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All Journal Majalah Kedokteran Bandung Global Medical and Health Communication Jurnal Kedokteran Anatomica (Anatomica Medical Journal) JURNAL IBNU SINA BIOMEDIKA Buletin Farmatera Hasil Pengabdian Kepada Masyarakat Martabe : Jurnal Pengabdian Kepada Masyarakat Jurnal Kesehatan Panrita Husada JURNAL ILMIAH MAKSITEK JURNAL ILMIAH SIMANTEK JURNAL ILMIAH KOHESI Ihsan: Jurnal Pengabdian Masyarakat Jurnal Implementa Husada Jurnal Ilmiah Wahana Pendidikan Muhammadiyah Medical Journal Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam Jurnal Kedokteran Ibnu Nafis Jurnal Pandu Husada Jurnal Kesehatan dan Kedokteran
Isra Thristy
Universitas Muhammadiyah Sumatera Utara
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Perbandingan Penggunaan Antipsikotik Atipikal Tunggal Dan Antipsikotik Atipikal Kombinasi Terhadap Kadar Ldl Pada Pasien Skizofrenia Toniara, Safriwan; thristy, Isra; Nuralita, Nanda Sari
Buletin Farmatera Vol 11, No 3 (2026)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v11i3.28213

Abstract

Abstract: Schizophrenia is a collection of psychotic disorders with irregularities in the thought process, which have the feeling that they are controlled by external forces, delusions, perceptual disorders and abnormal effects integrated with real situations or reality. The use of antipsychotics in schizophrenic patients is the treatment of this disease, especially the most commonly used atypical antipsychotic users. This study aims to compare LDL (low-density lipoprotein) levels in schizophrenia patients who use single atypical antipsychotics and combination atypical antipsychotics at Madani Hospital Medan, North Sumatra. This type of research is descriptive analytical using  a cross-sectional  method that takes data on variable-free bound variables at one time, which is housed at the Upt Health Laboratory. North Sumatra Provincial Health Office. The results of the Independent T-Test of the use of single antipsychotics and a combination of atypical antipsychotics on LDL levels in schizophrenia patients were p=0.001 (P≤0.05). There was a significant difference between the administration of a single atypical antipsychotic and a combination of atypical antipsychotics to LDL levels in patients with schizophrenia.
Antipyretic Activity of Spare Leaf Extract (Erythrina subumbrans (Hassk.) Merr.) on Pepton-Induced Male White Rats (Rattus norvegicus) Mandasari, Respia; Thristy, isra
Jurnal Kesehatan dan Kedokteran Vol. 5 No. 2 (2026): Juni: Jurnal Kesehatan dan Kedokteran
Publisher : Asosiasi Dosen Muda Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56127/jukeke.v5i2.2690

Abstract

Fever is a common physiological response of the body to infection, inflammation, or other pathological conditions and is characterized by an increase in body temperature above the normal range. Although antipyretic drugs such as paracetamol are widely used to reduce fever, the exploration of medicinal plants as alternative natural antipyretic agents remains important. Dadap serep leaves (Erythrina subumbrans (Hassk.) Merr.) are known to contain bioactive compounds such as flavonoids, saponins, tannins, alkaloids, and polyphenols, which are potentially associated with antipyretic and anti-inflammatory activity. Objective: This study aimed to evaluate the antipyretic activity of dadap serep leaf extract in peptone-induced male white rats (Rattus norvegicus) and to determine the most effective dose among 100, 200, and 400 mg/kgBW. Methods: This research was a laboratory experimental study using a pre-test and post-test control group design. A total of 30 male white rats were divided into five groups: negative control receiving 1% Na-CMC, positive control receiving paracetamol, and three treatment groups receiving dadap serep leaf extract at doses of 100, 200, and 400 mg/kgBW. Fever was induced by subcutaneous injection of 5% peptone, and rectal body temperature was measured at several observation times after treatment. Data were analyzed using One-Way ANOVA followed by the Tukey HSD post hoc test. Findings: The results showed that dadap serep leaf extract reduced rectal body temperature in peptone-induced rats. The strongest antipyretic effect was observed at a dose of 400 mg/kgBW, indicating that higher extract doses may produce a greater reduction in fever temperature. Implications: These findings indicate that dadap serep leaf extract has potential as a natural antipyretic agent and may support the development of plant-based fever management. The results may also provide a scientific basis for the traditional use of dadap serep leaves in reducing fever. Originality: The originality of this study lies in providing experimental evidence on the dose-dependent antipyretic effect of Erythrina subumbrans leaf extract in a peptone-induced fever model of male white rats.
Pencegahan Obesitas di Keluarga Sebagai Bom Waktu Di Masa Depan Amelia Eka Damayanty; Isra Thristy; Nanda Sari Nurlita
IHSAN : JURNAL PENGABDIAN MASYARAKAT Vol 8, No 1 (2026): Ihsan: Jurnal Pengabdian Masyarakat (April)
Publisher : University of Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/ihsan.v8i1.30458

Abstract

Obesitas merupakan faktor risiko pemicu timbulnya berbagai penyakit degeneratif yang bersifat kronis seperti hipertensi, diabetes mellitus, penyakit jantung dan pembuluh darah, perlemakan hati, gangguan fungsi ginjal hingga kanker, sehingga dapat menurunkan kualitas hidup dimasa depan sehingga dibutuhkan pencegahan obesitas sejak dini. Kegiatan ini bertujuan memberikan edukasi kepada masyarakat, meningkatkan pengetahuan dan informasi kepada masyarakat mengenai obesitas dan pencegahannya. Metode: Dilakukan edukasi kepada 38 orang kepala keluarga dikelurahan Tanjung Mulia Medan dengan metode ceramah, tanya jawab dan evaluasi sebelum dan sesudah edukasi.
Pencegahan Penyakit Degeneratif dan Faktor Risikonya Isra Thristy; Amelia Eka Damayanti; Nanda Sari Nuralita
IHSAN : JURNAL PENGABDIAN MASYARAKAT Vol 8, No 1 (2026): Ihsan: Jurnal Pengabdian Masyarakat (April)
Publisher : University of Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/ihsan.v8i1.25921

Abstract

Penyakit degeneratif, termasuk diabetes, hipertensi, penyakit jantung, dan stroke, telah menjadi salah satu masalah kesehatan utama di Indonesia, seiring dengan perubahan gaya hidup dan peningkatan harapan hidup. Di Indonesia, penyakit degeneratif kini merupakan penyebab utama morbiditas dan mortalitas, menggantikan penyakit menular yang sebelumnya mendominasi. Untuk mengatasi permasalahan penyakit degeneratif di masyarakat, terutama di wilayah seperti Kota Medan, diperlukan pendekatan yang komprehensif dan terintegrasi. Salah satu kegiatan yang dilakukan adalah peningkatan edukasi dan kesadaran masyarakat dan promosi gaya hidup sehat. Metode pendekatan yang digunakan dalam kegiatan ini adalah pendekatan penyuluhan. Tim Pengusul dan mitra bersama-sama menyusun rencana kegiatan, metode, tujuan, sasaran dan target yang harus dicapai. Dari kegiatan ini, didapatkan hasil pengetahuan peserta sebelum edukasi lebih banyak yang masih kurang (62,5%) mengenai penyakit degeneratif dan faktor risikonya dibandingkan setelah mendapatkan edukasi (20,8%). Setelah dilakukan edukasi terjadi peningkatan pengetahuan yang lebih baik (79,2%) dibandingkan sebelumnya (37,5%). Intervensi edukatif seperti ini penting dilakukan secara rutin dan menyeluruh untuk mencegah meningkatnya kasus penyakit degeneratif di Indonesia.
PENGARUH MINUMAN KOMBUCHA SALAK SIDEMPUAN TERHADAP KADAR HDL DAN LDL PADA TIKUS DIET TINGGI LEMAK Salsabila Khalda; Isra Thristy
Jurnal Kedokteran Ibnu Nafis Vol. 15 No. 1 (2026): Juni 2026
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/jkin.v15i1.1285

Abstract

Dyslipidemia is a metabolic disorder characterized by continuous alterations in plasma lipid levels. Kombucha, a fermented beverage produced from sweetened tea using SCOBY, has been reported to lower cholesterol levels. Research on kombucha continues to expand, particularly regarding the use of non-tea substrates for fermentation, such as salak fruit. This study aimed to analyze the effect of Sidempuan salak kombucha on HDL and LDL levels in male rats (Rattus norvegicus) induced with a high-fat diet. A true experimental method with a posttest-only control group design was employed, involving 32 rats divided into four groups: KN (standard feed for 6 weeks), K− (standard feed + high-fat diet for 6 weeks), P1 (standard feed + high-fat diet + 2.7 ml/day Sidempuan salak kombucha for 6 weeks), and P2 (standard feed + high-fat diet + 5.4 ml/day Sidempuan salak kombucha for 6 weeks). The collected data were analyzed using a One-Way ANOVA test. The results showed no significant differences in HDL and LDL levels among the four groups (p > 0.05). In conclusion, the administration of Sidempuan salak kombucha did not produce a significant effect on HDL and LDL levels in male rats induced with a high-fat diet.
Co-Authors ADINDA . Ahmad Handayani Amelia Eka Damayanti AMELIA EKA DAMAYANTI Amelia Eka Damayanty Ance Roslina Andi Ipaljri ANDRE PRAMUDIA KRISNA Br. Sembiring, Tiara Amanda Cut Mourisa Cut Mutia Mampatdi Damanik, Syifa Akbar DESI ELISA FLOWER Dorando, Raja Mahendra Putra Eka Damayanty, Amelia ELMEIDA EFFENDY ELVIANI . Fathinia Masyulani Harahap, Shofiah Rahmah Hasibuan, Hijriyah Putri Tarmizi Hutagaol, Nadya Utami IRFAN HAMDANI Koto, Ulfa Lubis, Debby Mirani Lubis, Eva Sahnita Mandasari, Respia Meizly Andina, Meizly MUHAMMAD AULIA RAHMAN Muhammad Edy Syahputra Nasution Muhammad Fajar Muhammad Jalaluddin Assuyuthi Chalil Muhammad Zulfikar Karim Chan Nanda Sari Nurlita Noval, Wildana Luthfi Nuralita, Nanda Sari Nurfadly, Nurfadly Nuryani Nuryani Nuryani Yani Oche Axena Yulhan Octaliana Sihaloho POPI LATIFAH BAWEAN Pratiwi, Annisa Nola Prayoko, Herdianto PUTRI NADIA Putri, Humairani Putri, Maduri Yaner Rahmi Sibagariang Rina Sari Mardia Rita Zahara, Rita ROJU LUBIS Saleha, Imamah Maratu Salsabila Khalda Sari, Ria Wilan Permata Sigit Kurniawan TARISA ANANDASMARA Toniara, Safriwan Tria Tiurma Lestari Yahwardiah Siregar Yenita . Yenita Yenita Yufi Yuwarditra YUFI YUWARDITRA