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All Journal Jurnal Biologi Tropis Nutriology: Jurnal Pangan, Gizi, Kesehatan Mandala of Health : A Scientific Journal
Sari, Padmi Kartika
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Public Health

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Aortic Stenosis Review: Pathophysiology, Clinical Symptoms, and Key Diagnostic Signs Maharani, Baiq Syarifaturrayyan; Febriana, Nanggi Qoriatul; Sari, Padmi Kartika; Maudina, Baiq Zaskia; Hakim, Baiq Sheila Oktalia
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10105

Abstract

Aortic stenosis is among the most common valvular heart diseases, particularly in the elderly, and remains a major cause of morbidity and mortality. It is characterized by narrowing of the aortic valve, leading to increased afterload, compensatory left ventricular hypertrophy, and eventual heart failure or sudden death. To summarize updated evidence on the pathophysiology, clinical manifestations, and diagnostic signs of aortic stenosis. A literature review was conducted through systematic searches of PubMed, ScienceDirect, and Google Scholar, prioritizing publications from the last ten years. Articles on anatomy, physiology, pathophysiology, clinical features, diagnostic findings, and disease progression were critically analyzed. Aortic stenosis develops through degenerative calcification, rheumatic autoimmune inflammation, or congenital malformation. Disease progression leads to elevated transvalvular gradient, reduced stroke volume, and left ventricular hypertrophy. Typical symptoms include angina, syncope, and heart failure. Key diagnostic signs are a crescendo–decrescendo systolic ejection murmur radiating to the carotid arteries and the Gallavardin phenomenon. Aortic stenosis is a progressive valvular disease with complex pathophysiological mechanisms. Comprehensive understanding of its biological processes, clinical manifestations, and diagnostic signs is essential to support early detection and timely management. Such efforts may reduce morbidity and mortality while paving the way for innovative therapeutic strategies in the future.
CURRENT DIAGNOSIS AND MANAGEMENT OF CROHN’S DISEASE: A LITERATURE-BASED REVIEW Pambudi, Novanda Ayu Dila Putri; Siregar, Chivan Agustinus; Santoso, Arysatya Syandana Ararya; Sari, Padmi Kartika; Rachman, Amanda Azkiyah; Hudhori, Syalsa; Muharis, Nihal Ahmad
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.17307

Abstract

Crohn’s disease is a chronic inflammatory disorder of the gastrointestinal tract with increasing global incidence, shifting from a predominantly Western condition to a rising burden in Asia and other developing regions. Diagnosis requires a multimodal approach, integrating history, laboratory testing, endoscopy with validated activity scores, histopathology, and imaging such as magnetic resonance enterography or intestinal ultrasound. The 2024 ECCO guidelines emphasize fecal biomarkers like calprotectin as non-invasive monitoring tools within a treat-to-target strategy. Management includes pharmacological therapy (corticosteroids, immunomodulators, biologics, and novel small molecules), non-pharmacological measures (exclusive enteral nutrition, micronutrient supplementation, and diet modification), and surgery for refractory strictures, perforations, or complex fistulas. Beyond physical symptoms, Crohn’s disease carries a significant psychosocial burden, underscoring the need for nutritional and psychological support. Despite therapeutic advances, no curative treatment exists. Future research should focus on identifying more accurate biomarkers, improving accessibility to advanced therapies in low-resource settings, and exploring innovative approaches such as precision medicine, microbiota-targeted therapy, and genetic-based interventions.
Hubungan Pemberian ASI Eksklusif dengan Kejadian Stunting: Studi Pendekatan Cross Sectional Sari, Padmi Kartika; Isnaeni, Wilya; Sari, Putu Suwita
Nutriology : Jurnal Pangan, Gizi, Kesehatan Vol. 6 No. 2 (2025): Oktober 2025
Publisher : Program Studi Gizi, Universitas Bumigora

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30812/nutriology.v6i2.5421

Abstract

Stunting is a crucial health problem in Indonesia due to its high prevalence of 21.6% in 2022. Stunting is influencedby many factors, one of which is exclusive breastfeeding. This study aims to determine the relationshipbetween exclusive breastfeeding and stunting in children (6-9 months) in the working area of the Labuhan HajiHealth Center, East Lombok Regency. This research method is observational analytic with a cross-sectional ap-approach. The sample size was 86, selected using a simple random sampling method. Primary data were obtainedfrom questionnaires on breastfeeding history, environmental sanitation, and complementary feeding history usingan interviewer-administered questionnaire. Secondary data were obtained from data at the Labuhan Haji HealthCenter. Data analysis of both variables was performed using the Chi-Square statistical test. Bivariate test results showed a significant association between exclusive breastfeeding and stunting in children (6-9 months) inthe working area of the Labuhan Haji Health Center, East Lombok Regency (p-value = 0,000; PR = 6,932). InConclusion: There is a significant association between exclusive breastfeeding and stunting in children (6-9 months)in the working area of the Labuhan Haji Health Center, East Lombok Regency.
Co-Authors Febriana, Nanggi Qoriatul Hakim, Baiq Sheila Oktalia Hudhori, Syalsa Isnaeni, Wilya Maharani, Baiq Syarifaturrayyan Maudina, Baiq Zaskia Muharis, Nihal Ahmad Pambudi, Novanda Ayu Dila Putri Rachman, Amanda Azkiyah Santoso, Arysatya Syandana Ararya Sari, Putu Suwita Siregar, Chivan Agustinus