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All Journal Jurnal Biologi Tropis Jurnal Ilmu Kedokteran dan Kesehatan
Widad, Najwa
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Potential of Marine Algae as Peripheral Neuropathy Therapy: An Article Review Widad, Najwa; Paerdoe, Lalu Dane Pemban; Qindi, Ahmad Sa’bi Al; Yulianti, Arwinda Febri; Hunaifi, Ilsa
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9412

Abstract

Peripheral neuropathy is a peripheral nerve disorders involving sensory, motor, or mixed nerves. First-line therapies for peripheral neuropathy, such as analgesics and SSRIs, often yield suboptimal therapeutic responses, have side effects, and provide inadequate disease control. Therefore, there is a need for adjuvant therapy utilizing bioactive compounds from natural sources, one of which is marine algae. Marine algae contain various compounds that have the potential to serve as safe and effective alternative adjuvant therapies for peripheral neuropathy. The literature used was collected from the PubMed, ScienceDirect, and Google Scholar databases with restrictions: publication years from 2015 to 2025 and in either Indonesian or English. The review indicated that several compounds found in marine algae, such as florotanins, terpenoids, polysaccharides, peptide proteins, essential amino acids, and omega-3 fatty acids, exhibited biological activities such as antioxidant, anti-inflammatory, and neuroprotective effects. These compounds showed potential as alternative adjuvant therapies for peripheral neuropathy. In conclusion, the compounds in marine algae demonstrated various biological activities, suggesting their potential for development as alternative adjuvant therapies for peripheral neuropathy. Further research is needed to test their safety and effectiveness before being applied in clinical practice.
Giant Cell Tumor of Bone, Tendon, and Soft Tissue: Pathogenesis and Clinical Manifestations Yulianti, Arwinda Febri; Paerdoe, Lalu Dane Pemban; Hidayat, Rahmat; Qindi, Ahmad Sa`bi Al; Hadinata, Lalu Gde Gilang Alid; Widad, Najwa; Febianisa, Tabitha Afifah; Pramesti, Evane Dyahayu; Khairifathiyyah, Khairifathiyyah; Amalia, Azka; Purnaning, Dyah
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10350

Abstract

Giant Cell Tumor (GCT) is a primary neoplasm that is intermediate malignant, characterized by aggressive local growth and the possibility of metastasis, especially to the lungs. Giant Cell Tumor (GCT) occurs in bones, tendons, and soft tissues. The purpose of this literature study is to identify differences in GCT manifestations in various anatomical locations, evaluate risk factors that contribute to tumor growth and recurrence, and assess the effectiveness of various therapeutic modalities that have been used, both conservative and operative. The method used is a literature study by reviewing various scientific journals obtained from the database. The findings show that Giant Cell Tumor (GCT) is a group of neoplasms that are histologically similar but have different clinical, molecular characteristics, and anatomical locations, including GCT in bones (GCTB), tendons (GCTTS), and soft tissues (GCTST). Although generally classified as benign, GCT can be locally aggressive with a risk of recurrence and in some cases is capable of metastasis, especially to the lungs. GCTB is most commonly found in the long bones of individuals aged 20–40 years and is characterized by the H3F3A mutation, which is an important diagnostic marker. GCTTS, which originates in the synovium, is more common in women aged 30–50 years and shows increased CSF1 expression due to a genetic translocation.
Diagnosis And Comprehensive Management Of Thyroid Storm: A Literature Review Husodo, Dewi Puspitorini; Pramudiantara, Gede Naradhea; Wibawa, Galang Edi; Suryantarini, Ni Wayan Puspa Wijaya; Widad, Najwa; Bramantyo, Rofi
Jurnal Ilmu Kedokteran dan Kesehatan Vol 13, No 4 (2026): Volume 13 Nomor 4
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v13i4.23240

Abstract

Thyroid storm is a life-threatening endocrine emergency characterized by severe hypermetabolism and multiorgan dysfunction with mortality rates ranging from 10–30%. Delayed diagnosis and inappropriate management significantly contribute to poor clinical outcomes. This study is a literature review conducted through systematic searches in PubMed, Google Scholar, Wiley, Springer, and ScienceDirect databases for articles published between 2015 and 2025 using keywords “thyroid storm,” “hyperthyroidism,” “emergency,” “diagnosis,” and “management.” A total of 30 relevant articles, including case reports, cohort studies, and original research, were analyzed descriptively. The findings show that thyroid storm occurs in approximately 1–2% of hospitalized hyperthyroid patients, with global mortality reaching 20–30% and 8–25% in Indonesia. Early diagnosis using the Burch-Wartofsky Point Scale (score 45), combined with Japanese Thyroid Association criteria, improves diagnostic accuracy and facilitates prompt treatment. Initial management focuses on ABCDE stabilization, fluid resuscitation, and supportive care, followed by pharmacological therapy including antithyroid drugs (propylthiouracil or methimazole), iodine, beta-blockers, and corticosteroids. In refractory cases, plasmapheresis may be required, while definitive therapy such as thyroidectomy or radioiodine is performed after achieving euthyroid status. Thyroid storm requires rapid recognition and a structured, multidisciplinary management approach, and integration of validated diagnostic tools with comprehensive treatment strategies is essential to improve patient outcomes and reduce mortality.
Co-Authors Amalia, Azka Bramantyo, Rofi Febianisa, Tabitha Afifah Hadinata, Lalu Gde Gilang Alid Husodo, Dewi Puspitorini Ilsa Hunaifi, Ilsa Khairifathiyyah, Khairifathiyyah Paerdoe, Lalu Dane Pemban Pramesti, Evane Dyahayu Pramudiantara, Gede Naradhea Purnaning, Dyah Qindi, Ahmad Sa`bi Al Qindi, Ahmad Sa’bi Al Rahmat Hidayat Suryantarini, Ni Wayan Puspa Wijaya Wibawa, Galang Edi Yulianti, Arwinda Febri