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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Farmasains : Jurnal Ilmiah Ilmu Kefarmasian PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Sains dan Praktis
Indri Hapsari
Universitas Muhammadiyah Purwokerto
Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Pemodelan Pelepasan In Vitro Tablet Floating Teofilin Dengan Program Ddsolver Agus Siswanto; Indri Hapsari; Yusni Ulfiani Zulaikha; Eva Rosmawati
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 13 No. 01 Juli 2016
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

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Abstract

ABSTRAK Disolusi merupakan elemen penting dalam pengembangan obat terutama terkait dengan absorpsi dan bioavailabilitas sediaan. Penelitian ini bertujuan untuk menentukan kinetika pelepasan tablet floating teofilin secara in vitro. Tablet floating teofilin dibuat dengan metode granulasi basah menggunakan bahan tambahan HPMC K4M CR, NaHCO3, laktosa, dan magnesium stearat. Hasil evaluasi sifat fisik menunjukkan bahwa tablet floating teofilin mempunyai bobot yang seragam (CV=1,93%), kekerasan yang baik (8,4 kg), dan kerapuhan yang rendah (0,05%). Evaluasi model pelepasan dengan program DDSolver menggunakan 2 kriteria: 1). Parameter statistik: R2adjusted, mean square error (MSE), weighted sum of squares (WSS), akaike information criterion (AIC), model selection criterion (MSC); 2). Visual goodness of fit (GOF). Hasil evaluasi data disolusi dengan program DDSolver menunjukkan bahwa pelepasan tablet floating teofilin mengikuti persamaan Weibull. Kurva disolusi berbentuk eksponensial dan pelepasan teofilin terjadi melalui mekanisme difusi. Kata kunci: tablet floating teofilin, DDSolver, pemodelan pelepasan obat. ABSTRACT The dissolution is an important element in drug development is mainly related to the absorption and bioavailability. The aim of this study was to determine in vitro dissolution study of theophylline floating tablet release kinetics model. The floating tablets were prepared by a wet granulation method with HPMC K4M CR, NaHCO3, lactose, and magnesium stearate as excipients. The result showed that the theophylline floating tablets had a weight uniformity (CV=1.93%), good hardness (8.4 kg), and low friability (0.05%). Dissolution data were evaluated using DDSolver conducted by 1). Statistical parameters: R2adjusted, mean square error (MSE), weighted sum of squares (WSS), akaike information criterion (AIC), model selection criterion (MSC); 2). Visual goodness of fit (GOF). The results showed that theophylline floating tablets release kinetics followed the Weibull equation. The dissolution curve is exponential shape and theophylline release occurs through a diffusion mechanism. Key words: floating tablet of theophylline, DDSolver, modeling of drug release.
THE EFFECTS OF HANDWASHING HABITS ON HEALTH PROTOCOLS ON SKIN HYDRATION LEVELS AND INCIDENCE OF IRRITANT CONTACT DERMATITIS Sustiawati _; Indri Hapsari; Irsalina Nurul Putri
Jurnal Farmasi Sains dan Praktis Vol 7 No 1 (2021)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i1.4667

Abstract

Background: Handwashing using soap or hand sanitizer is one of the health protocols that must be implemented by society to prevent the spreading of SARS-COV2 virus which can cause pneumonia, acute respiratory syndrome and death. The implementation of health protocols during the COVID-19 pandemic caused the habit of handwashing increase. Hence, it can lead to cause irritant contact dermatitis and dry hand skin due to frequent contact with soap or hand sanitizers. Method: This study is an observational study with the sample from the villager of Banyumas regency. The data collection was taken by cluster random sampling and accidental sampling. Results: Considering the health protocol, most of the villager used to wash their hands regularly and 3 respondents (3.00%) of them did not. 100 respondents took the data and 19 respondents (19.00%) have irritant contact dermatitis and the rest did not. Furthermore, for skin hydration levels with dehydration category (0% - 29%) are 50 respondents (50.00%), normal category (30% - 50%) are 38 respondents (38.00%) and hydration category (51% - 100 %) are 12 respondents (12.00%). Chi-Square analysis showed that there was no significant relationship between handwashing habit and the incidence of irritant contact dermatitis with the value of “P” is 0.394> 0.05 and there was a significant relationship between hand washing habits and skin hydration levels with the value of “P” is 0.010 <0, 05. Conclusion: Handwashing habits have a significant relationship to skin hydration levels.
THE INFLUENCES OF KNOWLEDGE, BEHAVIOUR AND ATTITUDE IN SELECTING POWDER TYPE: THE INCIDENCE OF ACNE VULGARIS Anggita Nur Fauzana; Indri Hapsari; Irsalina Nurul Putri; Githa Fungie Galistiani
Jurnal Farmasi Sains dan Praktis Vol 8 No 2 (May-August 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i2.4668

Abstract

Acne vulgaris is a chronic obstructive and inflammatory skin disease. It occurs in almost all adolescents with a prevalence of 90%. Powder is the most widely used cosmetic in the long term and one of the causes of Acne vulgaris which causes occlusion of pores on the skin surface. The purpose of this study was to analyze the effect of the level of knowledge, attitudes and behavior of choosing the type of powder on the incidence of acne vulgaris in Banyumas Regency. This study was an observational study with data collection techniques using cluster sampling and sampling technique by accidental sampling. The level of knowledge of women in the Banyumas Regency was dominated by the high category as many as 64 respondents (64.0%). The incidence of acne vulgaris out of 100 respondents, 67 (67.0%) of respondents had mild acne vulgaris, 22 respondents (22.0%) had moderate acne vulgaris and 1 respondent (1.0%) had severe acne vulgaris and the rest had no acne vulgaris. Chi-square analysis showed that there was a relationship between knowledge with behavior and attitude in choosing the type of powder to the incidence of acne vulgaris as evidenced by the p value of each variable, namely 0.044 and 0.028 (p <0.05). The level of knowledge with behavior and attitude in choosing the powder type had a significant relationship to the incidence of acne vulgaris in women in Banyumas Regency.
Co-Authors Agus Siswanto Anggita Nur Fauzana Anis Kusumawati Anjar Mahardian Kusuma Anwar Rosyadi Binar Asrining Dhiani Budiman, Arif Caesar, Rahma Yuanita Desy Sapmaimy Eva Rosmawati eva rosmawati Gayuh Kurniawan Genatrika, Erza Githa Fungie Galistiani Irsalina Nurul Putri Irsalina Nurul Putri Isna Nurkhikmah Pri Iswati Utami R. Adi Soeprijanto Rahma Yuanita Caesar Susmiatun Susmiatun susmiatun, susmiatun Sustiawati _ Wahyu Utaminingrum Yusni Ulfiani Zulaikha yusni ulfiani zulaikha