Article Per Year (5 Year)
p-Index From 2020 - 2025
1.704
P-Index
This Author published in this journals
All Journal Medula JK Unila (Jurnal Kedokteran Universitas Lampung) JCOMENT (Journal of Community Empowerment) Sains Medisina Jurnal Mahasiswa Ilmu Kesehatan Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Jurnal Praba: Jurnal Rumpun Kesehatan Umum
Ramadhan Triyandi
Unknown Affiliation
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

Published : 10 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 10 Documents
Search

 1 
Kajian Literatur: Aktivitas Antibakteri dari Ekstrak Daun Sirih (Piper betle L.) Terhadap Bakteri Staphylococcus aureus Nur Amrillah; Ramadhan Triyandi; Muhammad Iqbal; Citra Yuliyanda Pardilawati
Medula Vol 13 No 4 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i4.754

Abstract

Bacterial infection is a major health problem that affects many humans. The therapy used to treat bacterial infections generally uses antibiotics. However, the inappropriate and continuous selection and use of antibiotics can lead to the occurrence of antibiotic resistance in humans. Staphylococcus aureus is one of the most involved pathogenic bacteria in human bacterial infections. This bacterium is found in the normal skin microbiota of animals and humans. Staphylococcus aureus has infected as many as 20-30% of the healthy human population. Staphylococcus aureus produces antibiotic neutralizing enzymes resulting in resistance to many antibiotics. Many developing countries use medicinal plants as an alternative to treat infections. More than 700 species of betel leaf are found in the North and South of the world and are widely grown in most countries such as Indonesia, India, Sri Lanka, Malaysia, the Philippines, as well as other countries in Southeast Asia and East Africa. Boiled betel leaf (Piper betle L.) has been widely used in Indonesia as an alternative medicine. Betel leaf extract contains several chemical components such as terpenoids, alkaloids and phenolic compounds such as flavonoids, tannins and saponins. These components are known to have strong potential as antibacterial. This study article aims to find out whether betel leaf extract (Piper betle L.) has the ability to inhibit bacterial growth and what concentration of the extract is needed so that there is inhibition of activity and growth of Staphylococcus aureus.
Preferensi Penggunaan Obat Tradisional dan Obat Modern pada Masyarakat Desa Umbul Natar Lampung Selatan Muhammad Iqbal; Dwi Aulia Ramdini; Ramadhan Triyandi; Suharmanto Suharmanto
Jurnal Kedokteran Universitas Lampung Vol 6, No 2 (2022): JK Unila
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jkunila6294-105

Abstract

Penggunaan obat tradisional semakin berkembang di dunia, baik digunakan sebagai terapi komplementer maupun sebagai terapi utama kesehatan. Daya minat penggunaan obat tradisional dan modern cukup bervariasi antar populasi. Penelitian ini bertujuan untuk menganalisis lebih jauh tentang perilaku masyarakat dalam preferensi penggunaan obat tradisional dan obat modern berdasarkan aspek sumber informasi, ekonomi, dan sosial budaya. Penelitian ini bersifat deskriptif analitik dengan pendekatan cross-sectional. Target populasi studi adalah masyarakat di Desa Umbul Natar Kelurahan Jati Mulyo Kecamatan Jati Agung Lampung Selatan. Pengumpulan data dilakukan dengan menggunakan kuesioner. Analisis hubungan antara sumber informasi : keluarga inti (p<0,001), informasi orang terdekat (p<0,001), dan media sosial (p=0,040) berhubungan terhadap preferensi pemilihan obat. Faktor sosial budaya dalam indikator persepsi dan kepercayaan berhubungan dengan preferensi pemilihan obat.  Faktor ekonomi dalam persepsi murahnya pilihan obat (p=0,001) dan lama waktu pengobatan (p=0,049) berhubungan terhadap preferensi pemilihan obat. Hasil penelitian ini menunjukkan bahwa faktor sumber informasi, sosial budaya, dan ekonomi merupakan prediktor yang mempengaruhi preferensi pemilihan obat masyarakat.
Potensi Astragalus Sebagai Terapi Adjuvan Pada Pasien Glomerulonefritis Alfina Indah Nabila; Nabila Rayhan Yasmin; Rani Himayani; Ramadhan Triyandi
Medula Vol 13 No 5 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i5.783

Abstract

Glomerulonephritis is a medical term used to describe a condition that involves some kidney damages. Glomerulonephritis is an abnormality of the kidney that may lead to end-stage renal disease (ESRD). The current glomerulonephritis therapy is considered not fully effective due to the possibility of additional morbidity and complications that may occur. The use of Astragalus as adjuvant therapy can inhibit the progression of glomerulonephritis. The journals, that was reviewed, obtained from the Google Scholar, Sciencedirect, PubMed, and Springer with a publication year range of 2009-2023. The journals were selected to obtain valid and reliable journals, then do a literature review and article writing. Astragalus membranaceus has a bioactive content that can act as an immunomodulator, antiinflamation, and renoprotector. Astragalus is able to improve kidney function through IL-6 secretion and improve kidney interstitial fibrosis. Administration of Astragalus in combination with conventional therapy can reduce serum creatinine and proteinuria. Astragalus has potential as adjuvant therapy in glomerulonephritis patients.
Kajian Potensi Biji Pinang (Areca catechu L.) sebagai Antibakteri Fredison Fredison; Ramadhan Triyandi; Muhammad Iqbal; Dwi Aulia Ramdini; Suharmanto Suharmanto
Jurnal Kedokteran Universitas Lampung Vol 7, No 1 (2023): JURNAL KEDOKTERAN UNIVERSITAS LAMPUNG
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jkunila71%p

Abstract

Penyakit  infeksi   merupakan   penyebab  paling  utama  tingginya  angka kesakitan  dan  angka  kematian  terutama  pada  negara-negara  berkembang seperti  halnya  indonesia. Salah satu penatalaksanaan penderita penyakit infeksi adalah dengan pengobatan antibiotik. Tetapi tidak sedikit antibiotik digunakan secara irasional, berlebihan dan dalam jangka waktu yang lama. Hal ini menimbulkan masalah baru yaitu penurunan efek terapi dan meningkatnya resistensi bakteri terhadap antibiotik. Alternatif baru yang sedang terus diteliti dan dikembangkan adalah pengobatan menggunakan tanaman herbal atau tanaman obat. Bahan alami telah banyak digunakan dalam pengobatan atau dikenal dengan istilah "back to nature", yang berarti " kembali ke yang alami". Secara tradisional biji pinang telah lama dimanfaatkan sebagai obat. Biji pinang mengandung senyawa alkaloid, flavonoid, tanin, saponin, dan polifenol yang diketahui  berkhasiat  sebagai antibakteri. Kajian literatur ini bertujuan untuk mengetahui apakah ekstrak biji pinang (Areca catechu L.) dapat menghambat pertumbuhan bakteri baik gram positif maupun gram negatif. Dari hasil pengkajian diketahui bahwa ekstrak biji pinang (Areca catechu L.)  terbukti memiliki potensi yang baik sebagai antibakteri yang ditandai dengan adanya zona hambat yang terbentuk terhadap bakteri gram positif maupun gram negative yaitu bakteri  Branhamella catarrhalis, Escherichia coli, Lactobacillus casei, Staphilococcus aureus ATCC 25923, Staphylococcus aureus, Staphylococcus epidermidis, dan Streptococcus mutans dengan kategori diameter zona hambat dari lemah hingga sangat kuat. Kata Kunci: aktivitas antibakteri, Areca catechu L., biji pinang, diameter zona hambat
PELATIHAN IMPLEMENTASI FAILURE MODE EFFECT ANALYSIS (FMEA) UNTUK MENINGKATKAN KESELAMATAN PASIEN DI RUMAH SAKIT Bayu Anggileo Pramesona; Muhammad Iqbal; Ramadhan Triyandi; Dwita Nurmumpuni; Siti Husna
JCOMENT (Journal of Community Empowerment) Vol. 4 No. 3 (2023): Community Empowerment
Publisher : The Journal Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pada program patient safety, penggunaan Failure Mode Effect Analysis (FMEA) dapat digunakan sebagai salah satu metode efektif untuk mencegah insiden keselamatan pasien (IKP) sebelum terjadi. Namun, pelatihan implementasi FMEA ini belum pernah dilakukan di RSUD HM Ryacudu Kotabumi. Tujuan pengabdian masyarakat ini untuk meningkatkan pengetahuan dan pemahaman tim peningkatan mutu dan keselamatan pasien (PMKP), manajemen RS, dan kepala instalasi/unit untuk mempraktikkan pembuatan FMEA sebagai salah satu metode yang dapat digunakan sebagai manajemen risiko sehingga keselamatan pasien dapat terwujud. Pelatihan menggabungkan metode ceramah, diskusi interaktif dan latihan pembuatan FMEA ini dilaksanakan di aula RSUD HM Ryacudu Kotabumi pada 24 Agustus 2023 dengan melibatkan total 52 peserta terdiri dari manajemen RS yaitu direktur, tiga kepala bidang, sembilan kepala seksi, lima orang tim PMKP, serta 34 petugas kesehatan yang terdiri dari kepala instalasi, kepala ruang rawat inap dan rawat jalan. Pre dan post-test dilakukan untuk mengevaluasi pengetahuan peserta latih sebelum dan setelah pelatihan. Penilaian cara pembuatan FMEA dilakukan setelah latihan kasus. Hasil rata-rata skor pengetahuan peserta latih meningkat sebesar 72,8% setelah diberikan pelatihan. Peserta latih juga dapat mempraktikkan cara FMEA dengan benar. Pelatihan pembuatan FMEA terbukti efektif dalam meningkatkan pengetahuan manajemen RS, tim PMKP, dan para kepala instalasi/unit untuk membuat FMEA di RS. Perlu dilakukan pelatihan FMEA secara berkala dengan melibatkan seluruh elemen terkait guna meningkatkan keselamatan pasien di RS.
Literature Review: Modifikasi Bahan Aktif Farmasi (BAF) Dengan Metode Kokristal Zahra Fadilatusya'adah; Afriyani; Dwi Aulia Ramdini; Ramadhan Triyandi
Sains Medisina Vol 3 No 2 (2024): Sains Medisina
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Rute oral menjadi pilihan utama untuk penghantaran obat karena kemudahan dan penerimaan pasien yang baik, namun rute ini memiliki tantangan yaitu bioavailabilitas nya yang rendah akibat kelarutan yang buruk. Salah satu solusi yang menjanjikan untuk meningkatkan kelarutan dan disolusi dari obat adalah dengan pembentukan kokristal, yaitu material yang terdiri dari zat aktif dan koformer yang berinteraksi melalui ikatan non-kovalen. Tinjauan ini ditujukan untuk memberikan ulasan mengenai kokristalisasi sebagai metode untuk memperbaiki sifat fisikokimia Bahan Aktif Farmasi (BAF). Tinjauan ini merujuk pada beberapa sumber referensi dari berbagai literatur terkait definisi kokristal, koformer, dan metode pembuatan kokristal. Kokristal merupakan metode yang efektif dan berpotensi meningkatkan kelarutan, disolusi, stabilitas, dan bioavailabilitas sehingga efek terapeutik dari suatu zat aktif dapat meningkat tanpa mengubah aktivitas farmakologinya. Aplikasi metode kokristal pada pembentukan kokristal asam usnat-N-Methyl-D-Clucamnie terbukti mampu meningkatkan kelarutan dan laju disolusi sebanyak 24 kali dan 23 kali lebih besar dibandingkan dengan senyawa murninya. Terdapat beragam metode pembuatan kokristal seperti, solvent drop grinding, dry grinding, slurry, solvent evaporation, spray drying, dan metode anti-solvent, dengan keunggulannya masing-masing dalam meningkatkan sifat zat aktif. Pemilihan metode pembuatan kokristal disesuaikan oleh sifat dari bahan aktif farmasi, koformer yang digunakan, dan ketersediaan dari teknologi yang mendukung.
Potensi Aktivitas Antidiabetes Berbagai Jenis dan Varian Tanaman Mangga (Mangifera spp.) Agnes Monica Murisla; Zulpakor Oktoba; Femmy Andrifianie; Ramadhan Triyandi
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 2 (2025): Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i2.595

Abstract

Diabetes mellitus is a chronic disease with a significantly increasing global prevalence, especially in developing countries. Current treatments use synthetic antidiabetic drugs that are generally expensive and have various side effects. This study aims to examine the potential of mango plants (Mangifera spp.) as antidiabetic agents through a systematic literature review. Literature searches were conducted through the electronic databases PubMed and Google Scholar using the keywords "Mangifera/mango" and "antidiabetic". From the search results, 25 relevant articles were obtained for further review, consisting of 15 articles on in vitro testing and 10 articles on in vivo testing. The search results identified 17 mango plant variants worldwide that have been shown to have antidiabetic activity. Each mango species has unique characteristics and different nutritional content and bioactive compounds. Various parts of the mango plant, including leaves, fruits, seeds, and bark, contain bioactive compounds such as flavonoids, tannins, saponins, and terpenoids. These compounds contribute to antidiabetic activity through several mechanisms, namely inhibition of α-glucosidase and α-amylase enzymes, increased insulin sensitivity, and reduced blood glucose levels. Mango plant secondary metabolites are not only effective, but also have the potential to be an alternative antidiabetic treatment that is more affordable and safe compared to synthetic drugs. It can be concluded that Mangifera spp. has great potential to be developed as an innovative diabetes therapy. Further research through clinical trials is needed to confirm its effectiveness as an antidiabetic agent.
Kandungan Senyawa Fitokimia dan Aktivitas Antibakteri Ekstrak Daun Pepaya (Carica Papaya L.): Narrative Review Umniyah Tsabitah Zahrani; Ihsanti Dwi Rahayu; Atri Sri Ulandari; Ramadhan Triyandi
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 2 (2025): Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i2.599

Abstract

This narrative review article explores the potential of papaya leaves (Carica papaya L.) as an alternative antibacterial treatment due to the increasing problem of antibiotic resistance. Papaya leaves, commonly found in Indonesia, are known to have various pharmacological properties, including antibacterial effects. The article aims to collect and review existing literature on the phytochemical compounds and antibacterial activity of papaya leaf extract. Literature searches were conducted across several databases such as Google Scholar, NCBI, ResearchGate, and ScienceDirect using keywords like "antibacterial," "phytochemical screening," and "Carica papaya leaf." Articles from the last five years that were accessible in full text and relevant to the topic were selected, leading to the inclusion of 18 articles in the review.The findings indicate that papaya leaf extracts exhibit antibacterial properties against both gram-positive and gram-negative bacteria. The degree of antibacterial activity varies, ranging from weak to very strong inhibition. This antibacterial effect is attributed to the secondary metabolite compounds present in papaya leaves, including alkaloids, flavonoids, saponins, tannins, phenolics, terpenoids, and steroids. These compounds contribute to the biological activity of the extract, making it a promising candidate for further development as a natural antibacterial agent. Overall, this review underscores the importance of exploring medicinal plants like papaya leaves as viable alternatives to combat bacterial infections and address the growing issue of antibiotic resistance..
Literature Review: Manfaat Tradisional, Kandungan Fitokimia, Aktivitas Farmakologis, dan Potensi Pengembangan Sediaan Antibakteri dari Tumbuhan Kakao (Theobroma cacao L.) Agaphe Suluh Brahmantio; Ramadhan Triyandi; Zulpakor Oktoba; Femmy Andrifianie; Muhammad Iqbal
Jurnal Praba : Jurnal Rumpun Kesehatan Umum Vol. 3 No. 2 (2025): Juni : Jurnal Praba : Jurnal Rumpun Kesehatan Umum
Publisher : STIKES Columbia Asia Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62027/praba.v3i2.362

Abstract

The cacao plant (Theobroma cacao L.) has long been used in traditional medicine and has been proven to contain phytochemical compounds such as polyphenols, flavonoids, alkaloids, and tannins, which exhibit pharmacological activities, including antioxidant, anti-inflammatory, and antibacterial properties. This study aims to review the potential development of antibacterial formulations based on cacao extract through a literature review. The method used is a qualitative descriptive analysis of national and international journals published in the last 10 years. The review results indicate that extracts from cacao seeds, fruit peels, and leaves are effective in inhibiting the growth of various pathogenic bacteria, both Gram-positive and Gram-negative. Various formulations such as gels, creams, lotions, soaps, toothpaste, and mouthwash have been developed with promising results. The utilization of the cacao plant as an antibacterial agent in pharmaceutical formulations holds great potential as a natural alternative in the healthcare field while also adding value to cocoa industry by-products.
Potensi Antibakteri Ekstrak Bulu Babi Diadema setosum dan Echinometra Mathaei : Literature Review Natalia Michelle Simatupang; Ramadhan Triyandi; Ihsanti Dwi Rahayu; Femmy Andrifianie; Muhammad Iqbal
Jurnal Mahasiswa Ilmu Kesehatan Vol. 3 No. 3 (2025): Jurnal Mahasiswa Ilmu Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/jumkes.v3i3.2744

Abstract

The increasing incidence of bacterial resistance to antibiotics has become one of the major challenges in global health, necessitating the exploration of natural antibacterial sources as alternative treatments, such as bioactive compounds derived from sea urchins. This literature review aims to evaluate the antibacterial potential of sea urchin extracts based on existing research findings. The literature search was conducted using the PubMed and Google Scholar databases using the Boolean operators (AND, OR). Inclusion criteria include articles published between 2014 and 2024, available in full text, written in either Indonesian or English, and discussing the antibacterial activity of sea urchin extracts from the species Diadema setosum and/or Echinometra mathaei. Based on the selection process, eight articles met the inclusion criteria and were included in the review. The results of the literature review indicate that sea urchin extracts exhibit antibacterial activity against gram-negative bacteria, including Escherichia coli, Salmonella typhi, Salmonella typhimurium, Shigella flexneri, Pseudomonas aeruginosa, Aeromonas hydrophila, Acinetobacter sp., Citrobacter freundii, and Klebsiella pneumoniae, as well as gram-positive bacteria, including Propionibacterium acnes, Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, Staphylococcus epidermidis, Streptococcus mutans, and Streptococcus sobrinus. These antibacterial effects are attributed to the presence of secondary metabolites such as alkaloids, steroids, flavonoids, saponins, and phenolics.
Co-Authors Afriyani Agaphe Suluh Brahmantio Agnes Monica Murisla Alfina Indah Nabila Atri Sri Ulandari Bayu Anggileo Pramesona Citra Yuliyanda Pardilawati DWi Aulia Ramdini Dwita Nurmumpuni Femmy Andrifianie Fredison Fredison Ihsanti Dwi Rahayu Muhammad Iqbal Nabila Rayhan Yasmin Natalia Michelle Simatupang Nur Amrillah Oktoba, Zulpakor Rani Himayani Siti Husna Suharmanto Umniyah Tsabitah Zahrani Zahra Fadilatusya'adah