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Putra, Made Raditya Arhya
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Marine Organisms with Anti-Amyloid Effect Through Their Role as BACE1 Inhibitors for Preventive Effort in Alzheimer’s Disease: A Literature Review Putra, Made Raditya Arhya; Saputri, Legis Ocktaviana; Wicaksono, Teguh Budi; Nugraha, Kadek Nandita; Putri, Ajeng Ayu; Salsabila, Rika Kamila; Fidelia, Puspa Zalika
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7546

Abstract

Alzheimer’s Disease (AD) is a gradually worsening neurodegenerative condition characterized by the build-up of beta-amyloid proteins, resulting in a decline in cognitive abilities. β-site amyloid precursor protein cleaving enzyme-1 (BACE1) is known to play a role in the formation of beta-amyloid plaques. Thus, theoretically, inhibiting BACE1 can potentially prevent and slow down the accumulation of these plaques. This study is a literature review that compiles data from various research examining the inhibitory effects of compounds from marine organisms on the BACE1 enzyme. A comprehensive analysis was conducted on the available literature to evaluate the potential of these compounds.  19 marine organisms and 40 compounds were identified with low IC50 values, five compounds with notably low IC50 values were identified: (1) 8,8’-Bieckol [1.62 µM] from Ecklonia cava, (2) Phlorofucofuroeckol A [2.13 µM] and (3a) Dieckol [2.21 µM] from Eisenia bicyclis, (4) bis-(2,3,6-tribromo-4,5-dihydroxybenzyl) ether [2.32 µM] from Symphyocladia latiuscula, (3b) another Dieckol [2.34 µM] also from Ecklonia cava and (5) Heparan sulfate [2.89 µM] from Portunus pelagicus. These findings underscore the therapeutic potential of marine compounds as BACE1 inhibitors for AD. However, further research is needed to explore their bioavailability and clinical efficacy for practical application in preventing and treating Alzheimer’s Disease.
Aspiration Pneumonia: Patophysiology, Diagnosis and Treatment Kirana, Devi Chandra; Fathana, Prima Belia; Ristia, Ovia Intan; Mario, Andina Nabilah; Lukman, Dian Azizah; Abdiman, I Made Tobias; Putra, Made Raditya Arhya; Salsabila, Maida Sania
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.7897

Abstract

Aspiration pneumonia is one of the diseases that is often hidden and under-recognized. This disease contributes to a higher mortality rate compared to other types of pneumonia. This study aims to analyze the pathophysiology, diagnosis and management of aspiration pneumonia. The method used is a literature study by searching for literature published in PubMed, ScienceDirect, and Researchgate with the keywords "aspiration pneumonia", "aspiration pneumonia pathophysiology", "aspiration pneumonia diagnosis and treatment". Aspiration pneumonia can occur due to micro mechanisms or macro mechanisms. Micro mechanisms are mechanisms that cannot be observed while macro mechanisms often occur due to impaired swallowing. Aspiration experienced by pneumonia patients causes inflammation and disruption of the epithelium. The diagnosis of aspiration pneumonia can be established based on clinical symptoms and supporting examinations such as radiology and laboratory examinations. Management that can be carried out on aspiration pneumonia can be done with pharmacological and non-pharmacological management.
Co-Authors Abdiman, I Made Tobias Fidelia, Puspa Zalika Kirana, Devi Chandra Lukman, Dian Azizah Mario, Andina Nabilah Nugraha, Kadek Nandita Ocktaviana Saputri, Legis Prima Belia Fathana Putri, Ajeng Ayu Ristia, Ovia Intan Salsabila, Maida Sania Salsabila, Rika Kamila Teguh Budi Wicaksono