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All Journal Jurnal Biologi Tropis Jurnal Pengabdian Magister Pendidikan IPA Journal of Pharmaceutical and Health Research International Journal Of Science, Technology & Management (IJSTM) Sciences of Pharmacy Fundamental and Applied Research in Medicine and Allied Sciences Indonesia
Hartini, Putri Tri
Universitas Muhammadiyah Riau
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Transportation

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Potensi Buah Rimbang (Solanum torvum Sw.) sebagai Analgetik dengan Metode Induksi Asam Asetat dan plantar test Utami, Dinda Sari; Nasution, Melvi Ariati; Fauzi, Ziza Putri Aisyia; Sari, Syilvi Rinda; Hartini, Putri Tri; Rawitri, Kiki
Journal of Pharmaceutical and Health Research Vol 5 No 2 (2024): June 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i2.5057

Abstract

Abstract is Solanum torvum is a traditional medicine plant ingredient for treating stomach disease, relieving pain (analgesic), initiating blood circulation, removing cough (anti-tussing) and anti-inflammatory. At this examination, a phytochemical screening of powder and fruit extracts has been carried out. Simplicity characteristic tests and analgesic effect tests with acetate acid induction method and plantar tests with suspensions of ethanol extract are given in doses of 500, 1000 and 2000 mg/kgBB, metampiron suspense 2% positive ontrol, CMC suspense 0.5% as negative control as well as gland data are analyzed with ANOVA method. Results of screening of phytomia powder and ethanole extract contains secondary metabolite compounds of the classes of alkaloids, tannins, saponins, flavonoids, steoids and glycosides. Characteristic results of simplisia powder are 8% water content, 5.3% total ash content, 29.6% water-soluble sulphur content, 18.9% ethanol-solubility, 0.48% acid-insoluble ash content. Ethanol extract with 2000 mg/kgBB acetate acid induction method has the highest analgesic strength and effectiveness percentage of 55.9% and 86.04% for plantar test methods with hight analgetic values with 29,3±1,7 second.
Optimization of HPMC Aand Carbopol 940 Bases in the Formulation of Red Beet (Beta vulgaris L.) Gel Preparations as Hair Dye Hartini, Putri Tri; Fauzi, Ziza Putri Aisyia; Utami, Dinda Sari; Karo-Karo, Sry Ulina; Puteri, Cut Intan Annisa
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6661

Abstract

Red beet (Beta vulgaris L.) is grass-shaped plant with short stems. Betacyianine is a red or purplish red pigment, while the betaxantin pigment has yellow colour and when diluted in water will form a red solution. This study aims to formulate hair dye gel with red beet juiceas colorant, evaluate the coloring capacity of the gel, and evaluate the stability of the formulation. 114.43 grams red beet juice was obtained using juicer, with yield percentage 55.76%. Phytochemical screening indicated alkaloid, tannin, flavonoid and saponin content. Hair dye gel is formulated in three different concentrations, F1 (10%), F2 (20%), F3 (30%) using combination of Carbopol 940 (0.5%) and HPMC (1%) as gel base. Hair dye gel obtained has beet distinctive smell. Evaluation results for the three-formulation showed that the color changed in all formulas. Color changing is influenced by pH degree of the formulation and temperature. The original color of the preparation only stable for 5 days, then the color changed due to oxidation at room temperature. Stability evaluation was conducted using Cycling Test method for 6 cycles in 12 days. All formula showed discoloration after 6 cycles from purple to brownish and they also showed viscosity change, F1 13673,34 cPs; F2 11826,67 cPs; dan F3 10673,34 cPs.
Article Review: Potential use of Andaliman Fruit as an Antibacterial Karo-Karo, Sry Ulina; Nabila, Nabila; Hartini, Putri Tri; Andry, Muhammad; Ligo, Azzura; Rezaldi, Firman
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7423

Abstract

This research examines the potential of andaliman fruit (Zanthoxylum acanthopodium) as an antibacterial agent. Andaliman fruit is known to contain bioactive compounds such as alkaloids, flavonoids and saponins which have the potential to inhibit the growth of pathogenic bacteria. The antibacterial activity test was carried out using the agar diffusion method against several test bacteria, including Escherichia coli and Staphylococcus aureus. The results showed that andaliman fruit extract had significant antibacterial activity, indicated by the inhibition zone formed around the extract impregnation disc. The highest activity was noted against Staphylococcus aureus, which is a gram-positive bacterium. These findings indicate that andaliman fruit has the potential to be developed as an effective natural antibacterial agent. Further research is needed to identify the specific active compound and its antibacterial mechanism of action.
Edukasi Dan Pelatihan Pembuatan Minyak Rambut Herbal Berbahan Kemiri Untuk Pencegahan Rambut Rontok Di Kelurahan Paya Mabar, Kecamatan Stabat, Kabupaten Langkat Hartini, Putri Tri; Lubis, Syahnan Aly; Nabila; Sry Ulina Karo-karo; Ziza Putri Aisyia Fauzi
Jurnal Pengabdian Magister Pendidikan IPA Vol 8 No 4 (2025): Oktober-Desember 2025
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpmpi.v8i4.13040

Abstract

Hair loss is a common problem that impacts appearance and self-confidence, so a safe and effective natural solution is needed. Candlenut oil (Aleurites moluccanus) contains essential fatty acids and vitamin E which are beneficial in strengthening the hair and nourishing the scalp. This community service program was carried out in Paya Mabar Village, Stabat District, Langkat Regency, with the aim of increasing community knowledge and skills in making herbal hair oil made from candlenut. A total of 35 participants participated in the activity through counseling, demonstration, and hands-on practice, accompanied by evaluation using pre-test and post-test. The results showed an average knowledge increase of 38%, and 80% of participants succeeded in producing good quality hazelnut oil despite facing constraints on temperature regulation. This program proved effective in improving hair health literacy, natural ingredient processing skills, and opening up entrepreneurial opportunities based on local herbal products.
Formulation and Evaluation of Liposome Moringa Oleifera Seed Oil (Moringa oleifera L.) as Anti-aging Hartini, Putri Tri; Sumaiyah; Hasibuan, Poppy Anjelisa Zaitun
International Journal of Science, Technology & Management Vol. 3 No. 4 (2022): July 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i4.546

Abstract

Moringa oil is a natural vegetable oil obtained from the juice of the ripe kernels of the Moringa tree (Moringa oleifera L). Moringa seeds have an oil content of up to 40%, and have antioxidant activity with vitamin E content reaching 51% but have low stability. The purpose of this study was to find the best formulation as an anti-aging on liposome delivery system with a ratio of phosphatidylcholine soy lechitin and cholesterol. The method used is thin layer hydration (Thin Film Hydration). The results of the observation on the best formula are the 6th formula on organoleptic examination which is milky yellow in color, has a distinctive smell of lecithin and cholesterol and is in the form of a thick suspension, with a pH of 6.0, particle size 83.98nm using a particle size analyzer and entrapment efficiency of 96.8 % using a UV-Vis spectrophotometer.
Implementasi Pemanfaatan Teh Bunga Telang (Clitoria Ternatea) Sebagai Solusi Herbal Dalam Manajemen Hipertensi Dan Gula Darah Khazanah Nurain Nurdin; Sari Rahmadhani; Nurdina Putri; Rahmi Amini; Putri Tri Hartini; Dewi Gulyla Hari
Jurnal Pengabdian Magister Pendidikan IPA Vol 9 No 1 (2026): Januari - Maret 2026
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpmpi.v9i1.14244

Abstract

This community service program aimed to enhance community knowledge and skills in utilizing butterfly pea flower tea (Clitoria ternatea) as a supportive herbal approach for hypertension management and blood glucose control. The activity was conducted using an educational and applicative approach through the delivery of health-related materials and a demonstration of the proper and hygienic preparation of butterfly pea flower tea for the target community. The implementation method comprised preparation, execution, and evaluation stages, with improvements in participants’ knowledge assessed through pre-test and post-test questionnaires, as well as observations of participant engagement throughout the activity. The results indicated an increase in community understanding regarding the benefits, processing methods, and consumption of butterfly pea flower tea as a complementary therapy. Overall, this program contributed positively to community empowerment through the utilization of safe, affordable, and locally available herbal plants, with potential benefits in supporting the prevention and management of non-communicable diseases, particularly hypertension and blood glucose disorders.
Optimization of Dengue-EDIII – Hepatitis B-VLP Fusion Antigen Protein Expression in Mammalian Cell Systems and Preliminary Immunogenicity Testing in Mice Ziza Putri Aisyia Fauzi; Eka Nur Fatmawati; Putri Tri Hartini; Yuneka Saristiana; Husnunnisa
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 2 (2025): November, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i2.430

Abstract

The development of a safe and effective dengue vaccine remains challenging due to the risk of antibody-dependent enhancement (ADE) associated with imbalanced immune responses. This study aimed to optimize the expression of a dengue virus envelope domain III (EDIII) fusion antigen displayed on Hepatitis B core antigen virus-like particles (VLPs) and to evaluate its preliminary immunogenicity in a murine model. Optimization of antigen design and expression conditions resulted in a substantial increase in VLP production compared with the non-optimized construct. The purified VLPs showed uniform size, proper particle assembly, and preserved antigenic integrity. Immunization of mice induced high titers of EDIII-specific IgG and strong serotype-specific neutralizing antibodies against dengue virus serotype 2, while no antibody-dependent enhancement was detected in vitro. These findings indicate that the optimized EDIII–HBcAg VLP platform is highly immunogenic and demonstrates a favorable safety profile, supporting its potential as a promising subunit vaccine candidate for dengue virus.
Green Synthesis of Silver Nanoparticles Using Tamarind (Tamarindus indica) Leaf Extract and Their Application as an Antibiofilm Agent in Pseudomonas aeruginosa Infected Wounds Emma Jayanti Besan; Muhammad Nurul Fadel; Cut Intan Annisa Puteri; Dzukharian Munandar; Putri Tri Hartini
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 1 No. 2 (2025): November, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v1i2.434

Abstract

Multidrug-resistant Pseudomonas aeruginosa poses a significant challenge in chronic wound management due to its robust biofilm formation and antibiotic resistance. Green-synthesized silver nanoparticles (AgNPs) using Tamarindus indica (tamarind) leaf extract offer an eco-friendly and effective approach to combat these infections. The bioactive phytochemicals in tamarind leaves function as both reducing and stabilizing agents, producing biocompatible AgNPs with potent antimicrobial and antibiofilm activities. These nanoparticles disrupt bacterial membranes, generate reactive oxygen species, inhibit virulence factors such as pyocyanin, and compromise biofilm integrity. Incorporation of tamarind-derived AgNPs into hydrogels or composite wound dressings further enhances wound healing by maintaining a moist environment and providing sustained antimicrobial release. Although in vivo studies specifically using tamarind AgNPs against P. aeruginosa are limited, evidence from other plant-derived AgNPs supports their promising potential for treating biofilm-associated wound infections. Green synthesis using tamarind thus represents a sustainable strategy for developing next-generation antimicrobial wound therapies.
Breadfruit Peel Derived Pectin as a Natural Polymer for Gastroretentive Floating Beads of Amoxicillin: Formulation and Characterization Puteri, Cut Intan Annisa; Fauzi, Ziza Putri Aisyia; Rahmadani, Rahmadani; Sari, Febia; Hartini, Putri Tri
Sciences of Pharmacy Volume 5 Issue 3 (2026)
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0503648

Abstract

Amoxicillin is widely used to treat gastric infections; however, conventional oral dosage forms often exhibit rapid gastric emptying and short gastric residence time, which may reduce therapeutic effectiveness. Gastroretentive floating drug delivery systems can prolong gastric retention and provide sustained drug release. This study aimed to develop gastroretentive floating beads of amoxicillin using pectin extracted from breadfruit peel (Artocarpus altilis) and compare their characteristics with those prepared using commercial pectin. Floating beads were prepared by ionotropic gelation using calcium chloride as a crosslinking agent and sodium bicarbonate as a gas-forming agent. The beads were characterized for morphology, floating behavior, entrapment efficiency, and drug release. All evaluations were performed in triplicate (n = 3). The prepared beads exhibited spherical morphology with diameters of 0.24–0.42 mm and weights of 9.26–11.38 mg. Floating lag time ranged from 10–22 seconds, and all formulations remained buoyant for up to 8 hours. Entrapment efficiency ranged from 31–47%, with formulations prepared using commercial pectin showing values of 34–47% and breadfruit peel-derived pectin showing values of 31–43%, with formulation F3 containing 3.5% commercial pectin showing the highest value. In vitro drug release studies demonstrated sustained release of amoxicillin for up to 8 hours, whereas conventional tablets released 64.77% of the drug within 2 hours. Drug release followed the Higuchi model (R² = 0.989–0.996), indicating diffusion-controlled release. These findings demonstrate that breadfruit peel-derived pectin is a promising natural polymer for gastroretentive floating bead formulations and exhibits performance comparable to commercial pectin.
Co-Authors Dinda Sari Utami Dzukharian Munandar Eka Nur Fatmawati Emma Jayanti Besan Hari, Dewi Gulyla Hasibuan, Poppy Anjelisa Zaitun Husnunnisa Karo-Karo, Sry Ulina Khazanah Nurain Nurdin Kiki Rawitri Ligo, Azzura Muhammad Andry Muhammad Nurul Fadel Nabila Nabila, Nabila Nasution, Melvi Ariati Nurdina Putri Puteri, Cut Intan Annisa Rahmadani Rahmadani Rahmi Amini Sari, Febia Sari, Syilvi Rinda Siswahyudianto Sry Ulina Karo-karo Sumaiyah Syahnan Aly Lubis Yuneka Saristiana Ziza Putri Aisyia Fauzi