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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) PREPOTIF : Jurnal Kesehatan Masyarakat Buletin Kedokteran dan Kesehatan Prima PCJN Pharmaceutical and Clinical Journal of Nusantara
Ginting, Astriani Natalia Br
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Factors associated with self-medication practices of primary dysmenorrhea among students Sembiring, Ernesta Br.; Siburian , Friska Lasro Yanti; Suci, Tri; Ginting, Astriani Natalia Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6777

Abstract

Self-medication and home remedies are the most frequently used methods to relieve menstrual discomfort among female college students. The practice of self-medication varies among adolescent female students. Therefore, this study aimed to observe and analyze the factors associated with the practice of self-medication for primary dysmenorrhea among university students.This study used an analytical observational design with a cross-sectional approach, involving 207 female health students from Universitas Prima Indonesia. The sample was obtained through a purposive sampling technique. Data analysis included univariate analysis, bivariate analysis (chi-square and Fisher's exact test), and multivariate analysis (logistic regression). The prevalence of self-medication was reported to be 36.7%. Several factors were found to be associated with self-medication practices for primary dysmenorrhea among students, namely menstrual cycle (p<0.001, OR: 3.27, 95% CI 1.75-6.10), duration of pain during menstruation (p<0.001 OR: 3.85, 95% CI 2.10-7.07), and severity of pain (p=0.009 OR: 2.21, 95% CI 1.24-3.93). In contrast, age (p=0.316), academic year (p=0.889), family history (p=0.470), age at menarche (p=0.223), and menstrual duration (p=0.552) did not show a statistically significant association with self-medication practices for primary dysmenorrhea. The dominant factor influencing self-medication practices for primary dysmenorrhea was pain duration. Notably, self-medication with medications was found to be relatively low among health students with primary dysmenorrhea. Therefore, educational programs that address the limitations of self-medication with drugs need to be implemented effectively.
Factors influencing self-medication behaviour among non-health science students at Universitas Prima Indonesia Damanik, Dedech M. Sari; Siregar, Nur Aini; Paulina, Roslina; Suci, Tri; Ginting, Astriani Natalia Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6784

Abstract

Self-medication, defined as the use of medication without a prescription or professional guidance, is a global phenomenon with significant implications for both individual and public health. This behaviour is frequently motivated by the desire to alleviate minor ailments, avoid healthcare costs, or circumvent lengthy consultation waiting times. While it can constitute a component of responsible self-care, self-medication also carries risks such as adverse drug reactions, drug interactions, antibiotic resistance, and the potential for misuse. This research aimed to analyse the factors associated with self-medication behaviour among non-healthcare students at Universitas Prima Indonesia. The study employed an analytical observational design with a cross-sectional approach. Data were collected via an online questionnaire distributed to 188 undergraduate students from the Faculty of Economics at Universitas Prima Indonesia, selected using simple random sampling. The independent variables in this study were gender, knowledge of self-medication, peer recommendations, and academic stress, while the dependent variable was self-medication behaviour. Data analysis involved univariate statistics to describe the characteristics of each variable and bivariate analysis using the Chi-squared test to examine the relationships between variables. The results indicated that knowledge (OR=3.230; p=0.000), peer recommendations (OR=2.046; p=0.000), and academic stress (OR=1.552; p=0.002) were significantly associated with self-medication, whereas gender was not (p=0.126). It can be concluded that a lack of knowledge, peer influence, and academic stress increase the risk of self-medication. Educational interventions and mental health support are necessary to reduce unsafe self-medication practices.
An evaluation of patient satisfaction with pharmaceutical services at Munyang Kute Regional General Hospital Bengimiate, Nuriza; Hartopo, Haqi; Razoki, Razoki; Ginting, Astriani Natalia Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7173

Abstract

Patient satisfaction is a crucial indicator for assessing hospital service quality, in which pharmaceutical services play a vital role as a primary point of contact with patients. This study aimed to comprehensively evaluate the satisfaction level of outpatients with the pharmaceutical services at Munyang Kute Regional General Hospital. This research employed a descriptive quantitative design with a cross-sectional approach. A total of 90 respondents were selected through a purposive sampling technique based on predetermined criteria. The research instrument was an adapted questionnaire designed to measure satisfaction across five dimensions of service quality: tangibles, reliability, responsiveness, assurance, and empathy. The collected data were analyzed descriptively using SPSS software. The findings indicated that patients were generally satisfied with the pharmaceutical services they received. The highest level of satisfaction was observed in the responsiveness dimension, with a percentage of 69.72%. The other dimensions, in descending order, were tangibles (32.21%), empathy (27.19%), assurance (19.60%), and the lowest was the reliability dimension (16.00%). Overall, the patient perception of pharmaceutical services at Munyang Kute Regional General Hospital is positive. Nevertheless, there remains room for improvement, particularly in the reliability and assurance dimensions. Continuous quality improvement through enhanced patient education and optimization of facilities is highly recommended.
Effectiveness of transdermal patch formulation of Hibiscus rosa-sinensis L. leaf extract as an antipyretic in male rats induced with DPT vaccine Ketaren, Nessya Try Natasya Br; Ginting, Astriani Natalia Br; Meutia, Rena; Lubis, Asyrun Alkhari
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7546

Abstract

Fever is characterized by an elevation of body temperature above the normal range of 37.5°C and represents a physiological response to various health conditions such as infections or other diseases. Antipyretic drugs, including paracetamol and ibuprofen, are commonly used to manage fever. Ethanol extract of Hibiscus rosa-sinensis L. (kembang sepatu) leaves contains bioactive compounds such as tannins, flavonoids, saponins, carbohydrates, steroids, phenols, glycosides, quinones, terpenoids, cyclopeptides, and alkaloids, which may confer natural antipyretic properties. In this study, 3% and 5% (w/w) Hibiscus rosa-sinensis leaf ethanol extracts were formulated into transdermal patches and evaluated for their antipyretic efficacy in male rats induced with the Diphtheria-Pertussis-Tetanus (DPT) vaccine. The dried Hibiscus rosa-sinensis leaves were macerated using 96% ethanol. The concentrated extract was formulated into a hydroxypropyl methylcellulose (HPMC)-based transdermal patch. Phytochemical screening of the extract, stability testing of the transdermal patch, and statistical analysis of the antipyretic effect on DPT-induced male rats were conducted. Phytochemical screening of the 96% ethanol extract confirmed the presence of alkaloids, flavonoids, tannins, steroids, and saponins. The transdermal patch formulation demonstrated good stability over 21 days of storage. The 5% extract patch exhibited the highest antipyretic activity, significantly reducing fever in the experimental rats and showing effectiveness comparable to the positive control (paracetamol).
Glibenclamide prescription services profile in pharmacies of the Tapung Hilir District Merianis, Hotvera; Razoki, Razoki; Ginting, Astriani Natalia Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7553

Abstract

Prescription dispensing in pharmacies involves two key stages: screening and medication preparation. Screening, conducted by the pharmacist, covers administrative requirements, pharmaceutical suitability, and clinical considerations. Medication preparation includes compounding, labeling, packaging, dispensing, counseling, and monitoring. The overarching goal is to ensure that the medication prescribed is accurately and safely delivered to the patient. This study assessed the prescription service quality for glibenclamide in Tapung Hilir pharmacies. Ninety pharmacies were randomly sampled, and data were collected using a simulated patient approach, where researchers acted as patients' family members seeking glibenclamide. The instruments employed—prescription, scenario, protocol, and checklist—were validated for reliability. Results showed that 85 pharmacies (94.4%) dispensed the prescribed medication. However, patient information gathering was minimal: only 7.1% asked for the recipient’s identity, 18.8% for the patient’s address, and fewer than 5% inquired about prior medication use or understanding of administration. Critical clinical data such as patient age, symptomatology, therapy goals, concurrent medications, and allergy history were generally not obtained. On average, pharmacies asked only 0.4 out of 13 patient assessment questions. Regarding medication counseling, the frequency of drug use was explained by 42.4% of pharmacies, while other key information—indication, dose, side effects, treatment duration, and storage—was rarely provided. On average, only 1.2 out of 16 drug information items were communicated. Labels were provided by 65.9% of pharmacies, with only one using a distinguishable blue label. In conclusion, the involvement of pharmacy staff in the comprehensive provision of prescription services for glibenclamide remains limited in Tapung Hilir. Enhancement in patient assessment and information delivery is urgently needed to improve medication safety and effectiveness.
Antidiabetic Activity of Cep-Cepan Leaf Extract Nanoparticles (Castanopsis costata) in Streptozotocin-Induced White Rat Models Ginting, Astriani Natalia Br; Ginting, Chrismis Novalinda; Rusip, Gusbakti; Chiuman, Linda
Jurnal Penelitian Pendidikan IPA Vol 11 No 2 (2025): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i2.9408

Abstract

The cep-cepan plant (Castanopsis costata) from the Fagaceae family is traditionally used by the Karo community in Medan, North Sumatra, to treat diabetes mellitus, although its efficacy has not yet been scientifically proven. This study aimed to evaluate the effectiveness of the antidiabetic activity of cep-cepan leaf extract nanoparticles (Castanopsis costata) in a streptozotocin-induced white rat model. A total of 25 male white rats were divided into five treatment groups: a positive control group, a negative control group, and three experimental groups treated with extract concentrations of 25, 75, and 150 mg/kg body weight, respectively. Plasma glucose levels were measured every 72 hours for 15 days using blood samples taken from the tail. Pancreatic tissue was then examined, and the data were analyzed using one way anova. The findings showed significant antidiabetic activity in all treatment groups, with p < 0.001. The nanoparticle extract of cep-cepan leaves exhibited the highest antidiabetic potential at a dosage of 150 mg/kg, reducing blood glucose levels by 59.39%. These results suggest that the nanoparticle extract of cep-cepan leaves demonstrates antidiabetic activity in the streptozotocin-induced white rat model, and it has the potential to be developed as an alternative treatment for diabetes mellitus.
Co-Authors Amelia, Ade Asyrun Alkhairi Lubis Bengimiate, Nuriza Chiuman, Linda Damanik, Dedech M. Sari DAMERIA DAMERIA Ginting, Chrismis Novalinda Gusbakti Rusip Hartopo, Haqi Hotvera Merianis, Hotvera Ketaren, Nessya Try Natasya Br Lubis, Asyrun Alkhari Merianis, Hotvera Meutia, Rena Milka Rositi Sianipar Muhammad Yunus Paulina, Roslina Purba, Helprida GM Razoki, Razoki Sembiring, Ernesta Br. Siburian , Friska Lasro Yanti Sihombing, Tabita Ronauli Simanjuntak, Mafe Robbi Siregar, Nur Aini Sitanggang, Titin Krisdayanti Situngkir, Luwis Suci, Tri