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All Journal Jurnal Pengabdian Magister Pendidikan IPA AS-SHIHA: JURNAL KESEHATAN Journal Of Pharmacy
Rahmi Amini
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Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : Journal Of Pharmacy

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Studi Cross-Sectional Tentang Pengetahuan, Sikap, dan Praktik Terhadap Penggunaan Obat OTC Di Kalangan Mahasiswa Farmasi Universitas Muhammadiyah Riau Nursyafni; Nurbaiti; Reza laila Najmi; Rahmi Amini; Izza Aulia Risqika Nasution; Lilian Rahma Dayani; Najmi Hilaliyati
The Journal Of Pharmacy Vol. 2 No. 1 (2024): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

OTC (Over the Counter) drugs are a class of over-the-counter and limited over-the-counter drugs, which can be purchased without a prescription from a doctor, are safe, and effective when used according to the instructions on the drug packaging label. This study is a cross-sectional study that aims to evaluate the knowledge, attitudes, and practices towards the use of OTC drugs among Pharmacy students of the University of Muhammadiyah Riau. The study sample consisted of 86 respondents, consisting of 86% female and 14% male, with the majority aged 19-21 years. Data were collected using a validated questionnaire and analyzed using the Spearman correlation test to determine the relationship between knowledge, attitudes, and practices. The results showed that 62.8% of respondents had sufficient knowledge about OTC drugs, 64% had moderate attitudes, and 79.1% showed positive practices in the use of OTC drugs. Correlation analysis showed a significant positive relationship between knowledge and attitude (correlation coefficient: 0.362; p=0.001), knowledge and practice (correlation coefficient: 0.751; p=0.000), and attitude and practice (correlation coefficient: 0.553; p=0.000). These findings indicate that increasing knowledge about OTC drugs can contribute to more positive attitudes and better practices in their use. This study provides important insights for educational institutions in designing more effective educational programs to improve pharmacy students' knowledge, attitudes, and practices towards OTC drugs. Increased knowledge is expected to not only shape more positive attitudes, but also encourage safer and more responsible drug use practices
Pharmacokinetic Prediction, Drug-Like Properties, and Molecular Docking of Bioactive Compounds from Ethanol Extract of Uncaria nervosa Elmer Leaves Rahmawati, Noveri; Herli, Muhammad Azhari; Delvi Andrianingsih; Rahmi Amini
The Journal Of Pharmacy Vol. 3 No. 1 (2025): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Uncaria nervosa Elmer leaves are known to contain bioactive compounds with potential as natural drug candidates, yet their pharmacokinetic profiles, drug-likeness, and molecular affinity toward target proteins remain limitedly explored. This study aimed to evaluate the pharmacokinetic properties, drug-likeness, and molecular interaction potential of bioactive compounds from the ethanol extract of Uncaria nervosa leaves. An in silico approach was employed using SwissADME to analyze pharmacokinetic parameters (absorption, distribution metabolism, and excretion) and drug-likeness based on Lipinski’s and Veber’s rules, followed by molecular docking against proteins 6O0K and 2W3L using MOE software. The results showed that most compounds exhibited high gastrointestinal absorption, did not inhibit major CYP enzymes, and several complied with drug-likeness rules. Docking analysis revealed that ceratodictyol displayed the closest binding energy to the positive controls (doxorubicin and obatoclax), indicating strong molecular affinity, while N-formamide showed superior pharmacokinetic and drug-likeness properties. In conclusion, the combination of pharmacokinetic and docking data highlights ceratodictyol as the main candidate supported by N-formamide as a potential compound, suggesting that Uncaria nervosa leaf extract may serve as a promising natural source for anticancer drug development.
Co-Authors Delvi Andrianingsih Hari, Dewi Gulyla Hartini, Putri Tri Herli, Muhammad Azhari Isnaniar Izza Aulia Risqika Nasution Khazanah Nurain Nurdin Lilian Rahma Dayani Nailul Husna Najmi Hilaliyati Nisra Dayanti Zalukhu Noveri Rahmawati Nur Aida Nurbaiti Nurdina Putri Nursyafni Reza laila Najmi Siswahyudianto Suci Hidayani Wiwik Norlita Yulis Bonieght