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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) JURNAL FARMASIMED (JFM)
Ifa Aris Suminingtyas
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Medicine & Pharmacology

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Decoding Genetic Risk: A Genome-Wide Association and Functional Analysis of Variants Linked to Liver Cancer Susceptibility: Analysis of Variants Linked to Liver Cancer Susceptibility amukti, danang prasetyaning; Daru Estiningsih; Tetie Herlina; Latifa Amalia; Ifa Aris Suminingtyas; Moch. Saiful Bachri; Ria Indah Pratami; Imam Akbar; Muhammad Ma’ruf
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.14048

Abstract

Liver cancer is one of the leading causes of cancer death worldwide. Genetic factors play a role in determining a person's susceptibility to this disease. Genome-Wide Association Studies (GWAS) have identified several genetic variants associated with liver cancer, but their functional mechanisms still need to be further explored. Therefore, this study aims to identify genetic variants that contribute to liver cancer, evaluate their functional effects on proteins, analyze allele frequencies across global populations, and examine gene expression in various human tissues. This study used a bioinformatics approach to identify genetic variations associated with liver cancer from the GWAS Catalog. Five selected missense variants were analyzed using SIFT and PolyPhen-2 to assess their functional impact. Allele distributions in the global population were analyzed using 1000 Genomes Project data, and gene expression was analyzed using the GTEx Portal. The analysis identified 77 candidate genes with significant associations with liver cancer, based on p-values meeting the threshold (p < 5 × 10⁻⁸). Five genes in the Missense Variant category showed a strong association with liver cancer: IFNL3, SLC30A10, PNPLA3, OSMR, and CMTR2. In the analysis using SIFT and PolyPhen-2, the rs3096380 variant (CMTR2) was deleterious, and rs738409 (PNPLA3) and rs188273166 (SLC30A10) were deleterious and probably damaging, with the potential to disrupt protein function and contribute to the pathogenesis of liver cancer. Conclusion: Genetic variations rs738409 (PNPLA3) and rs188273166 (SLC30A10) are deleterious and probably damaging, potentially disrupting protein function and contributing to liver cancer pathogenesis.
The Role of Medication Adherence Companions on the Pharmacotherapy Outcomes of Hypertensive Patients at Bambanglipuro Community Health Center Aprianto A, Diki; Eva Nurinda; Ari Susiana Wulandari; Ade Puspitasari; Ifa Aris Suminingtyas
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/7r11af50

Abstract

Hypertension is a prevalent chronic condition in primary health care, particularly among geriatric patients requiring long-term therapy. Despite the availability of antihypertensive medications, achieving target blood pressure remains challenging and is often associated with poor medication adherence. Medication Adherence Companions (PMO) may improve adherence and enhance therapeutic outcomes. This study aimed to analyze the role of PMO in the pharmacotherapy outcomes of hypertensive patients at the Bambanglipuro Community Health Center. This analytic observational study with a cross-sectional design involved 101 geriatric patients diagnosed with hypertension. Data were collected using structured questionnaires covering patient characteristics, presence of PMO, medication adherence, and blood pressure control status. Data were analyzed descriptively and using multivariate logistic regression with a significance level of p < 0.05. The results showed that 64.4% of patients had a PMO, and 54.5% demonstrated high adherence. Patients with high adherence were more likely to achieve controlled blood pressure. Multivariate analysis revealed that the presence of PMO significantly increased the likelihood of controlled blood pressure (AOR = 2.77; 95% CI: 1.29–5.95; p = 0.009). Combination therapy was also significantly associated with blood pressure control (AOR = 2.25; p = 0.047). These findings suggest that Medication Adherence Companions can support successful hypertension pharmacotherapy among geriatric patients in primary health care settings.
Co-Authors Ade Puspitasari Aprianto A, Diki Ari Susiana Wulandari Danang Prasetyaning Amukti Daru Estiningsih Eva Nurinda Imam Akbar Latifa Amalia Moch. Saiful Bachri Muhammad Ma’ruf Ria Indah Pratami Tetie Herlina