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All Journal Health Notions Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Kesehatan Komunitas JURNAL KEBIDANAN KESTRA (JKK) Best Journal (Biology Education, Sains and Technology) Jurnal Doppler Jurnal Doppler JURNAL PENELITIAN KESMASY JURNAL PENELITIAN KEBIDANAN & KESPRO JURNAL PENELITIAN KEPERAWATAN MEDIK JURNAL INOVASI KESEHTAN MASYARAKAT Jurnal Pengabdian Masyarakat Putri Hijau Jurnal Kedokteran STM (Sains dan Teknologi Medik)
Siagian, Nurul Aini
Institut Kesehatan Deli Husada Delitua
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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The Effect of Pagoda Leaves Extracts on the Level of IL-6 of Female Rats Induced by Staphylococcus aureus Ibrahim, Fitriana; Prihantono, Prihantono; Ahmad, Mardiana; Siagian, Nurul Aini
Health Notions Vol 2 No 5 (2018): May 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.333 KB)

Abstract

The extract of Pagoda leaves can play roles as an anti-inflammatory, antioxidant, and antibacteria. Interleukin 6 (IL-6 henceforth) is the primary mediator in responding to the inflammation, while mastitis is caused by bacteria often found in the increased level of IL-6. This research aimed to unveil the effect of giving the extracts of Pagoda leaves on the level of IL-6 of female rats (Sprague dawley therefore) induced by staphylococcus aureus bacteria. This true experimental research employing pre- and post-test control design used eighteen rats chosen randomly. All rats were divided into three groups, namely negative control (placebo), positive control (amoxicillin 9.6 mg/ml/kgBB/hari/oral) and treatment group (amoxicillin 9.6 mg/ml/KgBB + EDP 50 mg/ml/KgBB/hari/oral). All groups were induced by S.aureus 0.2x108 CFU. Treatment was given for five days. Investigating the level of IL-6 was done using ELISA method. The data were anaylized using ANOVA formula followed by post hoc. The empirical findings showed that there was a difference in terms of the level of IL-6 in all of the groups ±24 before and after the induction of S.aureus. The result of investigating the level of IL-6 in the post-test was significant (ρ = 0.00), meaning that there was a significant difference, in which the negative control group, the level of IL-6 was insacalating; while it was dipping in both the positive and treatment groups. However, the treatment group experienced the most significant drop in terms of the level of IL-6. It can be concluded that Pagoda leaves can be used as a complementary therapy for mastitis illness caused by the S.aureus bacteria.
The Effect of Pagoda Leaves Extracts on the Level of IL-6 of Female Rats Induced by Staphylococcus Aureus Fitriana Ibrahim; Prihantono Prihantono; Mardiana Ahmad; Nurul Aini Siagian
Health Notions Vol 2, No 5 (2018): May
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.333 KB) | DOI: 10.33846/hn.v2i5.193

Abstract

The extract of Pagoda leaves can play roles as an anti-inflammatory, antioxidant, and antibacteria. Interleukin 6 (IL-6 henceforth) is the primary mediator in responding to the inflammation, while mastitis is caused by bacteria often found in the increased level of IL-6. This research aimed to unveil the effect of giving the extracts of Pagoda leaves on the level of IL-6 of female rats (Sprague dawley therefore) induced by Staphylococcus aureus. This true experimental research employing pre-test and post-test control design used eighteen rats chosen randomly. All rats were divided into three groups, namely negative control (placebo), positive control (amoxicillin 9.6 mg/ml/kgBB/hari/oral) and treatment group (amoxicillin 9.6 mg/ml/KgBB + EDP 50 mg/ml/KgBB/hari/oral). All groups were induced by S.aureus 0.2x108 CFU. Treatment was given for five days. Investigating the level of IL6 was done using ELISA method. The data were anaylized using ANOVA formula followed by post hoc. The empirical findings showed that there was a difference in terms of the level of IL-6 in all of the groups ±24 before and after the induction of S.aureus. The result of investigating the level of IL-6 in the post-test was significant (ρ = 0.00), meaning that there was a significant difference, in which the negative control group, the level of IL-6 was insacalating; while it was dipping in both the positive and treatment groups. However, the treatment group experienced the most significant drop in terms of the level of IL-6. It can be concluded that Pagoda leaves can be used as a complementary therapy for mastitis illness caused by the S.aureus bacteria. Keywords: Interleukin 6, Mastitis, Pagoda leaves, Staphylococcus Aureus
Co-Authors Ahmad, Mardiana Alprindo Sembiring Meliala Andayani Boang Manalu Andayani Boang Manalu Andayani Boang Manalu Andayani Boang Manalu Andayani Boang Manalu Andayani Boang Manalui Andriani Andriani Anggita, Rizliana Ariani, Peny Ariescha, Putri Ayu Ariescha, Putri Ayu Yessy Aryani, Peny Bahar, Dinillah Salsabila Damanik, Yunita Syahputri Dewi Tiansa Barus Eka Sri Wahyuni Eka Sri Wahyuni Eka Sriwahyuni Ela Nuraini Erlina Hayati Fitriana Ibrahim G.F Gustina Siregar G.F. Gustina Siregar Ginting, Daniel Suranta Ginting, Suventi Safrina Happy, Eva Harahap, Maharani Syahputri Hariati Hariati Hikmah, Khairatul Husna Sari Ibrahim, Fitriana Insani, Septa Dwi Israini Suriati Jayati, Mimin Ria Jufenti Zega Khairatul Hikmah Konsinur, Karmelya Amanda Kristin Natalia Kristin Natalia, Kristin Linda Margata Manalu, Andayani Boang Mardiah . Mardiana Ahmad Mardiana Ahmad Mendrofa, Wardah Nisa Fitri Muda, Sutan Syarif NANDA PRATAMA Nasution, Naimah Nency Melinda Nerdy, Nerdy Prihantono Prihantono Prihantono Prihantono Prihantono, Prihantono Purba, Tetty Junita Purti Ayu Yessy Ariescha Puspa Niat Putri Halawa Putri Ayu Yessie Ariescha Raden Mohamad Herdian Bhakti Rehulina Tarigan Saiful Batubara Sari, Husna Sari, Mediana Siddiq, Muhraza Silmi Hayati Siregar, Devi Linda SM Siregar, GF Gustina Sitanggang, Sari Sitepu, Arneil Sitepu, Marlen Sadrina Siti Nurul Faddilah Sitorus, Friska Ernita Stefani Anastasia Sitepu Sulaiman, Rasyid Sulastri Sulastri Suriani Suriani Syafira Nusaibah Tanjung, Dinda Sakhira Tarida Evelina Sihombing Tarigan, Salsalina Br Tetty Junita Purba Vitrilina Hutabarat Yulia Fahmila Yunita Syahputri Damanik