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Listyacahyani, Anggit
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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STUDI PEMANFAATAN ANTIBODI MONOKLONAL SEBAGAI TERAPI DAN DIAGNOSIS PADA PASIEN : ARTIKEL REVIEW Yuningsih, Rizma Kurniawati; Attaya, Kalisa; Yustitia, Nur Tahany; Maziya, Raehanul; Utari, Widi Gustita; Listyacahyani, Anggit
Jurnal Kesehatan Tambusai Vol. 6 No. 2 (2025): JUNI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i2.45406

Abstract

Antibodi monoklonal adalah protein yang diproduksi dari satu klon sel dan diklasifikasikan ke dalam empat jenis: murine, chimeric, humanized, dan antibodi manusia. Artikel ini bertujuan untuk meninjau pemanfaatan antibodi monoklonal dalam terapi dan diagnosis berbagai penyakit. Metode yang digunakan adalah Systematic Literature Review dari 13 artikel ilmiah yang diperoleh melalui database seperti PubMed, Google Scholar, dan ScienceDirect. Hasil studi menunjukkan bahwa antibodi monoklonal efektif dalam mendiagnosis penyakit menular (seperti MERS-CoV, TBC, malaria, zika, schistosomiasis) dan tidak menular (seperti penyakit Parkinson dan Alzheimer), dengan memanfaatkan interaksi spesifik antara antibodi-antigen melalui teknik seperti ELISA dan imunokromatografi. Sebagai terapi, antibodi ini digunakan untuk menangani berbagai penyakit seperti Alzheimer, asma, migrain vestibular, sepsis, HIV-1, rheumatoid arthritis, dan penyakit mata. Beberapa antibodi bekerja dengan mengikat target seperti amiloid, IL-13, CGRP, atau TNF-α untuk memodulasi respons imun dan mengurangi gejala penyakit. Efektivitas dan spesifisitas tinggi dari antibodi monoklonal menjadikannya alat penting dalam bidang kedokteran modern, baik dalam mendiagnosis secara akurat maupun memberikan terapi yang ditargetkan dengan efek samping minimal.
Literature Review: The Chemical Composition and Pharmacological Activities of Nannochloropsis sp Ulfiyah, Ryhadatul; Hijriadina, Zerati; Oktari, Baiq Khaeratinnisa; Anjanisa, Diah Hikmatin; Magvirahandini, Reivirly Khairadaty; Mutthoimah, Ulfatul; Listyacahyani, Anggit
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.8593

Abstract

The microalga Nannochloropsis sp. is a potential bioactive source with various applications in the pharmaceutical and health industries. This study aims to identify its chemical composition and evaluate its pharmacological activities, including antioxidant, antidiabetic, antibacterial, antihyperlipidemic, and cytotoxic properties. The method involves a literature review of relevant and recent scientific articles using specific keywords. The results indicate that Nannochloropsis sp. is rich in bioactive compounds, such as unsaturated fatty acids, flavonoids, and phenolics, which contribute to its biological activities. This microalga has been shown to effectively inhibit pathogenic bacterial growth, reduce blood sugar, cholesterol, and lipid levels, and possess potential anticancer activity. The study concludes that Nannochloropsis sp. has promising prospects as a natural raw material source for modern drug development. Further research is recommended to explore the mechanisms of its bioactive compounds and to develop formulations for products based on this microalga.
Literature Review: Genetic Engineering in Tuberculosis Vaccine Production Putri, Dhea Rizma Demula; Inggit, Baiq Putri Maharani Bine; Rahmatullah, Lalu Mas’ud; Dalila, Virga Fathiya; Utari, Weny Syafitri; Listyacahyani, Anggit
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8233

Abstract

The tuberculosis (TB) vaccine contains a weakened form of the TB-causing agent. Currently, much research has focused on developing an effective and safe TB vaccine through genetic engineering. This review aims to analyze genetic engineering techniques in the production of tuberculosis (TB) vaccines. The analysis was conducted by gathering research data from various studies published between 2014-2024, available in PubMed, ScienceDirect, and Google Scholar, using relevant keywords. Based on the literature review, several innovative methods in genetic engineering were identified, such as Polymerase Chain Reaction (PCR), Enzyme-Linked Immunosorbent Assay (ELISA), in silico methods, multi-epitope vaccine development, and protein fusion-based vaccine development. Although there are challenges related to vaccine stability and clinical safety testing, innovations in genetic engineering technology hold the promise of significant progress in developing a more effective and durable TB vaccine. Among these methods, protein fusion-based and multi-epitope vaccines show the most promising potential in terms of effectiveness and long-lasting immune response.
Literature Review: The Effect of Butterfly Pea Flower Kombucha Fermentation as Antibacterial Agent Hijriadina, Zerati; Shiddiqi, Buchary Rahman Ash; Amanda, Raina Julia; Wandila, Welsi; Putranto, Diouf Maulana Dwi; Rismiyati, Rismiyati; Listyacahyani, Anggit
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.8480

Abstract

Biotechnology involves the use of microorganisms supported by technology to produce goods and services, a practice that has been around for thousands of years. The application of biotechnology includes processing fermented beverage products. Kombucha is a traditional fermented tea drink that is carbonated and has a slightly sweet and sour taste. Butterfly pea flower contains anthocyanins, which act as antioxidants and antibacterial agents. Sugar serves as a nutrient for Scoby, helping with the fermentation process. This article review uses a scientific literature study, with data collected from Google Scholar, referencing 15 journals from the last 10 years. Scoby nutrients can include granulated sugar, palm sugar, Baduy forest honey, stevia sugar, and Tropicana Slim sugar. Each nutrient is given at concentrations of 20%, 30%, and 40%. The test results show that providing nutrients at a concentration of 40% produced a larger inhibition zone.
Co-Authors Amanda, Raina Julia Anjanisa, Diah Hikmatin Attaya, Kalisa Dalila, Virga Fathiya Hijriadina, Zerati Inggit, Baiq Putri Maharani Bine Magvirahandini, Reivirly Khairadaty Maziya, Raehanul Mutthoimah, Ulfatul Oktari, Baiq Khaeratinnisa Putranto, Diouf Maulana Dwi Putri, Dhea Rizma Demula Rahmatullah, Lalu Mas’ud RISMIYATI RISMIYATI Shiddiqi, Buchary Rahman Ash Ulfiyah, Ryhadatul Utari, Weny Syafitri Utari, Widi Gustita Wandila, Welsi Yuningsih, Rizma Kurniawati Yustitia, Nur Tahany