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Glibenclamide prescription services profile in pharmacies of the Tapung Hilir District Hotvera Merianis, Hotvera; Razoki, Razoki; Ginting, Astriani Natalia Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7553

Prescription dispensing in pharmacies involves two key stages: screening and medication preparation. Screening, conducted by the pharmacist, covers administrative requirements, pharmaceutical suitability, and clinical considerations. Medication preparation includes compounding, labeling, packaging, dispensing, counseling, and monitoring. The overarching goal is to ensure that the medication prescribed is accurately and safely delivered to the patient. This study assessed the prescription service quality for glibenclamide in Tapung Hilir pharmacies. Ninety pharmacies were randomly sampled, and data were collected using a simulated patient approach, where researchers acted as patients' family members seeking glibenclamide. The instruments employed—prescription, scenario, protocol, and checklist—were validated for reliability. Results showed that 85 pharmacies (94.4%) dispensed the prescribed medication. However, patient information gathering was minimal: only 7.1% asked for the recipient’s identity, 18.8% for the patient’s address, and fewer than 5% inquired about prior medication use or understanding of administration. Critical clinical data such as patient age, symptomatology, therapy goals, concurrent medications, and allergy history were generally not obtained. On average, pharmacies asked only 0.4 out of 13 patient assessment questions. Regarding medication counseling, the frequency of drug use was explained by 42.4% of pharmacies, while other key information—indication, dose, side effects, treatment duration, and storage—was rarely provided. On average, only 1.2 out of 16 drug information items were communicated. Labels were provided by 65.9% of pharmacies, with only one using a distinguishable blue label. In conclusion, the involvement of pharmacy staff in the comprehensive provision of prescription services for glibenclamide remains limited in Tapung Hilir. Enhancement in patient assessment and information delivery is urgently needed to improve medication safety and effectiveness.

Uji Efektivitas Gel Ekstrak Etanol Daun Asam Jawa dalam Proses Penyembuhan Luka Bakar pada Tikus Jantan Tiara Fortuna A.R; Muhammad Yunus; Astriani Natalia Br Ginting
Jurnal Rumpun Ilmu Kesehatan Vol. 5 No. 3 (2025): November: Jurnal Rumpun Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jrik.v5i3.5518

Burn injuries are a significant health problem because they damage the skin’s protective barrier, increase the risk of infection, and may cause severe complications if not treated properly. The healing process is complex and involves several cellular events, in which fibroblasts play a key role by producing collagen and forming granulation tissue. Recently, there has been growing interest in natural, herbal-based therapies for wound care. Tamarind leaves (Tamarindus indica) were chosen in this study because they contain flavonoids, polyphenols, tannins, and saponins, all of which have anti-inflammatory, antioxidant, and tissue-regenerating properties. The aim was to evaluate the effectiveness of ethanol extract gel of tamarind leaves at concentrations of 2.5%, 5%, and 10% in promoting fibroblast proliferation and healing of burn wounds in male rats (Rattus norvegicus). An experimental randomized design was used with six groups: normal control, neative control, positive control, and three treatment groups. Clinical observation and histopathological analysis showed that the extract gel accelerated wound closure significantly compared to the negative control. Fibroblast proliferation was higher in all treatment groups, with the 10% extract giving the best result, similar to Bioplacenton. These findings highlight tamarind leaves’ potential as a safe and affordable alternative for burn wound therapy.

Counseling students to improve fire safety knowledge and preparedness Simanjuntak, Mafe Robbi; Dameria, Dameria; Situngkir, Luwis; Sihombing, Tabita Ronauli; Ginting, Astriani Natalia Br; Sianipar, Milka Rositi
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6530

This research investigates the effectiveness of counseling methods, incorporating seminar models and PowerPoint presentations, in enhancing students’ knowledge and preparedness for fire emergency response at Universitas Prima Indonesia. A quantitative approach with a quasi-experimental, one-group pretest-posttest design was employed, involving 78 students from the Public Health Bachelor Program. The intervention comprised four counseling sessions covering basic fire knowledge, preparedness steps, emergency actions, and the use of firefighting equipment. Data was collected through questionnaires administered before and after the intervention, assessing students' knowledge of fire extinguishers, hydrants, fire alarms, assembly points, emergency exits, and emergency stairs. The results indicated a significant positive impact, with post-test scores for both knowledge and preparedness substantially higher than pre-test scores (p < 0.001). Before the intervention, only 25.6% of participants demonstrated good knowledge, while after the intervention, 97.4% achieved this level. Similarly, preparedness levels significantly increased, with 97.4% of participants feeling ready after the intervention compared to only 19.2% before. The study underscores the effectiveness of the implemented counseling methods and supports the recommendation for continuous fire safety education to ensure sustained preparedness.

Factors associated with self-medication practices of primary dysmenorrhea among students Sembiring, Ernesta Br.; Siburian , Friska Lasro Yanti; Suci, Tri; Ginting, Astriani Natalia Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6777

Self-medication and home remedies are the most frequently used methods to relieve menstrual discomfort among female college students. The practice of self-medication varies among adolescent female students. Therefore, this study aimed to observe and analyze the factors associated with the practice of self-medication for primary dysmenorrhea among university students.This study used an analytical observational design with a cross-sectional approach, involving 207 female health students from Universitas Prima Indonesia. The sample was obtained through a purposive sampling technique. Data analysis included univariate analysis, bivariate analysis (chi-square and Fisher's exact test), and multivariate analysis (logistic regression). The prevalence of self-medication was reported to be 36.7%. Several factors were found to be associated with self-medication practices for primary dysmenorrhea among students, namely menstrual cycle (p<0.001, OR: 3.27, 95% CI 1.75-6.10), duration of pain during menstruation (p<0.001 OR: 3.85, 95% CI 2.10-7.07), and severity of pain (p=0.009 OR: 2.21, 95% CI 1.24-3.93). In contrast, age (p=0.316), academic year (p=0.889), family history (p=0.470), age at menarche (p=0.223), and menstrual duration (p=0.552) did not show a statistically significant association with self-medication practices for primary dysmenorrhea. The dominant factor influencing self-medication practices for primary dysmenorrhea was pain duration. Notably, self-medication with medications was found to be relatively low among health students with primary dysmenorrhea. Therefore, educational programs that address the limitations of self-medication with drugs need to be implemented effectively.

Factors influencing self-medication behaviour among non-health science students at Universitas Prima Indonesia Damanik, Dedech M. Sari; Siregar, Nur Aini; Paulina, Roslina; Suci, Tri; Ginting, Astriani Natalia Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6784

Self-medication, defined as the use of medication without a prescription or professional guidance, is a global phenomenon with significant implications for both individual and public health. This behaviour is frequently motivated by the desire to alleviate minor ailments, avoid healthcare costs, or circumvent lengthy consultation waiting times. While it can constitute a component of responsible self-care, self-medication also carries risks such as adverse drug reactions, drug interactions, antibiotic resistance, and the potential for misuse. This research aimed to analyse the factors associated with self-medication behaviour among non-healthcare students at Universitas Prima Indonesia. The study employed an analytical observational design with a cross-sectional approach. Data were collected via an online questionnaire distributed to 188 undergraduate students from the Faculty of Economics at Universitas Prima Indonesia, selected using simple random sampling. The independent variables in this study were gender, knowledge of self-medication, peer recommendations, and academic stress, while the dependent variable was self-medication behaviour. Data analysis involved univariate statistics to describe the characteristics of each variable and bivariate analysis using the Chi-squared test to examine the relationships between variables. The results indicated that knowledge (OR=3.230; p=0.000), peer recommendations (OR=2.046; p=0.000), and academic stress (OR=1.552; p=0.002) were significantly associated with self-medication, whereas gender was not (p=0.126). It can be concluded that a lack of knowledge, peer influence, and academic stress increase the risk of self-medication. Educational interventions and mental health support are necessary to reduce unsafe self-medication practices.

An evaluation of patient satisfaction with pharmaceutical services at Munyang Kute Regional General Hospital Bengimiate, Nuriza; Hartopo, Haqi; Razoki, Razoki; Ginting, Astriani Natalia Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7173

Patient satisfaction is a crucial indicator for assessing hospital service quality, in which pharmaceutical services play a vital role as a primary point of contact with patients. This study aimed to comprehensively evaluate the satisfaction level of outpatients with the pharmaceutical services at Munyang Kute Regional General Hospital. This research employed a descriptive quantitative design with a cross-sectional approach. A total of 90 respondents were selected through a purposive sampling technique based on predetermined criteria. The research instrument was an adapted questionnaire designed to measure satisfaction across five dimensions of service quality: tangibles, reliability, responsiveness, assurance, and empathy. The collected data were analyzed descriptively using SPSS software. The findings indicated that patients were generally satisfied with the pharmaceutical services they received. The highest level of satisfaction was observed in the responsiveness dimension, with a percentage of 69.72%. The other dimensions, in descending order, were tangibles (32.21%), empathy (27.19%), assurance (19.60%), and the lowest was the reliability dimension (16.00%). Overall, the patient perception of pharmaceutical services at Munyang Kute Regional General Hospital is positive. Nevertheless, there remains room for improvement, particularly in the reliability and assurance dimensions. Continuous quality improvement through enhanced patient education and optimization of facilities is highly recommended.

Effectiveness of transdermal patch formulation of Hibiscus rosa-sinensis L. leaf extract as an antipyretic in male rats induced with DPT vaccine Ketaren, Nessya Try Natasya Br; Ginting, Astriani Natalia Br; Meutia, Rena; Lubis, Asyrun Alkhari
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7546

Fever is characterized by an elevation of body temperature above the normal range of 37.5°C and represents a physiological response to various health conditions such as infections or other diseases. Antipyretic drugs, including paracetamol and ibuprofen, are commonly used to manage fever. Ethanol extract of Hibiscus rosa-sinensis L. (kembang sepatu) leaves contains bioactive compounds such as tannins, flavonoids, saponins, carbohydrates, steroids, phenols, glycosides, quinones, terpenoids, cyclopeptides, and alkaloids, which may confer natural antipyretic properties. In this study, 3% and 5% (w/w) Hibiscus rosa-sinensis leaf ethanol extracts were formulated into transdermal patches and evaluated for their antipyretic efficacy in male rats induced with the Diphtheria-Pertussis-Tetanus (DPT) vaccine. The dried Hibiscus rosa-sinensis leaves were macerated using 96% ethanol. The concentrated extract was formulated into a hydroxypropyl methylcellulose (HPMC)-based transdermal patch. Phytochemical screening of the extract, stability testing of the transdermal patch, and statistical analysis of the antipyretic effect on DPT-induced male rats were conducted. Phytochemical screening of the 96% ethanol extract confirmed the presence of alkaloids, flavonoids, tannins, steroids, and saponins. The transdermal patch formulation demonstrated good stability over 21 days of storage. The 5% extract patch exhibited the highest antipyretic activity, significantly reducing fever in the experimental rats and showing effectiveness comparable to the positive control (paracetamol).

Glibenclamide prescription services profile in pharmacies of the Tapung Hilir District Merianis, Hotvera; Razoki, Razoki; Ginting, Astriani Natalia Br
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 2 (2025): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i2.7553

Prescription dispensing in pharmacies involves two key stages: screening and medication preparation. Screening, conducted by the pharmacist, covers administrative requirements, pharmaceutical suitability, and clinical considerations. Medication preparation includes compounding, labeling, packaging, dispensing, counseling, and monitoring. The overarching goal is to ensure that the medication prescribed is accurately and safely delivered to the patient. This study assessed the prescription service quality for glibenclamide in Tapung Hilir pharmacies. Ninety pharmacies were randomly sampled, and data were collected using a simulated patient approach, where researchers acted as patients' family members seeking glibenclamide. The instruments employed—prescription, scenario, protocol, and checklist—were validated for reliability. Results showed that 85 pharmacies (94.4%) dispensed the prescribed medication. However, patient information gathering was minimal: only 7.1% asked for the recipient’s identity, 18.8% for the patient’s address, and fewer than 5% inquired about prior medication use or understanding of administration. Critical clinical data such as patient age, symptomatology, therapy goals, concurrent medications, and allergy history were generally not obtained. On average, pharmacies asked only 0.4 out of 13 patient assessment questions. Regarding medication counseling, the frequency of drug use was explained by 42.4% of pharmacies, while other key information—indication, dose, side effects, treatment duration, and storage—was rarely provided. On average, only 1.2 out of 16 drug information items were communicated. Labels were provided by 65.9% of pharmacies, with only one using a distinguishable blue label. In conclusion, the involvement of pharmacy staff in the comprehensive provision of prescription services for glibenclamide remains limited in Tapung Hilir. Enhancement in patient assessment and information delivery is urgently needed to improve medication safety and effectiveness.

Formulasi dan Uji Aktivitas Antibakteri Gel Minyak Atsiri Rimpang Lengkuas Merah (Alpinia purpurata K. Schum) terhadap Propionibacterium acnes Astriani Natalia Br Ginting; Vera Estefania Kaban; Roy Indrianto Bangar; Daimah W. S. Harahap
INSOLOGI: Jurnal Sains dan Teknologi Vol. 4 No. 1 (2025): Februari 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v4i1.4844

Acne is a common dermatological condition caused by the bacterial infection of Propionibacterium acnes, leading to skin inflammation. Red galangal (Alpinia purpurata K. Schum) is known to exhibit antibacterial activity due to its essential oil content, flavonoids, and alkaloids. This study aims to formulate and evaluate the antibacterial activity of a gel preparation based on red galangal rhizome essential oil against Propionibacterium acnes. The research follows a laboratory experimental design, including the extraction of red galangal rhizome essential oil via maceration, formulation of the gel, and evaluation of its physical properties, such as pH, homogeneity, spreadability, and antibacterial activity using the disc diffusion method. The results demonstrated that the gel formulation met the required physicochemical standards, with a pH ranging from 6.4 to 6.8, good homogeneity, and an optimal spreadability of 5–7 cm. The antibacterial test revealed a significant inhibitory effect against Propionibacterium acnes, with an inhibition zone of up to 11.24 mm at a 15% concentration. These findings suggest that red galangal rhizome essential oil possesses strong antibacterial potential, making it a promising candidate for natural topical acne treatment. In conclusion, the red galangal essential oil gel exhibits favorable antibacterial activity against Propionibacterium acnes and has potential as an alternative acne treatment. Further studies are necessary to enhance the stability and efficacy of the formulation for optimal clinical applications.

Antidiabetic Activity of Cep-Cepan Leaf Extract Nanoparticles (Castanopsis costata) in Streptozotocin-Induced White Rat Models Astriani Natalia Br Ginting; Chrismis Novalinda Ginting; Gusbakti Rusip; Linda Chiuman
Jurnal Penelitian Pendidikan IPA Vol 11 No 2 (2025): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i2.9408

The cep-cepan plant (Castanopsis costata) from the Fagaceae family is traditionally used by the Karo community in Medan, North Sumatra, to treat diabetes mellitus, although its efficacy has not yet been scientifically proven. This study aimed to evaluate the effectiveness of the antidiabetic activity of cep-cepan leaf extract nanoparticles (Castanopsis costata) in a streptozotocin-induced white rat model. A total of 25 male white rats were divided into five treatment groups: a positive control group, a negative control group, and three experimental groups treated with extract concentrations of 25, 75, and 150 mg/kg body weight, respectively. Plasma glucose levels were measured every 72 hours for 15 days using blood samples taken from the tail. Pancreatic tissue was then examined, and the data were analyzed using one way anova. The findings showed significant antidiabetic activity in all treatment groups, with p < 0.001. The nanoparticle extract of cep-cepan leaves exhibited the highest antidiabetic potential at a dosage of 150 mg/kg, reducing blood glucose levels by 59.39%. These results suggest that the nanoparticle extract of cep-cepan leaves demonstrates antidiabetic activity in the streptozotocin-induced white rat model, and it has the potential to be developed as an alternative treatment for diabetes mellitus.

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