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All Journal BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Rumphius Pattimura Biological Journal
Rahayu, Sekar
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology

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The EFFECT OF COMBRETUM INDICUM LEAVES ON LIPID PROFILE AND HEMATOLOGY OF MICE INDUCED WITH ALLOXAN Rahayu, Sekar; Aryani, Retno; Rosadi, Imam; Nugroho, Rudy Agung
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol. 11 No. 1 (2024): Biolink Agustus
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v11i1.11441

Abstract

Diabetes has become one of the main causes of death throughout the world recent years. Diabetes symptoms include high blood glucose and hyperlipidemia. An rise in blood glucose can produce an increase in the amount of leukocytes and erythrocytes in the hematology profile. Consequently, this study was to ascertain how extract Combretum indicum leaves affected the lipid profile and hematological of mice given alloxan. The study sample included 36 male mice divided into six groups: normal control (KN) without treatment, negative control (K-) with alloxan treatment, positive control (K+) with alloxan and glibenclamide treatment, P1 with alloxan treatment and Combretum indicum extract dose 100 mg/kgBW, P2 with alloxan treatment and Combretum indicum extract dose 200 mg/kgBW, and P3 with alloxan treatment and Combretum indicum extract dose 400 mg/kgBW. After the mice hyperglycemia on day 3rd, the therapy was continued.  The treatment lasted for 20 days. On days 10 and 20, hematological and lipid profile measures were performed. Combretum indicum leaves have the ability to lower total cholesterol, LDL and triglyceride with ascalate HDL levels on 20 days of treatment. In addition, it markedly raised the percentage of lymphocytes and neutrophils with escalate the quantities of lymphocytes and neutrophils in alloxan induced mice. So, in aloxan-induced mice, this extract can reduce the effects of diabetes.
Histopathological Analysis of Liver Damage in Rasbora lateristriata Fish Induced by extract Butterfly Pea flower (Clitoria ternatea) Endar Pertiwi, Anggita; Illiyin, Sirayya; Sadewo, Imran; Rahayu, Sekar; Samparisna Rumansara, Papuani; Moli Podhi, Felisitas; Sularsah, Sais; Adelfiani, Adelfiani; Retnoaji, Bambang; Sofyantoro, Fajar; Nuriliani, Ardaning; Wijayanti, Nastiti; T.S.S.G. Saragih, Hendry; Rohmah, Zuliyati; Widiyanto, Slamet; Eka Putri Empra, Desi; Ariesti, Wiwin; Septriani, Nur Indah
RUMPHIUS Vol 8 No 1 (2026): RUMPHIUS Pattimura Biological Journal (in process)
Publisher : Universitas Pattimura

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Abstract

Butterfly pea flower (Clitoria ternatea) is an Indonesian native plant known for its medicinal properties due to its rich content of anthocyanins, flavonoids, and ternatins. Although widely recognized for its health benefits, the long-term effects of its bioactive compounds require careful evaluation. This study aimed to investigate the potential hepatotoxic effects of butterfly pea flower extract on the liver of Rasbora lateristriata fish. Fish were exposed to 0 (control), 50, 75, and 100 ppm of butterfly pea extract for four days, with four fish allocated per group. Histological markers, including necrosis, vacuolization, pyknosis, and hemorrhage, were assessed in liver tissues. Data were analyzed using the Kruskal-Wallis test and Mann-Whitney U test at a 95% confidence level. Results indicated that butterfly pea flower extract caused significant hepatic damage, with increased severity at higher concentrations. The most pronounced damage was observed at 75 ppm, suggesting an optimal dose for inducing oxidative stress. This study highlights the potential hepatotoxicity of butterfly pea flower extract in aquatic species and underscores the need for further research to evaluate its safety for therapeutic use.
Co-Authors Adelfiani, Adelfiani Ardaning Nuriliani Ariesti, Wiwin Aryani, Retno Bambang Retnoaji Eka Putri Empra, Desi Endar Pertiwi, Anggita Illiyin, Sirayya Imam Rosadi Moli Podhi, Felisitas Nastiti Wijayanti Rohmah, Zuliyati Rudy Agung Nugroho Sadewo, Imran Samparisna Rumansara, Papuani Septriani, Nur Indah Slamet Widiyanto Sofyantoro, Fajar Sularsah, Sais T.S.S.G. Saragih, Hendry