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All Journal Abdimasku : Jurnal Pengabdian Masyarakat Open Access Health Scientific Journal Jurnal Pengabdian Kepada Masyarakat: Kesehatan (JPKMK) Riset Informasi Kesehatan Strada Jurnal Ilmiah Kesehatan (SJIK) Strada Journal of Pharmacy
Putri, Luluk Aniqoh Meliana
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Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Journal : Strada Journal of Pharmacy

 1 
Test Antibacterial Activity from Ashitaba Stem Ethanol Extract (Angelica keiskei (Miq.) Koidz) Against Streptococcus mutans ATCC 25175 Luluk Aniqoh Meliana Putri
Strada Journal of Pharmacy Vol. 4 No. 1 (2022): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v4i1.47

Abstract

Ashitaba stems contain chemical compounds such as alkaloids, tannins, flavonoids and saponins. This study aimed to determine the antibacterial activity of ashitaba stem extract against Streptococcus mutans ATCC 25175. Ashitaba stem powder was extracted by maceration method with 96% ethanol solvent. The extract obtained was tested for antibacterial activity against Streptococcus mutans ATCC 25175 using the diffusion method with concentrations of 50%, 25%, 12.5% ​​and 6.25% to determine the concentration of the most active extract. The most active extract was known from the diameter of the inhibition zone which had the greatest value. The results showed that the ashitaba stem extract had antibacterial activity against Streptococcus mutans ATCC 25175. The 50% concentration of the ashitaba stem extract had an average inhibitory diameter of 18 mm which was the most active concentration of the ashitaba stem extract, the 25% concentration of the ashitaba stem extract had an average The average inhibitory diameter was 16.5 mm, the concentration of 12.5% ​​of the ashitaba stem extract had an average inhibitory diameter of 14.8 mm, the concentration of 6.25% of the ashitaba stem extract had an average inhibitory diameter of 12.5 mm.
Lip Cream Formulation With Natural Dyes From Secang Wood Leather Luluk Aniqoh Meliana; Juvita Herdianty; Arif Wijayanto
Strada Journal of Pharmacy Vol. 4 No. 2 (2022): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v4i2.65

Abstract

Colorants are an important part of decorative cosmetics, including in lip cream preparations. Secang bark (Caesalpinia Sappan) contains chemical compounds of flavonoids, polyphenols, tannins and essential oils. Researchers formulate lip cream preparations by utilizing natural pigments contained in the bark of secang wood. The preparations were made with various concentrations of sappan bark extract, namely 15%, 20%, and 25%. Evaluation of the preparations made is an evaluation of physical quality including organoleptic tests, homogeneity, pH, spreadability, adhesion, smearing power, photostability, and stability tests by centrifugation method. Evaluation of safety was carried out through irritation test with patch test method and preference test. The results of the evaluation of lip cream preparations showed that all formulas had good greasing power and homogeneity, were physically stable which was characterized by no separation, and had good dispersibility, spreadability, and stable pH value. All preparations during storage for 21 days did not show changes in texture and odor. Then in terms of color, both organoleptically and photostability testing did not show a decrease in color intensity. Based on respondents' responses, the most preferred formula is formula II with the addition of an extract of 20%.
Antibacterial Test of Liquid Soap Preparations Rambutan Peel Extract (Nephelium lappaceum Linn) the Growth of Staphylococcus Aureus Juvita Herdianty; Luluk Aniqoh Meliana Putri; Arif Wijayanto
Strada Journal of Pharmacy Vol. 4 No. 2 (2022): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v4i2.66

Abstract

Long-term use of antibiotics leads to resistance. Rambutan fruit is a fruit which grows seasonally, but the utilization of the fruit skin is still lacking. Several studies have been carried out but limited to the flesh and leaves. The purpose of this study was to utilize rambutan peel waste into a liquid soap preparation and then carry out an antibacterial test against Staphylococcus aureus bacteria. The content of compounds from the skin of rambutan fruit (Nephelium lappaceium Linn) is thought to have antibacterial properties. The content test was carried out using a phytochemical screening method. The screening results of rambutan peel extract showed the presence of alkaloids, flavonoids, saponins, and tannins. The antibacterial test method used the well diffusion method with concentrations of 20% 40%, 60% positive control of Biore liquid soap and negative control of soap base. The test parameters for liquid soap preparations include: organoleptic test, homogeneity test, pH test, foam height. The results showed the best concentration of 60% had the ability as an antibacterial against Staphylococcus aureus.
Test The Wound Healing Activity Of Nephelium Lappaceium Fructus Cortex Extract Ointment On New Zealand Rabbits Arif Wijayanto; Luluk Aniqoh Meliana Putri; Juvita Herdianty
Strada Journal of Pharmacy Vol. 4 No. 2 (2022): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v4i2.67

Abstract

Nephelium lappaceium Linn.(Rambutan) is a natural ingredient rich in active substances that are beneficial to human health. In this study, the use of Nephelium lappaceium fructus cortex was used for the healing of open wounds where Nephelium lappaceium fructus cortex contains tannins which are expected to help heal open wounds. The content test was carried out using the phytochemical screening method of Nephelium lappaceium fructus cortex extract which showed the presence of alkaloids, flavonoids, saponins, and tannins, then a wound healing test was carried out with Nephelium lappaceium fructus cortex extract which was divided into 5 groups randomly, namely normal, negative control (Vaseline album) , positive control (Betadine salp® each gram contains 10% Povidone Iodine), presented topically 7.5% and 15% Nephelium lappaceium fructus cortex extract ointment. The back skin of New Zealand rabbits is 3-5 months old, weighs 1500–2000grams, has normal and healthy activities and has agile activities, is normal and in healthy condition, then was injured with a punch biopsy with a diameter of 5 mm, a depth of ± 0.5 mm, then treatment according to the test group for 21 days. Parameters measured included wound diameter in rabbits. The results showed that the ointment extract of Nephelium lappaceium fructus cortex 15% had an open wound healing activity which was comparable to a positive control with an open wound healing activity of 0.2mm.
Effect Test of Analgesics (Paracetamol, Ibuprofen, and Antalgin) in Local Strain Male Mice with Acetic Acid Induction Using the Writhing Test Method Chinthia Devientasaria; Luluk Aniqoh Meliana Putri
Strada Journal of Pharmacy Vol. 5 No. 1 (2023): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v5i1.88

Abstract

Analgesic or pain blocking drugs are compounds that reduce or eliminate pain without causing loss of consciousness. NSAID (non-steroidal anti-inflammatory drugs) are heterogeneous compounds due to the different chemical structures of NSAID compounds, which are used to reduce mild to moderate pain, such as paracetamol, mefenamic acid, and ibuprofen. Paracetamol is used to reduce body heat caused by infection or something else. In addition, this drug also relieves pain at a mild to moderate level, this analgesic works directly on the body’s heat regulating center in the hypothalamus. The method use is writing test with acetic acid induction. The result of this study indicates that testing the effectiveness of the paracetamol, ibuprofen, and antalgin analgesic drugs in mice study showed that the analgesic power of antalgin was the best compared to paracetamol and ibuprofen.
Antibacterial Test Of Telang Flower Extract (Clitorea Ternatea L.) Against Pseudomonas Aeruginosa Luluk Aniqoh Meliana Putri; Chinthia Devientasaria
Strada Journal of Pharmacy Vol. 5 No. 2 (2023): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v5i2.96

Abstract

The butterfly pea flower is a shrub that can grow and live for years (perennial), can reach a height of 5 meters, has fine hair, and is woody at the base, the flower color is bright blue with a yellowish white color in the middle. Butterfly pea flower (Clitoria ternatea L.) is a plant that has long been used in medicine and has been proven to contain alkaloid and flavonoid secondary metabolite compounds which have antibacterial potential. Antibacterials are substances that can interfere with the growth or even kill bacteria by interfering with the metabolism of harmful microbes. The aim of this research was to determine the inhibitory power of telang flower simplicia extract (Clitoria ternatea L.) on the growth of Pseudomonas aeruginosa bacteria. This research aims to test the activity of butterfly pea flowers, namely by maceration using 70% ethanol solvent. For antibacterial testing using the disk diffusion method. Extracts are made in various concentrations of 10%, 20%, 30%. The positive control used was Chloramphenicol. The results of this research were that the average zone of inhibition of butterfly pea flower extract against Pseudomonas aeruginosa bacteria was 1.48 mm at 10% concentration, 2.41 mm at 20% concentration, and 5.70 mm at 30% concentration. These results show that butterfly pea flower extract has antibacterial activity against Pseudomonas aeruginosa bacteria, although the resulting inhibitory power is not strong. At a concentration of 30% butterfly pea flower extract, it has the greatest inhibitory effect on the growth of Pseudomonas aeruginosa bacteria than concentrations of 10% and 20%.
Antibacterial Activity Test of Ashitaba Leaf Extract Ointment Formulation (Angelica Keiskei (miq) Koidz) against Staphylococcus epidermidis Bacteria Luluk Aniqoh Meliana Putri; Devita Riafinola Andaririt
Strada Journal of Pharmacy Vol. 3 No. 1 (2021): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v3i1.138

Abstract

Acne is a condition in which the pores of the skin are blocked, causing inflamed pus pockets. One of the factors causing acne is bacteria. Staphylococcus epidermidis bacteria are bacteria found in acne. The use of medicinal plants is an alternative as a treatment for diseases including diseases caused by bacterial infections. Ashitaba leaves (Angelica Keiskei (miq) Koidz) positively contain alkaloids, saponins, tannins and flavonoids which play a role as antibacterials. The purpose of this study was to determine the antibacterial activity of the formulation of ashitaba leaf extract ointment preparations against Staphylococcus epidermidis bacteria that cause acne, using the well diffusion test method. Observation of the inhibitory power was tested on ashitaba leaf extract and ashitaba leaf extract ointment preparations with extract concentrations of Formula I 10%, Formula II 15%, Formula 20%. The results of this study are that the formulation of ashitaba leaf extract ointment preparations can have inhibitory power against Staphylococcus epidermidis bacteria. The highest inhibition zone in Formula III with an extract concentration of 20% with an inhibition zone diameter value of 7.27 mm.
Antibacterial Activity Test of Combination of Chitosan and Ethanol Extract of Cocoa Leaves (Theobroma Cacao L.) Against Salmonella Typhi Bacteria Saifullah Al Fahmi; Luluk Aniqoh Meliana Putri; Ivan Junius Mesak; Juvita Herdianty
Strada Journal of Pharmacy Vol. 6 No. 2 (2024): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v6i2.148

Abstract

Introduction:Typhoid fever is a systemic infectious disease caused by the bacterium Salmonella typhi. The increasing antibiotic resistance of Salmonella typhi has spurred interest in natural antibacterial agents. This study examines the antibacterial activity of a combination of chitosan and ethanol extract of cocoa leaves (Theobroma cacao L.) against Salmonella typhi. Methods: The research involved extracting cocoa leaves using ethanol and combining the extract with chitosan. The antibacterial activity was evaluated using the well diffusion method on Salmonella typhi. The combination of chitosan and cocoa leaf extract was tested at various concentrations, and chloramphenicol was used as a positive control. Results: The combination of chitosan and cocoa leaf extract showed significant antibacterial activity, with the best results obtained at higher concentrations. The zone of inhibition for the combination at 600 ppm was comparable to that of the positive control of chloramphenicol. Conclusion: The study suggests that the combination of chitosan and cocoa leaf extract has the potential to be developed as an alternative treatment for typhoid fever, particularly against antibiotic-resistant strains of Salmonella typhi.
The Potential of Quercetin as Parkinson's Disease Therapy Assessed From Binding Affinity To Adenosine A2a Receptor Using In-Silico Adjie Wahyu Pradana; Sri Rahayu Dwi Purnaningtyas; Devita Riafinola Andaririt; Luluk Aniqoh Meliana Putri
Strada Journal of Pharmacy Vol. 7 No. 1 (2025): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i1.156

Abstract

Parkinson's disease is a degenerative disease that causes impaired mobility and muscle control caused by decreased dopamine production in the brain. Parkinson's disease therapy is dopaminergic therapy using levodopa which works by replacing the reduced dopamine, the use of levodopa has side effects such as dizziness, nausea, and excessive sleepiness. The use of istradefylline with levodopa as a non-dopaminergic therapy in parkinson's reduces side effects and increases therapeutic targets. Quercetin is thought to have activity in improving motor function in parkinson's. The aim of this study was to look at the potential of quercetin as a parkinson's therapy. Objective: Finding the activity of quercetin as Parkinson's therapy compared with istradefylline using in-silico. Method: The design of this study is in-silico, which is a study using the help of computer calculations, the method used is molecular docking based on the principle of bonding compounds to receptors. Ligand compounds obtained from PubChem and receptor clusters obtained from Protein Data Bank. The docking Software used is Pyrex, and Discovery Studio Analizer. Independent variables in this study were quercetin and istradefylline, while the dependent variable was binding affinity ligand to adenosine A2a receptor. In this study, statistical analysis was conducted using an independent sample t-test. Results: In-silico test with molecular docking method showed each 9 ligand position to the receptor, the results of data analysis with the test of independent sample t-test, at the degree of significance α = 0.05 obtained statistical results with a significance value of 0.013 which means that the quercetin ligand has stronger potential compared to istradefylline. Quercetin has a binding affinity value of -8.1 kcal/mol, while istradefylline has a binding affinity value of -6.9 kcal / mol. Conclusion: Quercetin has been shown to have potential as an alternative therapy for parkinson's disease
Anti-Acne Activity Evaluation Of Cyperus rotundus L. Rhizome Fraction Gel Against Staphylococcus aureus And Propionibacterium acnes Qadariah, Musdalifah; Juvita Herdianty; Luluk Aniqoh Meliana Putri; Ardhi Broto Sumanto
Strada Journal of Pharmacy Vol. 7 No. 2 (2025): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i2.203

Abstract

Acne is an inflammatory skin condition often caused by bacteria such as Propionibacterium acnes and Staphylococcus aureus. The increasing incidence of antibiotic resistance encourages the search for alternatives from natural ingredients. Nut grass rhizome (Cyperus rotundus L.) is known to have antibacterial compounds. This study aimed to formulate a gel from the fractions of nut grass rhizome, test its activity against acne-causing bacteria, and identify the most potent fraction. This study employed a laboratory experimental design. The nut grass rhizome was extracted with 70% ethanol and then fractionated by liquid-liquid partitioning using n-hexane, ethyl acetate, and water as solvents. Each fraction was formulated into a gel at a 5% concentration, and its antibacterial activity was tested using the well diffusion method. All gel formulas met the physical quality evaluation requirements. The ethyl acetate fraction (F2) exhibited the strongest antibacterial activity, with an average inhibition zone of 19.48 ± 0.99 mm (moderate category) against Staphylococcus aureus and 25.86 ± 0.65 mm (strong category) against Propionibacterium acnes. The nut grass rhizome fraction gel preparation possesses anti-acne activity. The ethyl acetate fraction proved to be the most potent, showing efficacy against Propionibacterium acnes (inhibition zone 25.86 mm) that was statistically equivalent to the positive control (p = 0.767).
Co-Authors Adjie Wahyu Pradana Ardhi Broto Sumanto Arif Wijayanto Devientasari, Chinthia Devita Riafinola Ismi Rahmawati Ivan Junius Mesak Juvita Herdianty Lambertini, Imelda Lutpiani, Elpi Opstaria saptarini Purnaningtyas, Sri Rahayu Dwi Qadariah, Musdalifah Saifullah Al Fahmi