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PENINGKATAN PENGETAHUAN MASAYARAKAT DALAM MENGOLAH SAMPAH ORGANIK DI PKK DESA BADEAN BLIMBINGSARI BANYUWANGI Mushoffa, Mushoffa; , Muhammad Zulqurnain; Ana Nurjanah
PAKDEMAS : Jurnal Pengabdian Kepada Masyarakat Vol 4 No 1 (2024): Desember
Publisher : Fakultas Pertanian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58222/pakdemas.v4i1.311

Waste management has become a significant challenge in many regions, including Badean Village, Blimbingsari, Banyuwangi, where the volume of organic waste has increased due to population growth and economic activities. This community service program aimed to empower the local PKK (Family Welfare Program) women by training them in organic waste management through composting, Local Microorganisms (MOL) production, and eco-enzyme techniques. The program was conducted in two phases, on August 27-28 and October 1-2, 2024, involving experts, students, and village officials. The results showed an improvement in participants' knowledge and skills in transforming organic waste into valuable products such as organic fertilizers and multifunctional liquids. The effectiveness of the training was demonstrated by increased community participation in sustainable waste management. This program is expected to contribute to reducing waste volume in the village and enhance community welfare through the utilization of organic waste.

Design, Synthesis, and In Silico Study of Two N-Substituted Pyrazinamide Analogs as Potential Antituberculosis Agents Zulqurnain, Muhammad; Wati, First Ambar; Nurjanah, Ana; Kavin, Layli Adha Nadira; Afifah, Rizqi Nur; Suyatno; Santoso, Mardi
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 1 (2025): Edition January-April 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.014.01.7939

Tuberculosis (TB) is an infectious yet often overlooked disease that remains a significant global challenge. Pyrazinamide (PZA), a key drug in the first-line TB treatment regimen, is used to reduce the duration of therapy, making it a compound of great interest for further exploration. Two pyrazine-2-carboxamide analogs have been successfully synthesized and reported, followed by an in-silico evaluation of their potency as antituberculosis agents. Yamaguchi reagent was employed as a coupling agent between pyrazine-2-carboxylic acid and corresponding amine, yielding N-(cyclohexylmethyl) pyrazine-2-carboxamide (D) and N-(4-cyclooctyl) pyrazine-2-carboxamide (E) in 60% and 55%, respectively. The molecular docking analysis of compounds (D) and (E) demonstrated lower binding energies (-7.65 and -7.37 kcal/mol, respectively), in comparison with the standard TB drugs, pyrazinamide and isoniazid. Additionally, ADME and pharmacokinetics evaluations revealed that compounds (D) and (E) meet the essential criteria for oral drug candidacy. These findings suggest that the pyrazinamide analogs (D) and (E) hold significant potential as promising antimycobacterial agents for tuberculosis therapy.

STUDI IN SILICO SENYAWA HIBRID GABUNGAN PIRAZINAMIDA DENGAN ASAM 4-(2-AMINOTIAZOL-4-IL)BENZOAT Zulqurnain, Muhammmad; Nurjanah, Ana; Wati, First Ambar
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 6 No. 1 (2024): Publikasi Penelitian Kimia
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v6i1.3299

Saat ini, kasus TB terus menjadi tantangan global dengan lebih dari 10 juta kasus baru setiap tahun, dan lebih dari 500.000 di antaranya resisten terhadap obat TB. Indonesia menyumbang sekitar 10% dari total kasus TB global dan menempati peringkat kedua sebagai negara dengan jumlah kasus TB tertinggi di dunia. Peningkatan kasus TB kambuh dipicu oleh resistensi terhadap obat TB sehingga memerlukan pengembangan obat baru yang efektif, singkat dalam pengobatan, dan tidak rentan terhadap Mycobacterium tuberculosis. Pirazinamida merupakan salah satu obat komersial untuk menangani tuberkulosis. Cincin pirazin memiliki peran penting dalam aktivitas bakterisidal. Senyawa yang mengalami N-substitusi dengan 4-feniltiazol-2-amin dan perpanjangan fenil dengan subtitusi gugus asam karboksilat telah terbukti memiliki aktivitas yang efektif. Dalam penelitian ini, dilakukan analisis in silico terhadap senyawa hibrid yang mengombinasikan pirazinamida dengan Asam 4-(2-aminotiazol-4-il)benzoat. Studi in silico melibatkan penelitian studi penambatan, sifat fisikokimia, dan sifat farmakokinetik. Hasil analisis menunjukkan bahwa senyawa hibrid (5) dan (6) memiliki potensi sebagai penghambat protein InhA dan dapat dianggap sebagai kandidat obat oral.

Analysis of Chemistry Education Students' Perceptions Regarding the Use of ChatGPT for Organic Chemistry Learning Fikriya, Sakti Hidayati; Zulqurnain, Muhammad; Suharman, Andi; Ad’hiya, Eka
LAVOISIER: Chemistry Education Journal Vol 4, No 2 (2025): LAVOISIER: Chemistry Education Journal
Publisher : UIN Syekh Ali Hasan Ahmad Addary Padangsidimpuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24952/lavoisier.v4i2.17937

Advances in artificial intelligence technologies, such as ChatGPT, provide new opportunities for learning Organic Chemistry, a subject noted for its abstract and complex concepts. The purpose of this study is to investigate students' impressions of using ChatGPT as a learning tool for mastering Organic Chemistry subjects. This descriptive quantitative study included 87 Chemistry Education Study Program students from Sriwijaya University's Faculty of Teacher Training and Education. A Likert-scale survey was used to obtain data on frequency of usage, perception of use, perception of utility, prompt effort, and ethical awareness when using ChatGPT. The results revealed that 98.9% had used ChatGPT to learn Organic Chemistry; 74% thought ChatGPT was successful in promoting understanding of the content; and 72% recognized the efficiency of learning time. Thematic study revealed that ChatGPT aided in the smooth exposition of difficult concepts such as stereochemistry and chemical processes. However, 59% believed that the explanations' accuracy required further scientific validation. Respondents acknowledged the possibility of conceptualization errors if ChatGPT was utilized without lecturer guidance or evaluation of scientific sources. These findings support ChatGPT's potential as an adaptable and relevant Organic Chemistry learning tool for achieving 21st-century demands such as critical thinking and problem solving. Additional study recommendations include integrating ChatGPT into organic chemistry learning models and media.

Analysis of Chemistry Education Students' Perceptions Regarding the Use of ChatGPT for Organic Chemistry Learning Fikriya, Sakti Hidayati; Zulqurnain, Muhammad; Suharman, Andi; Ad’hiya, Eka
LAVOISIER: Chemistry Education Journal Vol 4, No 2 (2025): LAVOISIER: Chemistry Education Journal
Publisher : UIN Syekh Ali Hasan Ahmad Addary Padangsidimpuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24952/lavoisier.v4i2.17937

Advances in artificial intelligence technologies, such as ChatGPT, provide new opportunities for learning Organic Chemistry, a subject noted for its abstract and complex concepts. The purpose of this study is to investigate students' impressions of using ChatGPT as a learning tool for mastering Organic Chemistry subjects. This descriptive quantitative study included 87 Chemistry Education Study Program students from Sriwijaya University's Faculty of Teacher Training and Education. A Likert-scale survey was used to obtain data on frequency of usage, perception of use, perception of utility, prompt effort, and ethical awareness when using ChatGPT. The results revealed that 98.9% had used ChatGPT to learn Organic Chemistry; 74% thought ChatGPT was successful in promoting understanding of the content; and 72% recognized the efficiency of learning time. Thematic study revealed that ChatGPT aided in the smooth exposition of difficult concepts such as stereochemistry and chemical processes. However, 59% believed that the explanations' accuracy required further scientific validation. Respondents acknowledged the possibility of conceptualization errors if ChatGPT was utilized without lecturer guidance or evaluation of scientific sources. These findings support ChatGPT's potential as an adaptable and relevant Organic Chemistry learning tool for achieving 21st-century demands such as critical thinking and problem solving. Additional study recommendations include integrating ChatGPT into organic chemistry learning models and media.

DESAIN DAN EVALUASI IN SILICO TURUNAN BARU PIRAZINAMIDA BERBASIS 1,2,4-TRIAZOL SEBAGAI KANDIDAT OBAT ANTITUBERKULOSIS Zulqurnain, Muhammad; Fikriya, Sakti Hidayati; Suharman, Andi
Seminar Nasional Pendidikan IPA Ke III Tahun 2025 Vol 3, No 1 (2025): Prosiding Seminar Pendidikan IPA
Publisher : Seminar Nasional Pendidikan IPA Ke III Tahun 2025

Show Abstract | Download Original | Original Source | Check in Google Scholar

Tuberkulosis masih menjadi salah satu penyakit menular paling mematikan di dunia, sementara resistansi terhadap obat lini pertama seperti pirazinamida terus meningkat. Penelitian ini bertujuan untuk merancang dan mengevaluasi dua turunan pirazinamida yang disubstitusi dengan gugus 1,2,4-triazol sebagai kandidat antituberkulosis baru melalui pendekatan in silico. Senyawa yang dirancang meliputi N-(1-(4-hidroksibenzil)-1H-1,2,4-triazol-3-il)pirazin-2-karboksamida (D) dan 6-kloro-N-(1-(4-hidroksibenzil)-1H-1,2,4-triazol-3-il)pirazin-2-karboksamida (E), yang diuji sebagai inhibitor enzim enoyl-[acyl-carrier-protein] reductase (InhA) dari Mycobacterium tuberculosis. Evaluasi dilakukan melalui analisis sifat fisikokimia, farmakokinetika, dan penambatan molekul. Hasil analisis menunjukkan bahwa kedua senyawa memenuhi seluruh parameter kelayakan obat (drug-likeness) utama berdasarkan aturan Lipinski, Ghose, dan Veber, dengan profil absorpsi oral yang baik serta risiko interaksi obat yang rendah. Hasil penambatan molekul memperlihatkan bahwa senyawa (E) memiliki energi bebas pengikatan (ΔG) sebesar −9,55 kcal/mol dan membentuk interaksi hidrogen serta π–π penting dengan residu tirosin (TYR) A:158, treonin (THR) A:196, dan kofaktor nikotinamida adenin dinukleotida (NAD) A:500, menyerupai ligan referensi. Sementara itu, senyawa (D) juga menunjukkan interaksi stabil dan potensi penghambatan yang kompetitif. Dengan demikian, modifikasi struktur pirazinamida melalui penambahan gugus triazol dan hidroksifenil terbukti meningkatkan potensi penghambatan terhadap enzim InhA. Senyawa (E) menonjol sebagai kandidat inhibitor kompetitif yang potensial, sedangkan senyawa (D) tetap menjanjikan sebagai analog aktif untuk pengembangan obat antituberkulosis yang lebih spesifik dan efektif.

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