This study aimed to evaluate the effectiveness of the time-rushing game method in enhancing knowledge, skills, and self-efficacy in health-oriented disaster response simulations. A quasi-experimental one-group pretest-posttest design study was conducted with 114 nursing students. The Time Rushing Game measured knowledge, skills, and self-efficacy in conducting disaster-response simulations. The Time Rushing Game intervention consisted of triage, evacuation, and initial assessment procedures, each with a 10-minute time limit. After receiving the intervention or playing the disaster simulation, knowledge, skills, and self-efficacy were measured again. Knowledge and self-efficacy were measured using a questionnaire. Skills are measured using an observation sheet. There was a significant improvement in knowledge (p=0.000), skills (p=0.000), and self-efficacy (p=0.000) after the intervention using the Time Rushing Game learning method. The number of respondents who experienced an increase was 77 for knowledge and 106 for both skills and self-efficacy. Meanwhile, 37 respondents showed no change in knowledge, and 8 respondents each showed no change in skills and self-efficacy. The Time Rushing Game effectively enhanced students' knowledge, skills, and self-efficacy in health-oriented disaster response simulations. This learning method should be implemented not only in health-oriented disaster response simulations but also in other case-study-based simulations Keywords: Time Rushing Game, Knowledge, Skills, Self-Efficacy, Disaster Preparedness