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All Journal Majalah Kedokteran Bandung Global Medical and Health Communication Jurnal Kedokteran Anatomica (Anatomica Medical Journal) JURNAL IBNU SINA BIOMEDIKA Buletin Farmatera Hasil Pengabdian Kepada Masyarakat Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Kesehatan Panrita Husada JURNAL ILMIAH MAKSITEK JURNAL ILMIAH SIMANTEK JURNAL ILMIAH KOHESI Ihsan: Jurnal Pengabdian Masyarakat Jurnal Ilmiah Wahana Pendidikan Muhammadiyah Medical Journal Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam Jurnal Kedokteran Ibnu Nafis Jurnal Pandu Husada Jurnal Implementa Husada (JIH)
Isra Thristy
Universitas Muhammadiyah Sumatera Utara
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Hubungan Antara Anemia dalam Kehamilan dengan Berat Bayi Lahir Rendah (BBLR) di Rumah Sakit Budi Kemuliaan Kota Batam Isra Thristy; Andi Ipaljri; Octaliana Sihaloho
Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam Vol 11 No 3 (2021): Zona Kedokteran Program Studi Pendidikan Dokter Universitas Batam
Publisher : Universitas Batam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37776/zked.v11i3.936

Abstract

Latar Belakang: Angka kematian ibu hamil masih terhitung tinggi dan merupakan masalah yang menjadi prioritas di bidang Kesehatan, salah satu penyebab kematian ibu hamil adalah anemia pada kehamilan. Angka prevalensi anemia dalam kehamilan di Asia adalah 49,4%. Prevalensi anemia dalam kehamilan di Indonesia tahun 2013 sebesar 37,1% dan pada tahun 2018 mengalami peningkatan sebesar 48,9%, anemia pada ibu hamil dihubungkan dengan meningkatnya kelahiran Berat Bayi Lahir Rendah (BBLR) dengan prevalensi kasus BBLR di Indonesia mencapai 10,5%. Prevalensi Berat Bayi Lahir Rendah (BBLR) di Kepuluan Riau sebesar 34%. Pada Rumah Sakit Budi Kemuliaan Kota Batam dari 20 kasus ibu hamil yang mengalami anemia terdapat 16 kasus Berat Bayi Lahir Rendah (BBLR) dan 4 kasus Berat Bayi Lahir Normal. Metode: Metode penelitian ini adalah Cross Sectional yang dilakukan di Rumah Sakit Budi Kemuliaan Kota Batam pada bulan Januari 2021. Jumlah sampel sebanyak 71 ibu hamil yang diambil menggunakan Teknik Simple Random Sampling. Hasil penelitian dianalisis dengan uji chi square. Hasil: Hasil uji chi square menunjukkan terdapat hubungan yang bermakna antara Anemia dalam Kehamilan dengan Berat Bayi Lahir Rendah (BBLR) di Rumah Sakit Budi Kemuliaan Kota Batam dengan nilai p value = 0,000 (p<0,05). Simpulan: Berdasarkan penelitian ini dapat disimpulkan bahwa terdapat hubungan antara anemia dalam kehamilan dengan Berat Bayi Lahir Rendah (BBLR) di Rumah Sakit Budi Kemuliaan Kota Batam.
Hubungan Tekanan Darah Dengan Kadar Ureum Dan Kreatinin Pada Pasien Diabetes Melitus Tipe 2 Di Rumah Sakit Mohammadnatsir Ance Roslina; Amelia Eka Damayanti; Isra Thristy
Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam Vol 12 No 1 (2022): Zona Kedokteran Program Studi Pendidikan Dokter Universitas Batam
Publisher : Universitas Batam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37776/zked.v12i1.972

Abstract

Background:Diabetes mellitus is defined as a chronic metabolic disease or disorder with multi-etiology characterized by high blood sugar levels accompanied by metabolic disorders of carbohydrates, lipids, and proteins as a result of insufficiency of insulin function. Ureum and Creatinine levels are parameters for finding out kidney function and progression of chronic kidney disease as a result of Diabetes Mellitus. Methods:This research method is observational analysis with a cross sectional approach conducted at M.Natsir Hospital in Solok City in Oktober. The sampling technique is Total Sampling with a sample number of 133 respondents. Bivariate analysis was conducted to find out the correlation between blood pressure and ureum levels and creatinine patients with type 2 diabetes mellitus and tested and analyzed with spearman rho test which is useful to find out the variables with each other. Results:From the results of research found that blood pressure has a correlation with ureum and creatinine levels. Spearman Rho statistical test results obtained a value of p for blood pressure with ureum levels of 0.000 (<0.05) and a p value for blood pressure with creatinine levels of 0.000 (<0.05). Conclusion:Based on this study that there is a correlation between blood pressure and ureum and creatinine levels in patients with Type 2 Diabetes Mellitus at M.Natsir Hospital in Solok City.
PERBANDINGAN KADAR ASAM URAT DAN LAJU FILTRASI GLOMERULUS (LFG) PADA PASIEN GAGAL GINJAL KRONIK SEBELUM DAN SESUDAH HEMODIALISA ROJU LUBIS; ISRA THRISTY
JURNAL ILMIAH KOHESI Vol 7 No 1 (2023): JURNAL ILMIAH KOHESI
Publisher : LP2MTBM MAKARIOZ

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Abstract

Chronic Kidney Disease (CKD) is a global health problem that affects more than 200 million people worldwide.1 According to the Global Burden of Disease Study (2010), CKD was ranked the 27th leading cause of death worldwide in 1990, the ranking is increasing to be ranked 18th in 2019. This shows an increase in the number of CKD sufferers in the last 2 decades. According to the latest data according to the 7th Report of the Indonesian Renal Registry, every year Indonesia experiences an increase in patients undergoing hemodialysis, it is estimated that there are 17,193 new patients and 11,689 active patients with a mortality rate of 2,221 in 2019. The aim of this study was to describe uric acid levels and glomerular filtration rate (GFR) in patients with chronic renal failure before and after hemodialysis. The study was a descriptive non-retrospective cross-sectional study using secondary data in the form of medical records to see uric acid levels and LFG values before and after hemodialysis at the Rashida Kidney Hospital. Furthermore, the data were collected and processed using the Paired T-Test. Results: The results of the study of uric acid levels in patients with before and after hemodialysis showed p = 0.011 (p <0.05) and the LFG Values before and after with the discovery test p = 0.000 (p <0.05). finding the value between the before and after values on uric acid levels and LFGvalues
PERBANDINGAN PENGGUNAAN ANTIPSIKOTIK ATIPIKAL TUNGGAL DAN KOMBINASI TERHADAP KADAR KOLESTEROL PADA PASIEN SKIZOFRENIA TARISA ANANDASMARA; ISRA THRISTY
JURNAL ILMIAH MAKSITEK Vol 8 No 1 (2023): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Schizophrenia is a psychiatric disease that causes the most psychological and social problems. This disease requires antipsychotic therapy for a long time, so it is very possible in the treatment process to find problems in the use of antipsychotics, one of which is an increase in total cholesterol levels. This study aims to determine differences in total cholesterol levels in schizophrenia patients who use single and combination atypical antipsychotics at RSU. Madani Medan. The research design used is descriptive analytic with a cross-sectional study. The sample used in this study amounted to 30 samples. Samples were taken using a single atypical antipsychotic as many as 15 people and 15 people using a combination atypical antipsychotic. Then the sample is checked at UPT. The Regional Health Laboratory (KESDA) uses the CHOD-PAP (Cholesterol Oxidase-Peroxidase Aminoantypirin) method with a photometer. Then the data is processed with the SPSS program. From 30 samples used, it was found that 15 samples using a combination atypical antipsychotic experienced an increase in cholesterol levels (50%) and 15 samples using a single atypical antipsychotic did not experience an increase in cholesterol levels (50%). Based on the results of this study, it can be concluded that there is difference in cholesterol levels in the use of single and combined atypical antipsychotics in schizophrenic patients as evidenced the p-value obtained, which is 0.000 (p <0.05).
PERBANDINGAN PENGGUNAAN ANTIPSIKOTIK ATIPIKAL TUNGGAL DAN KOMBINASI TERHADAP KADAR GLUKOSA DARAH PADA PASIEN SKIZOFRENIA POPI LATIFAH BAWEAN; ISRA THRISTY
JURNAL ILMIAH KOHESI Vol 7 No 2 (2023): JURNAL ILMIAH KOHESI
Publisher : LP2MTBM MAKARIOZ

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Abstract

Schizophrenia is a severe mental disorder characterized by many disturbances in thinking, language, perception, and a sense of self-awareness. Pharmacotherapy in schizophrenic patients is the use of antipsychotics, either alone or in combination. In addition, antipsychotic drugs can be combined with other drugs such as antidepressants, antiparkinsonian. Concurrent administration of first-generation (typical) and second-generation (atypical) antipsychotics occurs when the administration of first/second generation antipsychotics has no effect. In the long term use of the drug can cause extrapyramidal symptoms, metabolic disorders such as increased blood glucose levels. To compare the use of single and combined atypical antipsychotics on blood glucose levels in schizophrenic patients.This research is a descriptive analytic study with a non-probability sampling technique that is carried out by taking venous blood, and then examining the blood in the laboratory using spectrophotometry. The number of samples used was 30 schizophrenic patients, of which 15 were taking a single antipsychotic drug, and 15 people taking a combination antipsychotic drug. Then the analysis was carried out using the Mann-Whitney test. The results of the Mann-Whitney test showed that there was a significant difference between the use of single antipsychotics and combination antipsychotics in schizophrenic patients with P value = 0.001 (p < 0.05). The use of combination antipsychotics has a higher risk than single antipsychotics.The use of single antipsychotics has a significant difference with combination antipsychotics on blood glucose levels in schizophrenic patients. Keywords: Schizophrenia, Antipsychotic Side Effects, Blood Glucose Level, Clozapine and Risperidone.
UJI EFEKTIVITAS SARI BUAH KURMA (PHOENIX DACTYLIFERA) TERHADAP JUMLAH TROMBOSIT MENCIT JANTAN (MUS MUSCULUS L) YANG DIBERI KOTRIMOKSAZOL PUTRI NADIA; YENITA YENITA; CUT MOURISA; ISRA THRISTY
JURNAL ILMIAH KOHESI Vol 7 No 2 (2023): JURNAL ILMIAH KOHESI
Publisher : LP2MTBM MAKARIOZ

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Abstract

Date palm suspension (Phoenix dactylifera) is a processed product from date palm, which has various ingredients that are beneficial for health. There was a study about the effectiveness of date palm suspension which aims to determine the effectiveness of date palm suspension to increasing the number of platelets in male mice (Mus musculus L) that given cotrimoxazole. This research use an experimental study with "Post test only control group design" and "Simple randomized sampling". This study used 35 male mice aged 2-3 months, weighing 20-30 grams were divided into 5 groups randomly. Negative control group, positive control group, and treatment group (I, II, III) with dose of 7 mg/kgBW, 14 mg/kgBW, 21 mg/kgBW. Cotrimoxazole was given for 8 days and date palm suspension was given for 2 days, then the platelet count was checked using an Automated Hematology Analyzer. The effectiveness of date palm suspension to increasing the platelet count of each test group was analyzed with One Way ANOVA statistical test. The results of statistical tests showed that date palm suspension with dose of 7 mg/kgBW, 14 mg/kgBW, 21 mg/kgBW could increase the platelet count of male mice that given cotrimoxazole, resulting in p<0.05 in all groups. Date palm juice (Pheonix dactylifera) is effective in increasing platelet levels, especially at a dose of 21 mg/kgBW. Keywords: Cotrimoxazole, Date palm suspension (Phoenix dactylifera), Platelets.
Gambaran Tingkat Stres dan kadar HDL Kolesterol Darah Pada Mahasiswa Fakultas Kedokteran Isra Thristy; Rina Sari Mardia; Cut Mutia Mampatdi; Muhammad Zulfikar Karim Chan
JURNAL PANDU HUSADA Vol 1, No 3 (2020)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jph.v1i3.4907

Abstract

Stres dapat diartikan sebagai respon tubuh tidak spesifik terhadap segala permintaan, keadaan dan bahaya yang berasal dari diri sendiri maupun lingkungan. Stresor adalah faktor-faktor dalam kehidupan manusia yang mengakibatkan terjadinya respon stres. Jenis stresor yang dialami para remaja dan anak-anak usia sekolah antara lain adalah stresor yang berasal dari tekanan di sekolah maupun di perkuliahan. Stres dapat berdampak pada tubuh berupa perubahan hormon yang memiliki efek metabolik terhadap karbohidrat, lemak dan protein. Penelitian ini merupakan deskriptif cross sectional. Populasi penelitian ini adalah mahasiswa fakultas kedokteran tingkat satu yang akan mengikuti ujian, dengan total sampel adalah 24 orang. Subjek dinilai hanya satu kali pada pemeriksaan darah dan penilaian stress menggunakan DASS 24, pada saat akan mengikuti ujian tanpa ada follow up. Hasil penelitian ini menggambarkan terdapat 29% sampel tanpa stres, 46% stress ringan, 17% stres sedang dan 8% stress berat. Sedangkan kadar HDL kolesterol 45,8% dalam keadaan normal dan 54,2% dalam keadaan rendah. Terdapat Kejadian stres pada mahasiswa tingkat satu yang akan mengikuti ujian dengan kadar HDL Kolesterol yang rendah.
Perbandingan Efektifitas Ekstrak Etanol Daun Afrika (Vernonia amygdalina Del) Dengan Simvastatin Terhadap Kadar Trigliserida Tikus Jantan Galur Wistar Yang Diinduksi Kuning Telur Nuryani Yani; Isra Thristy
JURNAL PANDU HUSADA Vol 2, No 1 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jph.v2i1.5369

Abstract

Dislipidemia adalah salah satu faktor risiko timbulnya penyakit kardiovaskular dan metabolik. Dalam mengatasi masalah tersebut, sering digunakan obat-obatan kimia seperti golongan statin. Masyarakat Indonesia mulai khawatir akan efek samping dari pengobatan menggunakan bahan kimia dan beralih menggunakan pengobatan herbal, salah satu tanaman tersebut yaitu daun Afrika. Penelitian ini bertujuan mem-bandingkan ekstrak daun Afrika dengan simvastatin dalam menurunkan kadar trigliserida tikus jantan yang diinduksi daun Afrika untuk mempercepat penurunan kadar trigliserida jika dibandingkan dengan simvastatin. Penelitian ini menggunakan metode eksperimental dengan rancangan Posttest with Control Group Design. Hasil penelitian menunjukkan bahwa terdapat perbedaan rata-rata kadar trigliserida pada kelima kelompok penelitian. Kombinasi ekstrak etanol daun Afrika 200 mg/kgBB/hari dengan simvastatin 1 mg/kgBB/hari mampu menurunkan kadar trigliserida tikus yang diinduksi kuning telur, namun efektivitasnya tidak berbeda bermakna dengan pemberian ekstrak etanol daun Afrika dosis tunggal maupun dengan pemberian simvastatin dosis tunggal.
HUBUNGAN POLIMORFISME GEN ANGIOTENSIN CONVERTING ENZYME DENGAN PERBAIKAN FRAKSI EJEKSI VENTRIKEL KIRI PADA PASIEN GAGAL JANTUNG KRONIK Handayani, Ahmad; Thristy, Isra; Andina, Meizly
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.5549

Abstract

Angiotensin-converting enzyme (ACE) is a circulating and membrane-bound enzyme in the renin-angiotensin system. Polymorphism is the presence of two or more alleles at a locus in a population. In patients with heart failure with impaired systolic function, the RAA system is activated. One of the main therapies in heart failure is the administration of angiotensin-converting enzyme blockers. This study aims to examine the relationship between angiotensin-converting enzyme gene polymorphisms with improvement in left ventricular ejection fraction (FEVK).This research is a prospective observational study using a convenient sampling technique, carried out at Mitra Medika Hospital Bandar Klippa, Deli Serdang. The number of samples in the study was 37 people. Each patient was examined for initial echocardiography and at least 1 month after treatment when clinical improvement was seen. All patients received treatment according to the standard guidelines for the management of chronic heart failure according to the European Society of Cardiology (ESC)/Indonesian Cardiovascular Specialist Doctors Association (PERKI). The majority of research subjects were male as much as 81% and the average age of the patients was 56 years. ACE gene polymorphism was dominated by gene II as much as 57%. The average FEVK value in the first measurement was 25.8% and in the second measurement, it increased to 34.4%. There was a significant change between FEVK I measurements by an average of 25% to 34% in the next measurement (p 0.05). In the analysis of the relationship, it was seen that the ACE gene polymorphism did not affect the improvement of the FEVK value.Treatment of chronic heart failure with a decrease in ejection fraction was seen to have a significant effect in increasing FEVK. There is no relationship between angiotensin-converting enzyme gene polymorphisms on response to therapy in patients with chronic heart failure in this study.
Relationship between Polymorphism of Angiotensin Converting Enzyme Gene with Symptoms of Depression in Schizophrenic Patients Nuralita, Nanda Sari; Thristy, Isra; Lubis, Debby Mirani
Buletin Farmatera Vol 7, No 1 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i1.9483

Abstract

In schizophrenic patients, symptoms of depression are often found which can lead to adverse effects on the treatment process, such as increasing the length of treatment, increasing the possibility of relapse, non-adherence in taking medication, and can also lead to suicide in schizophrenic patients. In schizophrenic patients, the activity of the central angiotensin converting enzyme (ACE) gene is altered and angiotensin II interacts with central dopamine, thereby contributing to the pathophysiology of schizophrenia. In addition, it is likely that the ACE gene variant is also involved in the development of depressive symptoms in schizophrenic patients. This research is a categorical analytic study with a cross sectional method, the sampling method is non-probability sampling with consecutive sampling type, with a total sample of 42 people. There was no significant difference between depression symptoms and ACE gene polymorphisms with P value = 0.746. There was no significant difference between depression symptoms and ACE gene polymorphisms.
Co-Authors ADINDA . Ahmad Handayani Amelia Eka Damayanti AMELIA EKA DAMAYANTI Amelia Eka Damayanty Ance Roslina Andi Ipaljri ANDRE PRAMUDIA KRISNA Br. Sembiring, Tiara Amanda Cut Mourisa Cut Mutia Mampatdi Damanik, Syifa Akbar DESI ELISA FLOWER Dorando, Raja Mahendra Putra Eka Damayanty, Amelia ELMEIDA EFFENDY ELVIANI . Fathinia Masyulani Harahap, Shofiah Rahmah Hasibuan, Hijriyah Putri Tarmizi Hutagaol, Nadya Utami IRFAN HAMDANI Koto, Ulfa Lubis, Debby Mirani Lubis, Eva Sahnita Meizly Andina, Meizly MUHAMMAD AULIA RAHMAN Muhammad Edy Syahputra Nasution Muhammad Fajar Muhammad Jalaluddin Assuyuthi Chalil Muhammad Zulfikar Karim Chan Nanda Sari Nurlita Noval, Wildana Luthfi Nuralita, Nanda Sari Nurfadly, Nurfadly Nuryani Nuryani Nuryani Yani Oche Axena Yulhan Octaliana Sihaloho POPI LATIFAH BAWEAN Pratiwi, Annisa Nola Prayoko, Herdianto PUTRI NADIA Putri, Humairani Putri, Maduri Yaner Rahmi Sibagariang Rina Sari Mardia Rita Zahara, Rita ROJU LUBIS Saleha, Imamah Maratu Salsabila Khalda Sari, Ria Wilan Permata Sigit Kurniawan TARISA ANANDASMARA Toniara, Safriwan Tria Tiurma Lestari Yahwardiah Siregar Yenita . Yenita Yenita YUFI YUWARDITRA Yufi Yuwarditra