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All Journal Jurnal Biologi Tropis Mandala of Health : A Scientific Journal
Pambudi, Novanda Ayu Dila Putri
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Public Health

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CURRENT DIAGNOSIS AND MANAGEMENT OF CROHN’S DISEASE: A LITERATURE-BASED REVIEW Pambudi, Novanda Ayu Dila Putri; Siregar, Chivan Agustinus; Santoso, Arysatya Syandana Ararya; Sari, Padmi Kartika; Rachman, Amanda Azkiyah; Hudhori, Syalsa; Muharis, Nihal Ahmad
Mandala Of Health Vol 18 No 2 (2025): Mandala of Health: A Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2025.18.2.17307

Abstract

Crohn’s disease is a chronic inflammatory disorder of the gastrointestinal tract with increasing global incidence, shifting from a predominantly Western condition to a rising burden in Asia and other developing regions. Diagnosis requires a multimodal approach, integrating history, laboratory testing, endoscopy with validated activity scores, histopathology, and imaging such as magnetic resonance enterography or intestinal ultrasound. The 2024 ECCO guidelines emphasize fecal biomarkers like calprotectin as non-invasive monitoring tools within a treat-to-target strategy. Management includes pharmacological therapy (corticosteroids, immunomodulators, biologics, and novel small molecules), non-pharmacological measures (exclusive enteral nutrition, micronutrient supplementation, and diet modification), and surgery for refractory strictures, perforations, or complex fistulas. Beyond physical symptoms, Crohn’s disease carries a significant psychosocial burden, underscoring the need for nutritional and psychological support. Despite therapeutic advances, no curative treatment exists. Future research should focus on identifying more accurate biomarkers, improving accessibility to advanced therapies in low-resource settings, and exploring innovative approaches such as precision medicine, microbiota-targeted therapy, and genetic-based interventions.
Feelings of Disappreciation in Health Workers: Impact Analysis and Improvement Efforts Siregar, Chivan; Pambudi, Novanda Ayu Dila Putri; Maharani, Baiq Syarifaturrayyan; Putri, Irma Santika
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10056

Abstract

Feelings of unappreciation among healthcare workers are a serious issue that often goes unnoticed. Contributing factors include lack of recognition from superiors and colleagues, unequal workload and compensation, and limited career development opportunities. These conditions negatively affect workers’ mental health and service quality. This study aims to identify the causes of unappreciation among healthcare workers, analyze its impact on well-being and performance, and propose strategies to enhance appreciation. A literature review was conducted using databases such as Google Scholar, PubMed, and ScienceDirect. Inclusion criteria included journal articles and books from the past ten years focusing on healthcare workers’ well-being, motivation, work environment, institutional rewards, and psychosocial aspects. Twenty-five key studies were critically reviewed. Underappreciation of healthcare workers has wide-ranging psychological, professional, and social impacts. Collaborative efforts between institutions, government, and society are essential to create a supportive environment, ensure fair recognition, and strengthen healthcare systems.
Literature Review: Pathophysiology, Clinical Features and Management of Cor Pulmonale Rameci, Hadil Hudati Awwari; Maya, Elyana Labib; Fauzan, Naufal Revaldy; Pambudi, Novanda Ayu Dila Putri; Anugrah, Yunan Prabu Jaya
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10357

Abstract

Cor pulmonale refers to a condition affecting the right ventricle of the heart due to increased pulmonary pressure causing dilation or hypertrophy. This article was compiled using a literature review method. This disorder can manifest acutely, often triggered by a massive pulmonary embolism, severe pneumonia, or Acute Respiratory Distress Syndrome (ARDS), or chronically, usually caused by Chronic Obstructive Pulmonary Disease (COPD), pulmonary fibrosis, bronchiectasis, sleep apnea, or obesity-related hypoventilation syndrome. The primary cause is a disturbance in ventilation-perfusion balance that progresses to pulmonary hypertension. Symptoms usually appear in the advanced stages and include shortness of breath, fatigue, weakness, fainting with exertion, chest discomfort, abdominal swelling, lower extremity edema, wheezing, and coughing. Diagnostic evaluation includes chest radiography, computed tomography (CT scan), electrocardiography (ECG), and cardiac catheterization, the latter being the definitive method. Treatment strategies aim to correct hypoxemia, relieve right ventricular strain, and address the underlying cause of the condition.
Co-Authors Anugrah, Yunan Prabu Jaya Fauzan, Naufal Revaldy Hudhori, Syalsa Irma Santika Putri Maharani, Baiq Syarifaturrayyan Maya, Elyana Labib Muharis, Nihal Ahmad Rachman, Amanda Azkiyah Rameci, Hadil Hudati Awwari Santoso, Arysatya Syandana Ararya Sari, Padmi Kartika Siregar, Chivan Siregar, Chivan Agustinus