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Literature Review: Pathophysiology, Clinical Features and Management of Cor Pulmonale Rameci, Hadil Hudati Awwari; Maya, Elyana Labib; Fauzan, Naufal Revaldy; Pambudi, Novanda Ayu Dila Putri; Anugrah, Yunan Prabu Jaya
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10357

Abstract

Cor pulmonale refers to a condition affecting the right ventricle of the heart due to increased pulmonary pressure causing dilation or hypertrophy. This article was compiled using a literature review method. This disorder can manifest acutely, often triggered by a massive pulmonary embolism, severe pneumonia, or Acute Respiratory Distress Syndrome (ARDS), or chronically, usually caused by Chronic Obstructive Pulmonary Disease (COPD), pulmonary fibrosis, bronchiectasis, sleep apnea, or obesity-related hypoventilation syndrome. The primary cause is a disturbance in ventilation-perfusion balance that progresses to pulmonary hypertension. Symptoms usually appear in the advanced stages and include shortness of breath, fatigue, weakness, fainting with exertion, chest discomfort, abdominal swelling, lower extremity edema, wheezing, and coughing. Diagnostic evaluation includes chest radiography, computed tomography (CT scan), electrocardiography (ECG), and cardiac catheterization, the latter being the definitive method. Treatment strategies aim to correct hypoxemia, relieve right ventricular strain, and address the underlying cause of the condition.
Labiopalatognathoschisis: A Systematic Review of Risk Factors, Diagnosis, and Therapeutic Approaches: A Systematic Review of Risk Factors, Diagnosis, and Therapeutic Approaches Suryadharma, Kadek A.; Rahma, Baiq Suyatmin; Candra, Tania Happy; Maya, Elyana Labib; Airlangga, Arya P.; Ningsih, Nur A. Ahya; Arigi, Lalu Ahmad Gamal
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10289

Abstract

Labiopalatognatoschisis, or cleft lip with or without cleft palate, is one of the most common craniofacial congenital anomalies, associated with functional, aesthetic, and psychosocial challenges. Its management is complex, requiring early detection and multidisciplinary care. This study aimed to identify major risk factors, evaluate diagnostic approaches, and review effective management strategies. A systematic literature review was conducted using PubMed, Google Scholar, and ProQuest for articles published between 2013 and 2023 with the terms “labiopalatognatoschisis,” “cleft lip,” and “cleft palate.” Studies addressing etiology, diagnosis, or management were included, while irrelevant publications were excluded. Findings showed that genetic predisposition, family history, maternal nutritional deficiencies, teratogenic drug use, and prenatal exposure to harmful substances are key risk factors. Prenatal ultrasonography and MRI can aid diagnosis, though cleft palate detection remains limited. Management requires staged surgical repair and coordinated input from plastic surgeons, ENT specialists, orthodontists, pediatricians, and speech therapists. The review concludes that enhancing prenatal screening, integrating psychosocial support, and advancing research on diagnostic accuracy and long-term multidisciplinary outcomes are crucial for improving prognosis and quality of life.