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All Journal Jurnal Biologi Tropis
Rahmatullah, Lalu Mas’ud
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Nucleoside Antiviral Therapy for Herpes Zoster: A Literature Review Ain, Nisrina Huurul; Rahmatullah, Lalu Mas’ud; Utari, Widi Gustita; Nuralyza, Imasayu; Salsabiella, Baiq Rani; Maghfirahandini, Reivirly Khairadaty; Aini, Siti Rahmatul; Nurhidayati, Nurhidayati
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.10006

Abstract

Herpes zoster is a viral skin infection caused by the reactivation of the varicella-zoster virus, which remains latent in the dorsal root ganglia of the spinal cord and the cranial sensory ganglia. One of the most widely used classes of antiviral agents in the treatment of herpes zoster is nucleoside analogs. This study aims to review the use of nucleoside analogs in the management of herpes zoster. The method employed was a literature review of relevant research articles. The findings indicate that nucleoside analogs commonly used in herpes zoster therapy include acyclovir, valacyclovir, famciclovir, and brivudine. These agents are administered in various doses, routes, and therapeutic purposes, such as alleviating acute symptoms, accelerating skin lesion healing, preventing postherpetic neuralgia, and serving as prophylactic therapy in special conditions such as cancer or organ transplantation. Overall, the use of nucleoside analogs has proven effective in inhibiting varicella-zoster virus replication, reducing symptom intensity, and minimizing the risk of complications.
Literature Review: Genetic Engineering in Tuberculosis Vaccine Production Putri, Dhea Rizma Demula; Inggit, Baiq Putri Maharani Bine; Rahmatullah, Lalu Mas’ud; Dalila, Virga Fathiya; Utari, Weny Syafitri; Listyacahyani, Anggit
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8233

Abstract

The tuberculosis (TB) vaccine contains a weakened form of the TB-causing agent. Currently, much research has focused on developing an effective and safe TB vaccine through genetic engineering. This review aims to analyze genetic engineering techniques in the production of tuberculosis (TB) vaccines. The analysis was conducted by gathering research data from various studies published between 2014-2024, available in PubMed, ScienceDirect, and Google Scholar, using relevant keywords. Based on the literature review, several innovative methods in genetic engineering were identified, such as Polymerase Chain Reaction (PCR), Enzyme-Linked Immunosorbent Assay (ELISA), in silico methods, multi-epitope vaccine development, and protein fusion-based vaccine development. Although there are challenges related to vaccine stability and clinical safety testing, innovations in genetic engineering technology hold the promise of significant progress in developing a more effective and durable TB vaccine. Among these methods, protein fusion-based and multi-epitope vaccines show the most promising potential in terms of effectiveness and long-lasting immune response.
Co-Authors Ain, Nisrina Huurul Aini, Siti Rahmatul Dalila, Virga Fathiya Inggit, Baiq Putri Maharani Bine Listyacahyani, Anggit Maghfirahandini, Reivirly Khairadaty Nuralyza, Imasayu Nurhidayati Nurhidayati Putri, Dhea Rizma Demula Salsabiella, Baiq Rani Utari, Weny Syafitri Utari, Widi Gustita