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Fidelia, Puspa Zalika
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Marine Organisms with Anti-Amyloid Effect Through Their Role as BACE1 Inhibitors for Preventive Effort in Alzheimer’s Disease: A Literature Review Putra, Made Raditya Arhya; Saputri, Legis Ocktaviana; Wicaksono, Teguh Budi; Nugraha, Kadek Nandita; Putri, Ajeng Ayu; Salsabila, Rika Kamila; Fidelia, Puspa Zalika
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7546

Abstract

Alzheimer’s Disease (AD) is a gradually worsening neurodegenerative condition characterized by the build-up of beta-amyloid proteins, resulting in a decline in cognitive abilities. β-site amyloid precursor protein cleaving enzyme-1 (BACE1) is known to play a role in the formation of beta-amyloid plaques. Thus, theoretically, inhibiting BACE1 can potentially prevent and slow down the accumulation of these plaques. This study is a literature review that compiles data from various research examining the inhibitory effects of compounds from marine organisms on the BACE1 enzyme. A comprehensive analysis was conducted on the available literature to evaluate the potential of these compounds.  19 marine organisms and 40 compounds were identified with low IC50 values, five compounds with notably low IC50 values were identified: (1) 8,8’-Bieckol [1.62 µM] from Ecklonia cava, (2) Phlorofucofuroeckol A [2.13 µM] and (3a) Dieckol [2.21 µM] from Eisenia bicyclis, (4) bis-(2,3,6-tribromo-4,5-dihydroxybenzyl) ether [2.32 µM] from Symphyocladia latiuscula, (3b) another Dieckol [2.34 µM] also from Ecklonia cava and (5) Heparan sulfate [2.89 µM] from Portunus pelagicus. These findings underscore the therapeutic potential of marine compounds as BACE1 inhibitors for AD. However, further research is needed to explore their bioavailability and clinical efficacy for practical application in preventing and treating Alzheimer’s Disease.
Gastric Lymphoma : A Literatur Review Pramudya, Rian; Alami, Fathimah Nur; Sesariana, Mayumi Agestia; Balqis, Ananda Amirah; Fidelia, Puspa Zalika; Yulianti, Nur Afni; Bahraen, Raehanul
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.7913

Abstract

Gastric lymphoma is the second most common finding in gastric malignancies worldwide. Gastric lymphoma is a lymphoproliferative disorder that originates in the stomach and encompasses various histological findings. In cases of gastric lymphoma, the most frequently diagnosed types are diffuse large B-cell lymphoma (DLBCL) and mucosa-associated lymphoid tissue (MALT) lymphoma. There is a known association between Helicobacter pylori infection and genetic mutations with the occurrence of gastrointestinal lymphoma. Treatment options for gastric lymphoma include observation, antibiotic therapy, radiation therapy, surgery, and chemotherapy. The therapy provided can be either monotherapy or a combination of treatments.
Literature Review: Acute Respiratory Distress Syndrome (ARDS) Oneiya, Baiq Aisha Aryuni; Ramadhita, Nova Izza Salsa; Makbul, Ini Hidayat; Mutia, Baiq Marceliya Anjani; Fidelia, Puspa Zalika; Amanullah, Mohammad Sany Rosafi; Rivlan, Muhammad Zaidan Fadlurrohman; Fathana, Prima Belia
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8037

Abstract

Acute Respiratory Distress Syndrome (ARDS) is a clinically and biologically heterogeneous disease with a wide range of etiologies and manifestations. ARDS contributes significantly to high morbidity, mortality, and treatment costs associated with lung disease incidence. This study aims to evaluate the clinical characteristics, diagnostic strategies, and effective management approaches in ARDS treatment to enhance clinical guidelines in intensive care practice. This study employs a literature review method by collecting relevant articles from scientific databases, including PubMed, ScienceDirect, Cochrane Library, Google Scholar, and Proquest. Selected articles are full-text publications in Indonesian and English, published between 2010 and 2023. A total of 15 articles that met the selection criteria were analyzed in this study. ARDS is a serious medical condition with a still concerning prognosis. Optimal management approaches, especially through the use of protective ventilation and prone positioning, have been shown to benefit patients. However, personalized therapy based on biomarkers and further molecular research is needed to further reduce mortality.
Co-Authors Alami, Fathimah Nur Amanullah, Mohammad Sany Rosafi Bahraen, Raehanul Balqis, Ananda Amirah Makbul, Ini Hidayat Mutia, Baiq Marceliya Anjani Nugraha, Kadek Nandita Ocktaviana Saputri, Legis Oneiya, Baiq Aisha Aryuni Pramudya, Rian Prima Belia Fathana Putra, Made Raditya Arhya Putri, Ajeng Ayu Ramadhita, Nova Izza Salsa Rivlan, Muhammad Zaidan Fadlurrohman Salsabila, Rika Kamila Sesariana, Mayumi Agestia Teguh Budi Wicaksono Yulianti, Nur Afni