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All Journal Jurnal Biologi Tropis Nutriology: Jurnal Pangan, Gizi, Kesehatan Mandala of Health : A Scientific Journal
Sari, Padmi Kartika
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Public Health

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Aortic Stenosis Review: Pathophysiology, Clinical Symptoms, and Key Diagnostic Signs Maharani, Baiq Syarifaturrayyan; Febriana, Nanggi Qoriatul; Sari, Padmi Kartika; Maudina, Baiq Zaskia; Hakim, Baiq Sheila Oktalia
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10105

Abstract

Aortic stenosis is among the most common valvular heart diseases, particularly in the elderly, and remains a major cause of morbidity and mortality. It is characterized by narrowing of the aortic valve, leading to increased afterload, compensatory left ventricular hypertrophy, and eventual heart failure or sudden death. To summarize updated evidence on the pathophysiology, clinical manifestations, and diagnostic signs of aortic stenosis. A literature review was conducted through systematic searches of PubMed, ScienceDirect, and Google Scholar, prioritizing publications from the last ten years. Articles on anatomy, physiology, pathophysiology, clinical features, diagnostic findings, and disease progression were critically analyzed. Aortic stenosis develops through degenerative calcification, rheumatic autoimmune inflammation, or congenital malformation. Disease progression leads to elevated transvalvular gradient, reduced stroke volume, and left ventricular hypertrophy. Typical symptoms include angina, syncope, and heart failure. Key diagnostic signs are a crescendo–decrescendo systolic ejection murmur radiating to the carotid arteries and the Gallavardin phenomenon. Aortic stenosis is a progressive valvular disease with complex pathophysiological mechanisms. Comprehensive understanding of its biological processes, clinical manifestations, and diagnostic signs is essential to support early detection and timely management. Such efforts may reduce morbidity and mortality while paving the way for innovative therapeutic strategies in the future.
CURRENT DIAGNOSIS AND MANAGEMENT OF CROHN’S DISEASE: A LITERATURE-BASED REVIEW Pambudi, Novanda Ayu Dila Putri; Siregar, Chivan Agustinus; Santoso, Arysatya Syandana Ararya; Sari, Padmi Kartika; Rachman, Amanda Azkiyah; Hudhori, Syalsa; Muharis, Nihal Ahmad
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.17307

Abstract

Crohn’s disease is a chronic inflammatory disorder of the gastrointestinal tract with increasing global incidence, shifting from a predominantly Western condition to a rising burden in Asia and other developing regions. Diagnosis requires a multimodal approach, integrating history, laboratory testing, endoscopy with validated activity scores, histopathology, and imaging such as magnetic resonance enterography or intestinal ultrasound. The 2024 ECCO guidelines emphasize fecal biomarkers like calprotectin as non-invasive monitoring tools within a treat-to-target strategy. Management includes pharmacological therapy (corticosteroids, immunomodulators, biologics, and novel small molecules), non-pharmacological measures (exclusive enteral nutrition, micronutrient supplementation, and diet modification), and surgery for refractory strictures, perforations, or complex fistulas. Beyond physical symptoms, Crohn’s disease carries a significant psychosocial burden, underscoring the need for nutritional and psychological support. Despite therapeutic advances, no curative treatment exists. Future research should focus on identifying more accurate biomarkers, improving accessibility to advanced therapies in low-resource settings, and exploring innovative approaches such as precision medicine, microbiota-targeted therapy, and genetic-based interventions.
Studi Cross Sectional Hubungan Pemberian ASI Eksklusif dengan Kejadian Stunting Sari, Padmi Kartika; Isnaeni, Wilya; Sari, Putu Suwita
Nutriology : Jurnal Pangan, Gizi, Kesehatan Vol. 6 No. 2 (2025): Oktober 2025
Publisher : Program Studi Gizi, Universitas Bumigora

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/nutriology.v6i2.5421

Abstract

Stunting is a crucial health problem in Indonesia due to its high prevalence of 21.6% in 2022. Stunting is influenced by many factors, one of which is exclusive breastfeeding. This study aims to determine the relationship between exclusive breastfeeding and stunting in children (6-9 months) in the working area of the Labuhan Haji Health Center, East Lombok Regency. This research method is observational analytic with a cross-sectional approach. The sample size was 86, selected using a simple random sampling method. Primary data were obtained from questionnaires on breastfeeding history, environmental sanitation, and complementary feeding history using an interviewer-administered questionnaire. Secondary data were obtained from data at the Labuhan Haji Health Center. Data analysis of both variables was performed using the Chi-Square statistical test. Bivariate test results showed a significant association between exclusive breastfeeding and stunting in children (6-9 months) in the working area of the Labuhan Haji Health Center, East Lombok Regency (p-value = 0,000; PR = 6,932). In Conclusion: There is a significant association between exclusive breastfeeding and stunting in children (6-9 months) in the working area of the Labuhan Haji Health Center, East Lombok Regency.
Specific Learning Disorder in School Age Children: A Literature Review on Early Detection and Its Challenges Maya, Elyana Labib; Rachman, Amanda Azkiyah; Patandianan, Firdaus Kamma; Sari, Padmi Kartika; Elizar, Lale Justin Amelinda
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10797

Abstract

Specific Learning Disorder (SLD) is a neurodevelopmental disorder that affects a child’s basic abilities in reading, writing, and arithmetic. This disorder is often undetected in the early stages, leading to long-term academic difficulties and psychosocial problems. This literature review aims to provide a comprehensive overview of SLD, including its definition, classification, risk factors, signs and symptoms, diagnostic criteria, as well as the challenges and barriers in early detection. The methodology employed in this review was a structured literature search and critical appraisal of relevant sources, including peer-reviewed journal articles, academic textbooks, and established diagnostic guidelines. The results of the review indicate that early detection and appropriate intervention are crucial in helping children with SLD achieve optimal development. The roles of teachers, pediatricians, and other professionals are essential in the detection and management of SLD. Challenges in early detection include lack of awareness, limited resources, stigma, the standardization of diagnostic tools, as well as constraints in research and funding. Specific Learning Disorder (SLD) is a neurodevelopmental disorder that affects children’s academic abilities, particularly in reading, writing, and arithmetic. Early detection is crucial to enable timely intervention and prevent long-term consequences; however, various challenges still hinder early detection.
Co-Authors Elizar, Lale Justin Amelinda Febriana, Nanggi Qoriatul Hakim, Baiq Sheila Oktalia Hudhori, Syalsa Isnaeni, Wilya Maharani, Baiq Syarifaturrayyan Maudina, Baiq Zaskia Maya, Elyana Labib Muharis, Nihal Ahmad Pambudi, Novanda Ayu Dila Putri Patandianan, Firdaus Kamma Rachman, Amanda Azkiyah Santoso, Arysatya Syandana Ararya Sari, Putu Suwita Siregar, Chivan Agustinus