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All Journal PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Buana Farma Buletin Kedokteran dan Kesehatan Prima PCJN Pharmaceutical and Clinical Journal of Nusantara Journal of Pharmaceutical and Sciences. Jurnal Penelitian Sains dan Kesehatan Avicenna
Ginting, Astriani Natalia Br
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Factors associated with self-medication practices of primary dysmenorrhea among students Sembiring, Ernesta Br.; Siburian , Friska Lasro Yanti; Suci, Tri; Ginting, Astriani Natalia Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6777

Abstract

Self-medication and home remedies are the most frequently used methods to relieve menstrual discomfort among female college students. The practice of self-medication varies among adolescent female students. Therefore, this study aimed to observe and analyze the factors associated with the practice of self-medication for primary dysmenorrhea among university students.This study used an analytical observational design with a cross-sectional approach, involving 207 female health students from Universitas Prima Indonesia. The sample was obtained through a purposive sampling technique. Data analysis included univariate analysis, bivariate analysis (chi-square and Fisher's exact test), and multivariate analysis (logistic regression). The prevalence of self-medication was reported to be 36.7%. Several factors were found to be associated with self-medication practices for primary dysmenorrhea among students, namely menstrual cycle (p<0.001, OR: 3.27, 95% CI 1.75-6.10), duration of pain during menstruation (p<0.001 OR: 3.85, 95% CI 2.10-7.07), and severity of pain (p=0.009 OR: 2.21, 95% CI 1.24-3.93). In contrast, age (p=0.316), academic year (p=0.889), family history (p=0.470), age at menarche (p=0.223), and menstrual duration (p=0.552) did not show a statistically significant association with self-medication practices for primary dysmenorrhea. The dominant factor influencing self-medication practices for primary dysmenorrhea was pain duration. Notably, self-medication with medications was found to be relatively low among health students with primary dysmenorrhea. Therefore, educational programs that address the limitations of self-medication with drugs need to be implemented effectively.
Factors influencing self-medication behaviour among non-health science students at Universitas Prima Indonesia Damanik, Dedech M. Sari; Siregar, Nur Aini; Paulina, Roslina; Suci, Tri; Ginting, Astriani Natalia Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6784

Abstract

Self-medication, defined as the use of medication without a prescription or professional guidance, is a global phenomenon with significant implications for both individual and public health. This behaviour is frequently motivated by the desire to alleviate minor ailments, avoid healthcare costs, or circumvent lengthy consultation waiting times. While it can constitute a component of responsible self-care, self-medication also carries risks such as adverse drug reactions, drug interactions, antibiotic resistance, and the potential for misuse. This research aimed to analyse the factors associated with self-medication behaviour among non-healthcare students at Universitas Prima Indonesia. The study employed an analytical observational design with a cross-sectional approach. Data were collected via an online questionnaire distributed to 188 undergraduate students from the Faculty of Economics at Universitas Prima Indonesia, selected using simple random sampling. The independent variables in this study were gender, knowledge of self-medication, peer recommendations, and academic stress, while the dependent variable was self-medication behaviour. Data analysis involved univariate statistics to describe the characteristics of each variable and bivariate analysis using the Chi-squared test to examine the relationships between variables. The results indicated that knowledge (OR=3.230; p=0.000), peer recommendations (OR=2.046; p=0.000), and academic stress (OR=1.552; p=0.002) were significantly associated with self-medication, whereas gender was not (p=0.126). It can be concluded that a lack of knowledge, peer influence, and academic stress increase the risk of self-medication. Educational interventions and mental health support are necessary to reduce unsafe self-medication practices.
An evaluation of patient satisfaction with pharmaceutical services at Munyang Kute Regional General Hospital Bengimiate, Nuriza; Hartopo, Haqi; Razoki, Razoki; Ginting, Astriani Natalia Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7173

Abstract

Patient satisfaction is a crucial indicator for assessing hospital service quality, in which pharmaceutical services play a vital role as a primary point of contact with patients. This study aimed to comprehensively evaluate the satisfaction level of outpatients with the pharmaceutical services at Munyang Kute Regional General Hospital. This research employed a descriptive quantitative design with a cross-sectional approach. A total of 90 respondents were selected through a purposive sampling technique based on predetermined criteria. The research instrument was an adapted questionnaire designed to measure satisfaction across five dimensions of service quality: tangibles, reliability, responsiveness, assurance, and empathy. The collected data were analyzed descriptively using SPSS software. The findings indicated that patients were generally satisfied with the pharmaceutical services they received. The highest level of satisfaction was observed in the responsiveness dimension, with a percentage of 69.72%. The other dimensions, in descending order, were tangibles (32.21%), empathy (27.19%), assurance (19.60%), and the lowest was the reliability dimension (16.00%). Overall, the patient perception of pharmaceutical services at Munyang Kute Regional General Hospital is positive. Nevertheless, there remains room for improvement, particularly in the reliability and assurance dimensions. Continuous quality improvement through enhanced patient education and optimization of facilities is highly recommended.
Effectiveness of transdermal patch formulation of Hibiscus rosa-sinensis L. leaf extract as an antipyretic in male rats induced with DPT vaccine Ketaren, Nessya Try Natasya Br; Ginting, Astriani Natalia Br; Meutia, Rena; Lubis, Asyrun Alkhari
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7546

Abstract

Fever is characterized by an elevation of body temperature above the normal range of 37.5°C and represents a physiological response to various health conditions such as infections or other diseases. Antipyretic drugs, including paracetamol and ibuprofen, are commonly used to manage fever. Ethanol extract of Hibiscus rosa-sinensis L. (kembang sepatu) leaves contains bioactive compounds such as tannins, flavonoids, saponins, carbohydrates, steroids, phenols, glycosides, quinones, terpenoids, cyclopeptides, and alkaloids, which may confer natural antipyretic properties. In this study, 3% and 5% (w/w) Hibiscus rosa-sinensis leaf ethanol extracts were formulated into transdermal patches and evaluated for their antipyretic efficacy in male rats induced with the Diphtheria-Pertussis-Tetanus (DPT) vaccine. The dried Hibiscus rosa-sinensis leaves were macerated using 96% ethanol. The concentrated extract was formulated into a hydroxypropyl methylcellulose (HPMC)-based transdermal patch. Phytochemical screening of the extract, stability testing of the transdermal patch, and statistical analysis of the antipyretic effect on DPT-induced male rats were conducted. Phytochemical screening of the 96% ethanol extract confirmed the presence of alkaloids, flavonoids, tannins, steroids, and saponins. The transdermal patch formulation demonstrated good stability over 21 days of storage. The 5% extract patch exhibited the highest antipyretic activity, significantly reducing fever in the experimental rats and showing effectiveness comparable to the positive control (paracetamol).
Glibenclamide prescription services profile in pharmacies of the Tapung Hilir District Merianis, Hotvera; Razoki, Razoki; Ginting, Astriani Natalia Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7553

Abstract

Prescription dispensing in pharmacies involves two key stages: screening and medication preparation. Screening, conducted by the pharmacist, covers administrative requirements, pharmaceutical suitability, and clinical considerations. Medication preparation includes compounding, labeling, packaging, dispensing, counseling, and monitoring. The overarching goal is to ensure that the medication prescribed is accurately and safely delivered to the patient. This study assessed the prescription service quality for glibenclamide in Tapung Hilir pharmacies. Ninety pharmacies were randomly sampled, and data were collected using a simulated patient approach, where researchers acted as patients' family members seeking glibenclamide. The instruments employed—prescription, scenario, protocol, and checklist—were validated for reliability. Results showed that 85 pharmacies (94.4%) dispensed the prescribed medication. However, patient information gathering was minimal: only 7.1% asked for the recipient’s identity, 18.8% for the patient’s address, and fewer than 5% inquired about prior medication use or understanding of administration. Critical clinical data such as patient age, symptomatology, therapy goals, concurrent medications, and allergy history were generally not obtained. On average, pharmacies asked only 0.4 out of 13 patient assessment questions. Regarding medication counseling, the frequency of drug use was explained by 42.4% of pharmacies, while other key information—indication, dose, side effects, treatment duration, and storage—was rarely provided. On average, only 1.2 out of 16 drug information items were communicated. Labels were provided by 65.9% of pharmacies, with only one using a distinguishable blue label. In conclusion, the involvement of pharmacy staff in the comprehensive provision of prescription services for glibenclamide remains limited in Tapung Hilir. Enhancement in patient assessment and information delivery is urgently needed to improve medication safety and effectiveness.
Formulasi Krim yang Mengandung Ekstrak Biji Kopi Robusta (Coffea canephora L.) dan Tantangannya dalam Menghambat Staphylococcus aureus: Studi Potensi Terapi Luka pada Penderita Diabetes Andari, Putri; Sembiring, Novitaria Br; Ginting, Astriani Natalia Br
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1425

Abstract

Diabetes mellitus is a chronic metabolic disorder that can cause wounds that are difficult to heal and susceptible to bacterial infection, especially Staphylococcus aureus. This study aims to formulate an antibacterial cream preparation containing robust coffee bean extract (Coffea canephora L.) and evaluate its activity against Staphylococcus aureus. The extract was obtained through maceration with 96% ethanol with a crude yield of 30% and an extract yield of 14.05%. Phytochemical screening showed the presence of alkaloids, flavonoids, tannins, phenols, saponins, and terpenoids. Antibacterial testing of the extract showed inhibitory activity against Staphylococcus aureus at concentrations of 30% (7.73–8.44 mm) and 50% (8.52–13.16 mm). The extract was then formulated into creams with varying concentrations of 0%, 30%, and 50%. All formulations met the physical parameters, except for the cream that did not contain the extract, which showed a pH higher than the ideal range for topical application and showed a decrease in spreadability with increasing extract concentration. However, testing the antibacterial activity of the cream preparations using the disk diffusion method did not produce an inhibition zone in any of the formulations tested. The results of this study indicate that although Robusta coffee bean extract shows activity in vitro, it has not been successfully applied in cream formulations with the existing bases and testing methods. These findings highlight the major challenges in developing natural topical preparations, particularly regarding the selection of formulation bases and appropriate evaluation methods for semisolid preparations.
EVALUASI PENGGUNAAN OBAT PADA PASIEN DISPEPSIA MENGGUNAKAN METODE ATC/DDD DI RUMAH SAKIT ROYAL PRIMA TAHUN 2022 Hutabarat, Rachel Epifanes; Harahap, Daimah Wirdatus Sanaun; Ginting, Astriani Natalia Br
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1677

Abstract

Dyspepsia is a common non-communicable disease that requires pharmacotherapy management according to clinical guidelines. Evaluation of drug use can be conducted using the ATC/DDD (Anatomical Therapeutic Chemical/Defined Daily Dose) and DU90% (Drug Utilization 90%) methods to describe prescribing patterns in healthcare facilities. This study aimed to evaluate drug use in dyspepsia patients at Royal Prima Hospital Medan in 2022 using a retrospective descriptive design using medical records of 180 patients from January–December 2022. Drugs were classified based on the WHO 2023 ATC system and analyzed using DDD calculations and the DU90% method. The results showed that four drugs included in the DU90% segment were omeprazole (tablets and injections) and ranitidine (tablets and injections), with a total contribution of 90.4% of the total DDD. The pattern of drug use is dominated by proton pump inhibitors and H₂ receptor antagonists, which are the main therapies in the management of dyspepsia based on the 2022 National Consensus on the Management of Dyspepsia and Helicobacter pylori Infection, so that the distribution of drug use obtained in this study shows compliance with national therapy recommendations.
UJI AKTIVITAS EKSTRAK ETANOL DAUN SIRIH CINA (PEPEROMIA PELLUCIDA L.) TERHADAP BAKTERI PSEUDOMONAS AERUGINOSA DAN PROPIONIBACTERIUM ACNES Sinaga, Helsi Herdiani; Ginting, Astriani Natalia br; Simanjuntak, Nerly Juli Pranita
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1678

Abstract

The Chinese betel leaf plant (Peperomia pellucida L.), a herbal plant belonging to the Piperaceae family, has antibiotic properties against the growth of acne-causing bacteria. The Chinese betel leaf plant is also known to have antibacterial activity. This study aimed to determine the antibacterial activity of the ethanol extract of Chinese betel leaf against Pseudomonas aeruginosa and Propionibacterium acnes. The method used was disc diffusion with varying concentrations of 10%, 20%, and 30%. Inhibition zone data were analyzed using a One-Way ANOVA test. The results showed that the ethanol extract of Chinese betel leaf was able to inhibit the growth of both bacteria and there was a significant difference between extract concentrations (p < 0.05). The ethanol extract of Chinese betel leaf has the potential as a natural antibacterial.
UJI AKTIVITAS ANTIOKSIDAN TERHADAP DAUN BAKUNG (CRINUM ASIATICUM L.) DENGAN PELARUT ETANOL DENGAN METODE DPPH (2,2-DHIPHENYL-1-PIRCYLHYDRAZYL) Louisa, Natasya; Ginting, Astriani Natalia Br; Simanjuntak, Nerly July Pranita; Simbolon, Marlina L
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1682

Abstract

Free radicals are one of the main factors causing oxidative stress, which contributes to various degenerative diseases. Natural antioxidants derived from plants have the potential to serve as safer alternatives to synthetic antioxidants. One plant with potential as a natural antioxidant source is bakung (Crinum asiaticum L.), which has long been traditionally used, although scientific studies on it remain limited. This study aimed to determine the antioxidant activity of the ethanol extract of bakung leaves (Crinum asiaticum L.) using the DPPH method and to examine its secondary metabolite profile. This experimental research employed maceration extraction using 96% ethanol, followed by phytochemical screening to identify classes of compounds and antioxidant activity testing using the DPPH method expressed as IC₅₀ values. The results showed that the ethanol extract of bakung leaves contains alkaloids, flavonoids, tannins, saponins, and triterpenoids/steroids. The antioxidant activity test indicated that the extract exhibited strong antioxidant activity with an IC₅₀ value of 13.73 µg/mL, although it was still lower than vitamin C as the positive control, which had an IC₅₀ value of 8.56 µg/mL. Based on these findings, it can be concluded that the ethanol extract of bakung leaves (Crinum asiaticum L.) has potential as a natural antioxidant source and holds promise for further development in the fields of pharmacy and natural product chemistry.
Analisis Potensi Interaksi Obat Golongan Proton Pump Inhibitor Pada Pasien Rawat Jalan di Rumah Sakit Royal Prima Tahun 2022 Aulia, Sri Cinta; Harahap, Daimah Wirdatus Sanaun; Ginting, Astriani Natalia Br
Jurnal Penelitian Sains dan Kesehatan Avicenna Vol 5 No 2 (2026): Jurnal Penelitian Sains dan Kesehatan Avicenna
Publisher : Lembaga Penelitian Dan Pengabdian Kepada Masyarakat (LPPM), Institut Teknologi Dan Kesehatan (ITK) Avicenna

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69677/avicenna.v5i2.305

Abstract

Latar Belakang: Penggunaan obat golongan Proton Pump Inhibitor (PPI) pada pasien rawat jalan sering disertai dengan pemberian obat lain, sehingga berpotensi menimbulkan interaksi obat. Interaksi obat dapat mempengaruhi efektivitas terapi dan meningkatkan risiko terjadinya efek samping. Tujuan: Penelitian ini bertujuan untuk menganalisis potensi interaksi obat golongan Proton Pump Inhibitor pada pasien rawat jalan di Rumah Sakit Royal Prima Medan tahun 2022. Metode: Penelitian ini menggunakan desain observasional retrospektif dengan sumber data berupa rekam medis pasien rawat jalan yang menerima terapi PPI. Analisis data dilakukan secara deskriptif untuk menggambarkan karakteristik pasien, jenis PPI yang digunakan, potensi interaksi obat, tingkat keparahan, serta mekanisme interaksi. Hasil: Hasil penelitian menunjukkan bahwa dari 242 pasien, terdapat 75 kasus potensi interaksi obat (30,99%) yang seluruhnya termasuk dalam kategori keparahan moderat. Mekanisme interaksi yang paling banyak ditemukan adalah farmakokinetik (98,67%). Kombinasi obat yang paling sering berpotensi menimbulkan interaksi adalah lansoprazole dengan sukralfat. Kesimpulan: Kesimpulan dari penelitian ini menunjukkan bahwa potensi interaksi obat golongan PPI pada pasien rawat jalan masih cukup tinggi. Oleh karena itu, diperlukan peran aktif apoteker dalam pemantauan terapi serta pengaturan waktu pemberian obat guna meningkatkan keamanan dan efektivitas pengobatan.
Co-Authors Amelia, Ade ANDARI, Putri Asyrun Alkhairi Lubis Aulia, Sri Cinta Bengimiate, Nuriza Damanik, Dedech M. Sari DAMERIA DAMERIA Harahap, Daimah Wirdatus Sanaun Hartopo, Haqi Hotvera Merianis, Hotvera Hutabarat, Rachel Epifanes Ketaren, Nessya Try Natasya Br Louisa, Natasya Lubis, Asyrun Alkhari Merianis, Hotvera Meutia, Rena Milka Rositi Sianipar Muhammad Yunus Paulina, Roslina Purba, Helprida GM Razoki, Razoki Sembiring, Ernesta Br. Sembiring, Novitaria Br Siburian , Friska Lasro Yanti Sihombing, Tabita Ronauli Simanjuntak, Mafe Robbi Simanjuntak, Nerly Juli Pranita Simanjuntak, Nerly July Pranita Simbolon, Marlina L Sinaga, Helsi Herdiani Siregar, Nur Aini Sitanggang, Titin Krisdayanti Situngkir, Luwis Suci, Tri