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All Journal International Journal of Health, Economics, and Social Sciences (IJHESS) Journal of Community and Clinical Pharmacy
Mohamad Aprianto Paneo
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Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Public Health Social Sciences

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Gambaran Kepatuhan Minum Obat Pada Psien Hipertensi Di Puskesmas Botupingge Di Kabupaten Bone Bolango Madania; Endah N. Djuwarno; Dizky Ramadani Putri Papeo; Mohamad Aprianto Paneo; baruadi., siti_yustika.; Manno, Mohamad Reski
Journal of Community and Clinical Pharmacy Vol. 2 No. 2 (2025): Volume 2, Number 2, 2025
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jccp.v2i2.183

Abstract

Hipertensi merupakan salah satu penyakit dengan pravalensi tertinggi. Salah satu masalah yang sering terjadi adalah ketidak patuhan pasien dalam pengobatan. Faktor penyebab ketidakpatuhan minum obat yaitu usia, jenis kelamin, pendidikan, dan pekerjaan. Kepatuhan dalam pengobatan dapat diartikan sebagai perilaku pasien yang mentaati semua nasehat dan petunjuk yang dianjurkan oleh kalangan tenaga medis untuk mencapai tujuan pengobatan. Tujuan penelitian ini untuk mengetahui kepatuhan minum obat pada pasien hipertensi di Puskesmas Botupingge Kabupaten Bone Bolango. Menggunakan kuesioner MMAS-8 terhadap 140 responden. Penelitian ini menggunakan metode observasional dan pengambilan data dilakukan dengan teknik purposive sampling. Hasil penelitian menunjukkan mayoritas pasien berusia 51-70 tahun sebesar 71,4%, berjenis kelamin perempuan sebesar 51,4%, pendidikan SD 56,4%, pekerjaan IRT dan Wiraswasta 35,7%. Berdasarkan gambaran kepatuhan minum obat pada pasien hipertensi di Puskesmas Botupingge dengan metode MMAS-8 termasuk dalam kategori patuh 63%.
Isolation and Characterization of Endophytic Fungi Producing L-Asparaginase Enzyme from Kencur Plant (Kaempferia galanga L.) Riyanti Djafar; Mahdalena Sy. Pakaya; A.Mu’thi Andy Suryadi; Mohamad Aprianto Paneo; Wiwit Zuriati Uno
International Journal of Health, Economics, and Social Sciences (IJHESS) Vol. 8 No. 2: April 2026
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/ijhess.v8i2.10927

Abstract

L-Asparaginase is an enzyme that catalyzes the hydrolysis of L-asparagine into L-aspartate and ammonia. This enzysne has important benefits in the medical field, particularly as a biological agent is the therapy of acute lymphoblastic leukemia, due to its ability to inhibit the growth of asparagine-dependent cancer cells. This study aims to isolate and characterize endophytic fungi derived from the rhizome of the aromatic ginger (Kaempferia galanga L.) plant, and to test the ability of these isolates to produce the L-asparaginase enzyme. The research method used is an experimental method conducted in a pharmaceutical microbiology laboratory Endophytic fungi were isolated using surface sterilization techniques and culturing on PDA media. Enzyme production was performed using the submerged fermentation method, while enzyme purification used the ammonium sulfate fractionation method with concentration ranges of 0-20%, 20-40%, 40-60%, 60-80%, and 80-100%. The L-asparaginase enzyme activity test was conducted using the Nesslerization method, with Asparagus as an inducer. The results showed that several endophytic fungal isolates were capable of producing L-asparaginase, as evidenced by a brownish color in the Nessler test. The purified fractions showed varying enzyme activity at each level of ammonium sulfate saturation. Thus,endophytic fungi from the aromatic ginger rhizome have potential as an alternative source for producing the L-asparaginase enzyme, which can be further developed in the fields of pharmacy and biotechnology
Co-Authors A.Mu’thi Andy Suryadi baruadi., siti_yustika. Dizky Ramadani Putri Papeo Endah N. Djuwarno Madania mahdalena sy. pakaya Manno, Mohamad Reski Riyanti Djafar Wiwit Zuriati Uno