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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Media Farmasi Indonesia
Latifa Amalia
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Other

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Formulation and SPF Evaluation of a Lip Oil Serum Combining Ethanol Extract of Butterfly Pea Flower and Lavender Oil Salsabila, Nurus Shobah; Annisa Fatmawati; Sundari Desi Nuryanti; Emelda; Ade Puspitasari; Latifa Amalia
Media Farmasi Indonesia Vol. 20 No. 2 (2025): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v20i2.341

Abstract

Exposure to ultraviolet (UV) radiation due to ozone layer depletion increases the risk of skin damage, particularly on the lips, which are more vulnerable due to their lack of melanin and sebaceous glands. This study aimed to formulate and evaluate the Sun Protection Factor (SPF) of a lip oil serum containing ethanol extract of butterfly pea flower (Clitoria ternatea L.) and lavender oil (Lavandula angustifolia). The formulation was prepared in a single base with four variants: a control (F0) and three active concentrations (F1, F2, F3). Physical evaluations included organoleptic tests, homogeneity, pH, spreadability, adhesion, and viscosity. The SPF values were assessed in vitro using UV-Vis spectrophotometry. All formulations demonstrated acceptable physical stability with pH values between 6.7–7.33, spreadability ranging from 6.85–7.34 cm, adhesion from 3.51–5.07 seconds, and viscosity from 777.6–839 cPS. The SPF increased proportionally with lavender oil concentration (F1 = 3.70, F2 = 4.09, F3 = 4.25), showing a strong positive correlation (r = 0.969). These findings suggest that the combined use of butterfly pea extract and lavender oil may offer mild UV protection and desirable physical properties, making it a promising candidate for natural, herbal-based lip care products.
Decoding Genetic Risk: A Genome-Wide Association and Functional Analysis of Variants Linked to Liver Cancer Susceptibility: Analysis of Variants Linked to Liver Cancer Susceptibility amukti, danang prasetyaning; Daru Estiningsih; Tetie Herlina; Latifa Amalia; Ifa Aris Suminingtyas; Moch. Saiful Bachri; Ria Indah Pratami; Imam Akbar; Muhammad Ma’ruf
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.14048

Abstract

Liver cancer is one of the leading causes of cancer death worldwide. Genetic factors play a role in determining a person's susceptibility to this disease. Genome-Wide Association Studies (GWAS) have identified several genetic variants associated with liver cancer, but their functional mechanisms still need to be further explored. Therefore, this study aims to identify genetic variants that contribute to liver cancer, evaluate their functional effects on proteins, analyze allele frequencies across global populations, and examine gene expression in various human tissues. This study used a bioinformatics approach to identify genetic variations associated with liver cancer from the GWAS Catalog. Five selected missense variants were analyzed using SIFT and PolyPhen-2 to assess their functional impact. Allele distributions in the global population were analyzed using 1000 Genomes Project data, and gene expression was analyzed using the GTEx Portal. The analysis identified 77 candidate genes with significant associations with liver cancer, based on p-values meeting the threshold (p < 5 × 10⁻⁸). Five genes in the Missense Variant category showed a strong association with liver cancer: IFNL3, SLC30A10, PNPLA3, OSMR, and CMTR2. In the analysis using SIFT and PolyPhen-2, the rs3096380 variant (CMTR2) was deleterious, and rs738409 (PNPLA3) and rs188273166 (SLC30A10) were deleterious and probably damaging, with the potential to disrupt protein function and contribute to the pathogenesis of liver cancer. Conclusion: Genetic variations rs738409 (PNPLA3) and rs188273166 (SLC30A10) are deleterious and probably damaging, potentially disrupting protein function and contributing to liver cancer pathogenesis.
Co-Authors Ade Puspitasari Annisa Fatmawati Danang Prasetyaning Amukti Daru Estiningsih Emelda Ifa Aris Suminingtyas Imam Akbar Moch. Saiful Bachri Muhammad Ma’ruf Nuryanti, Sundari Desi Ria Indah Pratami Salsabila, Nurus Shobah Tetie Herlina