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All Journal Kappa Journal Jurnal Pendidikan, Sains, Geologi, dan Geofisika (GeoScienceEd Journal) Media for Empowerment, Mobilization, and Innovation in Research & Community Indonesian Journal of Innovation in Education Research
Syahrial A
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Agriculture, Biological Sciences & Forestry Astronomy Chemistry Education Energy Languange, Linguistic, Communication & Media Mathematics Physics Social Sciences Other

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Journal : Kappa Journal

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The Influence of Skin Permeability and Electric Fields on Drug Permeation in Transdermal Systems: A Simulation-Based Study Using Pascal Taufik, Muhammad; Syahrial A
Kappa Journal Vol 8 No 3 (2024): Desember
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/kpj.v8i3.28845

Abstract

Transdermal drug delivery systems (TDDS) offer a promising non-invasive approach for drug administration, yet their effectiveness is often constrained by the permeability of the skin and the properties of the drug. This study investigates the combined impact of skin permeability and electric fields on drug permeation through the skin, using simulation data generated by a custom-developed program in Pascal. The simulation, based on Fick’s Law of Diffusion, incorporates the effects of iontophoresis (electric fields) on drug transport, adjusting parameters such as skin permeability, electric field strength, and drug characteristics. The results demonstrate that both skin permeability and electric field intensity significantly influence the rate of drug permeation. Notably, the highest flux was observed when both electric field strength (1.0 mA/cm²) and enhanced skin permeability (3.5 coefficient) were applied, with drug flux increasing by up to 5 times compared to passive diffusion. These findings underscore the substantial benefits of combining skin permeability enhancers, such as microneedles or chemical enhancers, with electric field application, offering valuable insights for developing more efficient TDDS. The results suggest that optimizing both parameters can significantly improve drug delivery, especially for low-permeability drugs.
Implementation of the GASING Method in Teaching Parabolic Motion: A Comparative Analysis of Learning Outcomes in Biology Education Taufik, Muhammad; Syahrial A
Kappa Journal Vol 8 No 3 (2024): Desember
Publisher : Universitas Hamzanwadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29408/kpj.v8i3.28890

Abstract

Teaching of physics concepts to non-physics majors presents significant challenges, particularly when it comes to helping students connect abstract physical principles with their primary field of study. This study investigates the effectiveness of the GASING (Graduated Assistance in Student-led Inquiry and Narrative learning through Guided experimentation) method in teaching parabolic motion to first-semester Biology Education students FKIP Universitas Mataram. Using a quasi-experimental design with two parallel classes (n = 54), we assessed the method’s effectiveness through pre- and post-tests, mini-projects, laboratory observations, and detailed student feedback questionnaires. Results demonstrated significant improvements in conceptual understanding, with mean scores increasing from 4.15 to 7.63 (Class D) and 7.56 (Class E), yielding a substantial effect size (Cohen’s d = 3.26). Both classes showed comparable performance in mini-projects (mean scores: 16.0/20 and 16.3/20). Student feedback across multiple engagement, clarity, and effectiveness measures consistently scored above 4.0/5. Statistical analysis revealed a significant correlation between student engagement and learning outcomes (r = 0.78, p < 0.001). These findings suggest that the GASING method effectively bridges the gap between physics concepts and biological applications while maintaining high student engagement and comprehension
Co-Authors Adella Ulyandana Jayatri Dian Wijaya Kurniawidi I Gde Mertha Ika Umratul Asni Aminy Joni Rokhmat Khaerus Syahidi Kormil Saputra Kurniawan Arizona Muhammad Sarjan MUHAMMAD TAUFIK MUHAMMAD TAUFIK Muhammad Zuhdi Rahmatun Inayah Ramdhani Sucilestari Syamsuddin Syamsuddin Syamsuddin WAHYUDI Yunitun Tamara