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Pengaruh Lama Penyimpanan terhadap Kerusakan Asam Lemak Omega-3 pada Air Susu Ibu (ASI) Ulfah Muawanah, Isnin Aulia; Aryani, Titin; Utami, Fitria Siswi; Sulistyaningsih, Sulistyaningsih
Kes Mas: Jurnal Fakultas Kesehatan Masyarakat Vol 10, No 2 (2016): Kes Mas: Jurnal Fakultas Kesehatan Masyarakat
Publisher : Universitas Ahmad Dahlan

Background: This quantitative research aimed to determine the effect of storage time to damage omega-3 fatty acids in breast milk (ASI). Method: Data were analyzed using GC-MS (Gas Chromatography-Mass Spectrometry) chromatograms of data. Results: The data generated was breast milk (ASI) stored in the freezer temperature (00C) for 0, 7 and 30 days had a percent relative contents of omega-3, respectively for 29.12, 28.24 and 6.24. Based on the Kruskal Wallis Test, obtained p value=0.018 (p<0.05). Conclusion: This statistical result showed that there was the effect of storage time to damage omega-3 fatty acids in breast milk.

PENGARUH LAMA PENYIMPANAN TERHADAP KERUSAKAN ASAM LEMAK OMEGA-3 PADA AIR SUSU IBU (ASI) Aryani, Titin; Utami, Fitria Siswi; Sulistyaningsih, Sulistyaningsih; Ulfah Mu'awanah, Isnin Aulia
Kes Mas: Jurnal Fakultas Kesehatan Masyarakat Vol 10, No 2 (2016): Kes Mas: Jurnal Fakultas Kesehatan Masyarakat
Publisher : Universitas Ahmad Dahlan

Background: This quantitative research aimed to determine the effect of storage time to damage omega-3 fatty acids in breast milk (ASI). Method: Data were analyzed using GC-MS (Gas Chromatography-Mass Spectrometry) chromatograms of data. Results: The data generated was breast milk (ASI) stored in the freezer temperature (00C) for 0, 7 and 30 days had a percent relative contents of omega-3, respectively for 29.12, 28.24 and 6.24. Based on the Kruskal Wallis Test, obtained p value=0.018 (p<0.05). Conclusion: This statistical result showed that there was the effect of storage time to damage omega-3 fatty acids in breast milk.

KAJIAN FITOKIMIA DAN PROKSIMAT TEPUNG KULIT PISANG MUSA SAPIENTUM DAN UJI ORGANOLEPTIKNYA PADA DONAT Aryani, Titin; Mu'awanah, Isnin Aulia Ulfah; Widyantara, Aji Bagus
GIZI INDONESIA Vol 43, No 1 (2020): Maret 2020
Publisher : PERSATUAN AHLI GIZI INDONESIA

All types of banana peel can be processed into flour. This study aims to conduct phytochemical and proximate studies of Musa sapientum banana peel flour and its organoleptic test on donuts. The research is quantitative. Phytochemical and proximate profiles were obtained from the results of laboratory tests, while the organoleptic profile of banana skin flour in making donuts was obtained from the results of donut acceptance tests on 60 panelists. The phytochemical profiles examined were antioxidant activity, anthocyanin and carotene levels. The organoleptic profile of Musa sapientum banana peel flour in making donuts examined was taste, color, texture, and aroma. Proximate profiles examined were water, ash, fat, protein, carbohydrate, fiber and yield content. The results showed that the antioxidant activity of Musa sapientum banana peel flour was 61.26 percent, anthocyanin levels 15.62 mg/100g, carotene 136.61 ppm, water content 6.92, ash content 1.89 percent, fat content 2.82 percent, protein content 5.31 percent, carbohydrate content 73.98 percent, fiber content 40.58 percent and yield 40.05 percent. Organoleptic profile of Musa sapientum donut banana flour with 25 percent of banana peel flour substituent on a scale of 1-5, taste parameters obtained values of 4.37, color 3.36, texture 3.54, aroma 3.68. The conclusion of the research is donuts made from Musa sapientum banana peel flour with 25 percent substituents of banana peel flour having a relatively good phytochemicals, proximate and organoleptic profile on donuts.

Aktivitas Antioksidan dan Kadar Vitamin C Daging Buah dan Sirup Buah Naga (Hylocereus costaricensis) Titin Aryani; Isnin Aulia Ulfah Mu’awanah
Biomedika Vol 12 No 2 (2019): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Research on antioxidant activity and vitamin C levels of dragon fruit and Hylocereus costaricensis dragon fruit syrup from Kulon Progo has been conducted. The purpose of this study was to study the antioxidant activity and levels of vitamin C in dragon fruit meat and dragon fruit syrup from Kulon Progo. The sampling method is done by purposive sampling method. The method of measuring antioxidant activity using DPPH (1,1-Diphenyl-2-picryl Hidrazil) immersion method was measured with a wavelength of 517 nm. The method of determining the level of vitamin C is carried out by the method of titration of Iodimetry using a standard solution of iodine. The results showed that the average antioxidant activity of dragon fruit was 67.81%, whereas in dragon fruit syrup was 42.81%. While the level of vitamin C in dragon fruit is 12.65% while in dragon fruit syrup is 3.667%. Can reduce the levels of antioxidants and vitamin C levels of dragon fruit higher than dragon fruit syrup.

A literature review: The relationship between welding fume exposure and welders' lung function disorders: toxicological study Isnin Aulia Ulfah Mu’awanah; Siti Nurkhasanah; Arif Yusuf Wicaksana
MEDIA ILMU KESEHATAN Vol 10 No 2 (2021): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v10i2.559

Background: Welding is the process of combining two types of metal or other material particles into one by melting and cooling processes. Welding fumes and welding metal fumes have a risk of lung function disorders in welding workers.Objective: This study aimed to discover the relationship between the effect of exposure to welding smoke and pulmonary function disorders in welding workshop workers based on the years of service and the use of PPE (masks).Methods: This research was a literature review using secondary data sources through the Google Scholar and Pubmed databases published in 2010-2020.Results: Vital lung capacity of ≥ 5 years welders have a higher risk of having lung function disorders. Welders who use PPE (masks) as many as 48 workers (21%) and 179 workers (79%) do not use PPE (masks) during the work. Welders who do not consistently wear masks are twice as likely to have lung function disorders. Conclusion: Welders having years of service ≥ 5 years are more at risk of experiencing lung function disorders than years of service < 5 years. The mask usage affects the welders’ lung function health.

PEMANTAPAN MUTU PEMERIKSAAN LDL PADA SERUM KONTROAPEMANTAPAN MUTU PEMERIKSAAN LDL PADA SERUM KONTROL KOMERSIAL SETELAH PENYIMPANAN SUHU RUANG L KOMERSIAL SETELAH PENYIMPANAN SUHU RUANG Palentin, Sonia; Aryani, Titin; Mu'awanah, Isnin Aulia Ulfah
Jurnal Kesehatan Tambusai Vol. 5 No. 4 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i4.34248

Pemeriksaan Low Density Lipoprotein (LDL) yang dilaksanakan di sejumlah laboratorium menggunakan metode enzimatis, dimana pengerjaannya dipengaruhi sejumlah faktor yang rentan mempengaruhi hasil. Salah satu faktor yang begitu berpengaruh ialah penyimpanan serum kontrol. Serum kontrol merupakan serum yang digunakan untuk melihat presisi pengujian laboratorium atau akurasi hasil pengujian harian. Serum kontrol yang digunakan di laboratorium khususnya pada pemeriksaan sampel kimia klinik adalah serum kontrol komersial. Penelitian ini bertujuan untuk mengetahui hasil pemeriksaan Low Density Lipoprotein serum kontrol komersial setelah penyimpanan suhu ruang selama 0 dan 7 jam. Metode yang dipergunakan ialah penelitian kuantitatif dengan desain quasi experimental dan pendekan cross sectional. Hasil yang diperoleh di pemeriksaan Low Density Lipoprotein diferensiasi selisih dan signifikansi menggunakan uji Independent Sample T-test yang disimpan selama 0 dan 7 jam sebesar 1,25% dengan p=0,032 memperlihatkan bahwasannya diperoleh perbedaan yang signifikan. Tidak terdapat hasil grafik Levey-Jennings yang melanggar Westgard Rule pada hasil pemeriksaan Low Density Lipoprotein (LDL) selama 0 jam dan terdapat hasil grafik Levey-Jennings yang melanggar Westgard Rule pada hasil pemeriksaan Low Density Lipoprotein (LDL) dengan serum kontrol komersial selama 7 yaitu aturan 12s dan 13s. Perlu untuk instansi laboratorium untuk tidak melakukan penyimpanan bahan kontrol pada suhu ruang 20°-25°C selama lebih dari 6 jam karena dapat mengakibatkan stabilitas kontrol berkurang dan menyebabkan penurunan hasil.

Evaluasi Klinis Presisi POCT dan Chemistry Analyzer dalam Pemeriksaan Glukosa Darah Sewaktu Pasien Diabetes Melitus Isnin Aulia Ulfah Mu’awanah; Zuvi Fridhoriansyah; Tirsayanti AD. Hamidi
Journal Scientific of Mandalika (JSM) e-ISSN 2745-5955 | p-ISSN 2809-0543 Vol. 6 No. 10 (2025)
Publisher : Institut Penelitian dan Pengembangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/10.36312/vol6iss10pp4107-4113

Diabetes mellitus (DM) is a global health problem with a steadily increasing prevalence, including in Indonesia. The International Diabetes Federation (IDF) 2021 reported that Indonesia ranks fifth worldwide with approximately 19.5 million people living with DM, projected to exceed 28 million by 2045. This situation highlights blood glucose testing as a key indicator for both diagnosis and therapy monitoring. Validation of measurement methods, either Point-of-Care Testing (POCT) or chemistry analyzer as the laboratory standard, is required to ensure result reliability before clinical implementation. This study aimed to evaluate the precision, agreement, and linear relationship between POCT and chemistry analyzer in random blood glucose testing of patients with type 2 DM. An experimental comparative design was conducted on 30 patients at Mokoyurli General Hospital, Central Sulawesi. Each blood sample was analyzed using both methods with three repetitions.The results showed mean %CV values of 0.83% for POCT and 0.26% for chemistry analyzer, both within the acceptable precision threshold (<2%). Bland–Altman analysis revealed a bias of –14.36 mg/dL with LoA ranging from –33.28 to 4.56 mg/dL. Pearson correlation demonstrated a very strong linear relationship (r = 0.985; p<0.001), while Lin’s CCC of 0.86 indicated moderate agreement. Linear regression identified constant bias (–12.08) and proportional bias (slope 0.95), with POCT consistently reporting lower values, particularly at higher glucose concentrations.Chemistry analyzer exhibited superior precision compared to POCT. Nevertheless, POCT provides clinically acceptable performance for rapid screening, though results at critical values should be confirmed using standard laboratory methods

Profil Kadar Ureum dan Kreatinin pada Penderita Nefropati Diabetik dengan Hemodialisis di RS PKU Muhammadiyah Gamping Widyantara, Aji Bagus; Mu'awanah, Isnin Aulia Ulfah; Anggraini, Lidya Monalisa Putri
MAHESA : Malahayati Health Student Journal Vol 4, No 5 (2024): Volume 4 Nomor 5 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i5.14209

ABSTRACT Diabetes Mellitus is a carbohydrate metabolism disorder characterized by excess glucose levels in the body and causes one of the kidney complications or Diabetic Nephropathy. Impaired renal function can be treated with hemodialysis and it can be recognized by the detection of ureum and creatinine levels. The study aims to determine the profile of ureum and creatinine levels in diabetic nephropathy patients with hemodialysis. This study employed a quantitative descriptive study with a cross sectional approach with secondary data collection of ureum and creatinine levels. Data was in the form of medical records of diabetic nephropathy patients with hemodialysis at PKU Muhammadiyah Gamping Hospital. The results of ureum and creatinine levels based on age with mean values respectively in adulthood, 135.47 mg/dL and 9.25 mg/dL while in elderly age respectively 135.95 mg/dL and 9.46 mg/dL. Ureum and creatinine levels in male patients had mean values of 141.08 mg/dL and 11.08 mg/dL respectively while in females the mean values were 131.9 mg/dL and 8.18 mg/dL respectively. Patients undergoing hemodialysis had different levels for old and new patients. Old patients (≥1 year) had mean ureum and creatinine levels of 137.23 mg/dL and 10.04 mg/dL respectively while new patients (<1 year) had mean values of 133.29 mg/dL and 8.27 mg/dL respectively. This study shows that ureum and creatinine levels in Diabetic Nephropathy patients with hemodialysis are higher than normal values. Keywords: Diabetic Nephropathy, Ureum, Creatinine ABSTRAK Diabetes Melitus merupakan gangguan metabolisme karbohidrat yang ditandai dengan kelebihan kadar glukosa dalam tubuh. diabetes menjadi penyebab salah satu komplikasi ginjal atau Nefropati Diabetik. Gangguan fungsi ginjal dapat dapat diatasi dengan hemodialisis dan ini dapat diketahui dengan deteksi adanya kadar ureum dan kreatinin. Tujuan penelitian ini untuk mengetahui profil kadar hemoglobin, ureum dan kreatinin pada penderita nefropati diabetik dengan hemodialisis. Penelitian ini menggunakan studi deskriptif kuantitatif pendekatan cross sectional dengan pengambilan data sekunder kadar ureum dan kreatinin. Data berupa rekam medis pasien nefropati diabetik dengan hemodialisis di RS PKU Muhammadiyah Gamping. Hasil kadar ureum dan kreatinin berdasarkan usia dengan nilai mean masing-masing pada usia dewasa, 135,47 mg/dL dan 9,25 mg/dL sedangkan pada usia lansia masing-masing 135,95 mg/dL dan 9,46 mg/dL. Kadar ureum dan kreatinin pada pasien laki-laki memiliki nilai mean masing-masing 141,08 mg/dL dan 11,08 mg/dL sedangkan pada wanita nilai mean masing-masing yaitu 131,9 mg/dL dan 8,18 mg/dL. Pasien yang menjalani hemodialisis memiliki perbedaan kadar bagi pasien lama dan pasien baru. Pasien lama (≥1 tahun) memiliki kadar ureum dan kreatinin rata-rata yaitu 137,23 mg/dL dan 10,04 mg/dL sedangkan pasien baru (<1 tahun) memiliki nilai mean masing-masing 133,29 mg/dL dan 8,27 mg/dL. Penelitian ini menunjukkan bahwa kadar ureum dan kreatinin pasien Nefropati Diabetik dengan hemodialisis lebih tinggi dari nilai normal. Kata Kunci: Nefropati Diabetik, Ureum, Kreatinin

HUBUNGAN PAPARAN TIMBAL DENGAN KADAR HEMOGLOBIN DAN HEMATOKRIT PEKERJA INDUSTRI KERAMIK DI PADUKUHAN KAJEN BERDASARKAN LAMA MASA KERJA Pratama, Ferdinanda Adji; Sri Martuti; Isnin Aulia Ulfah Mu’awanah
Indonesian Journal of Health Research Innovation Vol. 2 No. 4 (2025): Indonesian Journal of Health Research Innovation
Publisher : Yayasan Menawan Cerdas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64094/8amfwn36

Timbal merupakan unsur logam berat yang memiliki sifat beracun dan banyak digunakan dalam kehidupan masyarakat. Secara global, timbal menjadi bahan kimia lingkungan yang tersebar secara melimpah dan memiliki efek toksisitas yang berbahaya bagi kesehatan. Salah satu dampak kesehatan yang disebabkan paparan timbal adalah sistem hematopoetik yang berdampak pada penurunan kadar hemoglobin dan hematokrit. Paparan timbal yang terakumulasi dalam darah diakibatkan oleh faktor-faktor seperti pembakaran bahan bakar fosil, industri aki, industri keramik, industri cat, korosi sistem perpipaan, produk kosmetik, dan pestisida. Tujuan penelitian ini untuk mengetahui hubungan paparan timbal dengan kadar hemoglobin dan hematokrit pekerja industri keramik di Padukuhan Kajen berdasarkan masa kerja. Teknik pengolahan data menggunakan uji normalitas Saphiro wilk hasil yang didapatkan tidak normal, sehingga dilanjutkan dengan uji korelasi Spearman’s rho. Berdasarkan uji didapatkan hasil p-value >0,05. Hasil penelitian ini menunjukkan tidak terdapat adanya hubungan yang signifikan antara kadar timbal dalam darah dengan kadar hemoglobin dan hematokrit serta hubungan antara masa kerja dengan kadar timbal dalam darah. Penelitian ini menunjukkan bahwa kadar timbal tidak mempengaruhi hemoglobin dan hematokrit serta masa kerja tidak memiliki pengaruh terhadap akumulasi kadar timbal dalam darah

QUALITY CONTROL GLUKOSA DAN TRIGLISERIDA DENGAN GRAFIK LEVEY JENNINGS DI RSUD SLEMAN Khadijah, Siti; Aji Bagus Widyantara; Isnin Aulia Ulfah Mu’awanah
Indonesian Journal of Health Research Innovation Vol. 2 No. 4 (2025): Indonesian Journal of Health Research Innovation
Publisher : Yayasan Menawan Cerdas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64094/ajsfd804

Laboratorium klinik berperan penting dalam menunjang diagnosis dan pemantauan kondisi pasien termasuk kasus Diabetes Melitus melalui penyediaan hasil pemeriksaan yang akurat dan presisi. Penerapan sistem penjaminan mutu seperti Pemantapan Mutu Internal (PMI) yang melibatkan kegiatan Quality Control (QC) diperlukan untuk memastikan keandalan hasil tersebut. Penelitian ini bertujuan menganalisis hasil QC pemeriksaan glukosa darah sewaktu dan trigliserida di Laboratorium RSUD Sleman, yang menggunakan alat Cobas C311 Chemistry Analyzer untuk menilai stabilitas hasil pemeriksaan. Penelitian ini merupakan penelitian deskriptif kuantitatif dengan pendekatan cross-sectional menggunakan data sekunder dari hasil QC bulan Oktober hingga Desember 2024. Evaluasi QC dilakukan menggunakan grafik Levey-Jennings dan aturan Westgard dengan bahan kontrol harian komersial assayed merk Roche Level 1 (normal) dan Level 2 (high). Bahan kontrol ini berbentuk liofisilat (bubuk). Berdasarkan data QC periode tersebut, masih ditemukan penyimpangan aturan grafik levey-jennings yang memenuhi kriteria peringatan dan penolakan akibat kesalahan acak dan sistematis. Hasil uji akurasi dan presisi QC untuk pemeriksaan glukosa darah sewaktu dan trigliserida masih berada dalam batas toleransi, yaitu akurasi (±10%) dan presisi (5% dan 7%). Hasil evaluasi grafik levey-jennings berdasarkan aturan Westgard menunjukkan tidak adanya nilai kontrol yang memenuhi kriteria pelanggaran aturan , . Hasil penelitian ini menunjukkan bahwa evaluasi QC secara rutin penting dilakukan untuk menjaga kualitas hasil pemeriksaan laboratorium. Jika ada penyimpangan, perlu segera ditindaklanjuti agar hasil tetap valid dan dapat dipercaya.

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