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All Journal Jurnal Ilmiah Wahana Pendidikan Journal of Pharmaceutical and Sciences.
Aprillia, Cantika
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Perbandingan Efektivitas Antibiotik Terhadap Durasi Terapi Demam Tifoid Sholih, Mally Ghinan; Mulki, Munir Alinu; Nurhadis, Nurhadis; Akifah, Muthia Nur; Aprillia, Cantika; Maharani, Puteri Rahma; Subekti, Firli Reisya; Affandhy, Adhwa'a Kaylla
Jurnal Ilmiah Wahana Pendidikan Vol 11 No 1.D (2025): Jurnal Ilmiah Wahana Pendidikan 
Publisher : Peneliti.net

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Abstract

Demam tifoid merupakan penyakit yang sering terjadi di Indonesia, disebabkan oleh bakteri Salmonella typhi yang menyebar melalui jalur fecal-oral. Prevalensi demam tifoid di Indonesia mencapai 1,60%, dengan prevalensi tertinggi pada anak-anak berusia 5 hingga 14 tahun karena kebiasaan jajan sembarangandan kurangnya perhatian terhadap kebersihan diri . Pengobatan demam tifoid melibatkan pemberian antibiotik yang tepat dan perawatan suportif. Studi ini bertujuan untuk menganalisisefektivitas antibiotik dalam mengurangi durasi terapidemam tifoid, dengan fokus pada antibiotik seperticeftriaxone, cefotaxime, azithromycin, ciprofloxacin, kloramfenikol, dan tiamfenikol. Metode yang digunakan dalam penelitian initermasuk dalam jenis penelitian systematics literature review. Penelitian menunjukkan bahwa ceftriaxone lebih efektif dari pada kloramfenikol dalam mengatasi demam tifoid, dan kombinasi antibiotik seperti tiamfenikol dan ceftriaxone dapat mengurangi lama rawat inap. Azitromisin juga efektif untuk kasus tanpa komplikasi. Penggunaanantibiotik yang tepat penting untuk mengurangi case fatality rate. Terapi kombinasi dapat memperluas spektrumaktivitas antimikroba dan mencegah resistensi. Studi ini memberikan wawasan tentang pengobatan demam tifoiddengan antibiotik yang efektif, seperti ceftriaxone, azithromycin, dan kombinasi antibiotik tertentu. Pentingnya edukasi tentang kebersihan pribadi dan lingkungan juga disorot untuk mencegah penyebaran infeksi lebih lanjut. Dengan pemahaman yang lebih baiktentang efektivitas antibiotik dalam pengobatan demam tifoid, diharapkan dapat meningkatkan penanganan kasusdemam tifoid dan mengurangi dampak negatifnya.Kata kunci: Demam tifoid, Lama pengobatan, Terapi antibiotik, Efikasi obat, dan Efektivitas perbandingan
Kemajuan Bioteknologi dalam Diagnosis Tuberkulosis: Perkembangan Global dan Penerapannya di Indonesia Aprillia, Cantika; Zahra , Aliya Azkia; Malau , Jekmal; Ainaputri , Aliza Salsabila; Siboro , Dewi Pratiwi Purba; Apriyanti , Endeh; Nugraha , Afif Tri
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1309

Abstract

Tuberculosis (TB) remains a major global health burden, and Indonesia is among the countries with the highest incidence and mortality rates. Early and accurate diagnosis is essential for effective TB control; however, conventional diagnostic methods such as sputum smear microscopy, culture, chest radiography, and the tuberculin skin test continue to face limitations in sensitivity, specificity, turnaround time, and operational feasibility. This narrative review synthesizes global biotechnological developments in TB diagnostics and evaluates their potential applicability within the Indonesian healthcare system. A structured literature search was conducted using PubMed, ScienceDirect, and Google Scholar, applying Population, Intervention, Comparison, and Outcome (PICO) based inclusion and exclusion criteria. Key advances in molecular diagnostics include conventional polymerase chain reaction (PCR), real-time PCR, automated nucleic acid amplification test (NAAT) platforms such as GeneXpert, Xpert Ultra, and Truenat, as well as loop-mediated isothermal amplification (LAMP). Emerging innovations including CRISPR-based assays, biosensor platforms, microfluidic lab-on-chip devices, and nanotechnology-enhanced systems demonstrate improved sensitivity, portability, and testing speed, with potential for point-of-care implementation, although many require further field-based validation. No single diagnostic tool is universally optimal, as suitability depends on infrastructure availability, workforce capacity, and population needs. In Indonesia, persistent challenges include limited laboratory networks, high diagnostic costs, supply-chain constraints, and variability in human resource competence. Strengthening diagnostic systems, expanding decentralized testing, integrating digital health technologies, and supporting local production of diagnostic materials are critical to enable sustainable adoption and accelerate progress toward national TB elimination targets.
Menelusuri Perkembangan, Kondisi Terkini, dan Prospek Masa Depan Pengujian DNA dalam Aplikasi Forensik Manusia dan Non-Manusia: Tinjauan Naratif Siboro, Dewi Pratiwi Purba; Zahra, Aliya Azkia; Kasasiah, Ahsanal; Malau, Jekmal; Aprillia, Cantika; Ainaputri, Aliza Salsabila; Nugraha, Afif Tri; Aprianti, Endeh
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1389

Abstract

DNA typing has become a cornerstone of modern forensic science, profoundly influencing criminal investigations, forensic human identification, and non-human forensic applications. Since its introduction in the mid-1980s, forensic DNA analysis has evolved from restriction fragment length polymorphism-based methods to polymerase chain reaction-based short tandem repeat profiling, and more recently to sequence-based approaches enabled by massively parallel sequencing, resulting in substantial improvements in analytical sensitivity, robustness, and discriminatory power. This narrative review aims to trace the historical development, examine the current state, and explore future directions of DNA typing in both human and non-human forensic contexts, with particular emphasis on empirical case studies from Asia. A narrative review methodology was employed through a comprehensive analysis of peer-reviewed literature published between 2015 and 2026, sourced from major scientific databases including Google Scholar, PubMed, and ScienceDirect, with studies selected based on forensic relevance, methodological rigor, and regional significance. The review highlights the extensive application of DNA typing in routine criminal casework, disaster victim identification, missing persons investigations, wildlife forensic genetics, food fraud detection, and biosecurity, and documents emerging technologies such as portable DNA systems and CRISPR-based detection. Despite these advances, significant challenges remain related to data interpretation, validation requirements, contamination control, ethical and legal governance, and uneven forensic capacity across regions. Overall, this review underscores the continuing evolution of forensic DNA typing and emphasizes the importance of standardized protocols, interdisciplinary collaboration, and region-specific validation to ensure the reliable and responsible application of DNA evidence in modern forensic science.
Genetika dan Farmakogenomika untuk Kinerja Atletik: Tren Terkini dan Arah Masa Depan di ASEAN Nugraha, Afif Tri; Malau , Jekmal; Kasasiah , Ahsanal; Aprillia, Cantika; Ainaputri, Aliza Salsabila; Siboro , Dewi Pratiwi Purba
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1375

Abstract

The integration of sport genomics and pharmacogenomics has become a central pillar of precision sports medicine, enabling individualized training, nutrition, and medication/supplement strategies for athletes. This structured narrative review synthesizes literature published between 2015 and 2025 from PubMed, ScienceDirect, and Google Scholar, with particular emphasis on implementation relevance in ASEAN, especially Indonesia. Findings are organized into three major themes: (1) genetic contributions to strength and endurance phenotypes, body composition, recovery, and injury susceptibility; (2) pharmacogenomic implications for drug selection, dose optimization, therapeutic safety, and potential exercise with drug interactions (e.g., NSAIDs, inhaled bronchodilators, caffeine, and creatine); and (3) ethical, privacy, equity, and gene-doping considerations. Athletic performance is inherently polygenic; variants in genes such as ACTN3, ACE, PPARGC1A, PPARA, and VEGF-A contribute to the power–endurance spectrum and vascular–metabolic adaptation, while pharmacogenes including CYP2C9, CYP1A2, ADORA2A, and ADRB2 may modulate therapeutic efficacy and adverse-effect risk. Moreover, physical activity itself may influence drug metabolism and pharmacodynamic responses, underscoring the limitations of one-size-fits-all protocols. Overall, genetic information should be positioned as a complementary decision-support layer rather than a deterministic predictor in sports medicine practice. Strengthening implementation in ASEAN requires larger, well-characterized athlete cohorts, standardized marker panels, longitudinal data integration, and robust ethical–regulatory frameworks to ensure safe and evidence-based genomic application.
Co-Authors Affandhy, Adhwa'a Kaylla Ahsanal Kasasiah Ainaputri , Aliza Salsabila Ainaputri, Aliza Salsabila Akifah, Muthia Nur Aprianti, Endeh Apriyanti , Endeh Jekmal Malau Kasasiah , Ahsanal Maharani, Puteri Rahma Malau , Jekmal Munir Alinu Mulki Nugraha , Afif Tri Nugraha, Afif Tri Nurhadis, Nurhadis Sholih, Mally Ghinan Siboro , Dewi Pratiwi Purba Siboro, Dewi Pratiwi Purba Subekti, Firli Reisya Zahra , Aliya Azkia Zahra, Aliya Azkia