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Hambatan Akses Pelayanan Infertilitas pada Pasien dari Kawasan Urban dan Rural yang Berobat di Klinik Bayi Tabung Halim Fertility Center RSIA Stella Maris Halim, Binarwan; Girsang, Ermi; Nasution, Sri Lestari Ramadhani; Manalu, Putranto
MEDIA KESEHATAN MASYARAKAT INDONESIA Vol 19, No 4 (2020): MKMI
Publisher : Fakultas Kesehatan Masyarakat, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/mkmi.19.4.272-278

ABSTRAKLatar belakang: Masalah infertilitas dihadapi 15-20% pasangan usia subur yang membawa dampak masalah pada sosial dan psikologis kepada pasangan, keluarga maupun masyarakat. Secara garis besar, pasangan yang mengalami infertilitas akan menjalani proses panjang, dimana proses ini dapat menjadi beban ï¬sik dan psikologis bagi pasangan infertilitas. Saat ini terdapat 12% pasangan infertilitas yang tersebar di seluruh Indonesia baik di desa maupun di kota. Mengingat pelayanan infertilitas yang masih belum merata dan hanya terpusat pada kota-kota yang besar. Pelayanan kesuburan belum merambah ke seluruh lapisan masyarakat.Metode: Penelitian ini bertujuan untuk melihat perbedaan hambatan terhadap akses pelayanan infertilitas pada masyarakat urban dan rural yang berobat di Klinik Bayi Tabung Halim Fertility Center RSIA Stella Maris Medan. Jenis penelitian yang digunakan dalam penelitian ini adalah kuantitatif dengan teknik wawancara menggunakan kuesioner. Data yang diperoleh dilakukan analisis deskriptif dan analitik. Sebanyak 130 responden terbagi dalam dua kelompok masing masing 65 responden kelompok rural dan 65 responden kelompok urban.Hasil: Pada penelitian ini ditemukan tiga variabel yang signifikan (p=0,014, p=0,023 dan p=0,005) dalam analisis multivariat yaitu tingkat ekonomi dengan nilai OR 2,606 (95% IK 1,210-5,611), letak geografi dengan nilai OR 3,905 (95% IK 1,203-12,677), dan sosial budaya dengan nilai OR 5,299 (95% IK 1,659- 16,929).Simpulan: Terdapat perbedaan bermakna tingkat ekonomi, letak geografi dan sosial budaya pada pasien kawasan perkotaan dan perdesaan dalam akses pelayanan infertilitas di Klinik Bayi Tabung Halim Fertility Center RSIA Stella Maris Medan.Â Kata kunci: hambatan akses, infertilitas, urban, ruralABSTRACTTitle: Infertility Care Access Barriers in Patient of Urban and Rural Areas of the Treatment Clinic IVF Fertility Center RSIA Halim Stella MarisÂ Â Background: The problem of infertility is faced by 15-20% of couples of childbearing age that have an impact on social and psychological problems for couples, families and communities. Broadly speaking, infertile couples will undergo a long process, where this process can be physical and psychological burden for the couple infertility. Currently, there are 12% of couples infertility scattered throughout Indonesia, both in villages and cities. Given the infertility services that are still not evenly distributed and only focused on large cities. Fertility services have not penetrated to the whole society.Method: The research looked at how different barriers to access to infertility services in urban and rural communities who seek treatment at the Fertility Clinic Halim tube baby center RSIA Stella Maris Medan. This type of research used in this study is quantitative with interview techniques using a questionnaire. The data obtained were analyzed descriptively and analytically. A total of 130 respondents were divided into two groups each 65 rural respondents and 65 urban respondents.Result: This study found three significant variables (p = 0.014, p = 0.023 and p = 0.005) in multivariate analysis that economic level with OR 2.606 (95% CI 1.210 to 5.611), geography with OR 3.905 (95% CI 1.203 to 12.677), and socio-cultural with OR 5.299 (95% CI 1,659- 16.929).Conclusion: There are significant differences in economic levels, geographical and socio-cultural patient urban and rural areas in access to infertility services at the Clinic IVF Fertility Center RSIA Halim Stella Maris Medan.Â Keywords: barriers to access, infertility, urban, ruralÂ

Efektivitas madu sebagai gastroprotektif pada tikus putih yang diinduksi aspirin bedasarkan hasil histopatologi Meutia, Rena; Razoki, Razoki; Halim, Binarwan; Nasution, Chairul Radjab; Tarigan, Antje Irmella; Fioni, Fioni; Nardi, Leo
Buletin Kedokteran & Kesehatan Prima Vol. 1 No. 2 (2022): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Tukak lambung merupakan kerusakan jaringan mukosa, sub mukosa sampai lapisan otot lambung. Salah satu penyebabkan tukak lambung yaitu hipersekresi asam lambung sehingga terjadi kerusakan mukosa. Madu memiliki efek gastroprotektif, karena di dalam madu terdapat senyawa flavonoid, vitamin E, asam askorbat, dan katalase, Tujuan penelitian ini adalah untuk mengetahui aktivitas gastroprotektif akibat pemberian madu pada tikus yang diinduksi aspirin. Metode yang digunakan madu pada masing-masing pemberian tunggal diberikan 3 variasi kosentrasi yaitu madu 0,5; 0,75; dan 1 ml/kgbb. Parameter pengamatan meliputi biometrik makroskopis (jumlah tukak, pH tukak dan indeks tukak) dan mikroskopis (uji histopatologi). Bedasarkan hasil yang diperoleh bahwa bedasarkan pengamatan makroskopis terhadap perlakuan tunggal menunjukkan bahwa pemberian madu sebesar 1 ml/kgbb menunjukkan efek gastroprotektif dari kosentrasi lainnya. Kesimpulan: uji histopatologi pada dosis yang memiliki efek gastroprotektif dapat mengembalikan kohesi sel mukosa yang sebelumnya telah rusak akibat erosi.

Breadfruit leaf extract: A potential hypolipidemic and antioxidant agent in diabetes Tanjaya, Angela; Yunus, Muhammad; Nasution, Ali Napiah; Halim, Binarwan; Hutagalung, Mangatas HP; Sitanggang, Holan Dianju Melva Meinaria
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5462

Elevated total cholesterol levels are medically termed as hypercholesterolemia. Breadfruit leaves are recognized for their health benefits owing to the presence of secondary metabolites. This study aimed to investigate the effect of breadfruit leaf extract (Artocarpus altilis) on total cholesterol levels in white rats (Rattus norvegicus) and assess its antioxidant potential. Two control groups were established: negative control (1% Na-CMC) and positive control (simvastatin). The three treatment groups were administered different doses of the breadfruit leaf extract (100, 200, and 400 mg/kg body weight). Each group consisted of five rats. The results indicated that 400 mg/kg body weight of breadfruit leaf extract significantly reduced total cholesterol levels in rats by 29.27% (p<0.05). The antioxidant activity of breadfruit leaf extract was evaluated using the DPPH method at concentrations of 100, 200, 300, 400, and 500 μg/ml. The maximum wavelength used was 516 nm, and the absorbance was measured using a UV-Vis spectrophotometer. The linear regression equation obtained for breadfruit leaf extract was Y = 0.1171x + 35.76, with an IC50 value of 121.605 μg/ml, indicating moderate antioxidant activity. In contrast, the linear regression equation for vitamin C was Y = 0.6378x + 26.083, with an IC50 value of 37.499 μg/ml, indicating a very strong antioxidant activity.

Effect of Andaliman (Zanthoxylum Acanthopodium DC) Extracts on The Histological Display of Lewy Body in The Brain of Rotenone Induced Wistar Rats Afina, Lubna; Halim, Binarwan; Chiuman, Linda; Anggraeni, Wenti; Rizki, Kartika Sari
International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Vol 6 No 3 (2024)
Publisher : The Islamic Education and Multiculturalism Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47006/ijierm.v6i3.408

Dementia Lewy Body (DLB) is a form of dementia characterized by abnormal accumulation of α-synuclein protein in the brain, forming lewy bodies that damage the function of neurons and nervous system. This study aimed to evaluate the effect of andaliman fruit extract (Zanthoxylum Acanthopodium DC), which is rich in antioxidants, on the number of lewy bodies in the brain of rotenone-induced Wistar male rats. Histology analysis was performed to observe the number of lewy bodies in the brain. The results showed a significant decrease in the number of lewy bodies in the treatment group compared to the positive control group (p<0.05). Increasing the dose of andaliman extract was directly proportional to the decrease in the number of lewy bodies, with the highest dose (450 mg/kgBB) providing the best protective effect. These findings suggest that the antioxidant content in andaliman extract can neutralize the oxidative stress caused by rotenone, thus protecting neurons from damage. This study supports the development of andaliman extract as an alternative therapy to prevent or inhibit the progressivity of DLB.

EFFECT OF Zanthoxylum acanthopodium DC EXTRACT ON THE INCREASE OF BRAIN CELLS IN THE SUBSTANTIA NIGRA OF WISTAR RATS THAT ARE ROTENONE-INDUCED hafizha, Shalli; Halim, Binarwan; Chiuman, Linda
International Journal of Islamic Education, Research and Multiculturalism (IJIERM) Vol 6 No 3 (2024)
Publisher : The Islamic Education and Multiculturalism Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47006/ijierm.v6i3.413

Parkinson's disease (PD) is a neurodegenerative disorder due to the decline of dopaminergic neurons in the substantia nigra, with motor and non-motor symptoms. Oxidative stress, inflammation, and mitochondrial damage play a role in its pathogenesis. andaliman fruit (Zanthoxylum acanthopodium DC), rich in alkaloids and flavonoids, has potential as an antioxidant with neuroprotective effects. The purpose of the study was to determine the effect of andaliman fruit extract (Zanthoxylum acanthopodium DC) on the increase of brain cells in the substantia nigra of rotenone-induced Wistar rats as a Parkinson's model. This research uses an experimental quantitative study with a post-test control group design. Data were analyzed using One Way ANOVA with a significance level of p < 0.05. The results showed that 70% ethanol extract of andaliman fruit (Zanthoxylum acanthopodium DC) can reduce the number of necrosis cells in the brain. On the 29th day, the average number of necrosis cells in each group was 0.4±0.54 (K-), 4.8±0.83 (K+), 4.4±1.14 (P1), 3.4±0.54 (P2), and 1.2±0.44 (P3). The administration of extracts at doses of 150 mg/kgBB, 300 mg/kgBB, and 450 mg/kgBB can increase the regeneration of brain cells that experience necrosis. Histopathological observations showed that 70% ethanol extract of andaliman fruit improved the histological structure of brain cells in the substantia nigra area.

Efektivitas madu sebagai gastroprotektif pada tikus putih yang diinduksi aspirin bedasarkan hasil histopatologi Meutia, Rena; Razoki, Razoki; Halim, Binarwan; Nasution, Chairul Radjab; Tarigan, Antje Irmella; Fioni, Fioni; Nardi, Leo
Buletin Kedokteran & Kesehatan Prima Vol. 1 No. 2 (2022): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v1i2.2689

Tukak lambung merupakan kerusakan jaringan mukosa, sub mukosa sampai lapisan otot lambung. Salah satu penyebabkan tukak lambung yaitu hipersekresi asam lambung sehingga terjadi kerusakan mukosa. Madu memiliki efek gastroprotektif, karena di dalam madu terdapat senyawa flavonoid, vitamin E, asam askorbat, dan katalase, Tujuan penelitian ini adalah untuk mengetahui aktivitas gastroprotektif akibat pemberian madu pada tikus yang diinduksi aspirin. Metode yang digunakan madu pada masing-masing pemberian tunggal diberikan 3 variasi kosentrasi yaitu madu 0,5; 0,75; dan 1 ml/kgbb. Parameter pengamatan meliputi biometrik makroskopis (jumlah tukak, pH tukak dan indeks tukak) dan mikroskopis (uji histopatologi). Bedasarkan hasil yang diperoleh bahwa bedasarkan pengamatan makroskopis terhadap perlakuan tunggal menunjukkan bahwa pemberian madu sebesar 1 ml/kgbb menunjukkan efek gastroprotektif dari kosentrasi lainnya. Kesimpulan: uji histopatologi pada dosis yang memiliki efek gastroprotektif dapat mengembalikan kohesi sel mukosa yang sebelumnya telah rusak akibat erosi.

Breadfruit leaf extract: A potential hypolipidemic and antioxidant agent in diabetes Tanjaya, Angela; Yunus, Muhammad; Nasution, Ali Napiah; Halim, Binarwan; Hutagalung, Mangatas HP; Sitanggang, Holan Dianju Melva Meinaria
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5462

Elevated total cholesterol levels are medically termed as hypercholesterolemia. Breadfruit leaves are recognized for their health benefits owing to the presence of secondary metabolites. This study aimed to investigate the effect of breadfruit leaf extract (Artocarpus altilis) on total cholesterol levels in white rats (Rattus norvegicus) and assess its antioxidant potential. Two control groups were established: negative control (1% Na-CMC) and positive control (simvastatin). The three treatment groups were administered different doses of the breadfruit leaf extract (100, 200, and 400 mg/kg body weight). Each group consisted of five rats. The results indicated that 400 mg/kg body weight of breadfruit leaf extract significantly reduced total cholesterol levels in rats by 29.27% (p<0.05). The antioxidant activity of breadfruit leaf extract was evaluated using the DPPH method at concentrations of 100, 200, 300, 400, and 500 μg/ml. The maximum wavelength used was 516 nm, and the absorbance was measured using a UV-Vis spectrophotometer. The linear regression equation obtained for breadfruit leaf extract was Y = 0.1171x + 35.76, with an IC50 value of 121.605 μg/ml, indicating moderate antioxidant activity. In contrast, the linear regression equation for vitamin C was Y = 0.6378x + 26.083, with an IC50 value of 37.499 μg/ml, indicating a very strong antioxidant activity.

The Effect of Andaliman Fruit Extract (Zanthoxylum acanthopodium DC) on α-Synuclein Levels in Rotenon-Induced Wistar Rats Maulidza, Citra Puan; Halim, Binarwan; Chiuman, Linda; Nasution, Atika Rimalda; Theresia, Yohani
Jurnal Penelitian Pendidikan IPA Vol 11 No 2 (2025): February
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i2.10362

Parkinson's disease is a neurodegenerative disorder characterized by loss of dopamine and formation of α-synuclein aggregates in the substantia nigra pars compacta (SNpc). This study aims to evaluate α-synuclein levels in the plasma of rotenone-induced Wistar rats as a model of Parkinson's disease and the therapeutic effect of Andaliman fruit extract. The design of this study was experimental with 25 male Wistar rats divided into five groups, negative control group (K-, only given distilled water), positive control (K+, induced rotenone 3 mg/kgBB/day for two weeks), and three treatment groups (P1, P2, P3) induced rotenone and given Andaliman extract orally at a dose of 150 mg/kgBB, 300 mg/kgBB, and 450 mg/kgBB respectively for 14 days. Measurement of levels was performed using ELISA on day 14 after induction and day 28 after therapy. The results of one-way ANOVA analysis showed that Andaliman extract significantly reduced α-synuclein levels at all doses compared to the positive control (p=0.000). The decrease in α-synuclein levels indicates the potential of Andaliman fruit extract in reducing Parkinson's disease-related pathology in mouse models.

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