Sabri
Majalah Patologi Indonesia Vol 22 No 2 (2013): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (560.789 KB)

ABSTRAK Latar belakang Monosodium glutamate (MSG) merupakan zat aditif makanan yang masih kontroversial. Konsumsi MSG yang tinggi meningkatkan metabolisme glutamat, dan radikal bebas yang berbahaya bagi tubuh. Salah satu antioksidan yang dapat menangkal radikal bebas adalah madu. Penelitian ini bertujuan untuk menguji efek madu terhadap lesi hepar induk mencit yang dipicu oleh pemberian MSG pada saat kehamilan. Metode Penelitian bersifat eksperimental murni dengan rancangan acak lengkap (RAL), yang terdiri atas 5 kelompok, yaitu 1 kelompok kontrol (K) dan 4 kelompok perlakuan (P1-P4). Kelompok kontrol hanya diberi akuades selama kehamilan 0-18 hari. Selama kehamilan 0-18 hari, P1 diberi MSG 4 mg/g BB/hari, P2 diberi madu 0,15 g/20 g BB/hari, dan P4 diberi MSG 4 mg/g BB/hari dan madu 0,15 g/20 g BB/hari. P3 diberi MSG 4 mg/g BB/hari pada kehamilan 0-7 hari, dilanjutkan pemberian madu 0,15 g/20 g BB/hari pada kehamilan 8-18 hari. Pada usia kehamilan 18 hari, mencit dikorbankan dengan cara dislokasi leher dan dilakukan nekropsi pengambilan hepar. Hasil Pemberian MSG dengan dosis 4 mg/g BB bersifat hepatotoksik dibanding kontrol (p= 0,041). Pemberian madu mampu mengurangi efek hepatotoksik MSG. Kesimpulan Madu mampu mengurangi efek hepatotoksik dari paparan MSG. Kata kunci : Kehamilan, lesi hepar, madu, monosodium glutamate (MSG). ABSTRACT Background Monosodium glutamate (MSG), a food additive that is still a controversial. High consumption of MSG will increase glutamate metabolism and free radical. Honey as antioxidant can remove free radical. The purpose of study was to determine the effects of honey therapy against hepatic lesions induced by MSG during pregnancy Methods The study was a true experimental with a completely randomized design (CRD), which consists of a control group (K) and four treatment groups (P1-P4). The control group (K) was given distilled water during gestation days 0-18. During of 0-18 days of gestation, P1 were given MSG 4 mg/g body weight (BW)/day, P2 were given honey 0.15 g/20 g BW/day, and P4 were given MSG 0.15 g/20 g BW/day and honey 4 mg/g BW/day. P3 were given MSG 4 mg/g BW/day on days 0-7 of pregnancy, and continued provision of honey 0.15 g/20 g BW/day on days 8-18 of pregnancy. At gestational age 18 days, each treatment and control mice were killed by cervical dislocation and then dissected for liver. Results Giving of high doses of MSG to mice during pregnancy, give hepatotoxic effect compare control (p=0.041). Giving honey can reduce hepatotoxic of MSG effect. Conclusion Honey was able to reduce the hepatotoxic effects of MSG administration. Key words: Hepatic lesion, honey, monosodium glutamate (MSG), pregnancy.

Efek pemberian madu terhadap lesi hepar maternal mencit (mus musculus) dan gangguan perkembangan fetus yang dipapari monosodium glutamate (MSG) selama masa kehamilan Sufitni dr; Delyuzar dr; Emita Sabri
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 46, No 2 (2013): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (538.63 KB)

Introduction : Monosodium glutamate (MSG), a food additive that is still a controversial, where some states are safe, but partly it's harmful to health. High consumption of MSG will increase glutamate metabolism. It will increase free radical, which harmful to body. Honey as antioxidant can remove free radical. Giving honey in pregnant mice after giving MSG, will reduce the negative impact of MSG.The purpose of study was to determine the effects of honey therapy against fetal development disorder of mice and hepatic lesions induced by giving of MSG during pregnancyMethods : The study is purely experimental with a completely randomized design (CRD), which consists of five groups, there are one control group and four treatment groups. The control group was given distilled water only during gestation days 0-18. The first treatment were given MSG 4mg/g body weight/day, the second treatment were given honey 0.15g/20g body weight /day, and the fourth treatment were given MSG 0.15 g/20g body weight/day and honey 4mg/g body weight/day, as long as 0- 18 days of gestation. The third treatment groups were given MSG 4mg/g body weight/day on days 0-7 of pregnancy, and continued provision of honey 0.15g/20g body weight/day on days 8-18 of pregnancy. At gestational age 18 days, each treatment and control mice were killed by cervical dislocation and then dissected for liver and fetuses removalResult : Giving of high doses of MSG to mice during pregnancy, give embriotoxic effect, characterized by decreased the number of live fetuses up to 54.9% (P = 0.003) and increased the number of embrio resorption up to 58.86% (P = 0.02), and hepatotoxic effect compare control with P value = 0.041. Giving honey can reduce hepatotoxic and embriotoxic of MSG effect, particularly they are giving together will increase the number of live fetuses up to 100% and decrease the number of embrio resorption up to 0%.Key words : monosodium glutamate (MSG); fetal; development disorder; mice; pregnancy; hepatic lesion77 |

Characteristics of Thyroid Cancer Patients in Haji Adam Malik General Hospital Rizka Annisa Harahap; Pimpin Utama Pohan; Sufitni Sufitni
Indonesian Journal of Cancer Vol 15, No 3 (2021): September
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Thyroid cancer is the most common endocrine cancer, and its incidence has continuously increased in the last three decades all over the world. The national prevalence of thyroid cancer has not been recorded. Sex, obesity, and the size of thyroid nodules are the risk factors for thyroid cancer. The aim of this study is to acknowledge the characteristics of thyroid cancer patients in Haji Adam Malik General Hospital. Methods: This is a cross-sectional study and carried out among 97 patients with thyroid cancer at Haji Adam Malik General Hospital from 2013 until 2015. Secondary data were obtained by consecutive sampling techniques using medical records. The inclusion criteria are all patients diagnosed with thyroid cancer based on histopathological analysis. Data were analyzed descriptively using SPSS in percentage.Results: From 97 patients with thyroid cancer, it could be concluded that thyroid cancer is the most frequently diagnosed in the age group of 55–64 years (32.0%). Females were predominant that attributed to 71.1% than males (28.9%). The majority of thyroid cancer was diagnosed at stage IV (39.2%) with the most common histopathological feature of papillary thyroid carcinoma (46,4%). Thyroid cancer patients are usually found with normal BMI (37.1%) and nodule thyroid found with the diameter of ≥4cm (47.4%).Conclusions: In the 55–64-year age female group, thyroid cancer is most diagnosed at stage IV with papillary thyroid carcinoma. Thyroid cancer patients are usually found with normal BMI and the nodule size of ≥4 cm.

Antibiofilm Formation Activities of Ethanol Extract of Curcuma domestica Val. Rhizome Against Multidrug-resistant Acinetobacter baumannii Halimah Raina Nasution; Yuandani; Abdi Wira Septama; Sony Eka Nugraha; Sufitni
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.883

Abstract. Multidrug resistance is still a major health problem worldwide. Biofilm formation was related to the resistance of bacteria mechanism. Acinetobacter baumannii, one of the bacteria that cause nosocomial infections, is given particular attention due to its high prevalence of resistance. The current study address observing the antibacterial activity and antibiofilm formation activity of Curcuma domestica rhizome extract against multidrug-resistant Acinetobacter baumannii (MDR A.baumannii). Curcuma domestica rhizome was macerated by ethanol 96%. Determination of Minimum Inhibitory Concentration (MIC) was carried out by the microdilution method. Antibiofilm formation analysis was determined by standard quantitative using crystal violet-stained assay. Ethanol extract of C. domestica possesses antibacterial activity against MDR A. baumannii with MIC value 250 µg/mL. Additionally, the ethanol extract of C. domestica could inhibit the biofilm formation of MDR A.baumannii, thus percentage of biofilm formed only 23.7% and significance different with control after analyzed using ANOVA post hoc test Tukey. According to these results, ethanol extract of C. domestica revealed antibacterial activity and had the potency in suppressing the biofilm formation of MDR A.baumannii, thus could be utilized in clinical application, especially in MDR A.baumannii infection. Keywords: Antibiofilm, antibacterial, Curcuma domestica, multidrug-resistant, Acinetobacter baumannii

Intelligence quotient (IQ) outcome in children with early-treated congenital hypothyroidism: a systematic review and meta-analysis Whyra Pratama Said; Karina Sugih Arto; Winra Pratita; Sufitni Sufitni
Paediatrica Indonesiana Vol 63 No 4 (2023): July 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.4.2023.290-7

Background Congenital hypothyroidism (CH) is the most common congenital endocrine disorder in childhood and is one of the most preventable causes of intellectual disability (ID). Late initiation of thyroid hormone substitution therapy has a negative impact on intellectual abilities in CH patients. Objective To compare Intelligence Quotient (IQ) between children with CH who underwent early treatment among the children without CH. Methods We performed online literature searches of ScienceDirect, Pubmed, Cochrane Library, and Google Scholar. We included clinical studies that examined IQ scores in patients with early-treated CH and without CH. Review Manager 5.4 was used to perform the meta-analysis. Results Twelve studies comparing pediatric patients with and without CH were included in this meta-analysis, for a total of 808 patients. Based on data analysis, IQ levels of verbal IQ [mean difference (MD) -9.05; (95%CI -14.51 to -3.59); (P<0.00001)], performance IQ [MD -11.70; (95%CI -17.41 to -5.99); (P<0.00001)], and total IQ [MD -10.78; (95%CI -14.03 to -7.54); (P<0.00001)]. While verbal, performance, total, of the early-treated CH group were within the normal range, they were each significantly lower than those in the non-CH group. Conclusion This meta-analysis reveals that IQ scores in early-treated CH subjects were within normal limits, but significantly lower than that of normal controls.

Synergistic Antibacterial Activity of Curcuma domestica Val. Extract with Tetracycline Against Multidrug-resistant Acinetobacter baumannii Nasution, Halimah Raina; Yuandani, Yuandani; Septama, Abdi Wira; Nugraha, Sony Eka; Sufitni, Sufitni; Khairunnisa, Nur Aini
Molekul Vol 19 No 1 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.1.8593

Infections caused by multidrug-resistant (MDR) bacteria are on the rise globally. MDR is facilitated by overexpression of efflux pump and permeability changes of membrane. Acinetobacter baumannii is a pathogenic germ that causes a major problem in infection, also, there has been an increase in the incidence of resistance to various antibiotics. The present study highlights the synergistic of ethanolic extract of Curcuma domestica (EECD) rhizome with tetracycline against multidrug-resistant A. baumannii (MDR-Ab). Assessment of Minimum Inhibitory Concentration (MIC) was determined by microdilution using 96-well plates. The synergistic effect of EECD and tetracycline was determined by checkerboard method. The effect of EECD and tetracycline combination was investigated by bacteriolytic activity and inhibition of efflux pump by Ethidium Bromide (EtBr) accumulation assay. EECD presented the MIC value 250 µg/mL against MDR-Ab. Fractional Inhibitory Concentration Index (FICI) value of EECD and tetracycline combination was 0.4, which showed their synergistic effect. Additionally, the combination of EECD and tetracycline could inhibit the efflux pump in MDR-Ab. This combination can also compromise cell integrity by altering membrane permeability thus lysing the bacteria cells. According to these results, EECD and tetracycline combination has synergistic effects at some sites of action, and thus could be used as a breakthrough to overcome infection problems due to MDR-Ab. Keywords: Acinetobacter baumannii, antibacterial, Curcuma domestica, multidrug-resistant, tetracycline

Co-Authors Abdi Wira Septama Abdi Wira Septama Arto, Karina Sugih Aznan Lelo Delyuzar dr Delyuzar, Delyuzar Eka Nugraha, Sony Emita Sabri Feriyawati, Lita Halimah Raina Nasution Khairunnisa, Nur Aini Muhammad Ichwan Nasution, Halimah Raina Pimpin Utama Pohan Rizka Annisa Harahap Tengku Muhammad Reza Syahputra Whyra Pratama Said Winra Pratita Yuandani Yunita Sari Pane

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