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All Journal Mejuajua Jurnal Ilmu Kesehatan dan Gizi Jurnal Farmasi SYIFA Journal of Innovative and Creativity Jurnal Indah Sains dan Klinis
Fridelly Mairani
Universitas Sari Mutiara Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Formulasi dan Evaluasi Sediaan Body Scrub dari Ekstrak Etanol Daun Alpukat (Persea Americana Mill) Kombinasi Beras Ketan Putih (Oryza Sativa l Var Glutinous) Sebagai Pelembab Kulit Fridelly Mairani; Alya Izzani; Monica Suryani; Devina Chandra
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.7141

Abstract

Masyarakat sekarang sangat mendambakan kecantikan yang alami salah satunya dengan memiliki kulit yang bersih dan lembab. Untuk mendapaktkan kulit yang sehat,bersih dan lembab masyarakat dapat menggunakan sediaan kosmetik Body scrub yang berasal dari bahan alam maupun sintetis. Body scrub dapat membantu menutrisi kulit dengan tambahan bahan-bahan yang diperoleh dari alam seperti tumbuh-tumbuhan. Salah satu kandungan kimia yang terdapat pada daun alpukat yaitu Quersetin tersebut dapat didefinisikan sebagai senyawa kelompok flavonol terbesar dan termasuk senyawa flavonoid yang paling efektif untuk dapat melembabkan kulit dan juga sebagai antioksidan yang dapat menangkal radikal bebas. Penelitian ini bertujuan untuk membuat sediaan Body scrub dari ekstrak etanol daun alpukat yang dapat melembabkan kulit. Metode yang digunakan dalam penelitian ini yaitu metode eksperimental. Pembuatan ekstrak etanol daun alpukat dengan cara ekstraksi metode maerasi dan menggunakan pelarut etanol 96%. Konsentrasi kandungan daun alpukat yang terkandung bervariasi yaitu, 3%, 5% dan 7%. Hasil penelitian menunjukkan bahwa ekstrak etanol daun alpukat dapat diformulasikan kedalam sediaan Body scrub yang dapat melembabkan kulit, dan sediaan tersebut homogen, sediaan yang stabil uji pH yang dihasilkan 5,12-6,00. Sediaan Body scrub tidak menimbulkan iritasi pada kulit uji viskositas yang dihasilkan 2.573-3.334 cPs uji daya sebar rentan 5,76-5,93 cm uji tipe emulsi menunjkkan tipe M/A uji daya lekat yang dihasilkan 44-61 detik. Pada uji kelembaban konsentrasi 3%,5% dan 7% dapat melembabkan kulit, semakin tinggi konsentrasi ekstrak daun alpukat, semakin tinggi tingkat kelembaban yang di peroleh. Sediaan Body scrub F3 dengan konsentrasi 7% yang paling disukai (sangat suka) dikarenakan lebih dapat melembabkan kulit. Secara keseluruhan dapat disimpulkan bahwa ekstrak etanol daun alpukat dapat diformulasikan kedalam sediaan Body scrub dan memiliki kemampuan melembabkan kulit.
Jurnal Review: Aktivitas Biologis Jamu, Obat Herbal Terstandar, Dan Fitofarmaka Sebagai Antiinflamasi Fridelly Mairani; Jon Kenedy Marpaung; Rezza Fikrih Utama; Widya Fitri
Jurnal Farmasi SYIFA Vol 4 No 1 (2026): Jurnal Farmasi SYIFA
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/jfs.v4i1.1007

Abstract

Jamu, obat herbal terstandar, dan fitofarmaka merupakan bagian penting dari sistem pengobatan berbasis bahan alam di Indonesia yang didukung oleh kekayaan keanekaragaman hayati. Berbagai tanaman obat diketahui mengandung senyawa bioaktif seperti flavonoid, tanin, saponin, kurkuminoid dan senyawa fenolik yang berperan dalam aktivitas biologis, khususnya sebagai agen antiinflamasi. Review ini bertujuan untuk mengidentifikasi dan menganalisis aktivitas biologis jamu, obat herbal terstandar, dan fitofarmaka sebagai antiinflamasi. Penelitian ini merupakan review literatur sistematis yang bersumber dari Google Scholar, PubMed, ScienceDirect, dan Portal Garuda. Artikel yang diseleksi merupakan penelitian eksperimental in vitro dan in vivo yang menguji aktivitas biologis sediaan jamu, obat herbal terstandar dan fitofarmaka yang dipublikasikan pada periode 2020–2025. Data dianalisis secara kualitatif dengan membandingkan jenis sediaan, senyawa bioaktif, metode uji, serta hasil aktivitas biologis. Hasil kajian menunjukkan bahwa jamu, obat herbal terstandar, dan fitofarmaka memiliki aktivitas antiinflamasi yang signifikan, ditandai dengan penurunan edema dan penghambatan mediator inflamasi. Formulasi terstandar seperti gel, minyak, sirup, serbuk dan stick herbal meningkatkan stabilitas serta konsistensi efek terapeutik. Kesimpulan yang didapat dari hasil identifikasi dan analisis yaitu jamu, obat herbal terstandar, dan fitofarmaka terbukti memiliki potensi antiinflamasi yang kuat melalui aktivitas senyawa bioaktif seperti flavonoid, tanin, saponin, kurkuminoid dan senyawa fenolik. Senyawa-senyawa ini berperan dalam menghambat mediator inflamasi, mengurangi edema, serta melindungi jaringan dari stres oksidatif. Jamu, obat herbal terstandar, dan fitofarmaka memiliki potensi besar sebagai agen antiinflamasi yang aman dan efektif. Standarisasi sediaan dan pendekatan ilmiah yang tepat mendukung integrasi obat tradisional ke dalam praktik kesehatan modern berbasis bukti ilmiah.
ADMET Prediction Compounds of Polar Extract Curcuma rhizoma Sumardi Sumardi; Suprianto Suprianto; Suci Rahmadani Siregar; Arifin Putra Zai; Regina Elianda Tambubolon; Fridelly Mairani
Jurnal Indah Sains dan Klinis Vol 5 No 3 (2024): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v5i3.01

Abstract

The pharmacokinetic and metabolic profiles of polar extract compounds from Curcuma rhizoma were evaluated using ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) predictions. Most compounds exhibited high gastrointestinal (GI) absorption, with the exception of D-glucose, citric acid, and terpenoids such as alpha-pinene and zingiberene, which demonstrated low absorption, highlighting potential challenges for systemic bioavailability. Blood-brain barrier (BBB) permeability was observed in lipophilic compounds like xanthorrhizol, bisdemethoxycurcumin, and terpenoids, suggesting their potential for CNS-targeted therapies, while polar compounds, including D-glucose, citric acid, and most curcuminoids, were non-permeant. D-glucose was the only compound identified as a P-glycoprotein (Pgp) substrate, indicating minimal efflux-related limitations for other compounds. Selective cytochrome P450 (CYP) enzyme inhibition was detected in compounds such as xanthorrhizol, curcuminoids, and zingiberene, suggesting potential metabolic interactions in multi-drug contexts. Promising therapeutic candidates include curcuminoids and xanthorrhizol, while non-BBB-permeant and low-absorbing compounds may require formulation strategies or alternative applications. These findings provide valuable insights into the pharmacological optimization of Curcuma rhizoma compounds, offering a foundation for further research in drug discovery and development.
Peningkatan Pengetahuan tentang Manfaat Probiotik melalui Edukasi Kefarmasian pada Siswa SD Negeri 066652 Medan Fridelly Mairani; Syukur Berkat Waruwu Syukur; Dumartina Hutauruk; Cut Masyitah Thaib; Putri Afifah Khaisyah; Elmi Sariani Hasibuan
Mejuajua: Jurnal Pengabdian pada Masyarakat Vol. 6 No. 1 (2026): Agustus 2026
Publisher : Yayasan Penelitian dan Inovasi Sumatera (YPIS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/mejuajuaj.abdimas.v6i1.417

Abstract

The health of elementary school students forms the foundation for a healthy and productive generation. However, unhealthy dietary habits and unbalanced lifestyles can increase the risk of digestive tract disorders, which impact children's growth and development. This community service program aimed to enhance the knowledge of students at SD Negeri 066652 Medan regarding the importance of digestive health and the role of prebiotics and probiotics in supporting it. The activity took place on April 10, 2026, at SD Negeri 066652 Medan, North Sumatra, involving 40 students. The program utilized interactive seminars and workshops comprising material presentations, discussions, Q&A sessions, and interactive quizzes. The topics covered included the gut microbiome, factors influencing digestive health, and the benefits of consuming yogurt—a probiotic source containing Lactobacillus, Bifidobacterium, protein, calcium, vitamin D, and vitamin B12. Knowledge assessment was conducted via pre-tests (before the presentation) and post-tests (after the activity) using identical or equivalent questions. Evaluations also involved interactive quizzes and discussions with teachers regarding the activity's implementation and future program follow-ups. Results showed an increase in participant knowledge, evidenced by a rise in the proportion of students in the "good knowledge" category from 15% in the pre-test to 82% in the post-test—an increase of 67 percentage points. Meanwhile, the proportion of students with "poor knowledge" dropped from 45% to 0%, and those with "fair knowledge" decreased from 40% to 18%. These findings demonstrate that pharmaceutical education delivered through interactive seminars and workshops can improve students' understanding of digestive health and the benefits of prebiotics and probiotics. The program is expected to raise student awareness about maintaining digestive health and pave the way for future initiatives, such as education and training on probiotic beverage production for the surrounding community.
Edukasi Keamanan Penggunaan Skincare dalam Mencegah Kontaminasi Mikroba dan Menjaga Kesehatan Kulit Masyarakat Fridelly Mairani; Cut Masyitah; Syukur Berkat Waruwu
Jurnal Ilmu Kesehatan dan Gizi Vol. 4 No. 4 (2026): Oktober: Jurnal Ilmu Kesehatan dan Gizi
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jig.v4i4.9926

Abstract

Microbial contamination in skincare products may occur due to improper storage and usage, potentially causing various skin health problems, including skin irritation, allergic reactions, infections, and reduced product effectiveness. Limited public knowledge regarding skincare safety is one of the factors that increases this risk, particularly in relation to unhygienic application practices, sharing skincare products with others, and storing products under unsuitable environmental conditions. This community service activity aimed to improve public knowledge and awareness regarding the safe use of skincare products to prevent microbial contamination and maintain skin health. The methods employed included health education, interactive discussions, and counseling on the proper selection, use, and storage of skincare products in accordance with recommended hygiene practices. Participants were also encouraged to actively ask questions and discuss common issues encountered in their daily skincare routines. The results indicated an improvement in participants' understanding, with the average knowledge score increasing from 53.8% at pre-test to 90.1% at post-test. This educational program is expected to enhance safe skincare practices among the community, promote greater awareness of product hygiene, reduce the risk of microbial contamination, and ultimately support the maintenance of healthy skin through appropriate and consistent skincare habits
Co-Authors Alya Izzani Arifin Putra Zai Cut Masyitah Cut Masyitah Thaib Devina Chandra Dumartina Hutauruk Elmi Sariani Hasibuan Jon Kenedy Marpaung Monica Suryani Putri Afifah Khaisyah Regina Elianda Tambubolon Rezza Fikrih Utama Suci Rahmadani Siregar Sumardi Sumardi Suprianto Suprianto Syukur Berkat Waruwu Syukur Berkat Waruwu Syukur Widya Fitri