Garuda - Garba Rujukan Digital

The Potential of Quercetin as Parkinson's Disease Therapy Assessed From Binding Affinity To Adenosine A2a Receptor Using In-Silico Adjie Wahyu Pradana; Sri Rahayu Dwi Purnaningtyas; Devita Riafinola Andaririt; Luluk Aniqoh Meliana Putri
Strada Journal of Pharmacy Vol. 7 No. 1 (2025): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i1.156

Parkinson's disease is a degenerative disease that causes impaired mobility and muscle control caused by decreased dopamine production in the brain. Parkinson's disease therapy is dopaminergic therapy using levodopa which works by replacing the reduced dopamine, the use of levodopa has side effects such as dizziness, nausea, and excessive sleepiness. The use of istradefylline with levodopa as a non-dopaminergic therapy in parkinson's reduces side effects and increases therapeutic targets. Quercetin is thought to have activity in improving motor function in parkinson's. The aim of this study was to look at the potential of quercetin as a parkinson's therapy. Objective: Finding the activity of quercetin as Parkinson's therapy compared with istradefylline using in-silico. Method: The design of this study is in-silico, which is a study using the help of computer calculations, the method used is molecular docking based on the principle of bonding compounds to receptors. Ligand compounds obtained from PubChem and receptor clusters obtained from Protein Data Bank. The docking Software used is Pyrex, and Discovery Studio Analizer. Independent variables in this study were quercetin and istradefylline, while the dependent variable was binding affinity ligand to adenosine A2a receptor. In this study, statistical analysis was conducted using an independent sample t-test. Results: In-silico test with molecular docking method showed each 9 ligand position to the receptor, the results of data analysis with the test of independent sample t-test, at the degree of significance α = 0.05 obtained statistical results with a significance value of 0.013 which means that the quercetin ligand has stronger potential compared to istradefylline. Quercetin has a binding affinity value of -8.1 kcal/mol, while istradefylline has a binding affinity value of -6.9 kcal / mol. Conclusion: Quercetin has been shown to have potential as an alternative therapy for parkinson's disease

Effect of Ashitaba Leaf as Antibiofilm Against Pseudomonas aeruginosa and Staphylococcus aureus Luluk Aniqoh Meliana Putri; Ismi Rahmawati; Opstaria Saptarini
STRADA : Jurnal Ilmiah Kesehatan Vol. 14 No. 1 (2025): May
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjik.v14i1.1236

Infection is one of the serious health problems that will continue to grow in Indonesia. Indonesian people have used herbal medicines derived from plants such as ashitaba leaves which contain chemical compounds tannin, alkaloids, flavonoids and saponins to treat several diseases. This study aims to see the potential of extracts and fractions (n-hexane, water and ethyl acetate) to inhibit the formation, destroy biofilms against Pseudomonas aeruginosa and Staphylococcus aureus. The method used is antibacterial testing using the dilution method, observation of bacterial cell morphology using SEM. Results active ashitaba leaf fraction inhibits the formation and degrades Pseudomonas aeruginosa and Staphylococcus aureus biofilms is water. The location of the most active water fraction against Staphylococcus aureus bacteria is on the bacterial cell wall. The water fraction has antibacterial activity against Staphylococcus aureus with an MBC value of 12.5%, the location of the water fraction is on the bacterial cell wall.

Formulation And Physical Quality Test Of Black Glutinous Rice (Oryza Sativa L. Var. Glutinosa) And Olive Oil Body Scrub Herdianty, Juvita; Aniqoh Meliana Putri, Luluk; Wijayanto, Arif
Open Access Health Scientific Journal Vol. 6 No. 2 (2025): August 2025
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v6i2.97

Background: The purpose of using a body scrub is to remove dead skin cells and dirt, and unclog pores, resulting in brighter, whiter skin. Many types of body scrubs are available today, each with a variety of benefits, from smoothing to whitening. Black glutinous rice is currently a popular choice for use in cosmetics. Black glutinous rice contains 109.52–256.61 mg of anthocyanin per 100 grams. The antioxidant activity of anthocyanins can be enhanced by the presence of other phytochemicals, such as flavanols, catechins, or vitamins, which are also commonly found in fruit.Methods: This research method is experimental in making body scrub preparations from black sticky rice as the active ingredient with varying concentrations of 5%, 10%, and 15%. Evaluation of the body scrub preparations by looking at the results of the physical quality of the preparations which include organoleptic tests, homogeneity tests, pH tests, adhesion tests, and spreadability tests. The body scrub preparations will be tested for 3 days and stored at room temperature. Data are analyzed descriptively by comparing them to the Indonesian National Standard.Results: The results of the study showed that the preparation met the physical quality requirements, the results of organoleptic quality, namely the formulation of body scrub preparations F1, F2, and F3. The results of the pH test of F1, F2, F3 were in the range of 6.03-6.48, the results of the spreadability test showed results in the range of 4.48-6.98, and the adhesion test produced a range of 0.2.30 -0.2.45.Conclusion: The conclusion of this study is that the formulations F1, F2 and F3 with the addition of olive oil have good physical quality, are stable and meet the Indonesian National Standard.

Formulation of Fibrauren tinctoria Lour. Extract Serum, As an Antioxidant with the 1,1-Diphenyl 2-Picryhydrazyl (DPPH) Method Wijayanto, Arif; Herdianty, Juvita; Putri, Luluk Aniqoh Meliana; Sumanto, Ardhi Broto
Open Access Health Scientific Journal Vol. 6 No. 2 (2025): August 2025
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v6i2.125

Background: Serum is a preparation with a high concentration of active ingredients and low viscosity, which delivers a thin film of active ingredients to the skin surface. The use of Fibraurea tinctoria has been carried out since ancient times by the Dayak, Banjar, and Kutai tribes as a traditional treatment for liver disease, diabetes, and to increase the body's immunity from various causes of disease such as bacteria. Fibraurea tinctoria is believed to be able to ward off the negative effects caused by free radicals such as antioxidants.Methods: This experimental study investigated the antioxidant activity of Fibraurea tinctoria extract serum with varying concentrations of hydroxyethyl cellulose 1.0%, 1.5%, and 2.0% using the DPPH methods, which is simple, easy, fast, and sensitive, and requires a small sample. This method provides information on the reactivity of the tested compound with a stable radical. Evaluations of the Fibraurea tinctoria extract serum preparation was carried out by observing the results of physical quality tests, including organoleptic tests, homogeneity tests, pH tests, adhesion tests, and spreadability tests. The serum preparation was tested for 3 days and stored at room temperature. Data were analyzed descriptively by comparing it with the Indonesian National Standard.Results: The results showed that the serum extract preparations of Fibraurea tinctoria F1st, F2nd, and F3rd showed varying IC₅₀ values, where lower values indicated stronger antioxidant potential. Formulation F3rd showed the lowest IC₅₀ value (3.11 ppm), F2nd (3.74 ppm) and F1st (4.67 ppm), all of which were stronger than the base (5.11 ppm).Conclusion: In this research, formulations F1st, F2nd, and F3rd had the highest antioxidant activity, with F3rd at a concentration of 2.0%. The identified strong antioxidant activity is the main basis for the potential of Fibraurea tinctoria extract serum as an active antioxidant ingredient.

Anti-Acne Activity Evaluation Of Cyperus rotundus L. Rhizome Fraction Gel Against Staphylococcus aureus And Propionibacterium acnes Qadariah, Musdalifah; Juvita Herdianty; Luluk Aniqoh Meliana Putri; Ardhi Broto Sumanto
Strada Journal of Pharmacy Vol. 7 No. 2 (2025): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i2.203

Acne is an inflammatory skin condition often caused by bacteria such as Propionibacterium acnes and Staphylococcus aureus. The increasing incidence of antibiotic resistance encourages the search for alternatives from natural ingredients. Nut grass rhizome (Cyperus rotundus L.) is known to have antibacterial compounds. This study aimed to formulate a gel from the fractions of nut grass rhizome, test its activity against acne-causing bacteria, and identify the most potent fraction. This study employed a laboratory experimental design. The nut grass rhizome was extracted with 70% ethanol and then fractionated by liquid-liquid partitioning using n-hexane, ethyl acetate, and water as solvents. Each fraction was formulated into a gel at a 5% concentration, and its antibacterial activity was tested using the well diffusion method. All gel formulas met the physical quality evaluation requirements. The ethyl acetate fraction (F2) exhibited the strongest antibacterial activity, with an average inhibition zone of 19.48 ± 0.99 mm (moderate category) against Staphylococcus aureus and 25.86 ± 0.65 mm (strong category) against Propionibacterium acnes. The nut grass rhizome fraction gel preparation possesses anti-acne activity. The ethyl acetate fraction proved to be the most potent, showing efficacy against Propionibacterium acnes (inhibition zone 25.86 mm) that was statistically equivalent to the positive control (p = 0.767).

Analysis of Clinical Success in HIV/AIDS Patients with First-Line Antiretroviral Therapy Devientasari, Chinthia; Putri, Luluk Aniqoh Meliana
Open Access Health Scientific Journal Vol. 6 No. 2 (2025): August 2025
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v6i2.108

Background: Clinical success in HIV/AIDS patients undergoing antiretroviral therapy (ART) is influenced by various factors, including treatment adherence, regular follow-up visits, and monitoring of clinical outcomes such as weight gain and the absence of opportunistic infections (OIs). Opportunistic infections are considered a key indicator of ART failure and are strongly associated with advanced disease stages and low CD4 counts. This study aimed to analyze the demographic and clinical characteristics of HIV/AIDS patients and evaluate the relationship between body weight and the incidence of opportunistic infections in patients receiving ART.Methods: This cross-sectional study used retrospective data from 95 HIV/AIDS patients collected through consecutive sampling. Data included demographic variables (gender, age, marital status, education, occupation), clinical stage (WHO), CD4 count, body weight, ART regimen, and opportunistic infections. Data were analyzed using the Chi-square test, with a p-value ≤0.05 considered statistically significant.Results: Most patients were male (52.6%) and in the productive age range of 25–46 years (74.7%). The majority were married (54.7%), had low educational attainment, and were employed (76.8%). Clinically, 88.4% were at WHO stage III, and 80% had CD4 counts <350 cells/mm³. Low body weight (<60 kg) was found in 93.7% of patients. Opportunistic infections occurred in 26.3% of patients. A statistically significant association was found between body weight and opportunistic infections (p = 0.041). However, the OR of 1.086 (95% CI: 0.479–2.464) indicated no clinically significant difference in the risk of opportunistic infections between patients with body weight <60 kg and those >60 kg.Conclusion: Although low body weight was statistically associated with opportunistic infections, it did not present a significantly increased clinical risk. Nonetheless, opportunistic infections among patients highlights the importance of early intervention, nutritional support, and timely initiation of ART to improve treatment outcomes in HIV/AIDS management.

Edukasi Pemanfaatan Bahan Alam dalam Upaya Pengendalian Gula Darah pada Wali Murid di SD Tamanan Kota Kediri: Natural Materials Education in Blood Sugar Control Efforts at Tamanan Elementary School, Kediri City Putri, Luluk Aniqoh Meliana
Jurnal Pengabdian Kepada Masyarakat: Kesehatan Vol. 5 No. 4 (2025): Desember
Publisher : Sekolah Tinggi Ilmu Kesehatan Notokusumo Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstrak: Diabetes mellitus (DM) merupakan penyakit kronis yang memerlukan pengelolaan jangka panjang melalui terapi farmakologis dan nonfarmakologis. Salah satu pendekatan nonfarmakologis yang banyak diminati masyarakat adalah pemanfaatan bahan alam. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan dan keterampilan masyarakat dalam memanfaatkan bahan alam sebagai upaya pengendalian kadar gula darah. Kegiatan dilaksanakan di SD Tamanan Kota Kediri dengan sasaran orang tua/wali murid. Tahapan kegiatan meliputi pemeriksaan fisik, pengukuran tekanan darah, pemeriksaan kadar glukosa darah, serta pemberian edukasi melalui metode diskusi dan sharing menggunakan media booklet dan leaflet. Evaluasi dilakukan menggunakan pretest dan posttest untuk menilai peningkatan pengetahuan peserta. Hasil kegiatan menunjukkan adanya peningkatan pengetahuan peserta yang signifikan, ditunjukkan oleh nilai rata-rata pretest sebesar 41 dan meningkat menjadi 93 pada posttest. Edukasi ini diharapkan dapat meningkatkan kesadaran dan kemampuan masyarakat dalam memanfaatkan bahan alam secara tepat sebagai pendukung pengendalian kadar gula darah. Abstract: Diabetes mellitus (DM) is a chronic disease that required long-term management through pharmacological and non-pharmacological therapies. One non-pharmacological approach that is widely sought after by the community is the use of natural ingredients. This community service activity aims to increase the community's knowledge and skills in utilizing natural ingredients to control blood sugar levels. The activity was held at Tamanan Elementary School in Kediri City, targeting parents/guardians of students. The activity included physical examinations, blood pressure measurements, blood glucose level checks, and educational sessions through discussion and sharing using booklets and leaflets. Evaluation used pre- and post-tests to assess improvements in participants' knowledge. The activity results showed a significant increase in participants' knowledge, demonstrated by an average pre-test score of 41 and an increase to 93 in the post-test. This education is expected to increase community awareness and skills in the appropriate use of natural ingredients to support blood sugar control.

Effectiveness and Physical Quality Test of Ashitaba Leaf Extract Exfoliating Toner against Staphylococcus epidermidis and Propionibacterium acnes Putri, Luluk Aniqoh Meliana; Devita Riafinola Andaririt
Open Access Health Scientific Journal Vol. 7 No. 1 (2026): February 2026
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v7i1.134

Background: Acne (acne vulgaris) is a chronic inflammatory skin disease with a complex pathogenesis, involving the sebaceous glands and excessive colonization of acne-causing bacteria. In the modern era, the trend of using natural cosmetics is gaining momentum, not only in Indonesia but also globally. An example of a plant with great potential is Ashitaba. Ashitaba leaves have antibacterial. This study aimed to observe the physical quality test and antibacterial test of ashitaba leaf extract toner against Staphylococcus epidermidis and Propionibacterium acnes bacteria.Methods: The design in this study is an experimental method, physical quality tests include, Organoleptic tests are carried out visually, the components evaluated are the smell, shape, color and texture of the preparation, pH test and viscosity test. analysis of data from the physical quality test of the Ashitaba leaf extract facial toner, the physical characteristics of the preparation, including organoleptic, homogeneity, viscosity, and pH, of all three formulas met the parameters.Results: The toner tested against Staphylococcus epidermidis and Propionibacterium acnes bacteria had the largest inhibition zone, namely with an extract concentration of 20%.Conclusion: The toner tested against Staphylococcus epidermidis bacteria with a 20% extract had the largest inhibition zone of 27.6 mm, while Propionibacterium acnes bacteria with a 20% extract had the largest inhibition zone of 27.9 mm

Anti-Acne Activity Evaluation Of Cyperus rotundus L. Rhizome Fraction Gel Against Staphylococcus aureus And Propionibacterium acnes Qadariah, Musdalifah; Juvita Herdianty; Luluk Aniqoh Meliana Putri; Ardhi Broto Sumanto
Strada Journal of Pharmacy Vol. 7 No. 2 (2025): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i2.203

Acne is an inflammatory skin condition often caused by bacteria such as Propionibacterium acnes and Staphylococcus aureus. The increasing incidence of antibiotic resistance encourages the search for alternatives from natural ingredients. Nut grass rhizome (Cyperus rotundus L.) is known to have antibacterial compounds. This study aimed to formulate a gel from the fractions of nut grass rhizome, test its activity against acne-causing bacteria, and identify the most potent fraction. This study employed a laboratory experimental design. The nut grass rhizome was extracted with 70% ethanol and then fractionated by liquid-liquid partitioning using n-hexane, ethyl acetate, and water as solvents. Each fraction was formulated into a gel at a 5% concentration, and its antibacterial activity was tested using the well diffusion method. All gel formulas met the physical quality evaluation requirements. The ethyl acetate fraction (F2) exhibited the strongest antibacterial activity, with an average inhibition zone of 19.48 ± 0.99 mm (moderate category) against Staphylococcus aureus and 25.86 ± 0.65 mm (strong category) against Propionibacterium acnes. The nut grass rhizome fraction gel preparation possesses anti-acne activity. The ethyl acetate fraction proved to be the most potent, showing efficacy against Propionibacterium acnes (inhibition zone 25.86 mm) that was statistically equivalent to the positive control (p = 0.767).

Physicochemical Characterization and Phytochemical Screening of Citrus aurantifolia Lime Peel Ethanolic Extract from Kediri as Antibacterial Agent Putri, Luluk Aniqoh Meliana; Febrianto, Yahya
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 03 (2023): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58549/pcjn.v2i02.13

Citrus aurantifolia (Christm.) Swingle lime peel, widely discarded as agricultural waste in Kediri, East Java, Indonesia, is a promising source of bioactive compounds for antibacterial applications. Quality standardization of herbal materials is prerequisite for reproducible pharmacological activity, yet comprehensive physicochemical and microbiological characterization of lime peel simplicia from this region has not been reported. This study aimed to characterize the dried powder of C. aurantifolia lime peel collected from Kediri according to Indonesian Herbal Pharmacopoeia (IHP) standards, including microbial quality parameters (Total Aerobic Plate Count/ALT and Mold-Yeast Count/AKK), and to conduct phytochemical profiling of both simplicia and the ethanolic extract. Lime peels were cleaned, dried at 40–50°C, powdered, and characterized for water content (8.64%), water-soluble extract (26.67%), ethanol-soluble extract (18.14%), total ash (5.62%), acid-insoluble ash (0.35%), ALT (3.5 × 10³ CFU/g), and AKK (1.2 × 10² CFU/g)—all within IHP requirements. Phytochemical screening detected alkaloids, flavonoids, glycosides, saponins, tannins, and steroids/triterpenoids in both simplicia and extract. These findings establish a standardized pharmacognostic profile supporting the use of Kediri-sourced lime peel extract in evidence-based antibacterial research.

Title

Found 20 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 20 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 20 Documents
Search