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All Journal Jurnal Kesehatan: Jurnal Ilmu- Ilmu Keperawatan, Kebidanan, Farmasi dan Analis Kesehatan JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Sains dan Teknologi Journal of Innovative and Creativity Jurnal Sains Farmasi dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Erida Novriani
Universitas Prima Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Education Electrical & Electronics Engineering Energy Engineering Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Perbandingan Efektivitas Penggunaan Obat Oral Antiabetik Tunggal dan Kombinasi pada Pasien Diabetes Mellitus Tipe 2 di Rumah Sakit Umum Royal Prima Medan Ega Yos Sanda; Muhammad Yunus; Erida Novriani
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6857

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels, with a high prevalence in Indonesia. Pharmacological therapy using oral antidiabetic medications (OAD), either singly or in combination, is a primary approach to managing type 2 DM. Evaluating the effectiveness of therapy is essential to ensure the achievement of glycemic targets and to prevent complications. This study aims to compare the effectiveness of using single and combination oral antidiabetic medications in reducing blood glucose levels in patients with type 2 Diabetes Mellitus at Royal Prima General Hospital Medan. This study is a non-experimental observational study, utilizing a retrospective descriptive design with a cross-sectional approach. A sample of 60 patients with type 2 DM who were hospitalized between January - June 2024, consisted of 30 patients on single therapy and 30 patients on combination therapy. Data was taken from medical records, and the effectiveness was assessed based on the decrease in blood sugar levels over six days of treatment. The results of this study show that the average percentage decrease in blood sugar levels over 6 days for single oral antidiabetics was 28.87%, and the average reduction in blood sugar levels for combination antidiabetics was 31.34%. Combination therapy shows higher effectiveness in reducing blood sugar levels compared to single therapy. There is a difference in effectiveness between single OAD therapy and combination therapy in patients with T2DM. Combination therapy tends to be more effective and can be a rational alternative for patients who do not reach glycemic targets with monotherapy.
Evaluasi Formulasi Sediaan Floating Mikroenkapsulasi yang Mengandung Ekstrak Etanol Kunyit Putih (Curcuma Zedoaria Rosc.) Rika Mai Dinasari Br Sembiring; Razoki Razoki; Erida Novriani; Hariyadi Dharmawan Syahputra
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 1 (2025): Maret : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i1.7054

Abstract

This test aims to evaluate the formulation of floating microcapsule preparations containing ethanol extract of white turmeric (Curcuma zedoaria Rosc.), using chitosan, sodium alginate, and calcium chloride polymers as crosslinking agents. The preparation was formulated using the crosslinking method and tested based on its physical properties, which include moisture content, physical stability through cycle tests, resistance to the gastric and intestinal mucosa. The results showed that the microcapsule formulation was able to maintain the color and texture during the storage period well. The microcapsule durability test showed that the particles could survive in the gastric and intestinal mucosa for two hours. In addition, the water content is within the range that is in accordance with the requirements, namely, at a concentration of 0.25% there is (22%), a concentration of 0.5% there is (38.75%), a concentration of 0.75% there is (22.5%), and the blank has 20.5% water content. Based on previous research by Mardikasari et al., (2020) which used chitosan and alginate polymers. Through this method, this formulation shows the possibility as a technology-based drug delivery system that survives effectively in increasing the bioavailability of active substances from white turmeric.
Co-Authors Casey Dola Rebeca br Pinem Cindy Kurnia Sari Cut Rahil Sofia Devortivo Hartono Putra Ega Yos Sanda Hariyadi Dharmawan Syahputra Khansa Sabira Muhammad Yunus Novia Agustini Irmasyari Siregar Rachel Adriany Br Sinaga Razoki Razoki Lubis Razoki Razoki Rika Mai Dinasari Br Sembiring Roy Indrianto Bangar S Suci Della