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Lestari, Neli Aulia
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology

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Optimization of Eye Shadow Powder Formula Preparation of Buni Fruit Extract (Antidesma bunius L. Spreng) as Natural Dye Lestari, Neli Aulia; Hajrin, Wahida; Pratiwi, Eskarani Tri
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10140

Abstract

The use of synthetic dyes in cosmetics can cause side effects such as allergies. Therefore, the presence of natural dyes such as anthocyanins from berries is a safer alternative for the community. However, the stability of anthocyanins as natural dyes can be affected by pH. The purpose of this study was to determine the optimum concentration of citric acid and tartaric acid in eyeshadow powder preparations as pH stabilizers using the Simplex Lattice Design method. The research method used the sonication method. Then, the formulation results from running SLD were carried out and evaluated for particle size, adhesiveness, and pH. Data analysis used SLD to obtain the optimum formula. Then, the evaluation was carried out as before with additional evaluations of organoleptic tests, homogeneity and polish. Furthermore, the data were verified statistically with a one-sample t-test. The results obtained an extract yield of 22.9% and a positive anthocyanin content. Based on the SLD method, the optimum formula was obtained with a citric acid concentration of 1.49% and a tartaric acid concentration of 0.508%. Verification of the optimum formula showed no significant difference between the experimental response and the predicted response with a pH value of 5.75 ± 0.12; adhesive power of 11.66 ± 1.52%; and particle size of 126.32 ± 2.02 μm. The conclusion is that the optimum formula produces good physical characteristics and the verification results show agreement between the predicted response and the experimental results.
Article Review: Development of a new type of TB vaccine as a replacement for the BCG vaccine Sutanti, B. Novia Rahmadita; Ramdha, Ika Salsabila; Rizki, Alpha Alfi; Putri, Latifa Rahma; Lestari, Neli Aulia; Syaharani, Ninda; Sunarwidhi, Anggit Listyacahyani
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10884

Abstract

Tuberculosis (TB) remains a significant global public health threat. The existing BCG vaccine has limited effectiveness, particularly in preventing pulmonary TB in adults. This study aims to review the recent developments in the creation of new TB vaccines as alternatives to BCG. This research employs a systematic review method by collecting articles from the Google Scholar database. Inclusion criteria included articles published between 2014-2024 that are relevant to the development of new TB vaccines. Data analysis was conducted descriptively to identify potential vaccine candidates. Several new TB vaccine candidates have shown promising results, including TAT-Ag85B, MTBVAC, rBCG-LTAK63, and subunit vaccines such as Ag85A and LT70. These vaccines demonstrated increased immune responses and better protection compared to BCG in preclinical trials. Innovative approaches like the use of nanocarriers and prime-boost strategies also show potential in enhancing vaccine efficacy. The development of new TB vaccines indicates significant progress with several potential candidates that could replace or complement the BCG vaccine. However, further research is needed to evaluate the efficacy and safety of these vaccines in clinical trials in humans before they can be widely implemented.
Co-Authors Hajrin, Wahida Pratiwi, Eskarani Tri Putri, Latifa Rahma Ramdha, Ika Salsabila Rizki, Alpha Alfi Sunarwidhi, Anggit Listyacahyani Sutanti, B. Novia Rahmadita Syaharani, Ninda