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All Journal Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Lumbung Farmasi : Jurnal Ilmu Kefarmasian Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Insan Farmasi Indonesia Jurnal Farmasi Jurnal Buana Farma Binawan Student Journal Parapemikir Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian
Chandra, Pra Panca Bayu
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Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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AKTIVITAS ANTIBAKTERI MINYAK ATSIRI SEREH WANGI (Cymbopogon citratus) TERHADAP BAKTERI Escherichia coli, Propionibacterium acne, Staphylococcus aureus Hermawati, Ema; Tan, Ardy Tanfil; Chandra, Pra Panca Bayu
Jurnal Farmasi (Journal of Pharmacy) Vol 12, No 2 (2023)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v12i2.233

Abstract

Minyak sereh wangi  (Cymbopogon citratus) adalah salah satu minyak atsiri yang memiliki potensi sebagai antibakteri. Senyawa utama minyak sereh wangi adalah sitronellal, geraniol dan sitronellol. Tujuan penelitian ini adalah untuk mengetahui aktivitas penghambatan bakteri dari minyak atsiri sereh wangi terhadap bakteri Escherichia coli, Propionibactaerium acne, Staphylococcus aureus . Metode penelitian yang digunakan merupakan experimental laboratories dengan menggunakan rancangan dasar penelitian Rancangan Acak Lengkap (RAL) dengan pola faktorial lama inkubasi 24 jam pada suhu 37oC dan perbedaan konsentrasi minyak sereh wangi (Cymbopogon citratus) (10%, 20% dan 30%) dibandingkan dengan pebanding yaitu tetra siklin . Adapun uji antibakteri menggunakan metode difusi cakram. Hasil uji aktivitas antibakteri minyak atsiri sereh wangi (Cymbopogon citratus)  menunjukan hasil sebagai kategori kuat yaitu memiliki zona hambat berkisar antara 10-20 mm. Adapun konsentrasi optimum untuk menghambat bakteri Escherichia coli, Propionibacterium acne, Staphylococcus aureus adalah pada konsentrasi 30%. Kata kunci : Antibakteri, Minyak Atsiri Sereh Wangi (Cymbopogon citratus), bakteri Escherichia coli, Propionibacterium acne, Staphylococcus aureus  
FORMULASI SEDIAAN ROLL ON AROMATERAPI KOMBINASI MINYAK ATSIRI KRANGEAN (Litsea cubeba (Lour.) Pers.) DAN MINYAK ATSIRI LAVENDER (Lavandula angustifolia Miller) Chandra, Pra Panca Bayu; Efrilia, Mega; Handayani, Indri Astuti
Jurnal Insan Farmasi Indonesia Vol 7 No 1 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v7i1.1947

Abstract

Krangean and Lavender are natural ingredients producing essential oils. The use of krangean and lavender in the community as perfume ingredients. Krangean essential oil and lavender essential oil contain 1.8 cineol which has potential as aromatherapy. The purpose of the formulation of the Roll on aromatherapy preparation is to determine whether variations in the combination of krangean essential oil and lavender essential oil can affect the test parameters ((organoleptic test, homogeneity test, pH test and favorability test or hedon
PENGARUH KONSENTRASI ETANOL TERHADAP RENDEMEN EKSTRAK DAUN JATI BELANDA (Guazuma ulmifolia) DAN DAUN SUKUN (Artocarpus altilis) Falestin , Senny Listy Kartika; Efrilia, Mega; Chandra, Pra Panca Bayu; Loimalitna, Pricillya Maria; Sabrina, Alifa
Jurnal Insan Farmasi Indonesia Vol 7 No 2 (2024): JIFI : Special edition
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v7i2.2093

Abstract

Dutch teak leaves and breadfruit leaves are natural ingredients used  medicine. The secondary metabolite content Dutch teak and breadfruit leaf extracts believed to play a role in providing medicinal properties natural ingredients. Extracting natural ingredients with ethanol solvent can affect the yield. The aim research was to determine effect of variations in solvent concentration on the yield of Dutch teak and breadfruit leaf extracts. This research includes determination, collection and preparation of simplicia, making simplicia, extracts and determining the extract yield. This study, 20 grams of Dutch teak and breadfruit leaf powder were extracted with different solvent concentrations, namely 70%, 90% and 95% ethanol using maceration method. Replication was carried out in each solvent 3 times. Analyzed using descriptive methods and processed with Statistical Product and Service Solutions (SPSS) 26 tool. The highest yield research results were obtained from 70% ethanol extract of Dutch teak leaves (Guazuma ulmifolia) with an average of 2.79% ± 0.21 and extract ethanol 90% breadfruit leaves (Artocarpus altilis) with an average of 10.33% ± 0.33. The results the two way anova test, obtained a sig = 0.000 < 0.05 so that there were significant differences between plant groups and ethanol concentration the extract yield results.
UJI MUTU SIMPLISIA DAN EKSTRAK ETANOL 96% RIMPANG JAHE (Zingiber officinale Roscoe) Efrilia, Mega; Chandra, Pra Panca Bayu; Endrawati, Santi
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 1 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i1.6817

Abstract

Ginger (Zingiber officinale Roscoe) has long been commonly consumed as a spice and traditional medicine. The aim of the research was to test the quality of simplicia and ginger rhizome extract. The testing procedure consists of preliminary quality testing, testing specific and non-specific parameters. Fresh ginger rhizomes are processed to become simplicia powder. The simplicia was extracted using the maceration method using 96% ethanol solvent, then concentrated until a thick extract was obtained. Simplicia and extracts are subjected to quality testing. The results showed that the level of foreign organic matter of simplicia was 1.34%, the fine degree of simplicia was 4/18 through mesh sieve number 4 100% and number 18 was 96%. Identity of the research sample Zingiber officinale Roscoe. The levels of compounds in simplicia that are soluble in water and ethanol are 16.86 ± 0.45% and 6.81 ± 0.23%. The levels of compounds in the extract that were soluble in water and ethanol were 13.55 ± 0.21% and 13.72 ± 0.16%. Drying loss of simplicia is 0.80 ± 0.52% and extract is 9.53 ± 0.25%. The water content for simplicia is 9.03 ± 0.64% and extract is 12.33 ± 1.53%. The specific gravity of the simplicia is 0.7849 ± 0.06 g/mL and the extract is 0.85 ± 0.09 g/mL. The total ash content of simplicia was 4.09 ± 0.97% and the extract was 3.63 ± 0.44%. The water-soluble ash content in simplicia is 2.17 ± 0.31% and the extract is 2.6 ± 0.26%. The insoluble ash content of simplicia acid was 1.11 ± 0.32% and the extract was 0.5 ± 0.46%. Testing the quality of simplicia and ginger rhizome extract met the requirements, namely all specific parameters as well as non-specific parameters (drying loss, total ash and acid insoluble ash).
ANALISIS BERAT BADAN MENCIT (Mus musculus) KONDISI HIPERGLIKEMIK YANG DIBERIKAN SEDIAAN ORAL DAN GEL EKSTRAK BUAH OKRA (Abelmoschus esculentus L. Moench) CHANDRA, PRA PANCA BAYU; Christian, Yulius Evan
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 13 No 2 (2024): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v13i2.306

Abstract

Tanaman okra merupakan tanaman dengan kandungan metabolit sekunder yang memiliki potensi terhadap aktivitas farmakologi. Aktivitas farmakologi yang diharapkan dapat memperbaiki fungsi fisiologi hewan coba yang mengalami hiperglikemik sehingga berpengaruh terhadap berat badan hewan coba. Tujuan penelitian ini adalah untuk mengetahui pemberian ekstrak buah okra secara oral dan topikal terhadap berat badan mencit hiperglikemik. Sampel penelitian dikeringkan sampai menjadi serbuk, dimaserasi 5 hari dengan etanol 70% dan dipekatkan sampai kental. Mencit jantan galur Mus musculus dikondisikan hiperglikemik dengan STZ dosis 0,06 mg/gBB. Mencit dibagi menjadi 8 kelompok, yaitu kelompok 1 (kontrol Non-DM/oral CMC Na+gel plasebo), kelompok 2 (kontrol DM/oral CMC Na+gel plasebo), kelompok 3 (uji I/oral CMC Na+gel ekstrak buah okra 12%), kelompok 4 (uji II/oral glibenclamide+gel plasebo), kelompok 5 (uji III/oral glibenclamide+gel ekstrak buah okra 12%), kelompok 6 (uji IV/oral ekstrak buah okra+gel plasebo), kelompok 7 (uji V/oral ekstrak buah okra+gel ekstrak buah okra 6%), kelompok 8 (uji VI/oral ekstrak buah okra+gel ekstrak buah okra 12%). Dosis glibenclamide 5 mg/KgBB, dosis ekstrak buah okra 400 mg/KgBB serta dosis CMC Na 5 mL/KgBB. Terapi diberikan 1 kali sehari (oral dan topikal) selama 15 hari terapi yang dilihat pada hari ke-0, 5, 11 dan 15. Hasil penelitian menunjukan pada terapi hari ke 0 memberikan hasil uji beda yang signifikan (P<0,05) pada semua kelompok perlakuan. Perbedaan yang tidak signifikan terjadi pada terapi hari ke 5, 11, dan 15 dengan nilai P>0.05 yang menyatakan bahwa berat badan tidak memberikan perbedaan yang signifikan pada tiap kelompok perlakuan.
UJI ANGKA LEMPENG TOTAL dan ANGKA KAPANG KHAMIR EKSTRAK BUAH OKRA (Abelmoschus esculentus L.) Chandra, Pra Panca Bayu
Parapemikir : Jurnal Ilmiah Farmasi Vol 13, No 2 (2024): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v13i2.6643

Abstract

Okra fruit is an excellent plant used as a raw material for traditional medicine. Okra fruit as a raw material for medicine must go through a quality parameter testing process to make it safe to use. One of the extract quality parameters is the Total Plate Number (ALT) and Yeast Mold Number (AKK). This study aims to evaluate the suitability of microbial contamination and yeast mold in 70% ethanol extract of okra fruit against applicable regulations. Extraction of okra fruit by maceration method with 70% ethanol solvent for 5 days with a ratio of 1:10. The results obtained from 70% ethanol extract of okra fruit have organoleptic characteristics of thick, blackish brown color, typical okra odor and sour bitter taste. typical. The ALT and AKK values in the 70% ethanol extract of okra fruit are 0, fulfilling the safety and quality requirements for traditional medicines.
Penetapan Kadar Flavonoid Total Ekstrak Etanol 96% Daun Sukun (Artocarpus altilis) Chandra, Pra Panca Bayu
Parapemikir : Jurnal Ilmiah Farmasi Vol 14, No 3 (2025): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v14i3.9472

Abstract

Daun sukun (Artocarpus altilis) merupakan salah satu tanaman yang dapat digunakan untuk mengatasi berbagai penyakit. Salah satu senyawa didalam daun sukun diketahui mampu menghambat efek aktivitas radikal bebas adalah senyawa golongan flavonoid. Penelitian ini bertujuan untuk mengetahui rendemen dan kadar flavonoid total ekstrak daun sukun. Proses ekstraksi daun sukun dilakukan secara maserasi dengan pelarut etanol 96%. Hasil ekstraksi maserasi kemudian dilakukan proses penguapan hingga diperoleh ekstrak kental. Perhitungan rendemen ekstrak dengan membagi bobot ekstrak dengan bobot simplisia daun sukun. Kandungan flavonoid total ditetapkan menggunakan metode kolorimetri-Aluminium Klorida dengan instrumen spektrofotometri UV-Vis diperoleh kadar flavonoid total ekstrak daun sukun sebesar 960,56 mg/100 gram dengan nilai SD 0.75
MEASUREMENT OF QUALITY PARAMETERS OF SIMPLICIA AND EKSTRACT OF KECOMBRANG STEM (Etlingera elatior) Adini, Syilvi; Shobah, Afifah Nur; Chandra, Pra Panca Bayu
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 3 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i3.1752

Abstract

Kecombrang (Etlingera elatior) is a type of plant known to the Indonesian people as a medicinal plant for a long time. Kecombrang stem is empirically used to treat coughs, reduce fever, act as an antiseptic, treat diarrhoea and stomach pain. Kecombrang stem has the potential to be used as a raw material for herbal medicines. Plants used as raw materials for herbal medicines must meet quality requirements in accordance with the requirements of both specific and non-specific parameters. This study aimed to determine the quality of the simplicia and 96% ethanol extract of kecombrang stem. Simplicia and 96% ethanol extract were tested for specific parameters, including organoleptic, microscopic, and phytochemical screening. Non-specific parameter testing includes the measurement of moisture content, residual solvents, and microbial contamination. Tests of specific parameters on organoleptic kecombrang stem simplicia are light brown, aromatic odor, and tasteless. Microscopically, kecombrang stem simplicia was identified with fragments consisting of transport bundles, ladder-type transport bundles, fibers, and parenchyma with secretory cells. Phytochemical screening of kecombrang stem simplicia revealed the presence of alkaloids, phenolics, flavonoids, steroids, tannins, and saponins. The results of non-specific parameter testing on 96% ethanol extract of kecombrang stem showed 1.09% moisture content, 0.48% solvent residue, 0 CFU/g bacterial contamination, and yeast/mould. Kecombrang stem is a raw material for herbal medicine that meets the quality requirements of specific and non-specific parameters. Keywords: Etlingera elatior, Non-specific parameters, Simplicia quality, Specific parameters.
LITERATURE REVIEW: POTENSI OBAT BAHAN ALAM DARI TANAMAN SEMANGGI AIR (Marsilea crenata) Chandra, Pra Panca Bayu; Laksmitawati, Dian Ratih
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1383

Abstract

The use of plants as natural medicine is used because Indonesia has a wealth of natural resources. One of the plants used is water clover (Marsilea crenata). This plant is used as food and medicine. This study aims to identify the potential of natural medicine from water clover (Marsilea crenata). The research method in the literature study is to apply journal searches to the Google Scholar, Science Direct, and Pubmed databases with the keywords water clover (Marsilea crenata) and pharmacological activity. The journals used are national and international journals published from 2012 to 2025. The journals used are research on the potential of water clover as a natural medicine in silico, in vitro and in vivo. From the results of the literature study, 9 journals were obtained. After obtaining research data from journals, they were then combined and studied, then explained and explained systematically. The results of the study showed that water clover leaves in both extract and fraction forms have pharmacological activities including anticholesterolemia, antihyperglycemia, antioxidant, anti-inflammatory, HMG-CoA reductase enzyme inhibitory activity, sperm quality improvement activity in hyperglycemic mice, anti-neuroinflammatory serum. The content of secondary metabolites found in Marsilea crenata is a bioactive compound that is responsible for providing pharmacological activity.
AKTIVITAS ANTIJAMUR EKSTRAK ETANOL DAUN KARI TERHADAP Candida albicans ATCC 14053 Sari, Putri Eka; Chandra, Pra Panca Bayu; Lisnawati, Nia; Ami, Neng
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1400

Abstract

Medicinal plants are recognized as valuable sources of secondary metabolites with therapeutic potential. Candidiasis caused by Candida albicans is a common health problem in tropical regions. The prolonged use of synthetic antifungal agents may lead to resistance, highlighting the need for effective natural alternatives. Curry leaves (Murraya koenigii (L) Spreng) are known to contain flavonoids and alkaloids with potential antifungal activity. This study aimed to evaluate the antifungal activity of the 96% ethanol extract of curry leaves against Candida albicans ATCC 14503. The extract was prepared by maceration using 96% ethanol as the solvent. Phytochemical screening revealed the presence of flavonoids and saponins. The antifungal activity was tested using the disc diffusion method at concentrations of 6,25%, 12,5%, 25%, and 50%. Ketoconazole was used as positive control, while 96% ethanol served as a negative control. The test was performed in triplicate, and the inhibition zones were measured and averaged. The results showed that the 96% ethanol extract of curry leaves at all tested concentrations did not exhibited antifungal activity against C. albicans as indicated by the absence of inhibition zones on the media. It can be concluded that the extract, under the given conditions, was not effective in inhibiting fungal growth. This suggests that the extraction method and tested concentrations may not have been sufficient to isolate or concentrate the active compounds. Further studies using alternative extraction techniques, higher concentrations or isolated compounds are needed to better evaluate the antifungal potential of M. koenigii.
Co-Authors Adini, Syilvi Ami, Neng Dian Ratih Laksmitawati Efrilia, Mega Endrawati, Santi Falestin , Senny Listy Kartika Handayani, Indri Astuti Hermawati, Ema Ismyama, Dian Farida Lisnawati, Nia Loimalitna, Pricillya Maria Meryta, Aries PUTRI EKA SARI, PUTRI EKA Putri, Weni Pratiwi Sabrina, Alifa Shobah, Afifah Nur Tan, Ardy Tanfil Yulius Evan Christian