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All Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran Anatomica (Anatomica Medical Journal) JURNAL IBNU SINA BIOMEDIKA Buletin Farmatera JURNAL ILMIAH MAKSITEK JURNAL ILMIAH SIMANTEK JURNAL ILMIAH KOHESI Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Jurnal Pandu Husada Jurnal Kesehatan Republik Indonesia The Journal General Health and Pharmaceutical Sciences Research Jurnal Implementa Husada (JIH)
Ilham Hariaji
Universitas Muhammadiyah Sumatera Utara
Religion Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Uji Efektivitas Anxiolytic Ekstrak Teh Hijau (Camellia Sinensis) terhadap Tikus Model Kecemasan Dengan Metode Elevated Plus Maze M. Fiqri Maulana Harahap; Ilham Hariaji
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 2 (2026): Agustus: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i2.10169

Abstract

Introduction: Green tea (Camellia sinensis) is known for its anxiolytic benefits derived from L-theanine, EGCG, and caffeine, which influence neurotransmitters like GABA and dopamine and enhance alpha brain wave activity. Methods: This experimental study employed a post-test only with control group design. The subjects were 27 male Wistar rats induced with anxiety using the Forced Swim Test. Treatment was administered with green tea extract at a dose of 3.6 mg/kgBW. Anxiety levels were measured using the Elevated Plus Maze (EPM) method, focusing on the duration spent in open arms. Statistical analysis was conducted using One-Way ANOVA, followed by post-hoc Tukey tests to identify significant differences between groups. Results: The treatment group showed an average time in open arms of 114.22 seconds, approaching the positive control (fluoxetine ) at 117.67 seconds, and higher than the negative control (Placebo) at 90.33 seconds. Statistical analysis indicated significant differences among treatment groups (p < 0.001). Conclusion: Green tea extract demonstrated significant anxiolytic effects in reducing anxiety in a rat model.
Efek Pankreoprotektif Infusa Biji Ketumbar (Coriandrum Sativum) terhadap Kadar Glukosa Darah Puasa pada Tikus Jantan Putih Galur Wistar yang Diinduksi Aloksan Raja Mahendra Putra Dorando; Ilham Hariaji
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 2 (2026): Agustus: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i2.10176

Abstract

Diabetes mellitus is a disease characterized by high levels of glucose in the blood. This disease is caused by several factors, one of which is damage to pancreatic cells. Coriander seeds contain compounds that play a role in the protection and regeneration of pancreatic cells. There are several studies that state that coriander seeds can reduce blood glucose levels, but there is no research that states that coriander seeds can protect pancreatic cells. This study aims to determine the pancreoprotective effect of coriander seed infusion using blood glucose levels as a measurement indicator. This research uses an experimental design with a pretest and posttest design. Using 30 mice divided into 3 groups as research samples. This research was carried out by giving coriander infusion first and then giving alloxan as a trigger to increase the rats' blood glucose levels. The results of data analysis using the One Way Anova test showed a sigma value (p < 0.05) which stated that there was a significant difference between the pretest and posttest. There is an effect of giving coriander seed infusion (Coriandrum Sativum L) as a pancreoprotective effect on rat blood glucose levels.
Co-Authors Adinda Shafira ALZA HAMONANGAN PASARIBU Ance Roslina Anggi Yulisna Frisilia Saputri ARIL RIZALDI ASMAUL HABIBI AYUDYA, RINDA Bakhreni, Neyla Fitri ELMAN BOY Fadly Zahran Fani Ade Irma Fauzio, Revo Filza Amalia Putri FIRSTY DWI HIDAYATI SIRAIT Fitriani, Mutiara Frisilia Saputri, Anggi Yulisna Gurusinga, Nabira Maharani Humairah Medina Liza Lubis Jannah, Rhadatul KHAIRATUN NISA Linda, Putri Cici LUKMAN HAKIM ROMA MORA SIREGAR M. BIOMED M. Fiqri Maulana Harahap Manurung, Muhammad Akbar MERY MARLINA HSB Muhammad Fadhly Zahran Muhammad Iqbal Prayoga Murtanto, Dita Fazhari Nabila, Windy Nabira Maharani Gurusinga Namora Harahap, Asra Dewita Nasution, Muhammad Rizki Ramadhan Bagaskara Neyla Fitri Bakhreni Prayoga, Muhammad Iqbal Putri, Rania Gusmi Rafika Baradarkhasan Zega Raja Mahendra Putra Dorando Rania Gusmi Putri Revo Fauzio Rhadatul Jannah Rindi Ariska Silalahi Rizky Kurniawan Saidatul, Emma Dalen Sari Juliana Ariska Septrianto Muahammad Shafira, Adinda Shalin, Fonda Azarine SILALAHI, RINDI ARISKA SUKMA DWI KARTIKA Tambunan, Laila Nazmi Tosy Arna Dalimunthe Windy Nabila Yenita Yenita Zahran, Fadly