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Salsabila, Rika Kamila
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Marine Organisms with Anti-Amyloid Effect Through Their Role as BACE1 Inhibitors for Preventive Effort in Alzheimer’s Disease: A Literature Review Putra, Made Raditya Arhya; Saputri, Legis Ocktaviana; Wicaksono, Teguh Budi; Nugraha, Kadek Nandita; Putri, Ajeng Ayu; Salsabila, Rika Kamila; Fidelia, Puspa Zalika
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7546

Abstract

Alzheimer’s Disease (AD) is a gradually worsening neurodegenerative condition characterized by the build-up of beta-amyloid proteins, resulting in a decline in cognitive abilities. β-site amyloid precursor protein cleaving enzyme-1 (BACE1) is known to play a role in the formation of beta-amyloid plaques. Thus, theoretically, inhibiting BACE1 can potentially prevent and slow down the accumulation of these plaques. This study is a literature review that compiles data from various research examining the inhibitory effects of compounds from marine organisms on the BACE1 enzyme. A comprehensive analysis was conducted on the available literature to evaluate the potential of these compounds.  19 marine organisms and 40 compounds were identified with low IC50 values, five compounds with notably low IC50 values were identified: (1) 8,8’-Bieckol [1.62 µM] from Ecklonia cava, (2) Phlorofucofuroeckol A [2.13 µM] and (3a) Dieckol [2.21 µM] from Eisenia bicyclis, (4) bis-(2,3,6-tribromo-4,5-dihydroxybenzyl) ether [2.32 µM] from Symphyocladia latiuscula, (3b) another Dieckol [2.34 µM] also from Ecklonia cava and (5) Heparan sulfate [2.89 µM] from Portunus pelagicus. These findings underscore the therapeutic potential of marine compounds as BACE1 inhibitors for AD. However, further research is needed to explore their bioavailability and clinical efficacy for practical application in preventing and treating Alzheimer’s Disease.
Emergencies in The Maritime Field A Literatur Review Salsabila, Rika Kamila; Kamilah, Nilam Nurmilatun; Putri, Atina Rizki; Pramudia, Prananda Rizki; Rian Pramudya; Saraswati, Ni Wayan Citra Ayu; Amatullah, Tazkiyah Arafah; Hunaifi, Ilsa
Jurnal Biologi Tropis Vol. 24 No. 2b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i2b.7800

Abstract

Indonesia is the largest archipelagic country in the world, with extensive coastal and oceanic areas and a high diversity of marine biodiversity. The coastal regions of Indonesia serve as habitats for various types of marine animals that possess both beauty and potential dangers, particularly from marine animal stings. In addition to marine animal stings, decompression sickness also poses a serious emergency in the maritime context. The purpose of this article is to provide new insights into the importance of understanding and recognizing decompression syndrome, as well as the bites and stings caused by marine animals, as early indicators of emergencies in the maritime field. This understanding can enhance early detection, appropriate treatment, and awareness of complications arising from maritime emergencies. The article will focus on marine animals such as the blue-ringed octopus, sea urchins, pufferfish, lionfish, jellyfish, stingrays, and stonefish, which are associated with emergencies in the maritime field. Data sources were gathered through electronic searches on library databases including Google Scholar, ProQuest, MDPI, and PubMed to find articles discussing "emergencies in the maritime field.".
Co-Authors Amatullah, Tazkiyah Arafah Fidelia, Puspa Zalika Ilsa Hunaifi, Ilsa Kamilah, Nilam Nurmilatun Nugraha, Kadek Nandita Ocktaviana Saputri, Legis Pramudia, Prananda Rizki Putra, Made Raditya Arhya Putri, Ajeng Ayu Putri, Atina Rizki Rian Pramudya Saraswati, Ni Wayan Citra Ayu Teguh Budi Wicaksono