Kadri, Alfansuri
Departemen Neurologi, FK Universitas Sumatera Utara/RSUP Haji Adam Malik, Medan, Sumatera Utara, Indonesia

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Journal : Majalah Kedokteran Nusantara The Journal Of Medical School

Hubungan kadar adiponektin dengan migren dan tension type headache Eva Meutia; Alfansuri Kadri; Khairul P. Surbakti; Hasan Sjahrir
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 2 (2012): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Background: Migraine and tension type headache (TTH) are the primary headaches that most complained and can lead to disability significantly. Obesity is already known to be one of the headache chronification risk factors, and adiponectin is a cytokine that is secreted by adipocytes tissue primarily. Adiponectin has been known to play a role in modulated some inflammatory pathways of the primary headache pathophysiology or in central sensitization process in conjunction with chronic headache. Objective: To evaluate association level of adiponectin with migraine and TTH.Methods: This cross-sectional study was conducted in migraine and TTH patients who came to sefalgia outpatient department of Adam Malik Hospital, which sex-and age matched for this study sample. Each subject completed a questionnaire adapted from the research Ho KH and BK Ong-C, and do anthropometric examination also adiponectin examination at Prodia laboratory. Result: There is significantly difference of mean adiponectin level between migraine 7.58 (SD 4.69) and TTH 4.99 (SD 2.63) (P = 0.008). Association of adiponectin level with episodic migraine is found not significant (P = 0.35), but the significant association is found with TTH (P = 0.013), which adiponectin level is found higher in chronic TTH 8.5 (SD 1.39) than episodic TTH 4.64 (SD 2.47). From the Spearman correlation test, there is negative association between WHR with adiponectin level significantly (r = -0.28. P = 0.02).Conclusion: There is association between adiponectin level with TTH, but it’s not significant with episodic migraine, and there is negative association between WHR and adiponectin level.Keywords : migraine; tension type headache; adiponectin level; obesity; waist hip ratio
Hubungan antara kadar lipoprotein dengan kejadian stroke dan tumor otak Cut Diana Maya Theresa; Yuneldi Anwar; Alfansuri Kadri
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 47, No 3 (2014): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Background : Recent evidences showed correlation main class of lipoprotein with stroke and brain tumor. Stroke and brain tumor can caused by multifactor, and nutrition is one of their etiology.Objectives : This study aimed to investigate correlation between lipoprotein with stroke and brain tumor.Methods : This was a cross-sectional study, subjects with stroke (26 persons) and brain tumor (26 persons). All patients underwent physical and neurological examinations, neuroimaging and lipoprotein serum examinations. Results : Stroke subjects consisted of 17 (65.4%) women and 9 (34.6%) men, with mean age ±54.38 years. Mean HDL level was 38.96±15.66 mg/dL, mean LDL level was 131.69±32.37 mg/dL, mean VLDL level was 22.42±6.64 mg/dL. The LDL level were significantly correlated with stroke and had a moderate correlation (r=0.426, p=0.030). The HDL level were not significantly correlated with stroke and had a very weak correlation (r=-0.010, p=0.960). VLDL level were not significantly correlated with stroke and had a very weak correlation (r=-0.087, p=0.672). Brain tumor subjects consisted of 16 (61.5%) men and 10 (38.5%) women, with mean age ±46.46 years. Mean HDL level was 38.58±12.73 mg/dL, mean LDL level was 131.42±43.67 mg/dL, mean HDL level was 26.70±10.75 mg/dL. The LDL level were not significantly correlated with brain tumor and had a very weak correlation (r=-0.103, p=0.618). HDL level were not significantly correlated with brain tumor and had a very weak correlation (r=0.087, p=0.672). VLDL level were not significantly correlated with brain tumor and had a very weak correlation (r=0.031, p=0.881).Conclusion : There was a significant correlation between LDL level and stroke, but no significant corelation between HDL levels with stroke and VLDL levels with stroke . The HDL, LDL and VLDL levels were not significant corelation with brain tumor. Keywords : lipoprotein, HDL, LDL, VLDL, stroke,brain tumor