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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Biologi Tropis Jurnal Pengabdian Magister Pendidikan IPA Indonesian Physical Review Jurnal Ilmiah Farmako Bahari Indonesian Journal of Global Health research Jurnal Syntax Fusion : Jurnal Nasional Indonesia Jurnal Pepadu
Purnaning, Dyah
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Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Hubungan Tingkat Pengetahuan Terkait Pola Makan Dan Aktivitas Fisik Dengan Status Kadar Gula Darah Pada Pasien Diabetes Melitus Nurmujaahida, Nurmujaahida; Rahmadhona, Devi; Purnaning, Dyah
Jurnal Syntax Fusion Vol 2 No 10 (2022): Jurnal Syntax Fusion: Jurnal Nasional Indonesia
Publisher : CV RIFAINSTITUT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/fusion.v2i02.174

Abstract

Diabetes melitus merupakan kondisi klinis yang menggambarkan gangguan atau penurunan fungsi pankreas dalam menghasilkan insulin yang cukup bagi tubuh. Kurangnya pengetahuan tentang diabetes melitus mempengaruhi kepatuhan pasien dalam penanganan pengobatan. Hal ini memicu Peneliti untuk melakukan penelitian lebih lanjut terkait “Hubungan Tingkat Pengetahuan Terkait Pola Makan dan Aktivitas Fisik Dengan Status Kadar Gula Darah Pada Pasien Diabetes Melitus Di Rumah Sakit Umum Daerah Kota Mataram”. Penelitian ini menggunakan desain cross-sectional. Responden penelitian ini adalah penderita diabetes melitus rawat jalan yang terdaftar April 2021 - Mei 2021 di Rumah SakitnUmum Daerah Kota Mataram. Terdapat hubungan yang bermakna antara tingkat pengetahuan pola makan dengan status kadar gula darah pasien diabetes melitus dengan nilai p= 0.014 < 0,05. Serta terdapat hubungan yang bermakna antara tingkat pengetahuan aktivitas fisik dengan status kadar gula darah pasien diabetes melitus dengan nilai p = 0.000 < 0,05. Terdapat hubungan yang bermakna antara tingkat pengetahuan pola makan dan tingkat pengetahuan aktifitas fisik dengan status kadar gula darah pasien DM
Isolation of Chitosan Biopolymer from Nacre (Pinctada maxima) as Bone Scaffold Candidate Taufik S, Ahmad; Alawiyah, Geby; Rahayu, Susi; Kurniawidi, Dian W; Handayana, I Gusti Ngurah Yudi; Cahyawati, Triyana Dyah; Purnaning, Dyah; Amin, Muhamad
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.44794

Abstract

The rising incidence of bone injuries necessitates researching and developing safe bone replacement materials. Chitosan biopolymer is one of the available materials. Because it is non-toxic, biocompatible, and biodegradable, chitosan can be employed as a bone scaffold material. According to the European Pharmacopeia 6.0 (Eur: Ph 6.0), chitosan, with a deacetylation level of more than 70%, is safe for medicinal usage. The purpose of this research was to analyze the  characteristics of chitosan isolated from nacre and the influence of nacre powder mass  on the degree of deacetylation of  chitosan. Chitosan was extracted by the processes of deproteination, demineralization, and deacetylation. Organoleptic tests, yield calculations for each stage, examination of the degree of deacetylation, creation of functional groups, and vibrational modes based on Fourier Transform Infrared (FTIR) data were performed on the isolated chitosan. The produced chitosan exhibited the properties of being beige color, odorless, and in powder form. The yield of insulation results obtained by the mass of chitosan. 3.7 % of the mass of nacre powder. The resultant chitosan has the formation of hydroxyl (OH) and amine (NH2) groups and vibrational stretching and bending modes. The variation in nacre powder mass throughout the isolation procedure altered the degree of deacetylation of the resultant chitosan and the wave number spectra of the hydroxyl (OH) and amine (NH2) groups. Chitosan, with a mass of 80 grams of nacre powder and a value of 76.94%, exhibited the highest degree of deacetylation. Considering that the functional groups generated in chitosan are comparable to those in bone, chitosan is a potential material for bone scaffolds.
INFLUENCE OF COMPOSITION AND LYOPHILIZATION TIME ON PHYSICAL PROPERTIES OF HA/Cs/Coll/ HYDROXYPROPYL METHYLCELLULOSE BIOCOMPOSITES FOR BONE SCAFFOLDS Purnaning, Dyah; Hurnah, Hurnah; Taufik S, Ahmad; Rahayu, Susi; Kurniawidi, Dian W.; Hadi, Kasnawi Al
Indonesian Physical Review Vol. 8 No. 2 (2025)
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/ipr.v8i2.474

Abstract

Biomaterial implants are one of the alternatives to replace damaged organs in the body system temporarily (scaffolding) or permanently. Bone biomaterial implants can be obtained through the manufacture of HA/Cs/Coll (HA/Cs/Coll) biocompositeses with the addition of Hydroxypropyl Methylcellulose (HPMC) matrix. The objective is to evaluate how variations in material composition and lyophilization time affect the physical properties of the biocomposites, including density, compressive strength, Young’s modulus, and surface morphology. The manufacture of  biocomposites uses the mechanical thermal method for mixing materials and the freeze drying method for the biocomposites drying process. Composition ratios of HA:Cs/Coll were varied at 3:7, 5:5, and 7:3, while lyophilization durations were set at 24, 48, and 72 hours. Characterizations were performed through density measurements, mechanical testing using a Tensilon machine, and surface morphology analysis using a digital microscope. The results showed that the comparison of biocomposites with a ratio of 7:3 had the highest density of 0.150 gr/cm³, compressive strength of 0.046 MPa, and young modulus of 0.3 MPa. Meanwhile, the biocomposites that was lyophilized for 48 hours showed the best balance between a density of 0.145 gr/cm³, a compressive strength of 0.08 MPa, and a young modulus of 0.17 MPa. Morphological analysis revealed improved porosity and surface uniformity with longer freeze-drying times. Based on this, the resulting HA/Cs/Coll biocompositese has potential as an implant material but further research is needed to improve its mechanical properties by increasing the concentration of the binder, namely HPMC.
Effect of Injectable Bone Substitute Preparation Formulation on Microscopic and Macroscopic Characteristics for Bone Graft Alaydrus, M. Mukaddam; Rahayu, Susi; Purnaning, Dyah; Isa A.A, Maz; Oktri P, Awanda; Taufik S, Ahmad
Jurnal Ilmiah Farmako Bahari Vol 16 No 2 (2025): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v16i2.42506

Abstract

Biocompatible, mechanically stable, and easy-to-use injectable biomaterials are often needed for bone defects caused by trauma, disease, or surgery. This study aims to investigate the effect of polyvinyl alcohol (PVA) concentration on the microscopic and macroscopic characteristics of injectable bone substitute (IBS) formulations composed of Hydroxyapatite (HAp), chitosan, and PVA. The biopolymer chitosan was extracted from pearl oyster shell waste (Pinctada maxima), and HAp was synthesized via precipitation. The formulations were prepared with varied PVA concentrations (5%, 10%, and 15%) and evaluated for their structural, physicochemical, and functional properties. Fourier-transform infrared (FTIR) spectroscopy was employed to determine the presence of functional groups and molecular interactions. Results showed that increasing PVA content enhanced the intensity and sharpness of phosphate () bands, with Sample C (15% PVA) exhibiting the strongest interaction, indicated by a peak shift to 1047.32 cm⁻¹. Organoleptic observations revealed stable color across all samples, with increasing viscosity and paste-like consistency observed in higher PVA concentrations. Sample C had the highest viscosity (82.2 dPa·s) and the lowest injectability (92.43%), while Sample A exhibited the highest injectability (98.33%) and the lowest viscosity (2.79 dPa·s). Sample B (10% PVA) showed balanced characteristics with a viscosity of 38.93 dPa·s and injectability of 97.26%, aligning closely with ideal ranges for injectable biomaterials. Density measurements indicated that all samples approximated or exceeded the minimum density of healthy bone, with Sample C reaching 1.18 g/cm³. pH monitoring over 21 days revealed a consistent value of ~6, suggesting good chemical stability. These results demonstrate that the 15% PVA formulation achieves an optimal compromise between physicochemical properties and clinical applicability. This composite's injectability enables precise defect filling and promotes new bone formation, making it a superior and promising alternative as an injectable bone graft material in patients.
Bilateral Achilles Tendon Rupture Following A Fall from Height: Case Report Mahendra, I Gede Bramantya Surya; Purnaning, Dyah
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6960

Abstract

Achilles tendon rupture is an injury characterized by partial or complete disruption of the Achilles tendon, commonly caused by trauma or a sudden change in foot position. This condition accounts for approximately 20% of all major tendon ruptures. This study aims to present and analyze a rare case of bilateral Achilles tendon rupture, emphasizing the clinical presentation, diagnostic challenges, and management considerations. Men are at 2–12 times higher risk than women, with the incidence increasing between the ages of 40 and 59 years. Diagnosis is established through history taking, physical examination, and imaging modalities such as ultrasonography or MRI. We report a case of a 53-year-old male who presented with pain and swelling in both posterior ankles for the past three months, following a fall from a height of approximately four meters. The patient experienced limited mobility and required a walking aid. Physical examination revealed bilateral edema, a palpable defect in the Achilles tendon, tenderness, a positive Thompson test, and weakness of plantar flexion. MRI confirmed bilateral Achilles tendon rupture. The patient had previously undergone conservative management, including the application of an ankle strap and administration of nonsteroidal anti-inflammatory drugs, with no improvement. Bilateral Achilles tendon rupture is a rare condition, typically resulting from high-energy trauma. Delayed diagnosis and treatment may increase the risk of complications and long-term disability. Management options include conservative or surgical approaches, selected based on patient age, extent of rupture, and activity level. Bilateral Achilles tendon rupture following a fall from height is an uncommon case, highlighting the importance of prompt diagnosis and appropriate treatment to prevent permanent functional impairment.
Giant Cell Tumor of Bone, Tendon, and Soft Tissue: Pathogenesis and Clinical Manifestations Yulianti, Arwinda Febri; Paerdoe, Lalu Dane Pemban; Hidayat, Rahmat; Qindi, Ahmad Sa`bi Al; Hadinata, Lalu Gde Gilang Alid; Widad, Najwa; Febianisa, Tabitha Afifah; Pramesti, Evane Dyahayu; Khairifathiyyah, Khairifathiyyah; Amalia, Azka; Purnaning, Dyah
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10350

Abstract

Giant Cell Tumor (GCT) is a primary neoplasm that is intermediate malignant, characterized by aggressive local growth and the possibility of metastasis, especially to the lungs. Giant Cell Tumor (GCT) occurs in bones, tendons, and soft tissues. The purpose of this literature study is to identify differences in GCT manifestations in various anatomical locations, evaluate risk factors that contribute to tumor growth and recurrence, and assess the effectiveness of various therapeutic modalities that have been used, both conservative and operative. The method used is a literature study by reviewing various scientific journals obtained from the database. The findings show that Giant Cell Tumor (GCT) is a group of neoplasms that are histologically similar but have different clinical, molecular characteristics, and anatomical locations, including GCT in bones (GCTB), tendons (GCTTS), and soft tissues (GCTST). Although generally classified as benign, GCT can be locally aggressive with a risk of recurrence and in some cases is capable of metastasis, especially to the lungs. GCTB is most commonly found in the long bones of individuals aged 20–40 years and is characterized by the H3F3A mutation, which is an important diagnostic marker. GCTTS, which originates in the synovium, is more common in women aged 30–50 years and shows increased CSF1 expression due to a genetic translocation.
The Relationship Between Stunting and Anemia in Toddlers in Malaka Coastal Area, North Lombok Danianto, Ario; Cholidah, Rifana; Amalia, Emmy; Purnaning, Dyah
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7990

Abstract

Stunting is a major chronic nutritional problem with a high prevalence in Indonesia. This issue is crucial as it affects the quality of Indonesia's human resources in the future. One of the consequences of stunting is the increased incidence of anemia in toddlers. Anemia occurring early in life disrupts physical growth and leads to growth retardation. The relationship between anemia and stunting is an overlapping influence stemming from various levels. Efforts to prevent and reduce the rates of stunting and anemia must involve all parties comprehensively. Anemia in toddlers is a global health problem, both in terms of severity and prevalence. Globally, 1.6 million people are affected by anemia, and 47.4% of them are preschool-aged children. This study aims to determine the relationship between the occurrence of stunting and anemia in toddlers. The research was conducted through an analytical observational survey with a cross-sectional design. In this study, in the normal toddler group, of 26 samples, 25 children (96.15%) had normal Hb levels, and 1 child had mild anemia (3.85%). Meanwhile, in the 30 stunted toddlers, all samples had normal Hb levels (100%). The average Hb level in normal toddlers was 12.82 mg/dl, and in stunted toddlers, it was 12.81 mg/dl. No significant difference was found between the Hb levels of normal and stunted toddlers, with a p-value of 0.977 (p > 0.05).
The Study of Effectiveness of Chitosan from Pearl Oyster (Pinctada maxima) Shell as Antibacterial in Bone Scaffold Application Alaydrus, Mukaddam; Purnaning, Dyah; Ansyori, Maz Isa; Septiani, Nonik; Alawiyah, Geby; Rahayu, Susi; Taufik, Ahmad
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.8135

Abstract

Chitosan is a functional material with potential for bone scaffolds due to its antibacterial properties, biocompatibility, biodegradability, low toxicity, and ability to support tissue regeneration and prevent infections in graft implantation.This study aims to identify changes in functional groups in each isolation process and identify the effect of chitosan concentration  on the activity of Straphylococcus aureus and Escherichia coli bacteria. Chitosan isolation methods are demineralization, deproteination, decolorization, and deacetylation by microwave irradiation. Analysis of chitosan functional groups using FTIR, while antibacterial activity test using diffusion method. Isolation of chitosan from pearl oyster shells (Pinctada maxima sp.) obtained a degree of deacetylation of chitosan of 95.37%. Pearl oyster shell powder identified typical peaks of calcium carbonate (CaCO₃). The demineralized powder sample had calcium carbonate (CO₃²⁻) peaks that disappeared. Furthermore, the deproteinated powder sample produced peaks with amide groups (C=O dan N-H) of reduced protein. Decolorized powder samples did not show drastic changes in the bands of the deproteinated powder spectra, but the spectra could show cleaner and clearer peaks without any interference from pigments. The last, deacetylated powder sample showed a decrease in peak intensity in the 1650 cm⁻¹ (C=O amide). The analysis of the ability of chitosan to inhibit the growth of E. Coli and S. Aureus bacteria was effective at a minimum chitosan concentration of 20%. In comparison, antibacterial activity in S. aureus is better than in E. coli. Chitosan from this shell can serve as an antibacterial, but its manufacturing techniques need optimization for better efficacy.
The Knowledge Level of Elderly in Karang Taliwang Village and the Incidence of Low Back Pain in 2025 Lioni, Ni Kadek; Wedayani, Anak Agung Ayu Niti; Purnaning, Dyah; Alaydrus, Mukaddam
Jurnal Biologi Tropis Vol. 25 No. 1 (2025): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i1.8571

Abstract

Low Back Pain (LBP) is a prevalent musculoskeletal problem worldwide, particularly among the elderly population. This study aims to analyze the relationship between the level of knowledge among elderly individuals in Karang Taliwang Village and the incidence of LBP. A quantitative approach with a cross-sectional design was employed, using an ordinal scale to measure knowledge levels and a nominal scale for LBP incidence. The results indicate a significant relationship between knowledge levels and LBP incidence, where elderly individuals with lower knowledge levels tend to experience LBP more frequently. This study concludes that enhancing education on LBP risk factors and prevention is essential for reducing its prevalence among the elderly. The scientific implication of this study highlights the need for evidence-based educational interventions to lower LBP prevalence and improve the quality of life among older adults.
SIRKUSMSI ANAK YATIM DAN DHUAFA DAERAH PESISIR LOMBOK BARAT Zuhan, Arif; Priyanto, Bambang; Rohadi, Rohadi; Haikal, Zikrul; Sunanto, Sunanto; Nandana, Pandu Ishaq; Anshori, Maz Isa; Taufik, Ahmad; Purnaning, Dyah; Zulkarnaen, Decky Aditya
Jurnal Pepadu Vol 4 No 4 (2023): Jurnal Pepadu
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/pepadu.v4i4.3755

Abstract

Pendahuluan: Indonesia merupakan Negara kepulauan terbesar di dunia yang terdiri dari 17.499 Pulau sepanjang nusantara. Anak-anak yatim dan dhuafa merupakan salah satu sarana dosen untuk melaksanakan tridharma dalam bentuk kepedulian pelayanan kesehatan melalui sirkumsisi. Pelayanan kesehatan pada anak daerah pesisir dapat meningkatkan derajat kesehatan. Metode Kegiatan: dilakukan pelayanan kesehatan berupa khitanan massal pada yatim dan dhuafa pada 2 tempat yaitu Pondok Pesantren Subulassalam, Sekotong dan Masjid Baitutrrahman Kekalik, Mataram. Hasil: 20 Anak yatim dan dhuafa ikut serta dalam kegiatan. Teknik khitan yang digunakan adalah metode dorsumsisi dan dorsumsisi modifikasi. Kesimpulan: sirkumsisi bermanfaat untuk anak yatim daerah pesisir.
Co-Authors Ahmad Taufik Ahmad Taufik S Alawiyah, Geby Alaydrus, M. Mukaddam Alaydrus, Mukaddam Amalia, Azka Amalia, Emmy Anak Agung Ayu Niti Wedayani Andari, Marie Yuni Anshori, Maz Isa Ansyori, Maz Isa Ario Danianto, Ario Bambang Priyanto, Bambang Cahyawati, Triyana Dyah Decky Aditya Zulkarnaen Elizar, Lale Justin Amelia Febianisa, Tabitha Afifah Hadi, Kasnawi Al Hadinata, Lalu Gde Gilang Alid Haikal, Zikrul Handayana, I Gusti Ngurah Yudi Hurnah, Hurnah Isa A.A, Maz Jumsa, Muhammad Rizkinov Khairifathiyyah, Khairifathiyyah Kurniawidi, Dian W Kurniawidi, Dian W. Lioni, Ni Kadek Mahendra, I Gede Bramantya Surya Muhamad Amin Nandana, Pandu Ishaq Nurmujaahida, Nurmujaahida Oktri P, Awanda Paerdoe, Lalu Dane Pemban Pramesti, Evane Dyahayu Qindi, Ahmad Sa`bi Al Rahmadhona, Devi Rahmat Hidayat Rifana Cholidah, Rifana Rohadi Rohadi Septiani, Nonik Sunanto Sunanto Susi Rahayu Widad, Najwa Yulianti, Arwinda Febri Zuhan, Arif