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Ocular Manifestations of Von Hippel-Lindau Disease: a Rare Sight- Threatening Condition: Poster Presentation - Case Report - Resident Firda Muthia Elsyanty; Made Indra Widyanatha; Grimaldi Ihsan; Rova Virgana; Erwin Iskandar; Arief S. Kartasasmita
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/hc3z9k23

Abstract

Introduction : Von Hippel-Lindau (VHL) disease is a rare phacomatosis characterized by multi-organ neoplasia which usually manifests in young adulthood. Ocular manifestations of this disease are frequently presented initially before the involvement of other organ systems. Case Illustration : An 18-year-old girl came with a chief complaint of photopsia in the left eye and complete vision loss in the right eye for five years. The visual acuity of the right eye was no light perception and the left eye was 0.8. The anterior segment of the right eye showed iris neovascularization. The posterior segment of the left eye demonstrated multiple elevated red-yellowish lesions fed by a dilated and tortuous vessel. The head CT scan revealed multiple lesions at the pons and cerebellum. The patient was diagnosed with multiple retinal and brain hemangioblastomas due to VHL disease, neovascular glaucoma, and chronic retinal detachment of the right eye due to sequelae of VHL. The patient was treated with cryotherapy and laser photocoagulation of the left eye. Five-month post-cryotherapy follow-up showed the lesions were still active then she underwent the second cryotherapy. The lesions became whitish in appearance with smaller feeder vessels one month after the second cryotherapy and the visual acuity was preserved. Discussion : Retinal hemangioblastoma is the most common ocular manifestation of VHL disease. Prolonged ischemia causes sight-threatening complications including neovascular glaucoma and exudative retinal detachment. Prompt treatment of detected lesions is crucial for visual preservation. Conclusion : Early detection of VHL ocular manifestations plays a critical role in establishing the diagnosis and initiating treatment for a better prognosis.
Complete Resolution of Central Serous Chorioretinopathy Cases Treated with Low Power Mode Laser Technology : A Novel Approach: Poster Presentation - Case Series - Resident Grace Setiawan; Rova Virgana; Made Indra Widyanatha; Grimaldi Ihsan; Arief Sjamsulaksan Kartasasmita; Erwin Iskandar
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/qr43j813

Abstract

Introduction : Central serous chorioretinopathy (CSC) is an idiopathic condition mostly affecting men in their 20s to 50s. It is characterized by serous fluid accumulation behind the neurosensory retina resulting in a localized macular detachment. Aldosterone-receptor antagonist and photodynamic laser therapy are the current mainstay of treatments, although most CSC cases can resolves spontaneously within 2 to 3 months. Low power mode (LPM) laser has emerged as a new effective technology to treat CSC. Case Illustration : Case 1: A 50-year-old male was diagnosed with recurrent chronic CSC since 2 months ago. His visual acuity declined even after given oral aldosterone receptor antagonist for two weeks, so he was scheduled to undergo LPM. After three weeks of laser treatment, CSC resolved and the visual acuity improved (Figure1). Case 2 : A 47-year-old male complained of decreased vision and metamorphopsia on his right eye since two weeks ago. He was diagnosed with CSC and underwent LPM. Three weeks after LPM, his vision improved and the metamorphopsia resolved (Figure2). LPM helps the migration of retinal pigment epithelium (RPE) cells to restore the outer blood-retinal barrier through expression of heat shock proteins. We used MC-500ViXi laser system (Nidek Co., Gamagori, Japan) and the laser parameters used in this study were 100?m spot size, 0.01s exposure time, 0.25-0.5 spacing, and 30% LPM ratio. Discussion : Conclusion : LPM is a new yet promising treatment modalities to treat acute and chronic CSC. Its low power nature makes LPM a safe choice of treatment with less damage to the surrounding retina.
THE OUTCOME OF INTRAVITREAL BROLUCIZUMAB FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION TREATMENT: Poster Presentation - Case Report - Resident Gabriella Graziani; Grimaldi Ihsan; Made Indra Widyanatha; Rova Virgana; Arief S. Kartasasmita; Erwin Iskandar
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/nvxrf729

Abstract

Introduction : Age-related macular degeneration (AMD) is a disease that results in irreversible severe loss of central vision in people over 50 years old. Hence, anti-VEGF therapy has become a standard treatment for neovascular AMD. Brolucizumab is a single-chain antibody fragment that inhibits VEGF-A binding to VEGF receptors. It has a higher molar concentration that allows a greater reduction in the central subfield thickness (CST) Case Illustration : A 59-year-old male with a chief complaint of gradually blurred vision in the left eye for 2 years. BCVA of the left eye was 0.3, OCT showed a hyperreflective band in the sub-neurosensory space with subretinal fluid in the left eye (Figure 1), and OCT-A revealed choroidal neovascularization (Figure 2). The patient was diagnosed with AMD AREDS IV in the left eye. He had undergone three monthly injections of brolucizumab. BCVA of the left eye after injection improved to 1.0 and OCT imaging showed no subretinal fluid, no intraretinal fluid, and no pigment epithelial detachment. Discussion : Brolucizumab has a greater reduction in CST because of its high molecular concentration. Results of HAWK and HARRIER concluded that brolucizumab was non-inferior towards aflibercept in BCVA change at week 48. According to the HAWK trial, a greater reduction of CST was seen in week 16 among eyes treated with brolucizumab. Brolucizumab was also well tolerated and adverse event rates were similar to aflibercept. Conclusion : Brolucizumab could be an alternative treatment option considering its efficacy in improving visual acuity and reducing CST.
Structure and Macular Sensitivity Characteristic After Silicone Oil Removal in Primary Rhegmatogenous Retinal Detachment Haryono, Aditia Apriyanto; Widyanatha, Made Indra; Iskandar, Erwin; Kartasasmita, Arief Sjamsulaksan; Virgana, Rova; Ihsan, Grimaldi
Oftalmologi : Jurnal Kesehatan Mata Indonesia Vol 4 No 3 (2022): Jurnal Oftalmologi
Publisher : Pusat Mata Nasional Rumah Sakit Mata Cicendo Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ojkmi.v4i3.42

Abstract

Introduction: Silicone oil (SO) is an endotamponade to manage several retinal detachments.The emulsification of silicone oil is one of the complications that may occur in several patients. Retinal macular changes may occur even with successful tamponade. Purpose: to describethe structure and macular sensitivity characteristic after silicone oil removal in primary rhegmatogenous retinal detachment (RRD). Methods: a prospective, descriptive case series study of who underwent SO tamponade for primary RRD. Optical coherence tomography (OCT) and microperimetry (MP-3) were conducted before SO removal and one week after SO removal. Result: There were nine eyes that met the criteria. The mean age of the patients was 53.3±14 years. Most of the patients use silicon 1300 (66.67%) and under six months (77.8%) duration of silicone tamponade. After silicone oil removal, mean macular sensitivity in the central fovea decreased from 12.44 dB to 12.11 dB, and parafovea increased from 18.33 dB to 19.00 dB.The mean macular thickness in the fovea decreased from 269.89μm to 260μm. The mean macular thickness in parafovea was an increase from 316.16 to 328.00μm Conclusion: There was an increase in macular sensitivity and thickness at parafovea after one- week silicone oil removal in primary rhegmatogenous retinal detachment.
REVIEW 5 TAHUN KARAKTERISTIK KLINIS PASIEN BENDA ASING INTRAOKULAR DI PMN RS MATA CICENDO Desrina; Virgana, Rova; Kartasasmita, Arief S.; Iskandar, Erwin; Ihsan , Grimaldi; Widyanatha, Made Indra
Oftalmologi : Jurnal Kesehatan Mata Indonesia Vol 5 No 1 (2023): Jurnal Oftalmologi
Publisher : Pusat Mata Nasional Rumah Sakit Mata Cicendo Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ojkmi.v5i1.46

Abstract

Introduction: Intraocular foreign bodies (IOFBs) are defined as intraocularly retained, unintentional projectiles that require urgent diagnosis and treatment to prevent blindness or globe loss. IOFBs account for 18–41% of open globe injuries, and frequently cause severe visual loss in patients with ocular trauma.The purpose of this study are is to describe the characteristics of open-globe injuries with posterior segment intraocular foreign bodies (IOFB). Subject and Methods: Retrospective data of all patients with posterior segment IOFBs from 2017 to 2022 was conducted. Data including demographics, mechanism of injury, type of IOFB, method of diagnosis, presenting examination, medical and surgical treatment, visual outcomes, and complications were recorded. Result: There were 39 patients (eyes) with IOFB, 38 (97,4%) were male, 10 (25,6%) were 46-55 years old. The most common IOFB occurred at workplace 30 patient (85,7%), 29 (74,3%) were insuranced, surgery were performed 1- 4 days in 15 (38,5%. The most Ocular trauma score were 3 (38,5%) and 2 (35,9%) initial VA were light perception – hand movement (25 or 64,1%), final VA with BCVA were > 20/40 (30,8%) patients and 6/60-6/15 (25,6%). The posterior segment IOFB (51,3%, metallic IOFB 25 (61,5%). Cataract 74,3% and Endophthalmitis (20,5%) were found in initial examination patient with IOFB (13 or 37,1%). Late complication in post surgery IOFB patient was glaucoma 14,4%. Conclusions: The IOFB occurred most commonly in adults, men, at the workplace. The IOFB mostly was metallic, found in the posterior segment. Cataract and endoftalmitis were common in initial finding IOFB patients.
GAMBARAN KEPATUHAN BEROBAT PASIEN RETINOPATI DIABETIK DI PMN RS MATA CICENDO 2021?2022 Naqiya, Wafa; Virgana, Rova; Kartasasmita, Arief Sjamsulaksan
Oftalmologi : Jurnal Kesehatan Mata Indonesia Vol 5 No 2 (2023): Jurnal Oftalmologi Vol 5 No 2 2023
Publisher : Pusat Mata Nasional Rumah Sakit Mata Cicendo Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ojkmi.v5i2.54

Abstract

Pendahuluan: Retinopati diabetik (RD) merupakan komplikasi mikrovaskular penyakit diabetes melitus dengan angka pertumbuhan tinggi. Kepatuhan melakukan pemeriksaan rutin dan menjalankan tindakan khusus dapat mencegah progresivitas penyakit ini. Namun, penelitian mengenai gambaran kepatuhan berobat pasien retinopati diabetik belum pernah dilakukan di Indonesia. Penelitian ini bertujuan untuk mengetahui gambaran kepatuhan berobat pasien retinopati diabetik di PMN RS Mata Cicendo.  Metode: Penelitian ini merupakan penelitian observasional deskriptif dengan metode cross sectional, menggunakan data sekunder dari EMR, dan dilakukan pada periode 1 Januari 2021–31 Desember 2022 di PMN RS Mata Cicendo. Kepatuhan dinilai berdasarkan kepatuhan menjalankan masa awal pengobatan dan diukur melalui data tanggal registrasi, tindakan, dan perencanaan. Hasil penilaian kepatuhan kemudian dikelompokkan berdasarkan derajat retinopati diabetik, tipe diabetes melitus, jenis tindakan, jenis kelamin, usia, pekerjaan, pendidikan terakhir, dan domisili.  Hasil: Penelitian ini melibatkan 887 rekam medis dan 533 (60,1%) di antaranya dikategorikan patuh. Data menunjukkan persentase kepatuhan >60% pada pasien derajat berat seperti Proliverative Diabetic Retinopathy (61,6%); berjenis kelamin perempuan (60,2%); berusia muda kelompok 25–34 tahun (77,4%); berdomisili di Bandung Raya (64,4%) atau luar Jawa Barat (63,5%); berpendidikan terakhir tinggi sarjana muda (68,9%); bekerja sebagai pegawai swasta (67,1%), pengajar (72,7%), wiraswasta (61,3%), atau pensiunan (66,7%); memiliki tipe diabetes melitus terspesifikasi non-insulin dependent (64,2%) atau insulin dependent (80,9%); serta mendapat rekomendasi tindakan laser (64,1%).  Kesimpulan: Secara umum kepatuhan berobat pasien retinopati diabetik di PMN RS Mata Cicendo sudah mencapai >60%. Kepatuhan pasien kontrol dengan jangka waktu menengah (1–3 bulan), panjang (>6 bulan) masih harus ditingkatkan.
Good Results in Open Globe Injury Including Intraocular Foreign Body Widhyasti, Rahayu; Widyanatha, Made Indra; S. Kartasasmita, Arief; Iskandar, Erwin; Virgana, Rova; Ihsan, Grimaldi
Oftalmologi : Jurnal Kesehatan Mata Indonesia Vol 6 No 1 (2024): Oftalmologi: Jurnal Kesehatan Mata Indonesia
Publisher : Pusat Mata Nasional Rumah Sakit Mata Cicendo Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ojkmi.v6i1.61

Abstract

Introduction: The second most frequent cause of open globe injury (OGI) is an intraocular foreign body (IOFB), a serious ocular emergency that needs to be diagnosed and treated right once to avoid blindness. It can enter the eye and cause damage later on, resulting in direct harm. When treating post-traumatic endophthalmitis, an urgent pars plana vitrectomy (PPV) procedure helps maximize visual outcome. Case report: A 55-year-old male patient came to the Emergency Room Tertiary Eye Hospital with chief complaints of blurry vision, pain, and red-eye in his right eye 3 days before admission. The patient’s right eye was hit by a fragment of the sickle knife while mowing the grass in the yard without protective eyeglasses. His chief complaints getting worse accompanied by lacrimation. The patient was diagnosed with Open Globe Injury Type C Grade D Pupil B zone 1, suspected early endophthalmitis, traumatic cataract of the right eye, and hypertension. Pars plana vitrectomy, vitreous tap, antibiotic intravitreal injection (with Ceftazidime and Vancomycin), IOFB extraction, explore, corneal scraping on the wound, cultural resistance, primary hecting of the cornea were done. The visual acuity improved and the infection was resolved. The infection was treated, and visual acuity returned after a month. Conclusion: In ophthalmology, IOFB is one of the most frequent traumas and is regarded as an emergency. To identify this problem, a thorough ophthalmology examination and the relevant ancillary testing should be performed. A patient with good care will have a favorable visual prognosis.
Intraocular Pressure Changes of Rhegmatogenous Retinal Detachment Patients Following Pars Plana Vitrectomy in Tertiary Hospital Wardani, Sabrina Indri; Virgana, Rova
Oftalmologi : Jurnal Kesehatan Mata Indonesia Vol 6 No 1 (2024): Oftalmologi: Jurnal Kesehatan Mata Indonesia
Publisher : Pusat Mata Nasional Rumah Sakit Mata Cicendo Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ojkmi.v6i1.66

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Introduction: Rhegmatogenous retinal detachment (RRD) is one of the leading causes of vision loss worldwide. Retinal reattachment is the main target of RRD management. Pars plana vitrectomy (PPV) is one of the surgical approaches to reattach the retina by removing the vitreous gel and replacing it with tamponades. Several tamponades used in PPV may cause an alteration of intraocular pressure (IOP). Purpose: To report the IOP changes of RRD patients who underwent pars plana vitrectomy surgery Methods: A descriptive retrospective study was conducted on all RRD patients who underwent primary PPV with all tamponades at the National Eye Center, Cicendo Eye Hospital. This study has evaluated and observed the range of IOP across all the follow-up timelines post-surgery based on the endo tamponade used for the patients. Result: A total of 90 patients received intravitreal tamponade. The median IOP at baseline was 12 (4-21) mmHg. Secondary glaucoma mostly occurred in 1st and 3rd months post-PPV, 37.78% and 36.67% respectively. 80% of patients who received silicon oil 1300 centistoke experienced IOP elevation which occurred highly during 1-week and 1-month post PPV. 2.2% of patients underwent glaucoma filtering surgery to further control the IOP elevation. Conclusion: PPV procedure with several types of tamponades as vitreous substitution is one of the common approaches for patients with RRD. IOP elevation has been observed as one complication of PPV. Multiple factors may be attributable to IOP alteration. Monitoring of IOP before and after the surgery is mandatory to prevent secondary complications
Survival Analysis of Trabeculectomy and Phacotrabeculectomy in Primary Angle Closure Glaucoma Gustianty, Elsa; Shalim, Nikho Melga; Virgana, Rova; Prahasta, Andika; Rifada, R. Maula; Umbara, Sonie
Majalah Kedokteran Bandung Vol 56, No 4 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3594

Abstract

Glaucoma is the global leading cause of irreversible blindness. Primary angle closure glaucoma occurs most frequently in Asian populations, including in Indonesian population. Surgical management of Primary Angle Closure Glaucoma (PACG) includes cataract extraction, trabeculectomy, or combined phacotrabeculectomy. Many patients presented in the advanced stages of the disease with significant cataracts, requiring combined surgery. This study aimed to determine whether trabeculectomy alone was better in reducing intraocular pressure compared to phacotrabeculectomy in primary angle closure glaucoma. This was an analytic retrospective observational study reviewing medical records of  PACG patients underwent trabeculectomy or phacotrabeculectomy from January to December 2015, within a 5-year follow-up period of a tertiary eye hospital. The success rates of the two groups were assessed with Kaplan-Meier survival analysis. Success criteria were defined as > 20% reduction of IOP or  IOP <21 mmHg with or without medication. Results showed 104 and 41 eyes underwent trabeculectomy and  phacotrabeculectomy, respectively. The cumulative 5-year survival rate in trabeculectomy group was 58.6%, and 85.4% in phaco trabeculectomy. There was no statistical difference in the success rate between the trabeculectomy and phaco trabeculectomy groups (p=0.102). Postoperative complications observed in the phacotrabeculectomy group were one choroidal detachment,  one malignant glaucoma, and one vitreous prolapse. Thus, the cumulative success rate of phacotrabeculectomy was better than trabeculectomy after 5 years of follow up, albeit not statistically significant.
Prevalence and Associated Factors of Diabetic Retinopathy in People with Type 2 Diabetes Attending Community Based Diabetic Retinopathy Screening in Greater Bandung, Indonesia Halim, Aldiana; Syumarti, Syumarti; Rini, Mayang; Ratnaningsih, Nina; Iskandar, Erwin; Sovani, Iwan; Virgana, Rova; Dahlan, Muhammad Rinaldi
International Journal of Retina Vol 5 No 1 (2022): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2022.vol005.iss001.172

Abstract

Introduction: Determine the prevalence and associated factors of diabetic retinopathy (DR) among people with type 2 diabetes. Design: Cross-sectional study Methods: We obtained data of people with type 2 diabetes retrospectively from a community-based DR screening database in Greater Bandung, Indonesia. We encoded the two fields mydriatic 45-degree fundus images to estimate prevalence. The associated factors analysis used multivariate logistic regression. Results: We screened a total of 4,251 people with type 2 diabetes from January 2016 to December 2019. The overall age-standardised prevalence of any DR was 30.7% (95% CI: 28.7%-32.8%) and vision-threatening DR 7.6% (95% CI: 6.5%-9.0%). The following factors were associated with a higher prevalence of any DR: ages 50+ (OR:1.37; 95% CI:1.05-1.77), duration of diabetes five to ten years (OR:1.38; 95% CI:1.11-1.71) and more than ten years (OR:1.40; 95% CI:1.13-1.73), and postprandial blood glucose 200 mg/dl and higher (OR:1.27; 95% CI:1.03-1.52). The following factors were associated with a higher prevalence of vision-threatening DR: duration of diabetes five to ten years (OR:2.01; 95% CI:1.39-2.91) and more than ten years (OR:1.86; 95% CI:1.28-2.71), postprandial blood glucose 200 mg/dl or higher (OR:1.52; 95% CI:1.05-2.21) and systolic blood pressure 180 mmHg or higher (OR:2.67; 95% CI:1.16-6.17). Conclusion: Diabetic retinopathy is prevalent among people with type 2 diabetes. People with diabetes should regulate their blood glucose and blood pressure to prevent retinopathy related vision loss.